European Journal of Cancer (1965)最新文献_第2页

Effect of presurgical radiotherapy on the steroid receptor concentrations in primary breast carcinoma 术前放疗对原发性乳腺癌激素受体浓度的影响

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90269-3

J.PH. Janssens, J. Bonte, A. Drochmans, J. Mulier, J. Rutten, C. Wittevrongel, W. De Loecker

引用次数: 18

Metastasis from the brain of transplanted N-ethyl-N-nitrosourea-induced central nervous system tumors in rats 移植的n -乙基-n -亚硝基源诱导的大鼠中枢神经系统肿瘤的脑转移

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90275-9

Ch.J. Vecht , M.J. Van Zwieten , B. Maat , D.W. Van Bekkum

{"title":"Metastasis from the brain of transplanted N-ethyl-N-nitrosourea-induced central nervous system tumors in rats","authors":"Ch.J. Vecht , M.J. Van Zwieten , B. Maat , D.W. Van Bekkum","doi":"10.1016/0014-2964(81)90275-9","DOIUrl":"10.1016/0014-2964(81)90275-9","url":null,"abstract":"<div>Two transplantable rat central nervous system (CNS) tumors induced by N-ethyl-N-nitrosourea (ENU) were employed to study the mechanisms controlling extracranial metastasis from intracranial tumors. Cells derived from a serially passaged anaplastic astrocytoma and a malignant glioma were injected intracerebrally at doses of 104, 105 and 106 cells per rat (Sprague-Dawley and WAG/Rij rats). As soon as neurological dysfunction appeared, animals were sacrificed and examined histologically for (1) extracerebral outgrowth of the intracerebral tumor, (2) the presence of distant metastases within the CNS and (3) remote metastases outside the CNS. In addition to histology, a bioassay procedure was performed. Metastases were found in cervical lymph nodes (74%), lung (21%) and liver (5%). For both tumor groups, rats with both distant CNS metastases and local extracerebral outgrowth developed remote metastases more frequently (P < 0.05) than animals with intracerebral growth only. The data indicate that both local extracranial spread due to surgical intervention as well as local and distant invasion of leptomeninges promote extracranial metastatic spread.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 703-710"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90275-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18320802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Herpes Simplex Virus and human cancer. I. Relationship between human cervical tumours and Herpes Simplex Type 2 单纯疱疹病毒与人类癌症人类宫颈肿瘤与单纯疱疹2型的关系

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90273-5

E. Cassai , A. Rotola , G. Meneguzzi , G. Milanesi , S. Garsia , G. Remotti, G. Rizzi

引用次数: 9

Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias 5-氟尿嘧啶加环磷酰胺对移植性白血病的细胞毒作用

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90265-6

Giovanni Santelli , Fred Valeriote , Teresa Vietti , Dean Coulter

引用次数: 7

Hormone-dependent uterine sarcomas in GR mice GR小鼠的激素依赖性子宫肉瘤

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90266-8

Per Briand , Klaus Hou-Jensen , Susan M. Thorpe , Carsten Rose

引用次数: 11

Estrogens, estradiol receptors and peroxidase activity in human mammary carcinomas 乳腺癌中的雌激素、雌二醇受体和过氧化物酶活性

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90276-0

M.J. Duffy , M. O'Connell

引用次数: 11

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—I 奥扎磷细胞抑制剂的尿毒性及其预防研究——Ⅰ

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI: 10.1016/0014-2964(81)90261-9

Norbert Brock, Jörg Pohl, Jurij Stekar

{"title":"Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention—I","authors":"Norbert Brock, Jörg Pohl, Jurij Stekar","doi":"10.1016/0014-2964(81)90261-9","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90261-9","url":null,"abstract":"<div>The urotoxic potency of various (mainly alkylating) drugs was studied in an extensive series of experiments. It was found that damage to the kidneys and to the efferent urinary tract (haemorrhagic cystitis) is a specific side effect of compounds possessing the oxazaphosphorine ring. This effect is due to the renal excretion of toxic metabolites. The only carriers of urotoxicity are the renally eliminated fractions of the 4-hydroxy-oxazaphosphorines and acrolein which is formed spontaneously therefrom. Other oxazaphosphorine metabolites and breakdown products such as the directly alkylating phosphoric acid diamides, 4-keto-derivatives and carboxyderivatives, have at most only a very slight urotoxic potency. The relationships between the chemical structure and the urotoxicity have been clarified in the group of oxazaphosphorines. Using a standardised test model (rat) the urotoxic side effects of cytostatics were studied experimentally and were measured quantitatively. The urotoxic effects were found to be dose- and concentration-dependent and also showed a marked dependence on the pH. The manifestations of inflammation were more pronounced in an alkaline than in an acidic milieu.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 595-607"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90261-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72071302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 108

