Advanced Sensor Research最新文献_第2页

Non-Invasive Diagnosis of Hypertrophic Cardiomyopathy by Breath 呼吸法无创诊断肥厚性心肌病

Advanced Sensor Research Pub Date : 2025-05-19 DOI: 10.1002/adsr.70012

Yael Hershkovitz-Pollak, Manhal Habib, Yoav Y. Broza, Olga Katz, Harry Rakowski, Hossam Haick

{"title":"Non-Invasive Diagnosis of Hypertrophic Cardiomyopathy by Breath","authors":"Yael Hershkovitz-Pollak, Manhal Habib, Yoav Y. Broza, Olga Katz, Harry Rakowski, Hossam Haick","doi":"10.1002/adsr.70012","DOIUrl":"https://doi.org/10.1002/adsr.70012","url":null,"abstract":"Undetected in many patients, hypertrophic cardiomyopathy (HCM) is a widespread genetic heart disorder. Conventional diagnosis is based on physiological metrics such as blood pressure, imaging techniques, and genetic testing. Detection of HCM is crucial for proper follow-up, family screening, early treatment, and risk stratification to prevent sudden cardiac death. Therefore, there is an unmet need for fast and reliable diagnostic methods. This study introduces an innovative approach for the noninvasive, rapid, and accurate diagnosis of HCM by detecting patterns of volatile organic compounds (VOCs) in the patient's breath. Breath from 157 volunteers is collected on sorbent tubes and analyzed using a two-step approach, gas chromatography-mass spectrometry (GC-MS), and a developed nano-based sensor array. Initially, statistically significant differences in VOC patterns among sampled groups are identified using GC-MS. Then, the sensor array is used to differentiate between HCM patients and controls, resulting in the testing set, with 92.9% accuracy, 75% specificity, and 94.7% sensitivity. The sensors can further classify subcategories of HCM with >70.3% accuracy for all cases in the testing set. These findings show the applicability of the sensors setup and suggest that VOCs may be a promising noninvasive and real-time HCM diagnosis option.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-Effective Hierarchical Cobalt Nanostructured Laser-Induced Graphene for Enhanced Uric Acid Detection 具有成本效益的分层钴纳米结构激光诱导石墨烯增强尿酸检测

Advanced Sensor Research Pub Date : 2025-05-19 DOI: 10.1002/adsr.70003

Anju Joshi, Gymama Slaughter

{"title":"Cost-Effective Hierarchical Cobalt Nanostructured Laser-Induced Graphene for Enhanced Uric Acid Detection","authors":"Anju Joshi, Gymama Slaughter","doi":"10.1002/adsr.70003","DOIUrl":"https://doi.org/10.1002/adsr.70003","url":null,"abstract":"This study presents an innovative, cost-effective strategy to develop a flexible, enzyme-free biosensor for the sensitive detection of uric acid (UA). Utilizing electrochemically modified cobalt nanostructured on laser-induced graphene electrodes (CoNCs/LIG), this approach surpasses traditional noble metal-based electrocatalysts in sensitivity and affordability. The one-step electrochemical modification method is efficient and straightforward, enabling the uniform deposition of hierarchical flower-like cobalt nanostructures. These structures synergistically enhance the performance of the LIG, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM−1 cm−2 and a low detection limit of 3.66 µM for UA. The morphology and elemental composition of the CoNCs/LIG electrodes are characterized using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Beyond sensitivity, the sensor exhibited excellent selectivity, reliably resisting interference from competing biologically species such as ascorbic acid, dopamine, glycine, and glucose. Clinical utility is demonstrated in serum and artificial urine samples, achieving recovery rates ranging from (102.47%–104.46%). This work highlights the exceptional electrocatalytic efficiency of CoNCs/LIG-based flexible biosensors, offering a highly sensitive, selective, and cost-effective platform for UA detection, with promising applications in clinical diagnostics and health monitoring.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically Soft Implantable Electronics for Long-term Biosensing Applications 本质软植入电子长期生物传感应用

