Effect of an aromatic retinoic acid analog (Ro 10-9359) on growth of virus-induced papilloma (Shope) and related neoplasia of rabbits

Yohei Ito
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引用次数: 25

Abstract

An aromatic analog of retinoic acid (Ro 10-9359), a synthetic compound known to arrest development and growth of chemically-induced skin papillomas and carcinomas of mice, exerts a marked inhibitory effect on induction and development of virus-induced papilloma (Shope) of rabbit skin. The intramuscular administration of 12.5, 50 and 200 mg/kg given twice weekly during the induction phase of the neoplasia substantially inhibited the growth of the papilloma, this inhibition being dose-dependent. When the animals bearing well-established tumors were given a relatively large dose (200 mg/kg) of the compound, there was remarkable inhibition of the papillomatous growths and complete regression occurred in about 60%. The transplantable carcinomas Vx2 and Vx7, both of which originated from the Shope virus-induced papilloma, were less sensitive than their original papillomas to this treatment.

芳香族维甲酸类似物(ro10 -9359)对兔病毒诱导乳头状瘤(Shope)及相关肿瘤生长的影响
维甲酸(Ro 10-9359)的芳香类似物(Ro 10-9359)对兔皮肤病毒乳头瘤(Shope)的诱导和发展有明显的抑制作用。维甲酸是一种合成化合物,已知可阻止化学诱导的小鼠皮肤乳头瘤和癌的发育和生长。在瘤变诱导阶段,肌肉注射12.5、50和200 mg/kg,每周两次,显著抑制了乳头状瘤的生长,这种抑制作用是剂量依赖性的。当已形成肿瘤的动物被给予相对大剂量(200 mg/kg)的化合物时,乳头状瘤的生长有显著的抑制作用,约60%的乳头状瘤完全消退。可移植癌Vx2和Vx7,都起源于Shope病毒诱导的乳头瘤,对这种治疗的敏感性低于其原始乳头瘤。
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