Clinical Immunology Communications最新文献_第4页

Erratum to “A case of de novo seronegative inflammatory oligoarthritis associated with COVID-19 infection” Clinical Immunology Communications 2 (2022) 159–161/ “1例新发血清阴性炎性少关节炎合并COVID-19感染”临床免疫通讯2 (2022)159-161 /

Clinical Immunology Communications Pub Date : 2023-04-14 DOI: 10.1016/j.clicom.2023.03.001

Lily H. Sung , Natalya Surmachevska , Jose E. Rubio

引用次数: 0

X-Linked Inhibitor of Apoptosis (XIAP) deficiency presenting as hemophagocytic lymphohistiocytosis triggered by drug allergy X-Linked Inhibitor of Apoptosis (XIAP)缺乏表现为药物过敏引起的噬血细胞性淋巴组织细胞增多症

Clinical Immunology Communications Pub Date : 2023-02-24 DOI: 10.1016/j.clicom.2023.02.008

Amer Khojah , Ameera Bukhari , Aaruni Khanolkar , Imad Khojah , Abigail Lang

{"title":"X-Linked Inhibitor of Apoptosis (XIAP) deficiency presenting as hemophagocytic lymphohistiocytosis triggered by drug allergy","authors":"Amer Khojah , Ameera Bukhari , Aaruni Khanolkar , Imad Khojah , Abigail Lang","doi":"10.1016/j.clicom.2023.02.008","DOIUrl":"https://doi.org/10.1016/j.clicom.2023.02.008","url":null,"abstract":"<div>X-linked inhibitor of apoptosis (XIAP) deficiency is a primary immunodeficiency associated with recurrent hemophagocytic lymphohistiocytosis (HLH) episodes. The clinical phenotypes of XIAP deficiency vary, ranging from splenomegaly to life-threatening inflammation. We report a case of XIAP deficiency with unusual late-onset HLH presentation likely triggered by a drug allergy. A previously healthy adolescent boy presented to the hospital with fever and rash seven days after starting antibiotics for a neck abscess. Laboratory evaluation demonstrated cytopenias, elevated liver enzymes, and increased inflammatory markers. Initially, antibiotics were discontinued due to concern for drug rash. He continued to deteriorate clinically and became hypotensive. Additional testing revealed decreased NK cell function, as well as elevated ferritin, triglycerides, and soluble IL-2 receptor. SLAM-Associated Protein (SAP) and XIAP evaluation by flow cytometry demonstrated decreased XIAP expression. Subsequently, genetic testing revealed a known pathogenic mutation in BIRC4 (c.421_422del), confirming the diagnosis of XIAP deficiency.</div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49765146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic COVID-19大流行期间未经治疗的青少年皮肌炎儿童NK细胞数量降低

Clinical Immunology Communications Pub Date : 2023-02-18 DOI: 10.1016/j.clicom.2023.02.007

Christopher Costin , Gabrielle Morgan , Amer Khojah , Marisa Klein-Gitelman , Lauren M. Pachman

引用次数: 4

HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood 儿童早期自身免疫性中性粒细胞减少症患者的HNA特异性及其与HLA-DRB1和-DQB1的相关性

Clinical Immunology Communications Pub Date : 2023-02-14 DOI: 10.1016/j.clicom.2023.02.002

Kirstine Kløve-Mogensen , Rudi Steffensen , Hans Linde Nielsen , Tania Nicole Masmas , Andreas Glenthøj , Christina Friis Jensen , Thure Mors Haunstrup , Paul Ratcliffe , Petter Höglund , Henrik Hasle , Kaspar René Nielsen