Advanced Sensor Research Pub Date : 2025-05-19 DOI: 10.1002/adsr.202500002

Su Hyeon Lee, Hyo Jin Lee, Sohye Lee, Dae-Hyeong Kim, Hye Jin Kim, Sung-Hyuk Sunwoo

{"title":"Intrinsically Soft Implantable Electronics for Long-term Biosensing Applications","authors":"Su Hyeon Lee, Hyo Jin Lee, Sohye Lee, Dae-Hyeong Kim, Hye Jin Kim, Sung-Hyuk Sunwoo","doi":"10.1002/adsr.202500002","DOIUrl":"https://doi.org/10.1002/adsr.202500002","url":null,"abstract":"Implantable biosensors play a critical role in healthcare and medical research by enabling real-time monitoring of physiological signals with high precion. Compared to non-invasive biosensors, implantable biosensors offer superior fidelity by minimizing external noise and ensuring direct contact with target tissues. However, conventional implantable biosensors, often composed of intrinsically rigid materials such as silicon and metals, suffer from mechanical mismatches with soft biological tissues, leading to inflammatory responses, fibrotic encapsulation, and long-term instability. To address these challenges, recent advances have focused on the development of intrinsically soft materials, which leverage soft and stretchable materials to achieve long-term biocompatibility and seamless tissue integreation. These materials have shown significant promise in neural interfaces, cardiac monitoring, and soft bioelectrodes for cronic sensing and stimulation. This review provides a comprehensive overview of these emerging biosensors, starting with a discussion of the limitations of conventional implantable biosensors. It then examines key intrinsically soft materials, including encapsulation matrices and stretchable conductors, and explores strategies for minimally invasive implantation, chronic fixation, and biocompatibility enhancement. Additionally, specific application cases are highlighted to demonstrate their practical utility. Finally, remaining challenges and future research opportunities are discussed to guide the next generation of intrinsically soft implantable biosensors toward clinical translation.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Co-Assembly of Water-Soluble Conjugated Polyelectrolyte with Discernable Fluorescence Modulation for Antibiotic Detection 选择性共组装水溶性共轭聚电解质与可识别荧光调制用于抗生素检测

Advanced Sensor Research Pub Date : 2025-05-14 DOI: 10.1002/adsr.70013

Hyena Ji, Yesica Fernanda Florez-Villabona, Youngsun Kim, Yerim Kim, Yongju Kim, Seungyun Baik, Young Hun Seo, Sehoon Kim

{"title":"Selective Co-Assembly of Water-Soluble Conjugated Polyelectrolyte with Discernable Fluorescence Modulation for Antibiotic Detection","authors":"Hyena Ji, Yesica Fernanda Florez-Villabona, Youngsun Kim, Yerim Kim, Yongju Kim, Seungyun Baik, Young Hun Seo, Sehoon Kim","doi":"10.1002/adsr.70013","DOIUrl":"https://doi.org/10.1002/adsr.70013","url":null,"abstract":"Residual antibiotics threaten ecosystems and public health by fostering antibiotic resistance and water contamination. To address this, PQx-Ph, a water-soluble conjugated polyelectrolyte, is developed as a selective fluorescent probe for antibiotic detection. The sulfonate-functionalized architecture of PQx-Ph facilitates the molecular co-assembly with antibiotics, resulting in fluorescence responses through antibiotic-selective distinct mechanisms, i.e., aggregation-induced emission (AIE) and twisted intramolecular charge transfer (TICT). These antibiotic-selective mechanisms enable 1) fluorescence quenching upon co-assembly with kanamycin (KAN) due to electrostatic binding and 2) fluorescence enhancement upon co-assembly with erythromycin (ERY) through hydrophobic interactions and TICT stabilization. PQx-Ph exhibits remarkable selectivity toward KAN, demonstrating strong binding with minimal interference from various competing substances. PQx-Ph exhibits matrix-dependent sensing performance, achieving nanomolar-level KAN detection (LOD = 0.021 µm) in mild environments containing low levels of natural organic matter (NOM), and maintaining reliable micromolar-level sensitivity (LOD = 0.37–1.44 µm) in environmentally complex matrices such as synthetic urine, tap water, and NOM-rich water samples. Given its excellent water solubility, environmental stability, and structural adaptability, PQx-Ph emerges as a promising candidate for real-time monitoring of antibiotic contamination. Future integration into portable sensing platforms will broaden its applications in environmental and public health monitoring.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous In-Hand Shape and Temperature Recognition Using Flexible Multilayered Sensor Arrays for Sense-Based Robot Manipulation 基于传感机器人操作的柔性多层传感器阵列手部形状和温度同时识别

