Anti-Saccharomyces cerevisiae (ASCA) in patients with severe obesity undergoing bariatric surgery: 12-month follow-up.

Clinical Immunology Communications Pub Date : 2024-02-09 DOI:10.1016/j.clicom.2024.02.001

Emerita Quintina de Andrade Moura , Bruno Fonseca Nunes , Letícia de Oliveira Souza Bratti , Fabíola Branco Filippin Monteiro

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Abstract

Severe obesity is linked to a low-grade inflammatory process due to enlarged adipose tissue, resulting in elevated pro-inflammatory cytokines. Bariatric surgery induces anatomical changes, causing intestinal inflammation marked by anti-Saccharomyces cerevisiae (ASCA) antibodies. This study aimed to assess ASCA IgG/IgA levels preoperatively and 12 months post-surgery, correlating them with systemic inflammation markers (IL-6, CRP, MCP-1). Participants (BMI > 35 kg/m²) were recruited in South Brazil. Severe obesity individuals showed elevated IL-6 (p = 0.002), CRP (p<0.0001), and MCP-1 (p<0.0001) compared to lean controls. ASCA IgA was significantly higher in severe obesity (p = 0.0019). Post-surgery, ASCA IgG/IgA significantly decreased (p = 0.0046 and p<0.0001), along with IL-6, MCP-1, and CRP, confirming weight loss and reduced inflammation. Hypertrophic adipose tissue, producing pro-inflammatory cytokines, associates with increased intestinal inflammation. Bariatric surgery-induced anatomical changes contribute to long-term weight loss and reduced systemic and intestinal inflammation.

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对接受减肥手术的重度肥胖症患者进行抗酵母菌（ASCA）治疗：12 个月随访。

严重肥胖与低度炎症过程有关，因为脂肪组织增大，导致促炎细胞因子升高。减肥手术会引起解剖学上的变化，导致肠道炎症，并以抗酵母菌（ASCA）抗体为标志。本研究旨在评估术前和术后 12 个月的 ASCA IgG/IgA 水平，并将其与全身炎症指标（IL-6、CRP、MCP-1）相关联。我们在南巴西招募了一些参与者（体重指数为 35 kg/m2）。与瘦对照组相比，重度肥胖者的 IL-6 (p = 0.002)、CRP (p<0.0001) 和 MCP-1 (p<0.0001) 均有所升高。严重肥胖者的 ASCA IgA 明显更高（p = 0.0019）。手术后，ASCA IgG/IgA 明显降低（p = 0.0046 和 p<0.0001），IL-6、MCP-1 和 CRP 也明显降低，证实了体重减轻和炎症减轻。肥胖的脂肪组织会产生促炎细胞因子，与肠道炎症的增加有关。减肥手术引起的解剖学变化有助于长期减轻体重，减少全身和肠道炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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