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European Journal of Cancer (1965)最新文献

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European organization for research on treatment of cancer 欧洲癌症治疗研究组织
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90048-7
{"title":"European organization for research on treatment of cancer","authors":"","doi":"10.1016/0014-2964(81)90048-7","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90048-7","url":null,"abstract":"","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Page 262"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90048-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72047743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Liver cell control after discontinuation of DENA feeding in hepatocarcinogenesis 停止DENA喂养后肝细胞在肝癌发生中的控制
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90029-3
H. Barbason, E.H. Betz
{"title":"Liver cell control after discontinuation of DENA feeding in hepatocarcinogenesis","authors":"H. Barbason,&nbsp;E.H. Betz","doi":"10.1016/0014-2964(81)90029-3","DOIUrl":"10.1016/0014-2964(81)90029-3","url":null,"abstract":"<div><p>The mitotic response following a partial hepatectomy, the nyctohemeral rhythm of these mitoses and the ‘chalone activity’ measured by the inhibitory effect of liver extracts on the normal liver regeneration have been studied in order to estimate the evolution of mitotic control in the liver of rats treated by DENA for <em>2, 4, 6</em> and <em>10</em> weeks. These parameters and the pathological lesions (preneoplastic foci, neoplastic nodules and hepatomas) have been followed up after stopping the DENA feeding. A good correlation has been found between the malignant transformation of preneoplastic foci and the breakdown of the mitotic control. In animals treated by DENA for two weeks, the homeostatic control of mitoses remains normal for a minimum of <em>14</em> months and ‘preneoplastic foci’ persist without any further malignant transformation. After DENA feeding for <em>4</em> and <em>6</em> weeks, the subsequent malignant transformation occurs as a function of the mitotic disturbance: the longer the DENA feeding, the faster the homeostatic disturbance, the earlier the conceration. After DENA treatment for <em>10</em> weeks, the homeostatic regulation is lost and the neoplastic growth is triggered at the time of the DENA feeding cessation. In this case, the pattern of canceration is the same as when DENA is given continuously up to the time of death. It is concluded that ‘preneoplastic foci’ induced during the first two weeks of treatment cannot by themselves transform into a malignant tumor. To commit them irreversibly into malignancy, a subsequent action of the carcinogen is necessary; it may consist of the irreversible breakdown of the normal homostatic regulatory mechanism of liver cell proliferation.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 149-154"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90029-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17514361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
International conference on prostaglandins and cancer 1981 1981年前列腺素与癌症国际会议
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90047-5
{"title":"International conference on prostaglandins and cancer 1981","authors":"","doi":"10.1016/0014-2964(81)90047-5","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90047-5","url":null,"abstract":"","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Page 261"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90047-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72064475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined endocrine therapy and chemotherapy of mouse mammary tumors 小鼠乳腺肿瘤的内分泌联合化疗
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90030-X
Mels Sluyser, C.C.J. De Goeij, S.G. Evers
{"title":"Combined endocrine therapy and chemotherapy of mouse mammary tumors","authors":"Mels Sluyser,&nbsp;C.C.J. De Goeij,&nbsp;S.G. Evers","doi":"10.1016/0014-2964(81)90030-X","DOIUrl":"10.1016/0014-2964(81)90030-X","url":null,"abstract":"<div><p>Hormone-responsive mammary tumors of GR mice were treated with tamoxifen, cyclophosphamide, or with both drugs combined. Tamoxifen alone or cyclophosphamide alone caused inhibition of tumor growth, but more growth inhibition was obtained with the combined therapy.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 155-159"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90030-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Moloney murine leukemia virus variants with distinct p30 peptide maps are associated with different clinical types of leukemia 具有不同p30肽图的Moloney小鼠白血病病毒变体与不同临床类型的白血病相关
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90035-9