Melanoma of the skin: The problem of resection margins 皮肤黑色素瘤:切除边缘的问题

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90062-1

F. Rampen

引用次数: 22

Dose-dependent suppression of DNA synthesis in vitro as a predictor of clinical response in adult acute myeloblastic leukemia 体外DNA合成的剂量依赖性抑制作为成人急性髓母细胞白血病临床反应的预测因子

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90057-8

Gary M. Dosik , Barthel Barlogie , Dennis Johnston , David Mellard , Emil J Freireich

{"title":"Dose-dependent suppression of DNA synthesis in vitro as a predictor of clinical response in adult acute myeloblastic leukemia","authors":"Gary M. Dosik , Barthel Barlogie , Dennis Johnston , David Mellard , Emil J Freireich","doi":"10.1016/0014-2964(81)90057-8","DOIUrl":"10.1016/0014-2964(81)90057-8","url":null,"abstract":"<div>We determined for 14 patients with acute myeloblastic leukemia, prior to therapy with an anthracycline-ara-C combination, the relationship of clinical response to dose-dependent DNA synthesis inhibition produced by each agent on each patient's cultured leukemic cells. Using a microculture system ara-C and adriamycin sensitivity (D2) was determined for each patient based upon each individual's dose response curve. The 9 patients achieving complete remission and one patient who died during induction had D2 values to both agents less than 7, while 4 non-responding patients had D2 values in excess of 9. Correlation of D2 levels with in vivo chemotherapy-induced bone marrow cytoreduction was noted for adriamycin (P < 0.005) and for ara-C (P = 0.1). A relationship between in vitro ara-C and adriamycin sensitivity (P < 0.05) suggests that they act upon similar leukemic cell populations. Inhibition of thymidine synthesis over a range of concentrations deserves further study as a rapid in vitro test for drug sensitivity in acute myeloblastic leukemia.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 549-555"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90057-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17992704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Inhibition by chemotherapeutic agents of human bone marrow progenitor cells and clonogenic cells of a lymphoblastic cell line 化疗药物对人骨髓祖细胞和淋巴母细胞系克隆细胞的抑制作用

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90053-0

C.K.Oladipupo Williams , Takao Ohnuma, James F. Holland

{"title":"Inhibition by chemotherapeutic agents of human bone marrow progenitor cells and clonogenic cells of a lymphoblastic cell line","authors":"C.K.Oladipupo Williams , Takao Ohnuma, James F. Holland","doi":"10.1016/0014-2964(81)90053-0","DOIUrl":"10.1016/0014-2964(81)90053-0","url":null,"abstract":"<div>Using methylcellulose based semi-solid medium enriched with complete alpha medium and undialysed fetal calf serum, we compared the cytotoxic effects between the clonogenic cell (CFU) of a lymphoblastic leukemia cell line (MOLT-4) and normal bone marrow granulocytic progenitor cells (CFU-C) of methotrexate (MTX), vincristine (VCR), hydrocortisone (HC) and daunorubicin (DNR), as well as the reversibility by leukovorin (LV) of MTX cytotoxicity. The neoplastic cells were more markedly inhibited by MTX, VCR and HC following either brief or continuous exposure of the cell to the drugs. Inhibition by DNR was identical for both cell types. In order to reverse the inhibitory effects of MTX in MOLT-4 CFU, LV concentrations needed were at least one log order higher than MTX concentrations. At higher concentrations of MTX, LV reversal was less effective. Only one of four different human bone marrows studied were significantly inhibited by MTX under the experimental conditions. It is suggested that the high concentrations of nucleosides and deoxynucleosides present in the medium aborted the MTX cytotoxicity on CFU-C of normal human marrow but not on MOLT-4 CFU, while the differential inhibition observed with VCR and HC was due to greater sensitivity of the leukemic cells.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 519-526"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90053-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18022977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5