Advanced Sensor Research最新文献_第2页

Laser-Induced Graphene Cantilever Airflow Sensor Fabricated via Laser Cutting and Folding a Copper–Polyimide Film 用激光切割和折叠铜-聚酰亚胺薄膜制备激光诱导石墨烯悬臂式气流传感器

IF 3.5

Advanced Sensor Research Pub Date : 2025-08-19 DOI: 10.1002/adsr.202500091

Kei Ohara, Ryusei Ando, Kyota Shimada, Takuto Kishimoto, Rihachiro Nakashima, Hidetoshi Takahashi

{"title":"Laser-Induced Graphene Cantilever Airflow Sensor Fabricated via Laser Cutting and Folding a Copper–Polyimide Film","authors":"Kei Ohara, Ryusei Ando, Kyota Shimada, Takuto Kishimoto, Rihachiro Nakashima, Hidetoshi Takahashi","doi":"10.1002/adsr.202500091","DOIUrl":"https://doi.org/10.1002/adsr.202500091","url":null,"abstract":"Various animals in nature, particularly insects, are equipped with sensory hair capable of detecting minute fluid forces. Inspired by these biological structures, numerous airflow sensors have been developed using Si-based microelectromechanical systems. However, the complexity of the fabrication process and difficulty in integrating shape-controlled sensing elements remain significant challenges. Laser-induced graphene (LIG) has attracted increasing attention as a promising material for various physical sensors, owing to its high piezoresistive sensitivity and simple fabrication process. Polyimide (PI), which is widely used as a substrate for LIG formation, exhibits thermoplastic properties that enable the straightforward creation of 3D structures. This study proposes a single-axis airflow sensor featuring a vertically standing LIG cantilever. The fabrication process involved only a fiber laser for cutting the PI film, forming the LIG-sensing elements, and folding the cantilever structure. The fabricated sensor measured 25 mm × 25 mm at the base and 10.5 mm high. The fabricated sensor integrated surface-mounted circuits within its base. Wind tunnel experiments demonstrate that the sensor exhibits a quadratic response to wind speeds between −10 and 10 m s−1. This approach offers promising prospects for the development of 3D LIG sensing elements for airflow sensors.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Printed Recyclable and Flexible Thermocouple Temperature Sensors (Adv. Sensor Res. 8/2025) 印刷可回收和柔性热电偶温度传感器（ad . Sensor Res. 8/2025）

IF 3.5

Advanced Sensor Research Pub Date : 2025-08-08 DOI: 10.1002/adsr.70050

Xiaotao Wang, Lin Guo, Qihao Zhang, Yevhen Zabila, Rui Xu, Denys Makarov

引用次数: 0

Issue Information (Adv. Sensor Res. 8/2025) 发布信息（Adv. Sensor Res. 8/2025）

IF 3.5

Advanced Sensor Research Pub Date : 2025-08-08 DOI: 10.1002/adsr.70008

引用次数: 0

Ultrasensitive Detection of FKBP12 Using a Synthetic Receptor-Functionalized QCM Nanoplatform 利用合成受体功能化QCM纳米平台超灵敏检测FKBP12

IF 3.5

Advanced Sensor Research Pub Date : 2025-08-07 DOI: 10.1002/adsr.202500053

Martina Tozzetti, Maria Raffaella Martina, Giacomo Lucchesi, Kristian Vasa, Ahtsham Ishaq, Laura Marsili, Piero Procacci, Stefano Menichetti, Gabriella Caminati