Birgitta Åsjö , Elena Buetti , Eva-Maria Fenyö , Heidi Diggelmann , George Klein
{"title":"Moloney murine leukemia virus variants with distinct p30 peptide maps are associated with different clinical types of leukemia","authors":"Birgitta Åsjö ,&nbsp;Elena Buetti ,&nbsp;Eva-Maria Fenyö ,&nbsp;Heidi Diggelmann ,&nbsp;George Klein","doi":"10.1016/0014-2964(81)90035-9","DOIUrl":"10.1016/0014-2964(81)90035-9","url":null,"abstract":"<div><p>Mouse leukemias arising after neonatal inoculation of Moloney MuLV (M-MuLV) are of two main types. One is characterized by enlargement of spleen and lymph nodes, and has a normal diploid karyotype. Thymus enlargement is the most prominent feature of the second type, with or without spleen involvement. About half of the thymomas are trisomic with an extra chromosome <em>15</em>. C-type viruses isolated from the two leukemia types differed with regard to their <em>p30</em> peptide maps. The <em>p30s</em> isolated from the preleukemic tissues of a <em>4-weeks</em>-old, neonatally MuLV-inoculated mouse were either of the ‘thymic’ or the ‘splenic’ type. These results suggest that the two virus types were already present in the original inoculum and had homed to different tissues. The peptide maps of the corresponding <em>gp70</em> molecules showed no organ-related pattern: each virus isolate had a distinct <em>gp70</em> profile.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 187-192"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90035-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Estimation of differential in vitro sensitivity of non-hodgkin lymphomas to anticancer drugs 非霍奇金淋巴瘤对抗癌药物体外敏感性差异的评估
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90039-6
Ornella Sanfilippo , Maria Grazia Daidone , Aurora Costa , Renzo Canetta , Rosella Silvestrini
{"title":"Estimation of differential in vitro sensitivity of non-hodgkin lymphomas to anticancer drugs","authors":"Ornella Sanfilippo ,&nbsp;Maria Grazia Daidone ,&nbsp;Aurora Costa ,&nbsp;Renzo Canetta ,&nbsp;Rosella Silvestrini","doi":"10.1016/0014-2964(81)90039-6","DOIUrl":"10.1016/0014-2964(81)90039-6","url":null,"abstract":"<div><p>The sensitivity to adriamycin, prednisolone, bleomycin and vincristine of human lymphoma cells in short-term culture was studied in <em>30</em> non-Hodgkin lymphomas (NHL). As indicators of drug action, the interference on [<em><sup>3</sup>H</em>]thymidine and [<em><sup>3</sup>H</em>]uridine incorporation was studied. The <em>in vitro</em> sensitivity to the drugs was then compared with the clinical response to treatment. On the basis of the retrospective analysis the <em>in vitro</em> sensitivity indexes were defined taking into account the biologic aggressivity of the tumor. A statistically significant correlation between the <em>in vitro</em> sensitivity to adriamycin and prednisolone and complete remission, relapse-free time and survival was observed in highly proliferative NHL, while in low proliferative NHL the <em>in vitro</em> sensitivity was statistically associated only to relapse-free survival within <em>22</em> months.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 217-226"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90039-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17232278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Prognostic significance of serum proteins in invasive bladder cancer 血清蛋白在侵袭性膀胱癌症中的预后意义
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90044-X
J. O'Quigley , Sarah Haworth , E.H. Cooper , W. Haije , B. Van der Werf-Messing , B. Richard , M.R.G. Robinson
{"title":"Prognostic significance of serum proteins in invasive bladder cancer","authors":"J. O'Quigley ,&nbsp;Sarah Haworth ,&nbsp;E.H. Cooper ,&nbsp;W. Haije ,&nbsp;B. Van der Werf-Messing ,&nbsp;B. Richard ,&nbsp;M.R.G. Robinson","doi":"10.1016/0014-2964(81)90044-X","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90044-X","url":null,"abstract":"<div><p>This study demonstrates that the survivial of patients with UICC category <em>T3</em> and <em>T4</em> bladder cancer is strongly correlated with pre-treatment levels of serum acute phase reactant proteins and albumin. A more accurate assessment of the prognosis is obtained than by considering stage and the type of operation alone.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 251-255"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90044-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72100876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Effects of several dimethylbenzacridines on secondary hamster embryo cells: Neoplastic transformation 几种二甲基苯并吖啶对继发性仓鼠胚胎细胞的影响:肿瘤转化
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90034-7
D. Papadopoulo, S. Levy, V. Poirier, C. Pene, P. Markovits, M. Hubert-Habart
