Advanced Sensor Research最新文献_第10页

Sensors for Antibiotics Susceptibility Testing—Recent Advances 抗生素药敏试验传感器--最新进展

Advanced Sensor Research Pub Date : 2024-07-12 DOI: 10.1002/adsr.202400046

Oliver Riester, Stefan Laufer, Roland Mertelsmann, Hans-Peter Deigner

引用次数: 0

Diabetes Management in Transition: Market Insights and Technological Advancements in CGM and Insulin Delivery 转型期的糖尿病管理：CGM 和胰岛素输送的市场洞察与技术进步

Advanced Sensor Research Pub Date : 2024-07-11 DOI: 10.1002/adsr.202400048

Tae Sang Yu, Soojeong Song, Junwoo Yea, Kyung-In Jang

{"title":"Diabetes Management in Transition: Market Insights and Technological Advancements in CGM and Insulin Delivery","authors":"Tae Sang Yu, Soojeong Song, Junwoo Yea, Kyung-In Jang","doi":"10.1002/adsr.202400048","DOIUrl":"10.1002/adsr.202400048","url":null,"abstract":"Continuous Glucose Monitoring (CGM) systems are revolutionizing the real-time tracking of blood glucose levels, a cornerstone in effective diabetes management and optimal glycemic control. Transitioning from the “intermittent readings” offered by traditional Blood Glucose Monitoring (BGM) methods, CGM delivers an “uninterrupted flow” of glucose data, enabling a “more detailed” strategy for meeting treatment goals. Initially, the “uptake of CGM faced hurdles due to doubts about its precision, but continuous advancements in technology have not only resolved these concerns but also confirms CGM as a dependable and impactful instrument in diabetes management”. Concurrently, advancements in insulin pump technology have improved their portability and ease of use, greatly increasing patient adoption. The market reflects a growing demand for such innovative healthcare solutions, driven by an increased awareness of diabetes management and bolstered by supportive healthcare policies. Future prospects for CGM and insulin pump technologies are incredibly promising, offering the potential for highly personalized care and sophisticated treatment strategies. This paper aims to explore how the synergy between ongoing technological developments and evolving market dynamics is set to redefine the diabetes care paradigm, positioning CGM and insulin pumps as essential elements in enhancing the quality of life for individuals with diabetes.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Renal Diagnosis: Graphene-Enhanced Lab-On-a-Chip for Multiplexed Kidney Biomarker Detection in Capillary Blood 改变肾脏诊断：石墨烯增强型芯片实验室用于毛细管血液中多重肾脏生物标记物检测

Advanced Sensor Research Pub Date : 2024-07-10 DOI: 10.1002/adsr.202400061

Joaquin F. Diforti, Thomas Cunningham, Zaira Zegalo, Esteban Piccinini, Waldemar A. Marmisollé, Jose M. Piccinini, Omar Azzaroni

{"title":"Transforming Renal Diagnosis: Graphene-Enhanced Lab-On-a-Chip for Multiplexed Kidney Biomarker Detection in Capillary Blood","authors":"Joaquin F. Diforti, Thomas Cunningham, Zaira Zegalo, Esteban Piccinini, Waldemar A. Marmisollé, Jose M. Piccinini, Omar Azzaroni","doi":"10.1002/adsr.202400061","DOIUrl":"10.1002/adsr.202400061","url":null,"abstract":"Chronic kidney disease (CKD) is a significant global health concern, impacting over 10% of the world population. Despite advances in home-based treatments, CKD diagnosis and monitoring remain centralized in large laboratories. This work reports on the development of a Graphene-based Lab-On-a-Chip (G-LOC) for the self-testing of multiple renal function biomarkers in capillary blood. G-LOC integrates bioelectronic sensors with a 3D-printed microfluidic system that enables the multiplex quantification of urea, potassium, sodium, and chloride, from one drop of blood. The potentials of three graphene sensors modified with ion-selective membranes and enzymes are simultaneously measured. The analytical performance of the test is evaluated in terms of linearity, accuracy, and coefficient of variability (CV). Accuracy values higher than 98.7%, and CV values lower than 10.8% are obtained for all the biomarkers. Correlation and Bland–Altman plots show good correlation (slopes in the range of 0.94–1.15) and high agreement of G-LOC with a reference method. It is also demonstrated that the test can correctly differentiate biomarker levels normally obtained for healthy people, early-stage CKD, and end-stage CKD. Finally, user experience is studied with a group of untrained volunteers who highlight the simple usability of the test and its suitability for at-home diagnostics.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Optical Microrings on Fiber Facet for Broadband Ultrasound Detection 光纤面集成光学微环用于宽带超声检测