{"title":"HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood","authors":"Kirstine Kløve-Mogensen , Rudi Steffensen , Hans Linde Nielsen , Tania Nicole Masmas , Andreas Glenthøj , Christina Friis Jensen , Thure Mors Haunstrup , Paul Ratcliffe , Petter Höglund , Henrik Hasle , Kaspar René Nielsen","doi":"10.1016/j.clicom.2023.02.002","DOIUrl":"https://doi.org/10.1016/j.clicom.2023.02.002","url":null,"abstract":"<div>Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte antigens (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in 160 antibody positive patients and compared with 1000 controls. Increased risk was observed for DRB1*10, DRB1*14, DRB1*16 and DQB1*05, and lower risk for DRB1*04, DRB1*13 and DQB1*03. Haplotypes with higher risk included: DRB1*10/DQB1*05, DRB1*14/DQB1*05 and DRB1*16/DQB1*05, while DRB1*04/DQB1*03, DRB1*07/DQB1*02, and DRB1*13/DQB1*06 were associated with lower risk. Associated HLA-DRB1 and –DQB1 differed between patients positive for anti-HNA-1a-specific antibodies and patients positive for broad reactive anti-FcγRIIIb antibodies. DRB1*01, DRB1*04 and DQB1*03 was only associated for anti-HNA-1a positive, and DRB1*10 was restricted to broad reactive anti-FcγRIIIb positive. Strong association between AIN and HLA-DRB1 and -DQB1 alleles and haplotypes suggested that they play a role in susceptibility or protection. Different associations regarding FcγRIIIb antibody specificities could indicate disease heterogeneity.</div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49749432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of mortality in patients with COVID-19 by flow cytometry 流式细胞术预测COVID-19患者死亡率

Clinical Immunology Communications Pub Date : 2023-02-11 DOI: 10.1016/j.clicom.2023.02.003

Marco Bonilla Izquierdo , Ana María Navas Romo , Aurora Gema Sicilia Zafra , Juan de Dios López-González Garrido

引用次数: 0

Protective role of human beta-defensin-2 and cathelicidin in high risk close household contacts of pulmonary tuberculosis 人β-防御素-2和组织蛋白酶对肺结核高危家庭密切接触者的保护作用

Clinical Immunology Communications Pub Date : 2023-02-10 DOI: 10.1016/j.clicom.2023.02.006

Sudhasini Panda , Shah Faisal , Diravya M Seelan , Manisha Dagar , Lokesh Mandlecha , Vidushi Varshney , Mridul Sharma , Kalpana Luthra , Neeraj Kumar Gupta , Archana Singh

{"title":"Protective role of human beta-defensin-2 and cathelicidin in high risk close household contacts of pulmonary tuberculosis","authors":"Sudhasini Panda , Shah Faisal , Diravya M Seelan , Manisha Dagar , Lokesh Mandlecha , Vidushi Varshney , Mridul Sharma , Kalpana Luthra , Neeraj Kumar Gupta , Archana Singh","doi":"10.1016/j.clicom.2023.02.006","DOIUrl":"https://doi.org/10.1016/j.clicom.2023.02.006","url":null,"abstract":"<div>Host-defense peptides (HDPs) such as human beta-defensin-2 (hBD-2) and cathelicidin (LL37) are essential components of innate immune response against tuberculosis (TB) infection, which could also be assessed for diagnostic potential in spectrum of TB infection. We assessed mRNA and circulating levels of HDPs in pulmonary TB (PTB) patients and their household contacts (HHCs). hBD-2 and LL37 were found to be significantly higher in both PTB and HHCs suggestive of bacterial exposure which was further corroborated by higher levels of HDPs in mantoux positive HHCs (latent TB). Higher levels of HDPs in HHCs may suggest protective host response against infection as indicated by inverse relation of LL37 with disease severity in PTB. Both peptides demonstrated high levels of sensitivity and specificity, although hBD-2 proved to be a better HDP for distinguishing LTBI from active TB at a cutoff of 3904 pg/ml. However, follow-up studies are required to validate these findings.</div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49749275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Interleukin-6 blockade a viable strategy to prevent progression of acute respiratory distress syndrome in non-COVID viral pneumonia? 白细胞介素-6阻断是预防非covid病毒肺炎急性呼吸窘迫综合征进展的可行策略吗?

