M. Edery , J. Goussard , L. Dehennin , R. Scholler , J. Reiffsteck , M.A. Drosdowsky
{"title":"用质谱和放射免疫分析法测定乳腺肿瘤中内源性雌二醇-17β的浓度：与受体含量的关系","authors":"M. Edery , J. Goussard , L. Dehennin , R. Scholler , J. Reiffsteck , M.A. Drosdowsky","doi":"10.1016/0014-2964(81)90220-6","DOIUrl":null,"url":null,"abstract":"<div><p>Oestradiol-<em>17</em>β was determined in human breast tumours by radioimmunoassay and gas chromatography-mass spectrometry. Simultaneous determination of the oestradiol and progesterone receptor content was carried out. Oestradiol receptor positive tumours contained a greater statistically significant oestradiol concentration than receptor negative tumours.</p><p>Our results indicate that (a) the use of gas chromatography-mass spectrometry is more valid in measuring endogenous oestradiol-<em>17</em>β content, (b) false negative receptor assays due to the presence of endogenous oestrogens are unlikely.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 115-120"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90220-6","citationCount":"103","resultStr":"{\"title\":\"Endogenous oestradiol-17β concentration in breast tumours determined by mass fragmentography and by radioimmunoassay: Relationship to receptor content\",\"authors\":\"M. Edery , J. Goussard , L. Dehennin , R. Scholler , J. Reiffsteck , M.A. Drosdowsky\",\"doi\":\"10.1016/0014-2964(81)90220-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oestradiol-<em>17</em>β was determined in human breast tumours by radioimmunoassay and gas chromatography-mass spectrometry. Simultaneous determination of the oestradiol and progesterone receptor content was carried out. Oestradiol receptor positive tumours contained a greater statistically significant oestradiol concentration than receptor negative tumours.</p><p>Our results indicate that (a) the use of gas chromatography-mass spectrometry is more valid in measuring endogenous oestradiol-<em>17</em>β content, (b) false negative receptor assays due to the presence of endogenous oestrogens are unlikely.</p></div>\",\"PeriodicalId\":100497,\"journal\":{\"name\":\"European Journal of Cancer (1965)\",\"volume\":\"17 1\",\"pages\":\"Pages 115-120\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0014-2964(81)90220-6\",\"citationCount\":\"103\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer (1965)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0014296481902206\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481902206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Endogenous oestradiol-17β concentration in breast tumours determined by mass fragmentography and by radioimmunoassay: Relationship to receptor content
Oestradiol-17β was determined in human breast tumours by radioimmunoassay and gas chromatography-mass spectrometry. Simultaneous determination of the oestradiol and progesterone receptor content was carried out. Oestradiol receptor positive tumours contained a greater statistically significant oestradiol concentration than receptor negative tumours.
Our results indicate that (a) the use of gas chromatography-mass spectrometry is more valid in measuring endogenous oestradiol-17β content, (b) false negative receptor assays due to the presence of endogenous oestrogens are unlikely.
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