{"title":"Effect of an aromatic retinoic acid analog (Ro 10-9359) on growth of virus-induced papilloma (Shope) and related neoplasia of rabbits","authors":"Yohei Ito","doi":"10.1016/0014-2964(81)90209-7","DOIUrl":null,"url":null,"abstract":"<div><p>An aromatic analog of retinoic acid (Ro <em>10-9359</em>), a synthetic compound known to arrest development and growth of chemically-induced skin papillomas and carcinomas of mice, exerts a marked inhibitory effect on induction and development of virus-induced papilloma (Shope) of rabbit skin. The intramuscular administration of <em>12.5, 50</em> and <em>200 mg/kg</em> given twice weekly during the induction phase of the neoplasia substantially inhibited the growth of the papilloma, this inhibition being dose-dependent. When the animals bearing well-established tumors were given a relatively large dose <em>(200 mg/kg)</em> of the compound, there was remarkable inhibition of the papillomatous growths and complete regression occurred in about <em>60%</em>. The transplantable carcinomas Vx<em>2</em> and Vx<em>7</em>, both of which originated from the Shope virus-induced papilloma, were less sensitive than their original papillomas to this treatment.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 35-42"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90209-7","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481902097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 25
Abstract
An aromatic analog of retinoic acid (Ro 10-9359), a synthetic compound known to arrest development and growth of chemically-induced skin papillomas and carcinomas of mice, exerts a marked inhibitory effect on induction and development of virus-induced papilloma (Shope) of rabbit skin. The intramuscular administration of 12.5, 50 and 200 mg/kg given twice weekly during the induction phase of the neoplasia substantially inhibited the growth of the papilloma, this inhibition being dose-dependent. When the animals bearing well-established tumors were given a relatively large dose (200 mg/kg) of the compound, there was remarkable inhibition of the papillomatous growths and complete regression occurred in about 60%. The transplantable carcinomas Vx2 and Vx7, both of which originated from the Shope virus-induced papilloma, were less sensitive than their original papillomas to this treatment.