Clinical Immunology Communications Pub Date : 2023-02-10 DOI: 10.1016/j.clicom.2023.02.004

Rana Prathap Padappayil , Siva Naga S. Yarrarapu , Raghu Tiperneni , Boning Li

引用次数: 0

GROWTH HORMONE, IMMUNOSENESCENCE AND VACCINATION FAILURE IN THE ELDERLY 老年人的生长激素、免疫衰老和疫苗接种失败

Clinical Immunology Communications Pub Date : 2023-02-10 DOI: 10.1016/j.clicom.2023.02.005

José E Belizário, Miguel Garay-Malpartida

{"title":"GROWTH HORMONE, IMMUNOSENESCENCE AND VACCINATION FAILURE IN THE ELDERLY","authors":"José E Belizário, Miguel Garay-Malpartida","doi":"10.1016/j.clicom.2023.02.005","DOIUrl":"https://doi.org/10.1016/j.clicom.2023.02.005","url":null,"abstract":"<div>In the aging population, the longitudinal decrease in the secretion of steroidal and polypeptides growth hormones is directly associated with accumulation of senescent cells in tissues and organs. The cellular hypo-replicative senescence state is caused by metabolic stress and persistent DNA damage, which lead to the activation of the p16INK4a cell-cycle inhibitor, retinoblastoma and p53 pathways. Aging increases the susceptibility to physical frailty, sarcopenia, diabetes, atherosclerosis, infectious disease and cancer in the older adults. As a consequence of immunosenescence and reduced immunoreactivity of the innate and adaptive systems, seniors have a weak response to vaccination. The high doses of vaccines have been recommended to boost growth and activation of memory T and B cells in non-responsive older individuals, but it is not sufficient for long-term protection. The treatment with recombinant human growth hormone has been shown to regenerate thymus and increase the repertoire of naive T cells CD4+ and CD8+ T cell and B cell subsets in people with age-related diseases, chronic viral infection and immunodeficiencies. This review presents an update on senescence biology and their clinical immunological manifestations in the elderly. We describe possible immune mechanisms by which personalized recombinant growth hormone therapy could act to prolong the effectiveness of the vaccines recommended to older adults.</div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49765148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis of humoral and cellular immunity after SARS-CoV-2 vaccination in patients with multiple sclerosis treated with immunomodulatory drugs 免疫调节药物治疗多发性硬化症患者接种SARS-CoV-2疫苗后体液免疫和细胞免疫分析

Clinical Immunology Communications Pub Date : 2023-02-04 DOI: 10.1016/j.clicom.2023.02.001

Virginia Meca-Lallana , Laura Esparcia-Pinedo , Clara Aguirre , Carolina Díaz-Pérez , Ainhoa Gutierrez-Cobos , Mónica Sobrado , Estefanía Carabajal , Beatriz del Río , Noelia Ropero , Ramón Villagrasa , José Vivancos , Francisco Sanchez-Madrid , Arantzazu Alfranca

引用次数: 1

Partial recovery of SARS-CoV-2 immunity after booster vaccination in renal transplant recipients 肾移植受者加强接种后SARS-CoV-2免疫的部分恢复

Clinical Immunology Communications Pub Date : 2022-12-11 DOI: 10.1016/j.clicom.2022.12.001

J.M. Urra , P. Castro , N. Jiménez , E. Moral , C. Vozmediano

{"title":"Partial recovery of SARS-CoV-2 immunity after booster vaccination in renal transplant recipients","authors":"J.M. Urra , P. Castro , N. Jiménez , E. Moral , C. Vozmediano","doi":"10.1016/j.clicom.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.clicom.2022.12.001","url":null,"abstract":"<div>The pandemic caused by the SARS-CoV-2 coronavirus has been especially detrimental to patients with end-stage renal disease. History with other vaccines suggests that patients with renal disease may not respond adequately to the SARS-CoV-2 vaccine. The aim of this study is to evaluate the immunity to SARS-CoV-2 mRNA vaccines in renal patients. Post SARS-CoV-2 vaccination first, and after the booster dose, antibodies and cellular immunity were studied in patients on hemodialysis (N = 20), peritoneal dialysis (N = 10) and renal transplantation (N = 10). After the two doses of vaccine, there was an effective immunity in dialysis patients, with 100% seroconversion and 87% detection of cellular immunity (85% in hemodialysis and 90% in peritoneal dialysis). In contrast, in renal transplant recipients there was only 50% seroconversion and cellular immunity was detected in 30% of patients. After the booster dose, all dialysis patients achieved a cellular and antibody immunity, whereas in transplant patients, despite improvement, 20% did not produce antibodies and in 37.5% cellular immunity could not be detected. The mRNA vaccine plus booster performs excellently in dialysis patients, whereas in kidney transplant recipients, despite the booster, complete immunization is not achieved.</div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49749322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1