发布求助
文献互助 智能选刊 最新文献

European Journal of Cancer (1965)最新文献

筛选
英文 中文
Estrogen receptor assay: Interlaboratory and intralaboratory variations in the measurement of receptors using dextran-coated charcoal technique: A study sponsored by E.C.O.G. 雌激素受体测定:使用右旋糖酐包覆木炭技术测量受体的实验室间和实验室内变化:E.C.O.G.赞助的一项研究
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90267-X
Shanthi Raam , Rebecca Gelman , Joseph L. Cohen
{"title":"Estrogen receptor assay: Interlaboratory and intralaboratory variations in the measurement of receptors using dextran-coated charcoal technique: A study sponsored by E.C.O.G.","authors":"Shanthi Raam ,&nbsp;Rebecca Gelman ,&nbsp;Joseph L. Cohen","doi":"10.1016/0014-2964(81)90267-X","DOIUrl":"10.1016/0014-2964(81)90267-X","url":null,"abstract":"<div><p>Six laboratories performing estrogen receptor analysis in breast cancer for patients included in clinical protocols of the Eastern Cooperative Oncology Group participated in a quality control study for estrogen receptor assay. Three tissue powders containing <em>10–50 femtomoles</em> of estrogen receptors/<em>mg</em> cytosol protein were distributed and the results analyzed for interlaboratory and intralaboratory variations. Frequency of misclassification of the receptor-positive powders as receptor-negative was related to the quantity of receptors. All labs except one were able to distinguish “low content” from “medium content” and the “medium” from the “high content” powders despite the variability in the numerical values reported for the powders. Two of the six labs reported consistently low values for all samples and the results of one lab were consistently higher than the average of the values obtained for the powders. These results could not be explained by the variations in protein content reported by these laboratories for different powders. Implications of the degree of inter-lab and intra-lab variations in the assay results are discussed with reference to their effect on selecting patients for hormonal vs chemotherapy. Based on the results of this study, tentative suggestions for quality control for the receptor assay are also made.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 643-649"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90267-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17236851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Immunological properties of rat embryonal carcinoma cells 大鼠胚胎癌细胞的免疫学特性
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90262-0
B. Park, L. Van Hove , H. Sobis, M. Vandeputte
{"title":"Immunological properties of rat embryonal carcinoma cells","authors":"B. Park,&nbsp;L. Van Hove ,&nbsp;H. Sobis,&nbsp;M. Vandeputte","doi":"10.1016/0014-2964(81)90262-0","DOIUrl":"10.1016/0014-2964(81)90262-0","url":null,"abstract":"<div><p>The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by <em>in vivo</em> and <em>in vitro</em> assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 609-613"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90262-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17849007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synergism between hyperthermia and cyclophosphamide in vivo: The effect of dose fractionation 体内热疗与环磷酰胺的协同作用:剂量分级的影响
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90272-3
G. Hazan , E. Ben-Hur , A. Yerushalmi
{"title":"Synergism between hyperthermia and cyclophosphamide in vivo: The effect of dose fractionation","authors":"G. Hazan ,&nbsp;E. Ben-Hur ,&nbsp;A. Yerushalmi","doi":"10.1016/0014-2964(81)90272-3","DOIUrl":"10.1016/0014-2964(81)90272-3","url":null,"abstract":"<div><p>The synergistic anti-tumor interaction between heat and cyclophosphamide (CP) was investigated. Synergism between local hyperthermia (<em>42.5°C, 30 min</em>) and CP was observed in mice bearing the Lewis lung carcinoma tumor in their hind leg. Local hyperthermia reduced the CP dose needed for cure or a specific tumor growth delay. CP was less effective when given in fractions. A fractionated dose regimen was more effective than CP alone when combined with heat. The thermal enhancement ratio was larger when CP was administered in more than three fractions. It is concluded that combined heat and CP chemotherapy of cancer may be clinically feasible.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 681-684"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90272-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18320801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Antitumour activity of substituted 9-anilinoacridines—Comparison of in vivo and in vitro testing systems 取代9-苯胺吖啶的抗肿瘤活性——体内和体外测试系统的比较
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90271-1
Bruce C. Baguley , Rosalee Nash
