Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis

Clinical Immunology Communications Pub Date : 2024-02-22 DOI:10.1016/j.clicom.2024.02.002

Amer Khojah , Madeline Schutt , Gabrielle Morgan , Ameera Bukhari , Nicolas Bensen , Aaruni Khanolkar , Lauren M. Pachman

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Abstract

This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ T cells decreased from 5.1 to 2.9 (P < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (P < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (r = 0.39, P = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ T cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ T cells percentage and neopterin levels. A correlation between HLA-DR+ T cells percentage and serum neopterin was noted in untreated JDM patients.

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未经治疗的幼年皮肌炎患者中 HLA-DR T 细胞比例增加

本研究调查了幼年皮肌炎（JDM）儿童治疗前后活化 T 细胞上的 HLA-DR 表达和血清蝶呤水平。研究共纳入 69 名 JDM 儿童（18 岁以下）。在19%的未治疗病例中观察到HLA-DR+ T细胞升高（7%）。治疗后，HLA-DR+ T 细胞平均值从 5.1 降至 2.9（P <0.001），血清新蝶呤水平从 19.3 降至 9.1 nmol/L（P <0.0001）。血清蝶呤与 HLA-DR T 细胞百分比呈正相关（r = 0.39，P = 0.01）。静脉注射类固醇治疗后，HLA-DR+ T 细胞的比例提高了 47.4%，血清蝶呤水平降低了 50.5%，而口服类固醇组的比例分别为 14.8% 和 34.1%。总之，治疗（尤其是静脉注射类固醇）能明显改善 HLA-DR+ T 细胞的比例和新蝶呤水平。在未经治疗的 JDM 患者中，HLA-DR+ T 细胞百分比与血清蝶呤之间存在相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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