Advanced Sensor Research Pub Date : 2025-05-12 DOI: 10.1002/adsr.70004

Seong-Min Im, Byeong-Sun Park, Jaehwan Jang, Sungeun Hong, Changjoo Nam, Young Tack Lee, Min-gu Kim

{"title":"Simultaneous In-Hand Shape and Temperature Recognition Using Flexible Multilayered Sensor Arrays for Sense-Based Robot Manipulation","authors":"Seong-Min Im, Byeong-Sun Park, Jaehwan Jang, Sungeun Hong, Changjoo Nam, Young Tack Lee, Min-gu Kim","doi":"10.1002/adsr.70004","DOIUrl":"https://doi.org/10.1002/adsr.70004","url":null,"abstract":"Artificial tactile systems play a pivotal role in advancing human-machine interaction technology by enabling precise physical interaction with objects and environments. Tactile information, such as pressure and temperature, allows robots to manipulate objects accurately and interact safely with humans. To facilitate this, a robotic skin integrating flexible pressure and temperature sensor arrays has been developed. The capacitive pressure sensor, inspired by human skin and utilizing a micro-dome structure, demonstrates fast, stable, and sensitive performance under applied pressure. Also, the resistive temperature sensor, based on reduced graphene oxide, exhibits highly sensitive responses to temperature changes, characterized by rapid and linear behavior. These sensors are vertically integrated into a multilayered system capable of simultaneously detecting real-time pressure and temperature distribution. This integrated sensor system, when incorporated into a robotic gripper, enables accurate identification of object shapes and surface temperatures during manipulation tasks. By pairing the sensor system with a camera that captures macroscopic visual information, including areas not directly visible, robots achieve enhanced manipulation capabilities through the synergy of visual context and detailed tactile input. This development represents a fundamental technology for multimodal tactile recognition and highlights its potential applications in artificial intelligence-driven visual-tactile fusion technologies.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Transistor-Based Biosensors for Viral RNA Detection and Variant Monitoring: From SARS-CoV-2 to Effective Management of Future Pandemics 基于晶体管的有机生物传感器用于病毒RNA检测和变异监测：从SARS-CoV-2到未来大流行的有效管理