{"title":"Ultrasensitive Detection of FKBP12 Using a Synthetic Receptor-Functionalized QCM Nanoplatform","authors":"Martina Tozzetti, Maria Raffaella Martina, Giacomo Lucchesi, Kristian Vasa, Ahtsham Ishaq, Laura Marsili, Piero Procacci, Stefano Menichetti, Gabriella Caminati","doi":"10.1002/adsr.202500053","DOIUrl":"https://doi.org/10.1002/adsr.202500053","url":null,"abstract":"FKBP12, a peptidyl-prolyl isomerase implicated in cancer, neurodegenerative diseases, and post-transplant anti-rejection mechanisms, represents a critical biomarker for early diagnosis and monitoring. Here, a novel diagnostic nanoplatform is presented for the detection of FKBP12 at nanomolar to picomolar concentrations in biological fluids. The platform integrates a gold-coated Quartz Crystal Microbalance (QCM) functionalized with a synthetic receptor (GPS-SH1) and spacers within a Self-Assembled Monolayer (SAM), enabling direct and label-free detection of FKBP12 in complex biological samples. A careful strategy for the in-silico design and custom synthesis of the receptor is adopted, ensuring optimal binding affinity and additional chemical functionalities for surface chemisorption. The designed nano-architecture demonstrates exceptional sensitivity, with a detection limit in the picomolar range, and high selectivity, as confirmed by minimal interference from abundant serum proteins such as Serum Albumin and Immune Gamma Globulin. Furthermore, the SAM-functionalized sensors exhibit remarkable stability, retaining functionality for up to six months under storage conditions. This work not only advances the field of nanoscale biosensing but also provides a robust, reusable tool for FKBP12 detection, with potential applications in point-of-care diagnostics and personalized medicine. The platform's ability to operate in biologically relevant environments underscores its promise for real-world healthcare applications, including early disease diagnostics.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-Based Optical Biosensors for SARS-CoV-2 Detection: A Retrospective of the Pandemic 基于纳米材料的SARS-CoV-2光学生物传感器：大流行回顾

IF 3.5

Advanced Sensor Research Pub Date : 2025-08-06 DOI: 10.1002/adsr.202400188

Flavie Martin, Scott G. Harroun, Michel Meunier

{"title":"Nanomaterial-Based Optical Biosensors for SARS-CoV-2 Detection: A Retrospective of the Pandemic","authors":"Flavie Martin, Scott G. Harroun, Michel Meunier","doi":"10.1002/adsr.202400188","DOIUrl":"10.1002/adsr.202400188","url":null,"abstract":"From 2020 to 2023, the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global health crisis, as millions of people worldwide contracted the coronavirus disease of 2019 (COVID-19). Conventional diagnostic techniques, such as reverse transcription-quantitative polymerase chain reaction (RT-PCR), struggled to meet increasing testing needs required for a pandemic owing to significant downsides hindering their large-scale use. In efforts to curb the effects of the pandemic and to meet the increasing demand for fast and accurate point-of-care (POC) testing, scientists and industries alike raced to engineer new diagnosis methods and adapt previously developed ones. Now that the COVID-19 pandemic has passed, the present review aims to provide the reader with an overview of recent advances in biosensing resulting from these efforts and to offer insight for future pandemics. This review focuses on nanomaterial-based optical biosensors, which are central to multiple emerging diagnostic tools. It covers techniques such as lateral flow immunoassays (LFIA), plasmonic biosensors based on surface plasmon resonance (SPR) and localized SPR (LSPR), surface-enhanced Raman spectroscopy (SERS), and surface-enhanced fluorescence (SEF). LFIAs played an important role in the COVID-19 pandemic and will continue to shape biosensing in future pandemics, while other techniques are yet to reach commercialization despite recent strides.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Polydioxanone as a Substrate for Fully Resorbable Implantable Sensors 探索聚二氧杂环酮作为完全可吸收植入式传感器的衬底

IF 3.5

Advanced Sensor Research Pub Date : 2025-07-30 DOI: 10.1002/adsr.202400157

Finn Jaekel, Rakesh Nair, Laura Teuerle, Hans Kleemann, Kai Uhlig, Anna Katharina Sambale, Daniel C. Freund, Dennis Wahl, Eberhard Grambow, Sebastian Hinz, Clemens Schafmayer, Jochen Hampe, Karl Leo

{"title":"Exploring Polydioxanone as a Substrate for Fully Resorbable Implantable Sensors","authors":"Finn Jaekel, Rakesh Nair, Laura Teuerle, Hans Kleemann, Kai Uhlig, Anna Katharina Sambale, Daniel C. Freund, Dennis Wahl, Eberhard Grambow, Sebastian Hinz, Clemens Schafmayer, Jochen Hampe, Karl Leo","doi":"10.1002/adsr.202400157","DOIUrl":"https://doi.org/10.1002/adsr.202400157","url":null,"abstract":"Implantable and resorbable electronic devices show excellent potential for short-term medical monitoring, especially in the context of post-surgical care. Bioresorbable sensors are of special interest, as they eliminate the need for surgical retrieval, thereby reducing patient risk and clinical burden. In this work, Polydioxanone (PDO) is explored, a medically licensed, flexible, resorbable material, as a promising substrate for the integration of bioresorbable electronic components. Using a targeted, bottom-up approach, the feasibility of integrating basic electronic elements and sensors is demonstrated directly on PDO, including resistive temperature sensors, conductivity sensors for electrolytic environments, organic electrochemical transistors, and passive antennas for potential wireless communication. This work highlights the potential of PDO as a platform material for future fully resorbable medical devices and contributes to the growing toolkit for fully resorbable sensor technologies.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naphthalimide Derivatives as Film-Based Fluorescent Sensors for Rapid Detection of Illicit Drugs 萘酰亚胺衍生物薄膜荧光传感器用于毒品快速检测

