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Observational Study of the Deceleration Parameter in (boldsymbol{f(R,L_{m})}) Theory of Gravity (boldsymbol{f(R,L_{m})}) 中减速参数的观测研究引力理论

IF 1.2 4区物理与天体物理

Gravitation and Cosmology Pub Date : 2025-03-02 DOI: 10.1134/S0202289324700518

Bhupendra Kumar Shukla, D. Sofuoğlu, A. Beesham, Ala Ouguergouz, Shashi Narayan Shukla

引用次数: 0

Covalent organic framework derived single-atom copper nanozymes for the detection of amyloid-β peptide and study of amyloidogenesis. 用于检测淀粉样蛋白-β肽和研究淀粉样蛋白生成的共价有机框架衍生单原子铜纳米酶。

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1007/s00216-024-05683-1

Yuxin Wei, Qingqing Bai, Xinlu Ning, Xiaofan Bai, Jie Lv, Meng Li

{"title":"Covalent organic framework derived single-atom copper nanozymes for the detection of amyloid-β peptide and study of amyloidogenesis.","authors":"Yuxin Wei, Qingqing Bai, Xinlu Ning, Xiaofan Bai, Jie Lv, Meng Li","doi":"10.1007/s00216-024-05683-1","DOIUrl":"10.1007/s00216-024-05683-1","url":null,"abstract":"Sensitive and accurate detection of the amyloid-β (Aβ) monomer is of fundamental significance for early diagnosis of Alzheimer's disease (AD). Herein, inspired by the specific Cu-Aβ monomer coordination, a cutting-edge colorimetric assay based on single-atom Cu anchored N-doped carbon nanospheres (Cu-NCNSs) was developed for Aβ monomer detection and an amyloidogenesis study. By directly pyrolyzing Cu2+-incorporated covalent organic frameworks (COFs), the resulting Cu-NCNSs with a high loading of Cu (8.04 wt %) exhibited outstanding peroxidase-like activity. The strong binding affinity of Aβ monomer to Cu-NCNSs effectively inhibited their catalytic activity, providing the basis for the colorimetric assay. The Cu-NCNSs-based sensor showed a detection limit of 1.182 nM for Aβ monomer, surpassing traditional techniques in terms of efficiency, accuracy and simplicity. Moreover, the system was successfully utilized for Aβ monomer detection in rat cerebrospinal fluid (CSF). Notably, the distinct inhibitory effects of monomeric and aggregated Aβ species on the catalytic activity of Cu-NCNSs were allowed for monitoring of the dynamic aggregation process of Aβ. Compared to thioflavin T (ThT), the most widely used amyloid dye, the detection system exhibited greater sensitivity towards toxic Aβ oligomers, which was crucial for early AD diagnosis and treatment. Our work not only sheds light on the rational design of highly active single-atom nanozymes from COFs but also expands the potential applications of nanozymes in early disease diagnosis.","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1081-1092"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AuNPs/GO/Pt microneedle electrochemical sensor for in situ monitoring of hydrogen peroxide in tomato stems in response to wounding stimulation.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1007/s00216-024-05728-5

Xiaolong Yang, Doudou Huo, Yiran Tian, Xingliu Geng, Liang Xu, Daji Zhong, Rong Zhou, Songzhi Xu, Yali Zhang, Lijun Sun

{"title":"AuNPs/GO/Pt microneedle electrochemical sensor for in situ monitoring of hydrogen peroxide in tomato stems in response to wounding stimulation.","authors":"Xiaolong Yang, Doudou Huo, Yiran Tian, Xingliu Geng, Liang Xu, Daji Zhong, Rong Zhou, Songzhi Xu, Yali Zhang, Lijun Sun","doi":"10.1007/s00216-024-05728-5","DOIUrl":"10.1007/s00216-024-05728-5","url":null,"abstract":"Hydrogen peroxide (H2O2) is a critical signaling molecule with significant roles in various physiological processes in plants. Understanding its regulation through in situ monitoring could offer deeper insights into plant responses and stress mechanisms. In this study, we developed a microneedle electrochemical sensor to monitor H2O2 in situ, offering deeper insights into plant stress responses. The sensor features a platinum wire (100 µm diameter) modified with graphene oxide (GO) and gold nanoparticles (AuNPs) as the working electrode, an Ag/AgCl wire (100 µm diameter) as the reference electrode, and an untreated platinum wire (100 µm diameter) as the counter electrode. This innovative design enhances sensitivity and selectivity through the high catalytic activity of AuNPs, increased surface area from GO, and the superior conductivity of platinum. Operating at a low potential of -0.2 V to minimize interference, the sensor detects H2O2 concentrations from 10 to 1000 µM with high accuracy. In situ monitoring of H2O2 dynamics in tomato stems under the wounding stimulation reveals that H2O2 concentration increases as the sensor approaches the wound site, indicating localized production and transport of H2O2. This approach not only improves H2O2 monitoring in plant systems but also paves the way for exploring its generation, transport, and elimination mechanisms.","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1067-1079"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Next-Generation Membrane Bioreactors: Innovations, Challenges, and Future Directions

