European Journal of Cancer (1965)最新文献_第3页

Progestogen and oestrogen receptor activity in ovary-dependent and ovary-independent tumours of the rat 大鼠卵巢依赖性和卵巢非依赖性肿瘤中孕激素和雌激素受体的活性

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90061-X

R.A. Hawkins, A. Tesdale , B. Freedman , J. Telford, W.R. Miller

引用次数: 1

Variant translocation in a non endemic case of Burkitt's lymphoma: t (8;22) in an Epstein-Barr virus negative tumour and in a derived cell line 伯基特淋巴瘤非地方性病例的变异易位:t(8;22)在Epstein-Barr病毒阴性肿瘤和衍生细胞系

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90060-8

Suzanne Bertrand , Roland Berger , Thierry Philip , Alain Bernheim , Paul-Andre Bryon , Jacques Bertoglio , Jean-Franc̊ois Doré , Maud Brunat-Mentigny , Gilbert M. Lenoir

引用次数: 36

Oestrogen receptor assay—Limitation of the method 雌激素受体测定方法的局限性

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90050-5

Hans Skovgaard Poulsen

{"title":"Oestrogen receptor assay—Limitation of the method","authors":"Hans Skovgaard Poulsen","doi":"10.1016/0014-2964(81)90050-5","DOIUrl":"10.1016/0014-2964(81)90050-5","url":null,"abstract":"<div>The variability of estimates of Kd and binding capacity (fmol oestrogen bound/mg cytosol protein) of oestrogen receptors (RC) which may arise from different cytosol protein concentrations (0.25–5 mg/ml), different charcoal concentrations (0.25–5 mg/ml) and cytosols from different, histologically comparable portions of the same tumour has been studied using a dextran-coated charcoal (DCC) assay. Kd value correlated positively to protein concentration and negatively to charcoal concentration, whereas the binding capacity remained constant over a wide range of protein concentrations. In receptor-poor tumours, low cytosol protein contents precluded a distinction between specific and non-specific oestrogen binding. Both in receptor-rich and receptor-poor tumours, increasing charcoal concentrations added to the incubation mixture decreased the cytosol protein concentration and thus removed RC complexes as well as excess of oestrogen. Both in receptor-rich and receptor-poor tumours, a wide variation in recptor content was observed within histologically comparable portions of the same tumour (from 0 to 300 fmol/mg protein).</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 495-501"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90050-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18312050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Third meeting of the European hyperthermia group 欧洲热疗小组第三次会议

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90066-9

引用次数: 0

Studies on the high- and low-affinity rosette-forming T-lymphocytes in patients with Hodgkin's and non-Hodgkin's lymphoma 霍奇金淋巴瘤和非霍奇金淋巴瘤患者高亲和力和低亲和力玫瑰花形t淋巴细胞的研究

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90059-1

Salam Kadhim , Robert C. Rees , Christopher W. Potter , Richard Walker , Barry W. Hancock

{"title":"Studies on the high- and low-affinity rosette-forming T-lymphocytes in patients with Hodgkin's and non-Hodgkin's lymphoma","authors":"Salam Kadhim , Robert C. Rees , Christopher W. Potter , Richard Walker , Barry W. Hancock","doi":"10.1016/0014-2964(81)90059-1","DOIUrl":"10.1016/0014-2964(81)90059-1","url":null,"abstract":"<div>The total number of lymphocytes and the number and proportion of high-(29°C) and low- (4°C) affinity E (erythrocyte) rosette-forming cells (RFC) from the peripheral blood of 33 patients with Hodgkin's and 41 patients with non-Hodgkin's lymphoma was assessed, and compared with results obtained from normal controls. Analysis of results was performed on groups of patients subdivided according to age, histological type and stage of disease. Patients with Hodgkin's disease showed a decrease in RFC which was attributed to a reduction in low-affinity RFC; this decrease could not be related to any particular histological type or stage of disease. Patients with non-Hodgkin's lymphoma showed, in addition to a decrease in low-affinity RFC, a significant decrease in high-affinity RFC. The observed decrease in peripheral blood T cell numbers of non-Hodgkin's lymphoma patients did not correlate with the type of disease, but patients with clinical stage IV showed a more pronounced reduction in the number of high- and low-affinity RFC when compared with other groups.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 569-575"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90059-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18022978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The origin of metastatic heterogeneity in tumors 肿瘤转移异质性的起源

