TBE-antibody titer study: Is a booster already necessary after 5 years?

Clinical Immunology Communications Pub Date : 2023-11-09 DOI:10.1016/j.clicom.2023.11.001

Katharina Mahlfleisch, Susanne Pauschenwein, Thomas Pekar

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Abstract

As long as there is only symptomatic treatment against thick-borne encephalitis (TBE) available, vaccination is considered the only prevention against infection.

The national vaccination recommendations prescribe a booster vaccination every 5 years after a basic vaccination has been carried out. This study deals with the question if antibodies in sufficient concentration exist or not when the last immunization had been five years ago.

The TBE titer was determined in 168 subjects using indirect ELISA and the vaccination history was collected.

The results show that 97.3 % of the participants have a sufficient titer 5 years after the last booster vaccination. The time period since the last booster and the type of the vaccine influence the antibody level the most. In conclusion, it was found that by controlling the titer, it is possible to postpone a booster vaccination, if the immunization is still sufficient.

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tbe抗体滴度研究:5年后是否需要加强?

只要对厚源性脑炎(TBE)只有对症治疗，疫苗接种就被认为是预防感染的唯一方法。国家疫苗接种建议规定，在进行基本疫苗接种后，每5年进行一次加强疫苗接种。本研究涉及的问题，是否有足够浓度的抗体存在时，最后一次免疫是在五年前。采用间接ELISA法测定168例患者的TBE滴度，并收集疫苗接种史。结果显示，97.3%的参与者在最后一次加强疫苗接种5年后有足够的滴度。自最后一次加强疫苗以来的时间周期和疫苗类型对抗体水平影响最大。总之，通过控制滴度，如果免疫仍然足够，可以推迟加强疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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