单纯疱疹病毒与人类癌症2寻找唇部肿瘤与1型单纯疱疹的关系

European Journal of Cancer (1965) Pub Date : 1981-06-01 DOI:10.1016/0014-2964(81)90274-7

E. Cassai , A. Rotola , D. Di Luca , R. Manservigi , G. Meneguzzi , G. Milanesi , A. Califano

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引用次数: 9

摘要

58例阴唇肿瘤中有30例出现细胞增殖。所有细胞培养均未出现1型单纯疱疹病毒(HSV-1)特异性抗原。肿瘤细胞培养显示出与正常唇组织、HEp-2和BHK细胞相同的对HSV-1的敏感性。用印迹法检测了12例阴唇肿瘤中HSV-1 DNA的存在。该技术的灵敏度使得每个细胞可以显示0.5个病毒基因组当量。在所有被检测的肿瘤中都没有检测到病毒DNA。

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Herpes Simplex Virus and human cancer. II. Search for relationship between labial tumours and Herpes Simplex Type 1

Cellular proliferation was obtained from 30 out of 58 labial tumours examined. None of the cellular cultures obtained presented Herpes Simplex Virus type 1 (HSV-1) specific antigens. Tumour cell cultures demonstrated the same susceptibility to HSV-1 as cells from normal lip tissue, HEp-2 and BHK cells. The presence of HSV-1 DNA was investigated in 12 labial tumours by the blotting technique. The sensitivity of the technique made it possible to reveal 0.5 viral genome equivalent per cell. Viral DNA was not detected in any of the tumours tested.

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来源期刊

European Journal of Cancer (1965)

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