Advanced Sensor Research Pub Date : 2024-06-28 DOI: 10.1002/adsr.202400076

Jialve Sun, Feiyang Hou, Shengfei Feng, Changhui Li

引用次数: 0

Platinum Decorated Palladium Nanowires for Room-Temperature Hydrogen Detection 用于室温氢探测的铂装饰钯纳米线

Advanced Sensor Research Pub Date : 2024-06-24 DOI: 10.1002/adsr.202400013

Abhishek Kumar, Yaoli Zhao, Sadaf Mohsenifard, Vaishali Maheshkar, Thomas Thundat, Mark T. Swihart

{"title":"Platinum Decorated Palladium Nanowires for Room-Temperature Hydrogen Detection","authors":"Abhishek Kumar, Yaoli Zhao, Sadaf Mohsenifard, Vaishali Maheshkar, Thomas Thundat, Mark T. Swihart","doi":"10.1002/adsr.202400013","DOIUrl":"https://doi.org/10.1002/adsr.202400013","url":null,"abstract":"The use of hydrogen as an energy carrier will require low-cost, low-power hydrogen sensors. Toward this goal, penta-twinned palladium nanowires (Pd NWs) are synthesized and fabricated sensors from them by drop-casting. Pd NWs drop-cast onto an interdigitated electrode (IDE) gave a response of 0.3% to 1 vol.% H2, with response and recovery times of 12 and 20 s, respectively. However, they exhibited a negative response (decreased resistance) at low H2 concentrations. Pd NWs on a paper substrate provided a tenfold higher response to 1 vol.% H2, with response and recovery times of 10 s each, but still exhibited negative response at low H2 concentration. Exposing the Pd NW-on-paper sensor to ozone-generating UV light degraded the PVP used in Pd NW synthesis, eliminating the reverse sensing response, and providing a response of 5% to 1 vol.% H2, with response and recovery times of 15 s. This allowed reliable H2 detection down to 100 ppm H2. Finally, coating the Pd NWs with a small amount of Pt (<5%) reduced the response and recovery times to 5 s by catalyzing H2 dissociation. This work provides a path to low-cost sensors to enable the safe use of H2 as an energy carrier.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoflowers Templated CuO/Cu Hybrid Metasurface for Sensitive THz-TDS Detection of Acetylcholine 用于乙酰胆碱灵敏 THz-TDS 检测的纳米流模板化 CuO/Cu 混合金属表面