Advanced Sensor Research Pub Date : 2025-05-08 DOI: 10.1002/adsr.70000

Stefano Lai, Roberto Cusano, Alessandra Scano, Giorgio Fotia, Annalisa Bonfiglio

{"title":"Organic Transistor-Based Biosensors for Viral RNA Detection and Variant Monitoring: From SARS-CoV-2 to Effective Management of Future Pandemics","authors":"Stefano Lai, Roberto Cusano, Alessandra Scano, Giorgio Fotia, Annalisa Bonfiglio","doi":"10.1002/adsr.70000","DOIUrl":"https://doi.org/10.1002/adsr.70000","url":null,"abstract":"The COVID-19 crisis has defined the need of novel approaches for a straightforward management of pandemic and epidemic conditions. Here, an approach based on electronic sensing of viral RNA is proposed for both virus detection and variant tracking. The sensing strategy of the Organic Charge-Modulated Field-Effect Transistor (OCMFET) is employed for the development of a multi-sensing platform, capable of parallel evaluation of control references and investigated samples. PCR-free detection of viral genomic RNA is demonstrated at different target concentrations, with optimal discrimination with respect to negative control. Moreover, the same approach is feasible for virus variant tracking, as a screening strategy for mutation detection in PCR-amplified samples: the approach can be used for a rationalization of RNA sequencing procedures, which are difficult to perform in the acute phases of pandemics, but are fundamental for an effective pandemic management. The results pave the way for novel strategies to enhance cost-effectiveness, easiness-of-use in combination with selectivity and sensitivity in virus detection during severe pandemic conditions, and a more effective variant tracking by optimizing the access to sequencing resources even during the acute phases of pandemic.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A High-Performance Miniaturized Frequency Shift Detection System for QCM-Based Gravimetric Sensing (Adv. Sensor Res. 5/2025) 基于qcm的重力传感的高性能小型化频移检测系统（ad . Sensor Res. 5/2025）

Advanced Sensor Research Pub Date : 2025-05-07 DOI: 10.1002/adsr.70006

Chenyang Gao, Shuyu Fan, Wei Li, Yongbing Wang, Qianwen Xia, Dibo Hou, Yunqi Cao

引用次数: 0

Issue Information (Adv. Sensor Res. 5/2025) 发布信息（ad . Sensor Res. 5/2025）

Advanced Sensor Research Pub Date : 2025-05-07 DOI: 10.1002/adsr.70007

引用次数: 0

Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives (Adv. Sensor Res. 5/2025) 光学微纤维生物医学传感器：分类、应用和未来展望（ad . Sensor Res. 5/2025）

Advanced Sensor Research Pub Date : 2025-05-07 DOI: 10.1002/adsr.70005

Lili Liang, Fei Xie, Li Jin, Bowen Yang, Li-Peng Sun, Bai-Ou Guan

引用次数: 0

Modulating Signal Generation in Aptamer-Based CNT-FET Biosensors by Controlling the Functionalization Route 通过控制功能化路径调制适体碳纳米管场效应晶体管生物传感器的信号生成

Advanced Sensor Research Pub Date : 2025-05-06 DOI: 10.1002/adsr.70002

Haosen Miao, Gririraj Manoharan, Ahran Lim, Peter Mirau, Jorge L. Chávez, Chang-Seuk Lee, Matteo Palma

{"title":"Modulating Signal Generation in Aptamer-Based CNT-FET Biosensors by Controlling the Functionalization Route","authors":"Haosen Miao, Gririraj Manoharan, Ahran Lim, Peter Mirau, Jorge L. Chávez, Chang-Seuk Lee, Matteo Palma","doi":"10.1002/adsr.70002","DOIUrl":"https://doi.org/10.1002/adsr.70002","url":null,"abstract":"The identification of biomarkers is key to the early detection of physiological dysfunction. Nanoscale field-effect transistors (FETs) modified with target-specific receptors enable direct target sensing, offering enhanced sensitivity due to nanoscale channel confinement. In this regard, single-walled carbon nanotubes (SWCNTs) have emerged as strong candidates for the development of transistor-based biosensors. Understanding the structural parameters that affect sensing performance in such nanoscale electrical detection platforms is essential for their reliable and controllable use. Here, this is investigated that how different assembly strategies employed in the construction of nanoscale aptamer-based SWCNT-FET biosensors can dramatically affect their signal generation, with conductance increasing or decreasing for the same aptamer-cortisol recognition event. a cortisol-binding DNA aptamer exhibiting well-characterized conformational behavior is employed, as a model receptor to explore the influence of different surface functionalization strategies on SWCNT-based biosensors performance. Through combined electrical and optical characterization, this is elucidated that how aptamer conformation governs local electrostatic changes within the Debye length, which in turn modulates the electrostatic gating of the devices. This work offers insight into effective design strategies for the construction of biosensors functionalized with electrostatically active molecular receptors.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0