Anti-Saccharomyces cerevisiae (ASCA) in patients with severe obesity undergoing bariatric surgery: 12-month follow-up.

Emerita Quintina de Andrade Moura , Bruno Fonseca Nunes , Letícia de Oliveira Souza Bratti , Fabíola Branco Filippin Monteiro
{"title":"Anti-Saccharomyces cerevisiae (ASCA) in patients with severe obesity undergoing bariatric surgery: 12-month follow-up.","authors":"Emerita Quintina de Andrade Moura ,&nbsp;Bruno Fonseca Nunes ,&nbsp;Letícia de Oliveira Souza Bratti ,&nbsp;Fabíola Branco Filippin Monteiro","doi":"10.1016/j.clicom.2024.02.001","DOIUrl":null,"url":null,"abstract":"<div><p>Severe obesity is linked to a low-grade inflammatory process due to enlarged adipose tissue, resulting in elevated pro-inflammatory cytokines. Bariatric surgery induces anatomical changes, causing intestinal inflammation marked by anti-Saccharomyces cerevisiae (ASCA) antibodies. This study aimed to assess ASCA IgG/IgA levels preoperatively and 12 months post-surgery, correlating them with systemic inflammation markers (IL-6, CRP, MCP-1). Participants (BMI &gt; 35 kg/m<sup>2</sup>) were recruited in South Brazil. Severe obesity individuals showed elevated IL-6 (<em>p</em> = 0.002), CRP (<em>p</em>&lt;0.0001), and MCP-1 (<em>p</em>&lt;0.0001) compared to lean controls. ASCA IgA was significantly higher in severe obesity (<em>p</em> = 0.0019). Post-surgery, ASCA IgG/IgA significantly decreased (<em>p</em> = 0.0046 and <em>p</em>&lt;0.0001), along with IL-6, MCP-1, and CRP, confirming weight loss and reduced inflammation. Hypertrophic adipose tissue, producing pro-inflammatory cytokines, associates with increased intestinal inflammation. Bariatric surgery-induced anatomical changes contribute to long-term weight loss and reduced systemic and intestinal inflammation.</p></div>","PeriodicalId":100269,"journal":{"name":"Clinical Immunology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772613424000027/pdfft?md5=c057dcb1c1af28dc7e6c2a63f5eb5bcd&pid=1-s2.0-S2772613424000027-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Immunology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772613424000027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Severe obesity is linked to a low-grade inflammatory process due to enlarged adipose tissue, resulting in elevated pro-inflammatory cytokines. Bariatric surgery induces anatomical changes, causing intestinal inflammation marked by anti-Saccharomyces cerevisiae (ASCA) antibodies. This study aimed to assess ASCA IgG/IgA levels preoperatively and 12 months post-surgery, correlating them with systemic inflammation markers (IL-6, CRP, MCP-1). Participants (BMI > 35 kg/m2) were recruited in South Brazil. Severe obesity individuals showed elevated IL-6 (p = 0.002), CRP (p<0.0001), and MCP-1 (p<0.0001) compared to lean controls. ASCA IgA was significantly higher in severe obesity (p = 0.0019). Post-surgery, ASCA IgG/IgA significantly decreased (p = 0.0046 and p<0.0001), along with IL-6, MCP-1, and CRP, confirming weight loss and reduced inflammation. Hypertrophic adipose tissue, producing pro-inflammatory cytokines, associates with increased intestinal inflammation. Bariatric surgery-induced anatomical changes contribute to long-term weight loss and reduced systemic and intestinal inflammation.

对接受减肥手术的重度肥胖症患者进行抗酵母菌(ASCA)治疗:12 个月随访。
严重肥胖与低度炎症过程有关,因为脂肪组织增大,导致促炎细胞因子升高。减肥手术会引起解剖学上的变化,导致肠道炎症,并以抗酵母菌(ASCA)抗体为标志。本研究旨在评估术前和术后 12 个月的 ASCA IgG/IgA 水平,并将其与全身炎症指标(IL-6、CRP、MCP-1)相关联。我们在南巴西招募了一些参与者(体重指数为 35 kg/m2)。与瘦对照组相比,重度肥胖者的 IL-6 (p = 0.002)、CRP (p<0.0001) 和 MCP-1 (p<0.0001) 均有所升高。严重肥胖者的 ASCA IgA 明显更高(p = 0.0019)。手术后,ASCA IgG/IgA 明显降低(p = 0.0046 和 p<0.0001),IL-6、MCP-1 和 CRP 也明显降低,证实了体重减轻和炎症减轻。肥胖的脂肪组织会产生促炎细胞因子,与肠道炎症的增加有关。减肥手术引起的解剖学变化有助于长期减轻体重,减少全身和肠道炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信