IF 3.5

Advanced Sensor Research Pub Date : 2025-07-30 DOI: 10.1002/adsr.202500063

Ming Chen, Harrison Stitt, Ronan Chu, Jos C. M. Kistemaker, Ian A. Wood, Paul L. Burn, Ian R. Gentle, Paul E. Shaw

{"title":"Naphthalimide Derivatives as Film-Based Fluorescent Sensors for Rapid Detection of Illicit Drugs","authors":"Ming Chen, Harrison Stitt, Ronan Chu, Jos C. M. Kistemaker, Ian A. Wood, Paul L. Burn, Ian R. Gentle, Paul E. Shaw","doi":"10.1002/adsr.202500063","DOIUrl":"https://doi.org/10.1002/adsr.202500063","url":null,"abstract":"Film-based fluorescence sensors are attractive for illicit drugs detection due to their potential for rapid response, low limits of detection, and portability. However, it is still a significant challenge to achieve real-time identification of suspected illicit drugs using fluorescence detection. Herein, four novel 1,8-naphthalimide (NI) derivatives with different substituents at the 4-position, namely NI-1 [phenyl], NI-2 [4-({2-ethylhexyl}oxy)phenyl], NI-3 [4,4''-bis({2-ethylhexyl}oxy)-(1,1':3',1''-terphenyl)-5'-yl] and NI-4 [4-(dimesitylboraneyl)phenyl] are reported. The four NI derivatives had different thin film optoelectronic properties and mass densities, and showed distinct fluorescence responses to methamphetamine hydrochloride, 3,4-methylenedioxyamphetamine hydrochloride, cocaine hydrochloride, fentanyl hydrochloride, and tetrahydrocannabinol. The contrasting fluorescence responses of NI-1, NI-2, NI-3 and NI-4 were utilized as the basis for a constructed sensor array, which can distinguish between five drugs, three compounds commonly found around the home (paracetamol, aspirin and caffeine) and a null class (a blank swab) in 18 s with a mean classification accuracy of 81%. By grouping analyte predictions into binary “drug” and “other” categories, a 94% mean classification accuracy is achieved. This highlights the potential for thin film fluorescent NI derivatives to be used for rapid on-site drug screening.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors 植入式葡萄糖传感器的双重异物反应缓解策略

IF 3.5

Advanced Sensor Research Pub Date : 2025-07-28 DOI: 10.1002/adsr.202500031

Taron M. Bradshaw, Mikaylin E. Nogler, Matthew F. Warchol, Micah L. Willis, Alejandro R. Walker, Robert Maile, Shannon M. Wallet, Elizabeth P. Merricks, Timothy C. Nichols, Mark H. Schoenfisch

{"title":"Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors","authors":"Taron M. Bradshaw, Mikaylin E. Nogler, Matthew F. Warchol, Micah L. Willis, Alejandro R. Walker, Robert Maile, Shannon M. Wallet, Elizabeth P. Merricks, Timothy C. Nichols, Mark H. Schoenfisch","doi":"10.1002/adsr.202500031","DOIUrl":"10.1002/adsr.202500031","url":null,"abstract":"While nitric oxide (NO) release from polyurethane (PU) sensor membranes has shown promise as a foreign body response (FBR) mitigation strategy to enhance the performance of implantable glucose sensors, its utility is ultimately limited by release duration. Further improvement is envisioned by combining electrospun fibers with NO release. Electrospinning process parameters that produce average fiber diameters of 670 and 1460 nm as the outer membrane of NO-releasing glucose sensors, are developed to not impact NO-release or sensor performance. An in vivo evaluation in a diabetic porcine model demonstrates a reduced inflammatory response for 670 versus 1460 nm fibers. This benefit appears to continue with a robust pro-wound healing response beyond the NO-release duration. At short periods (i.e., 11-d post-implantation), FBR mitigation is attributed to NO release and not the presence of fibers. Still, no negative effects are observed with the 670 nm fibers in this acute phase of the FBR. Taken together, the tissue response data demonstrate 670 nm fibers as a promising long-term FBR mitigation strategy.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Label-Free FET Based Biosensor for Detection of Engineered CAR T-Cells at Single Cell Resolution 基于FET的无标签生物传感器在单细胞分辨率下检测工程化CAR - t细胞

