植入式葡萄糖传感器的双重异物反应缓解策略

IF 3.5
Taron M. Bradshaw, Mikaylin E. Nogler, Matthew F. Warchol, Micah L. Willis, Alejandro R. Walker, Robert Maile, Shannon M. Wallet, Elizabeth P. Merricks, Timothy C. Nichols, Mark H. Schoenfisch
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引用次数: 0

摘要

虽然从聚氨酯(PU)传感器膜中释放一氧化氮(NO)有望作为一种缓解异物反应(FBR)的策略来提高植入式葡萄糖传感器的性能,但其效用最终受到释放时间的限制。进一步的改进设想通过结合静电纺纤维与NO释放。采用静电纺丝工艺参数制备一氧化氮释放型葡萄糖传感器外膜,其平均纤维直径为670 nm和1460 nm,不影响一氧化氮释放和传感器性能。在糖尿病猪模型中进行的体内评估表明,670 nm纤维与1460 nm纤维相比,炎症反应减少。在no释放持续时间之外,这种益处似乎继续具有强大的促伤口愈合反应。在短时间内(即植入后11天),FBR的缓解归因于NO的释放,而不是纤维的存在。然而,在FBR的急性期,670 nm纤维没有观察到负面影响。综上所述,组织响应数据表明,670 nm纤维是一种很有前景的长期FBR缓解策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors

While nitric oxide (NO) release from polyurethane (PU) sensor membranes has shown promise as a foreign body response (FBR) mitigation strategy to enhance the performance of implantable glucose sensors, its utility is ultimately limited by release duration. Further improvement is envisioned by combining electrospun fibers with NO release. Electrospinning process parameters that produce average fiber diameters of 670 and 1460 nm as the outer membrane of NO-releasing glucose sensors, are developed to not impact NO-release or sensor performance. An in vivo evaluation in a diabetic porcine model demonstrates a reduced inflammatory response for 670 versus 1460 nm fibers. This benefit appears to continue with a robust pro-wound healing response beyond the NO-release duration. At short periods (i.e., 11-d post-implantation), FBR mitigation is attributed to NO release and not the presence of fibers. Still, no negative effects are observed with the 670 nm fibers in this acute phase of the FBR. Taken together, the tissue response data demonstrate 670 nm fibers as a promising long-term FBR mitigation strategy.

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