成人抗IFNγ自身抗体患者的弥散性结核、巨细胞病毒血症和噬血细胞淋巴组织囊积综合征——病例报告和简要回顾

G.I. Butel-Simoes , C. Kiss , K. Kong , L.B. Rosen , L.M. Hosking , S. Barnes , G.A. Jenkin , S. Megaloudis , B. Kumar , S.M. Holland , S. Ojaimi
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引用次数: 0

摘要

我们报告了一例患有播散性肺结核、巨细胞病毒血症和吞噬细胞性淋巴组织囊肿综合征的成年女性病例,该综合征与中和性抗干扰素γ(IFNγ)自身抗体相关,在患者血清存在的情况下,通过缺乏IFNγ刺激的STAT1磷酸化来证明。还简要介绍了抗IFNγ自身抗体引起的免疫缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review

We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of patient sera. A brief review of immunodeficiency caused by anti-IFNγ autoantibodies is also described.

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