{"title":"A High-Performance Miniaturized Frequency Shift Detection System for QCM-Based Gravimetric Sensing (Adv. Sensor Res. 5/2025)","authors":"Chenyang Gao, Shuyu Fan, Wei Li, Yongbing Wang, Qianwen Xia, Dibo Hou, Yunqi Cao","doi":"10.1002/adsr.70006","DOIUrl":"https://doi.org/10.1002/adsr.70006","url":null,"abstract":"<p><b>Quartz Crystal Microbalance</b></p><p>A miniaturized frequency shift detection system based on a phase-locked loop (PLL) circuit is proposed for simplifying quartz crystal microbalance (QCM) measurement, possessing excellent performance of high sensitivity, resolution, linearity, and accuracy compared with a commercial frequency analyzer. The proposed system has the potential for enabling long-term, in-situ detection, and promoting large-scale applications of QCM. More details can be found in article 2400148 by Yunqi Cao and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives (Adv. Sensor Res. 5/2025)","authors":"Lili Liang, Fei Xie, Li Jin, Bowen Yang, Li-Peng Sun, Bai-Ou Guan","doi":"10.1002/adsr.70005","DOIUrl":"https://doi.org/10.1002/adsr.70005","url":null,"abstract":"<p><b>Optical Microfiber Biomedical Sensors</b></p><p>Optical microfiber biosensors, a revolutionary biomedical technology, offer high sensitivity, specificity, and versatility for biomarker detection, health monitoring, and treatment. This review highlights their significance, examines recent advancements, challenges, and outlines future developments. More details can be found in article 2400185 by Li-Peng Sun and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohsen Samadi, Jana Marie Meyer, Elizaveta Spetzler, Benjamin Spetzler, Jeffrey McCord, Fabian Lofink, Martina Gerken
{"title":"Modeling of High-Sensitivity SAW Magnetic Field Sensors with Au-SiO2 Phononic Crystals","authors":"Mohsen Samadi, Jana Marie Meyer, Elizaveta Spetzler, Benjamin Spetzler, Jeffrey McCord, Fabian Lofink, Martina Gerken","doi":"10.1002/adsr.202500008","DOIUrl":"https://doi.org/10.1002/adsr.202500008","url":null,"abstract":"<p>The development of high-sensitivity magnetic field sensors is crucial for precise magnetic field detection. In this context, a theoretical model is presented for a highly sensitive surface acoustic wave (SAW) magnetic field sensor incorporating phononic crystal (PnC) structures composed of Au pillars embedded within a SiO<sub>2</sub> guiding layer. Rectangular and triangular PnC configurations are studied and their potential for improving sensor performance are assessed. In the design, the PnC is integrated into the SiO<sub>2</sub> guiding layer to preserve the continuous magnetostrictive layer, enhancing its interaction with the SAW. Results from the simulations indicate that the proposed sensor can achieve a nearly two orders of magnitude increase in sensitivity compared to a continuous delay line of similar dimensions, and an eightfold improvement over a previous sensor design with PnCs composed of magnetostrictive pillars. This improved performance is attributed to the enhanced interaction between the SAW and the continuous magnetostrictive layer, driven by resonance effects within the PnC. These findings highlight the significant potential of incorporating PnCs into SAW sensors for future high-performance magnetic field sensing.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of Highly Stretchable, Self-Adhesive Ionic Conductive Hydrogels for Wearable Strain Sensors","authors":"Huawei Gao, Yupan Han, Mengjie Huang, Jianwei Li, Hongling Sun, Guojie Li, Lin Dong, Xianhu Liu, Chuntai Liu, Changyu Shen","doi":"10.1002/adsr.202500005","DOIUrl":"https://doi.org/10.1002/adsr.202500005","url":null,"abstract":"<p>Conductive hydrogels (CHs) have received numerous attentions for potential applications in flexible electronics. However, the construction of high-performance CHs with high stretchability, favorable electrical conductivity, and reversible adhesiveness simultaneously still remains a great challenge. Herein, an ionic CH with the above characteristics is proposed via introducing phytic acid (PA) into semi-interpenetrating cross-linked network of poly(acrylamide-co-N-(hydroxymethyl) acrylamide) and chitosan hydrogels. The synergy of hydrogen bonds and electrostatic interactions endows the obtained hydrogel with high stretchability (1131%), toughness (88.32 kJ·m<sup>−3</sup>), and satisfactory adhesiveness (25.78 kPa to wood). The presence of PA enables the composite hydrogel to exhibit favorable electrical conductivity. Impressively, the resultant hydrogel can be assembled into the wearable strain sensor to present high sensitivity of 1.32 in the wide strain response range (0–1131%), rapid response time (340 ms), and excellent cyclic stability. More importantly, the prepared stain sensor can precisely recognize complicated human movements and physiological activities and realize the information encryption, making this hydrogel a promising candidate for preparing high-performance electronics.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haider N. Sultani, Ibrahim M. Morgan, Hidayat Hussain, Haleh H. Haeri, Dariush Hinderberger, Goran N. Kaluđerović, Bernhard Westermann