Advanced Sensor Research Pub Date : 2024-06-22 DOI: 10.1002/adsr.202400041

Soo Hyun Lee, Taeyeon Kim, Minah Seo

{"title":"Nanoflowers Templated CuO/Cu Hybrid Metasurface for Sensitive THz-TDS Detection of Acetylcholine","authors":"Soo Hyun Lee, Taeyeon Kim, Minah Seo","doi":"10.1002/adsr.202400041","DOIUrl":"https://doi.org/10.1002/adsr.202400041","url":null,"abstract":"Achieving sensitive detection using terahertz (THz) time-domain spectroscopy (TDS) remains challenging due to the low probabilities of molecules being positioned within microscale active regions of typical THz metamaterials. The hybrid metamaterials are prepared with expanded active surface areas by templating CuO nanoflowers into Cu nanoslots through the one-step hydrothermal method. The optimum condition of CuO/Cu nanoslots is achieved with variations in optical transmittance and without alteration of resonance frequency (fres). The enhancement of detection efficiency is obtained with acetylcholine (ACh), which has a hydrolysis-transformable characteristic. The cleavage of ACh into two molecules, namely choline and acetic acid, poses a challenge for direct THz-TDS detection. This is because the altered molecular energy states do not match with the resonance frequencies of pristine Cu nanoslots. Since the CuO nanoflowers with high chemical reactivity became corroded by acetic acid, sufficient signal variations are observed. As a portion of CuO nanoflowers is decreased, the transmittance gradually reached the original state (i.e., recovery). For the ACh, the comparison of sensing performance (i.e., sensitivity, limit-of-detection, and correlation coefficient) between the CuO/Cu and Cu nanoslots is intensively performed.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible, Wearable Mechano-Acoustic Sensors for Real-Time, Wireless Monitoring of Low Frequency Body Sounds 用于实时、无线监测低频体声的柔性可穿戴机械声学传感器

Advanced Sensor Research Pub Date : 2024-06-20 DOI: 10.1002/adsr.202400039

Trung Thien Hoang, Alexander Mark Cunio, Sinuo Zhao, Thanh-Vinh Nguyen, Shuhua Peng, Stephanie Liaw, Tracie Barber, Jin Zhang, Syamak Farajikhah, Fariba Dehghani, Thanh Nho Do, Hoang-Phuong Phan

{"title":"Flexible, Wearable Mechano-Acoustic Sensors for Real-Time, Wireless Monitoring of Low Frequency Body Sounds","authors":"Trung Thien Hoang, Alexander Mark Cunio, Sinuo Zhao, Thanh-Vinh Nguyen, Shuhua Peng, Stephanie Liaw, Tracie Barber, Jin Zhang, Syamak Farajikhah, Fariba Dehghani, Thanh Nho Do, Hoang-Phuong Phan","doi":"10.1002/adsr.202400039","DOIUrl":"https://doi.org/10.1002/adsr.202400039","url":null,"abstract":"Measurements of low-frequency physiological signals, such as heart rate and pulse waves, play an essential role in biomedical applications for the early diagnosis of abnormal cardiovascular activities. Recent advances in flexible mechanical electronics represent a novel concept of miniaturized, wearable sensors for heart rate measurement that can be used in ambulatory environments. However, most mechanical sensors require the sensing element to be placed directly on the skin surface, which can lead to performance degradation or device damage due to significant skin deformation or external forces from skin-object interactions. This work addresses this challenge by developing soft, stretchable mechano-acoustic sensing platforms where all sensing components are not directly subjected to skin movement or deformation. Instead, this design allows cardiovascular pulse waves to propagate through a hollow, flexible microchannel, to vibrate the piezoresistive sensing element. Experimental studies demonstrate a complete wireless sensing system capable of detecting pulse waves and heart rates, with results consistent with those of commercially available devices. The proposed sensing concept allows for the develop of other wireless and flexible sensing systems such as a flexible air-channel pad for detecting swallowing patterns from users’ laryngeal movements, facilitating a non-invasive and remote platform for potential monitoring, and assessment of dysphagia.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Characterization of a Dual-Interval Elastic Force Sensor for Robot-Assisted Microinjection 用于机器人辅助显微注射的双区间弹性力传感器的设计与特性分析