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90049-9

I.J. Fidler, I.R. Hart

{"title":"The origin of metastatic heterogeneity in tumors","authors":"I.J. Fidler, I.R. Hart","doi":"10.1016/0014-2964(81)90049-9","DOIUrl":"10.1016/0014-2964(81)90049-9","url":null,"abstract":"<div>These studies were conducted to determine whether the metastatic heterogeneity that is frequently observed in primary neoplasms is a consequence of multicellular transformation or acquired genetic variability. <math><mtext>BALB</mtext><mtext>c</mtext></math> embryo fibroblasts were infected in vitro with mouse sarcoma virus. Six tumor colonies, each derived from a single transformed cell, were isolated and propagated as individual cell lines. Twenty-four days after virus infection, mice were injected s.c. or i.v. with viable cells harvested from the individual lines. Subcutaneous tumors developed in nearly all of the mice and regressed 30 days after inoculation. In contrast, the production of lung tumor colonies varied significantly among the cell lines. Moreover, the individual lines were found to be heterogeneous. This conclusion is based on results of experiments in which two cell lines exhibiting either a low or high propensity to produce lung tumor colonies were subcloned. Cells from these subclones were injected i.v. into syngeneic mice. The subclones differed significantly among themselves and from the parent culture in their ability to produce lung tumor colonies. We conclude that regardless of whether neoplasms are unicellular or multicellular in origin, they can be heterogeneous and contain subpopulations of cells with different metastatic properties by the time of diagnosis.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 487-491"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90049-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17333988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 91

Urinary putrescine and plasma lactate dehydrogenase as markers of experimental adenocarcinoma growth 尿腐胺和血浆乳酸脱氢酶作为实验性腺癌生长的标志物

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90052-9

Siw Anehus , Gun Bengtsson , Gunnar Andersson , Göran Carlsson , Larsolof Hafström , Torsten Yngner , Olle Heby

{"title":"Urinary putrescine and plasma lactate dehydrogenase as markers of experimental adenocarcinoma growth","authors":"Siw Anehus , Gun Bengtsson , Gunnar Andersson , Göran Carlsson , Larsolof Hafström , Torsten Yngner , Olle Heby","doi":"10.1016/0014-2964(81)90052-9","DOIUrl":"10.1016/0014-2964(81)90052-9","url":null,"abstract":"<div>The objective of this study was to assess, in a controlled experimental system, whether changes in urinary polyamine excretion reflect growth of a solid tumor, and whether such changes are dependent on the location of the tumor. A transplantable N-methyl-N′-nitro-N-nitrosoguanidine-induced adenocarcinoma (NG-W1) was grown intrahepatically or s.c. in male Wistar rats. Tumor size was measured at various time intervals and blood samples and 24-hr urines were collected. Analyses of 24-hr urines for their polyamine content, using a thin-layer chromatographic method for the separation of the dansylated polyamine derivatives, revealed a positive correlation between the 24-hr putrescine output and the increasing tumor burden. Notably, the 24-hr urine volume was found to parallel the increase in 24-hr putrescine excretion. The 24-hr urinary excretion of spermidine remained constant throughout tumor growth as did that of creatinine. Analyses of blood plasma for its lactate dehydrogenase activity, using a spectrophotometric technique, indicated no relationship between plasma lactate dehydrogenase activity and tumor burden, except at a large tumor mass. The increase in 24-hr urinary putrescine excretion in rats harboring an intrahepatic tumor preceded that which occurred in rats harboring an s.c. tumor. This time lapse was attributable to the fact that the tumor growth characteristics, including vascularization, differed between the two locations; intrahepatic tumors having more extensive growth and better vascularization than s.c. tumors. The fact that the urine putrescine excretion, particularly in a site such as the liver, is an early marker of tumor progression, indicates that this polyamine may be helpful in appraising relapse and recurrence of cancer.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 5","pages":"Pages 511-518"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90052-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18312051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Radiation response of two human malignant melanomas grown in athymic nude mice 两种人类恶性黑色素瘤在胸腺裸鼠体内生长的辐射反应

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90054-2

T.P. Flaten, E.K. Rofstad, T. Brustad

引用次数: 25

Observations on pulmonary metastases in patients after single doses and multiple fractions of fast neutrons and cobalt-60 gamma rays 快中子和钴-60伽马射线单剂量和多组分照射后患者肺转移的观察

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90056-6

Jan.J. Battermann , Klaas Breur , Guus A.M. Hart , Henny A. van Peperzeel

引用次数: 158

Third breast cancer working conference of the E.O.R.T.C. breast cancer cooperative group 中华民国癌症乳腺癌合作小组第三届癌症工作会议

European Journal of Cancer (1965) Pub Date : 1981-05-01 DOI: 10.1016/0014-2964(81)90065-7

引用次数: 0