{"title":"Synthesis of Rhodamine TEMPO Conjugates via Isonitrile-Based Multicomponent-Reactions for Mitochondria-Targeted ROS-Detection in Cancer Cells","authors":"Haider N. Sultani, Ibrahim M. Morgan, Hidayat Hussain, Haleh H. Haeri, Dariush Hinderberger, Goran N. Kaluđerović, Bernhard Westermann","doi":"10.1002/adsr.202400180","DOIUrl":"https://doi.org/10.1002/adsr.202400180","url":null,"abstract":"<p>A novel series of profluorescent rhodamine nitroxide conjugates are synthesized utilizing well-known isonitrile-based multicomponent reactions (IMCRs). The synthesized conjugates are rationally designed as mitochondria-targeting probes for the detection of reactive oxygen species in living cells. Herein, the synthesized probes demonstrate high selectivity to target the mitochondria of both of PC3- and NIH3T3-cells which represent cancer and normal cell lines. Attaching TEMPO nitroxide to rhodamine leads to fluorescence quenching, allowing for ROS detection and quantification. The prepared sensors provide a reliable method for distinguishing between different oxidative environments in living organisms through different levels of fluorescence to be measured. The use of the Ugi multicomponent reaction enables an efficient and versatile synthetic approach, offering significant advantages over previously reported methods for constructing ROS-detecting probes. The simplicity of the reaction setup and the ability to generate a diverse library of products by varying Ugi components make this protocol highly adaptable for further chemical modification and potential applications in biological systems.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Sinibaldi, Francesco Chiavaioli, Agostino Occhicone, Norbert Danz, Peter Munzert, Francesco Baldini, Ambra Giannetti, Francesco Michelotti
{"title":"Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis","authors":"Alberto Sinibaldi, Francesco Chiavaioli, Agostino Occhicone, Norbert Danz, Peter Munzert, Francesco Baldini, Ambra Giannetti, Francesco Michelotti","doi":"10.1002/adsr.202400164","DOIUrl":"https://doi.org/10.1002/adsr.202400164","url":null,"abstract":"<p>Alzheimer's disease (AD) is a progressive neurological disorder that gradually impairs all cognitive functions. The diagnosis typically requires a combination of cognitive assessments, neuroimaging techniques, and biomarker analysis. In healthy neurons, Tau protein stabilizes microtubules, which are vital for maintaining the structure and proper functioning of nerve cells. However, elevated levels of Tau in cerebrospinal or other body fluids can be related to the progression of Alzheimer's disease. This study introduces an optical technique that employs a dual label-free and fluorescence operation mode to detect Tau protein in both standard running buffer and cerebrospinal fluid. This innovative method enables label-free analysis of the bio-conjugation process on biochips used for resolved fluorescence-based Tau detection. This work successfully demonstrates Tau protein detection in both matrixes, achieving an outstanding limit of detection of 2.4 pM in cerebrospinal fluid. Moreover, the analysis of the dose-response curve allows to estimate the dissociation constant (K<sub>D</sub> = 18 nM) for Tau interactions, yielding values that are in excellent agreement with existing literature using other techniques. These aspects highlight the added value of this technique, providing a valuable tool for investigating Alzheimer's-related biomarkers, as demonstrated in this study with Tau protein.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in Early Warning of Thermal Runaway in Lithium-Ion Battery Energy Storage Systems","authors":"Duzhao Han, Juan Wang, Chengxian Yin, Yuxin Zhao","doi":"10.1002/adsr.202400165","DOIUrl":"https://doi.org/10.1002/adsr.202400165","url":null,"abstract":"<p>Thermal runaway is a critical safety concern in lithium-ion battery energy storage systems. This review comprehensively analyzes state-of-the-art sensing technologies and strategies for early detection and warning of thermal runaway events. The primary inducing factors, evolution mechanism, and characteristic reactions at various stages are discussed. Detectable signals during thermal runaway, including temperature, gas emissions, pressure, strain, and acoustic signals, are examined, along with advancements in corresponding sensing technologies. The importance of sensor implantation, collaboration, and communication within battery cells is highlighted, as well as the development of intelligent algorithms and early warning models. Miniaturized, integrated, and arrayed sensors within battery cells are identified as an inevitable trend in advancing safety monitoring systems. Intrinsically safe design of future battery systems, considering distinct thermal runaway characteristics of emerging technologies, is crucial for enhancing safety and reliability. Future research shall focus on developing advanced sensing technologies for real-time, in situ monitoring, establishing a new paradigm for thermal runaway diagnosis using intelligent algorithms, and integrating battery models with these algorithms for accurate state estimation and early warnings. This review provides insights to guide the development of advanced sensing and early warning strategies, facilitating the widespread adoption of renewable energy storage technologies.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa
{"title":"Empirical Modification of Force Fields for the Development of Peptide-Based Gas Sensors (Adv. Sensor Res. 4/2025)","authors":"Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa","doi":"10.1002/adsr.202570008","DOIUrl":"https://doi.org/10.1002/adsr.202570008","url":null,"abstract":"<p><b>Empirical Force Fields Optimization for Gas Dynamics</b></p><p>In article 2400122, Thuc Anh Ngo, Genki Yoshikawa, and co-workers introduce an innovative artificial nose concept using peptide-based sensors for selective gas molecule detection. Optimized molecular modeling targets gas-phase interactions, enhancing detection accuracy. This approach offers potential applications in medical diagnostics, blending biology with advanced technology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202570008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}