{"title":"Effects of several dimethylbenzacridines on secondary hamster embryo cells: Neoplastic transformation","authors":"D. Papadopoulo,&nbsp;S. Levy,&nbsp;V. Poirier,&nbsp;C. Pene,&nbsp;P. Markovits,&nbsp;M. Hubert-Habart","doi":"10.1016/0014-2964(81)90034-7","DOIUrl":"10.1016/0014-2964(81)90034-7","url":null,"abstract":"<div><p>Several dimethylbenz[c]acridines and their isomers dimethylbenz[a]acridines were studied for their capacity to induce malignant transformation in secondary hamster embryo cells. Transformation was evaluated by the ability of transformed cells to provoke tumor formation in syngenic animals. <em>7,8</em>-Dimethylbenz[c]acridine, <em>7,10</em>-dimethylbenz[c]acridine, as well as a mixture of both, caused malignant transformation of hamster embryo cells, but not <em>7,9</em>-dimethylbenz[c]acridine. Cultures treated with <em>10,12</em>-dimethylbenz[a]acridine and <em>9,12</em>-dimethylbenz[a]acridine did not become malignant and showed a decreased life-span <em>in vitro</em>. Untreated control cells retained their original characteristics and when injected in animals did not produce tumors throughout the whole experiment.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 179-186"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90034-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Use of serial carcinoembryonic antigen assays in detecting relapses in breast cancer involving high risk of metastasis 使用系列癌胚抗原检测乳腺癌复发的高风险转移
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90041-4
J.F. Chatal, F. Chupin, G. Ricolleau, J.L. Tellier, A. Le Mevel, P. Fumoleau, O. Godin, B.P. Le Mevel
{"title":"Use of serial carcinoembryonic antigen assays in detecting relapses in breast cancer involving high risk of metastasis","authors":"J.F. Chatal,&nbsp;F. Chupin,&nbsp;G. Ricolleau,&nbsp;J.L. Tellier,&nbsp;A. Le Mevel,&nbsp;P. Fumoleau,&nbsp;O. Godin,&nbsp;B.P. Le Mevel","doi":"10.1016/0014-2964(81)90041-4","DOIUrl":"10.1016/0014-2964(81)90041-4","url":null,"abstract":"<div><p>Serial CEA assays on serum using the direct radioimmunoassay method (Marcoule, France) were performed on <em>76</em> breast cancer patients with node involvement or rapid local development of tumors who were undergoing chemotherapy. The patients were followed up for a mean period of <em>28 months</em>, and assays were repeated every <em>2.5 months</em> on average. Out of <em>521</em> assays performed on <em>49</em> patients who remained in complete remission, there were 37 instances of significant, but transitory, rise in CEA level which, in <em>8</em> cases, could be attributed to intercurrent benign inflammation. In <em>15</em> out of <em>27</em> patients who had relapses, there was a significant and persistent rise in CEA level which, in <em>11</em> cases, preceded clinical signs by <em>6 months</em> on average. In the <em>12</em> other cases, CEA level remained constant and normal despite relapse.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 233-238"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90041-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
A phase II study of oral VP-16-213 in non-seminomatous testicular cancer 口服VP-16-213治疗非半瘤性睾丸癌的II期研究
European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90043-8
F. Cavalli , O. Klepp , J. Renard , M. Röhrt , P. Alberto , for the E.O.R.T.C. Early Clinical Trials Group
{"title":"A phase II study of oral VP-16-213 in non-seminomatous testicular cancer","authors":"F. Cavalli ,&nbsp;O. Klepp ,&nbsp;J. Renard ,&nbsp;M. Röhrt ,&nbsp;P. Alberto ,&nbsp;for the E.O.R.T.C. Early Clinical Trials Group","doi":"10.1016/0014-2964(81)90043-8","DOIUrl":"10.1016/0014-2964(81)90043-8","url":null,"abstract":"<div><p>In a disease-oriented phase <em>II</em> study, thirty-three patients with advanced non-seminomatous testicular cancer were treated with oral <em>VP-16-213 175 mg/m<sup>2</sup>/day</em> for three consecutive days repeated every week. All patients had previously received extensive chemotherapy and twenty patients also had prior radiotherapy, Of <em>30</em> evaluable patients, <em>6</em> experienced partial remission for a median duration of <em>3.5 months</em>, whereas minor regression or stabilization of the disease was achieved in <em>7</em> patients for a median duration of <em>2.5 months</em>. Leukopenia was dose-limiting and resulted in dose reduction or treatment delay in <em>55%</em> of the scheduled courses. The definite antitumor activity of <em>VP-16-213</em> in non-seminomatous testicular cancer warrants its incorporation into combination chemotherapy for this disease.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 245-249"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90043-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
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