{"title":"大鼠胚胎癌细胞的免疫学特性","authors":"B. Park, L. Van Hove , H. Sobis, M. Vandeputte","doi":"10.1016/0014-2964(81)90262-0","DOIUrl":null,"url":null,"abstract":"<div><p>The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by <em>in vivo</em> and <em>in vitro</em> assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 609-613"},"PeriodicalIF":0.0000,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90262-0","citationCount":"4","resultStr":"{\"title\":\"Immunological properties of rat embryonal carcinoma cells\",\"authors\":\"B. Park, L. Van Hove , H. Sobis, M. Vandeputte\",\"doi\":\"10.1016/0014-2964(81)90262-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by <em>in vivo</em> and <em>in vitro</em> assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.</p></div>\",\"PeriodicalId\":100497,\"journal\":{\"name\":\"European Journal of Cancer (1965)\",\"volume\":\"17 6\",\"pages\":\"Pages 609-613\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0014-2964(81)90262-0\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer (1965)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0014296481902620\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481902620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunological properties of rat embryonal carcinoma cells
The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by in vivo and in vitro assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.
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