IF 3.5

Advanced Sensor Research Pub Date : 2025-07-27 DOI: 10.1002/adsr.202500029

Trang Anh Nguyen-Le, Isli Cela, Anja Feldmann, Chang-Ki Baek, Michael Bachmann, Larysa Baraban

{"title":"Label-Free FET Based Biosensor for Detection of Engineered CAR T-Cells at Single Cell Resolution","authors":"Trang Anh Nguyen-Le, Isli Cela, Anja Feldmann, Chang-Ki Baek, Michael Bachmann, Larysa Baraban","doi":"10.1002/adsr.202500029","DOIUrl":"10.1002/adsr.202500029","url":null,"abstract":"Immunotherapy has revolutionized cancer treatment, with Chimeric Antigen Receptor (CAR) T-cell therapy emerging as a highly effective approach for, e.g., hematological malignancies. However, the complexity of this living drug necessitates efficient methods to ensure the identity of the engineered cells during manufacturing and post-infusion therapy monitoring. In this study, a proof-of-concept is presented using a silicon nanowire field-effect transistor (SiNW FET) nanosensing platform capable of label-free, real-time identification and quantification of CAR T-cells at single-cell resolution. The nanosensor's functionalized surface mimics tumor antigens, enabling selective interaction with CAR-expressing cells. This platform demonstrates exceptional specificity by distinguishing CAR T-cells from wild-type T-cells and quantifying cell populations with ultrasensitivity. These results establish the SiNW FET nanosensing platform as a promising tool for streamlining CAR T-cell manufacturing and post-treatment monitoring, improving quality assurance, and advancing clinical applications in immunotherapy.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing Synergistic Effect in Pd-Doped Mesoporous γ-Al2O3/SnO2 for Multiple Freon Refrigerant Gases Detection 利用pd掺杂介孔γ-Al2O3/SnO2的协同效应检测多种氟利昂制冷剂气体

IF 3.5

Advanced Sensor Research Pub Date : 2025-07-24 DOI: 10.1002/adsr.202500046

Jiahong Wen, Yaxin Wang, Ruoning Chu, Jinhai Li, Ze Chen, Yongjun Zhang, Xiaoyu Zhao, Qi-Qi Fu

{"title":"Utilizing Synergistic Effect in Pd-Doped Mesoporous γ-Al2O3/SnO2 for Multiple Freon Refrigerant Gases Detection","authors":"Jiahong Wen, Yaxin Wang, Ruoning Chu, Jinhai Li, Ze Chen, Yongjun Zhang, Xiaoyu Zhao, Qi-Qi Fu","doi":"10.1002/adsr.202500046","DOIUrl":"10.1002/adsr.202500046","url":null,"abstract":"Freon refrigerants, whose leakage will cause serious safety and environmental issues, have an urgent need of developing leakage detection technologies. Conventional metal oxide semiconductor (MOS) gas sensors exhibit limited efficacy in detecting halogenated Freons due to their chemical inertness and weak charge-transfer interactions. While recent innovations employing mesoporous γ-Al2O3 overlayers have enabled Freon detection via catalytic decomposition sensing mechanism, the achieved sensing performance remains suboptimal. In this work, this issue is addressed by engineering a Pd-doped mesoporous γ-Al2O3/SnO2 (Pd-γ-Al2O3/SnO2) gas sensor. The doped Pd atoms not only accelerate the decomposition of Freon molecules on the catalytic layer but also induce the Schottky-barrier effect in the SnO2 sensing layer. Benefiting from the synergistic effect, the Pd-γ-Al2O3/SnO2 gas sensor shows outstanding response, good stability, repeatability, selectivity, and rarely-reported universality in sensing different Freon gases. Notably, a valuable solution is demonstrated in the leakage detection of next-generation refrigerants, Freon R1234yf. The sensing mechanism is deduced by exhaust gas components identification. These results highlight the promising potential for addressing the real-world needs of Freon refrigerant leakage detection technology.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0