Advanced Sensor Research Pub Date : 2024-06-17 DOI: 10.1002/adsr.202400047

Zekui Lyu, Nana Ai, Wei Ge, Qingsong Xu

{"title":"Design and Characterization of a Dual-Interval Elastic Force Sensor for Robot-Assisted Microinjection","authors":"Zekui Lyu, Nana Ai, Wei Ge, Qingsong Xu","doi":"10.1002/adsr.202400047","DOIUrl":"https://doi.org/10.1002/adsr.202400047","url":null,"abstract":"Robot-assisted microinjection has been widely implemented in the field of experimental biology research. Force perception is more accurate than visual feedback in determining the state of interaction between the micropipette and the biological sample. The existing micro-force sensors are difficult to directly combine with micropipettes to fully utilize their capabilities. This paper develops a new integrated force-sensing microinjector with both micro-force sensing and micropipette carrying functions using a symmetrical compliant guide mechanism and highly sensitive semiconductor strain gauges. Overload protection is considered in the structure design of the sensor, which is beneficial in reducing damage caused by displacement overshot due to misuse. The mechanical performance of the proposed dual-interval force sensing device is verified through theoretical derivation, simulation analysis, and experimental testing. The sensitivity, resolution, accuracy, dynamic response, stability, and repeatability of the sensor are investigated and evaluated in the established experimental platform. Finally, puncture experiments are conducted on zebrafish larvae and crab eggs using the proposed force-sensing microinjector. The results indicate that the sensor is effective in recording force signals during penetration of the sample.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noble Metal Nanoparticle-Based Aptasensors: A Powerful Tool for Exosomal Detection

Advanced Sensor Research Pub Date : 2024-06-17 DOI: 10.1002/adsr.202400002

Jingyu Sun, Wei Hu, Nuo Xu, Jonathan Makris, Felicia Spadavecchia, Hongjun Wang

{"title":"Noble Metal Nanoparticle-Based Aptasensors: A Powerful Tool for Exosomal Detection","authors":"Jingyu Sun, Wei Hu, Nuo Xu, Jonathan Makris, Felicia Spadavecchia, Hongjun Wang","doi":"10.1002/adsr.202400002","DOIUrl":"https://doi.org/10.1002/adsr.202400002","url":null,"abstract":"Exosomes, secreted by various types of cells, play a crucial role in cell-to-cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early biomarkers for different diseases. Clearly, exosomal detection with a high sensitivity and specificity becomes highly essential to advance the understanding of disease progression and to develop early diagnostic modalities. Among different types of biosensors, aptasensors have received significant attention as the diagnostic tools considering their programmability and targeting ability. Noble metal nanomaterials possess distinctive physicochemical properties, allowing for ready functionalization with aptamers via both physical adsorption and chemical immobilization. By utilizing the aptamers as the recognition elements, noble metal nanoparticle-based aptasensors offer a promising platform for rapid, cost-effective, and sensitive in situ detection of exosomes. In this review, the progress will summarized in exosomes as a biomarker for diseases and the recent advances in the use of noble metal nanoparticle/aptamer-based sensors for analysis of exosomes and other extracellular vesicles.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143116156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Surface Plasmon Resonance Sensing using a van der Waals Heterostructure 使用范德华异质结构的电化学表面等离子体共振传感技术

Advanced Sensor Research Pub Date : 2024-06-17 DOI: 10.1002/adsr.202400028

Robert Jungnickel, Kannan Balasubramanian

{"title":"Electrochemical Surface Plasmon Resonance Sensing using a van der Waals Heterostructure","authors":"Robert Jungnickel, Kannan Balasubramanian","doi":"10.1002/adsr.202400028","DOIUrl":"https://doi.org/10.1002/adsr.202400028","url":null,"abstract":"Coupling surface plasmon resonance (SPR) sensing with electrochemistry (EC) is a promising analytical strategy to obtain information about interfacial phenomena in heterogeneous reactions. Typical EC-SPR sensors utilize a metal film both as the plasmonic material and as the working electrode. In this configuration, the eigenmodulation of the plasmonic properties of the metal film under applied potential results in a background signal, which hampers the unambiguous interpretation of the sensor response due to redox reactions. Here, a new strategy is presented to overcome this disadvantage by using a van der Waals heterostructure (vdW-HS) as the working electrode. The vdW-HS comprises of a graphene / hexagonal boron nitride (hBN) stack on a gold film of a standard SPR sensor. It is shown here that the background signal is completely suppressed enabling the unambiguous analysis of SPR sensor response due to electrochemical reactions. It is further observed that the potential dependent plasmonic signals are not just a reproduction of the electrochemical current and subtle differences can be traced back to the diffusive nature of the redox active species. Finally, it is demonstrated that EC-SPR can be used as a complementary method to distinguish if the electrochemical response is mainly surface-bound or due to diffusion.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0