{"title":"Antitumour activity of substituted 9-anilinoacridines—Comparison of in vivo and in vitro testing systems","authors":"Bruce C. Baguley ,&nbsp;Rosalee Nash","doi":"10.1016/0014-2964(81)90271-1","DOIUrl":"10.1016/0014-2964(81)90271-1","url":null,"abstract":"<div><p>The search for derivatives of <em>9</em>-anilinoacridine by Cain and co-workers <em>[1]</em> using murine <em>L1210</em> leukemia as a test system, culminated in the synthesis of <em>4′-(9</em>-acridinylamino)methanesulphon-<em>m</em>-anisidide (<em>m</em>-AMSA, NSC <em>249,992</em>), which is now undergoing clinical trial. The steps on the development of this and related compounds have been retraced using <em>L1210</em> cells in culture. The results obtained with the <em>in vitro</em> system have indicated <em>m</em>-AMSA to have an appropriate choice of substituents for optimal activity, in agreement with results of the corresponding <em>in vivo</em> test system. <em>m</em>-AMSA causes a <em>50</em>% inhibition of <em>L1210</em> cell growth in culture under standard conditions (<em>3</em> day cultures) at <em>3.5 × 10<sup>−8</sup> M</em>. Three compounds in which the substituent on the anilino ring contains a second benzene ring are highly active in culture, one being <em>100</em>-fold more active than <em>m</em>-AMSA.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 671-679"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90271-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17944228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
Tumor inhibition by metallocenes: Activity against leukemias and detection of the systemic effect 茂金属的肿瘤抑制作用:抗白血病活性及全身效应的检测
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90270-X
P. Köpf-Maier , W. Wagner , B. Hesse , H. Köpf
{"title":"Tumor inhibition by metallocenes: Activity against leukemias and detection of the systemic effect","authors":"P. Köpf-Maier ,&nbsp;W. Wagner ,&nbsp;B. Hesse ,&nbsp;H. Köpf","doi":"10.1016/0014-2964(81)90270-X","DOIUrl":"10.1016/0014-2964(81)90270-X","url":null,"abstract":"<div><p>The antitumor activity of two representatives of the metallocene dihalides, titanocene dichloride (TDC) and vanadocene dichloride (VDC), is investigated by the use of various experimental tumor systems. Against the lymphoid leukemia <em>L1210</em> and the lymphocytic leukemia <em>P388</em>, TDC and VDC induce significant increases of life span corresponding to T/C values which exceed <em>125%</em>. On treating advanced stages of fluid EAT with single doses, TDC causes, when applied within <em>5 days</em> after transplantation, the survival of <em>80–100%</em> of the treated animals, whereas VDC cures progressed stages of fluid EAT to a much minor extent. Investigations using a solid EAT subcutaneously growing in the nuchal region show that the intraperitoneally applied metallocene dihalides are able to inhibit tumor growth in a highly significant manner so that the minimum tumor sizes attain <em>14%</em> (TDC) or <em>31%</em> (VDC) of the control values. This result indicates that the antiproliferative activity of the metallocene dihalides is based on a systemic effect.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 665-669"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90270-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18320800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Recent journal contents 最近的日记账内容
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90278-4
{"title":"Recent journal contents","authors":"","doi":"10.1016/0014-2964(81)90278-4","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90278-4","url":null,"abstract":"","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Page 716"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90278-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72070331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious complications and host immune defense in acute leukemia 急性白血病的感染并发症与宿主免疫防御
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90263-2
Mila Nedelkova, Svetla Bacalova, Bojana Georgieva
{"title":"Infectious complications and host immune defense in acute leukemia","authors":"Mila Nedelkova,&nbsp;Svetla Bacalova,&nbsp;Bojana Georgieva","doi":"10.1016/0014-2964(81)90263-2","DOIUrl":"10.1016/0014-2964(81)90263-2","url":null,"abstract":"<div><p>Microbiological and immunological studies were carried out on <em>73</em> acute leukemia patients in order to establish the relationship between the host immune defense and the frequency and severity of infections. Pronounced disturbances in the functional activity of granulocytes, the total complement hemolytic activity and <em>C</em><sub>3</sub> component of the complement are found during induction chemotherapy; in this period the infectious complications are more frequent and severe than at the onset of the disease. No relationship is established between serum lysozyme levels and resistance to infections. The elevated immunoglobulins G and M as a possible response to the infectious agents are considered. It is emphasized that a pronounced immunosuppression as well as the most frequent infectious complications are found in patients in relapse.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 617-622"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90263-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18320795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A murine ovarian tumor with unique metastasizing capacity 一种具有独特转移能力的小鼠卵巢肿瘤
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90268-1
Giulio Alessandri, Raffaella Giavazzi, Paolo Falautano, Federico Spreafico, Silvio Garattini, Alberto Mantovani
{"title":"A murine ovarian tumor with unique metastasizing capacity","authors":"Giulio Alessandri,&nbsp;Raffaella Giavazzi,&nbsp;Paolo Falautano,&nbsp;Federico Spreafico,&nbsp;Silvio Garattini,&nbsp;Alberto Mantovani","doi":"10.1016/0014-2964(81)90268-1","DOIUrl":"10.1016/0014-2964(81)90268-1","url":null,"abstract":"<div><p>A transplanted murine ovarian tumor (M5076/73A, M5, of <span><math><mtext>C57B1</mtext><mtext>6</mtext></math></span> origin) with unique metastatic potential is described. After i.m. or s.c. inoculation of the <em>M5</em> ovarian tumor, spontaneous metastases were consistently observed in liver, spleen, kidney, ovary and uterus, but lung lesions were not usually found. Even after i.v. inoculation the tumor showed a selective tropism for the abdominal organs mentioned. When <em>M5</em> ovarian carcinoma cells were injected i.p., the tumor grew as scattered lesions in the abdomen and resulted in carcinomatous ascites. Surgical excision of i.m. tumors as early as <em>5days</em> after implantation failed to protect mice against metastases, suggesting early widespread dissemination from the primary lesion. The tumor was poorly immunogenic as assessed by <em>in vivo</em> immunization with irradiated cells and by concomitant immunity experiments.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 651-653"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90268-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18320798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Effects of cytosine arabinoside on DNA synthesis as predictor for acute myelocytic leukemia (AML) patients' response to chemotherapy 阿拉伯糖胞嘧啶对DNA合成的影响作为急性髓细胞白血病(AML)患者化疗反应的预测因子
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90264-4
Joshua Epstein, Harvey Preisler
{"title":"Effects of cytosine arabinoside on DNA synthesis as predictor for acute myelocytic leukemia (AML) patients' response to chemotherapy","authors":"Joshua Epstein,&nbsp;Harvey Preisler","doi":"10.1016/0014-2964(81)90264-4","DOIUrl":"10.1016/0014-2964(81)90264-4","url":null,"abstract":"<div><p>Bone marrow cells from <em>25</em> AML patients were exposed to cytosine arabinoside and the effects of the drug on the incorporation of <em><sup>3</sup>H</em>-TdR by the cells were measured and compared to the response of the patients to antileukemia chemotherapy with ara C and an anthracycline. The majority of the leukemic cells of the patients in whom bone marrow hypoplasia was not achieved as a result of treatment were classified as resistant to the drugs administered. Incubation with <em>0.3 μg/ml</em> ara C inhibited DNA synthesis in <em>11</em> of <em>12</em> resistant patients by <em>20–95%</em>. Exposure to <em>3.0 μg/ml</em> drug inhibited the incorporation of <em><sup>3</sup>H-TdR</em> in <em>10</em> of <em>11</em> resistant patients by <em>38–98%</em>. The <em>in vivo</em> resistance of the leukemic cells to ara C was not reflected by the <em>in vitro</em> response of the synthesis of DNA by these cells to ara C. The effects of ara C on DNA synthesis were also not correlated to the drug's effects on the clonogenic cells in <em>21</em> bone marrow specimens. We conclude that the effects of ara C on DNA synthesis are not predictive to a patient's response to therapy, nor do they reflect the cytocidal effects of the drug on the clonogenic cells.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 623-628"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90264-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17997244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Herpes Simplex Virus and human cancer. II. Search for relationship between labial tumours and Herpes Simplex Type 1 单纯疱疹病毒与人类癌症2寻找唇部肿瘤与1型单纯疱疹的关系
European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90274-7
E. Cassai , A. Rotola , D. Di Luca , R. Manservigi , G. Meneguzzi , G. Milanesi , A. Califano
{"title":"Herpes Simplex Virus and human cancer. II. Search for relationship between labial tumours and Herpes Simplex Type 1","authors":"E. Cassai ,&nbsp;A. Rotola ,&nbsp;D. Di Luca ,&nbsp;R. Manservigi ,&nbsp;G. Meneguzzi ,&nbsp;G. Milanesi ,&nbsp;A. Califano","doi":"10.1016/0014-2964(81)90274-7","DOIUrl":"10.1016/0014-2964(81)90274-7","url":null,"abstract":"<div><p>Cellular proliferation was obtained from <em>30</em> out of <em>58</em> labial tumours examined. None of the cellular cultures obtained presented Herpes Simplex Virus type <em>1</em> (HSV-<em>1</em>) specific antigens. Tumour cell cultures demonstrated the same susceptibility to HSV-<em>1</em> as cells from normal lip tissue, HEp-<em>2</em> and BHK cells. The presence of HSV-<em>1</em> DNA was investigated in <em>12</em> labial tumours by the blotting technique. The sensitivity of the technique made it possible to reveal <em>0.5</em> viral genome equivalent per cell. Viral DNA was not detected in any of the tumours tested.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 695-702"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90274-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17335068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信