IF 6.4 2区环境科学与生态学

Current Pollution Reports Pub Date : 2025-03-01 DOI: 10.1007/s40726-025-00345-x

K. Khoiruddin, R. Boopathy, S. Kawi, I. G. Wenten

{"title":"Towards Next-Generation Membrane Bioreactors: Innovations, Challenges, and Future Directions","authors":"K. Khoiruddin, R. Boopathy, S. Kawi, I. G. Wenten","doi":"10.1007/s40726-025-00345-x","DOIUrl":"10.1007/s40726-025-00345-x","url":null,"abstract":"<div><h3>Purpose of Review</h3>This review provides a comprehensive analysis of the current state and future prospects of membrane bioreactors (MBRs), focusing on recent advancements in membrane materials, innovative design concepts, and strategies to optimize biodegradation processes. Additionally, it highlights the transformative role of artificial intelligence (AI), machine learning (ML), and hybrid configurations in advancing MBR.<h3>Recent Findings</h3> Hybrid MBR systems that incorporate advanced oxidation processes (AOPs) and other processes demonstrate enhanced micropollutant removal and treatment efficiency. MBR with nanocomposite and bio-inspired membranes exhibit improved fouling resistance, water flux, and mechanical strength. Significant innovations also include the application of AI-driven models, such as random forests and neural networks, to predict fouling behavior and optimize operational parameters in MBRs.<h3>Summary</h3>Recent progress in MBR technology, especially through new membrane materials and hybrid systems, plays an important role in improving MBR performance for contaminant removal and reducing fouling in wastewater treatment. Additionally, incorporating AI and optimizing operational parameters can further improve the efficiency, effectiveness, and reliability of these systems. </div>","PeriodicalId":528,"journal":{"name":"Current Pollution Reports","volume":"11 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Si/NiSi2/Si(111) Heterostructures Obtained by Solid-Phase Deposition

IF 0.5

Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques Pub Date : 2025-03-01 DOI: 10.1134/S1027451024701337

N. M. Mustafoeva, A. K. Tashatov, B. E. Umirzakov, M. B. Mamatova

引用次数: 0

Time-of-Flight Neutron Reflectometer for the DARIA Compact Neutron Source: Monte Carlo Simulation

IF 0.5

Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques Pub Date : 2025-03-01 DOI: 10.1134/S102745102470160X

N. A. Grigoryeva, N. A. Kovalenko, S. V. Grigoriev

引用次数: 0

X-Ray Phase Analysis of Composites after Temperature Modification of Titanium Dioxide with Melamine at Different Quantities of Initial Components

IF 0.5

Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques Pub Date : 2025-03-01 DOI: 10.1134/S1027451024701362

I. B. Dorosheva, S. A. Petrova, A. A. Rempel’

{"title":"X-Ray Phase Analysis of Composites after Temperature Modification of Titanium Dioxide with Melamine at Different Quantities of Initial Components","authors":"I. B. Dorosheva, S. A. Petrova, A. A. Rempel’","doi":"10.1134/S1027451024701362","DOIUrl":"10.1134/S1027451024701362","url":null,"abstract":"Composites based on melamine and titanium dioxide at different initial ratios 4 : 1, 6 : 1, 8 : 1, and 10 : 1 were obtained by polymerization in air at a temperature of 550°C. The morphology of the samples was investigated, and the elemental mapping of the sample composition was carried out using scanning electron microscopy. It was found that the initial melamine particles have a size of more than 20 μm, and its polymerization leads to the formation of g-C3N4 layers up to 5 μm in size. TiO2 particles have an average size of 150 nm, and the resulting g-C3N4/TiO2 heterostructures consist of particles with a size of 20–30 nm, which form agglomerates of about 2 μm in size. It was shown that the specific surface area decreases from 67 to 41 m2/g with increasing melamine content in the initial mixture. A single-phase composition TiN0.24O1.88 was formed when the initial components were mixed at a ratio of 4 : 1. When the ratio of the initial melamine and titanium dioxide was increased to 8 : 1 and 10 : 1, a two-phase system was formed, which consisted of Ti0.72O2 in an amount from 12 to 13% and C3N4 in an amount from 87 to 88%. During synthesis at a ratio of 6 : 1, two phases were also formed, but the C3N4 content in it was significantly less, up to 5%.","PeriodicalId":671,"journal":{"name":"Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques","volume":"18 6","pages":"1430 - 1435"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Zinc Implanted Silicon Nitride Film

IF 0.5

Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques Pub Date : 2025-03-01 DOI: 10.1134/S1027451024701519

V. V. Privezentsev, A. A. Firsov, V. S. Kulikauskas, D. A. Kiselev, B. R. Senatulin

{"title":"Study of Zinc Implanted Silicon Nitride Film","authors":"V. V. Privezentsev, A. A. Firsov, V. S. Kulikauskas, D. A. Kiselev, B. R. Senatulin","doi":"10.1134/S1027451024701519","DOIUrl":"10.1134/S1027451024701519","url":null,"abstract":"The results of studying nanoclusters at the interface of a Si3N4 film on a Si substrate implanted with 64Zn+ ions with a dose of 5 × 1016/cm2 and an energy of 40 keV are presented. The Si3N4 film was deposited on a silicon substrate using a gas-phase method. Then the implanted samples were annealed in air in steps of 100°C for 1 h at each step in the temperature range of 400–700°C. The surface morphology of the samples was studied using scanning probe microscopy. The profiles of the implanted impurity and film elements, as well as the chemical state of the Zn ion, were studied using X-ray photoelectron and Auger electron spectroscopy. The shock pulse method revealed that after implantation individual metallic zinc nanoclusters with a size of about 100 nm or less are present near the surface of the Si3N4 film. During the annealing process, they grow and simultaneously transform into the ZnSiN2 phase and, possibly, into the phases of zinc oxide and silicide near the surface. After annealing at a temperature of 700°C, Zn-containing nanoclusters with a size of about 100 nm are formed in the Si3N4 film.","PeriodicalId":671,"journal":{"name":"Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques","volume":"18 6","pages":"1538 - 1544"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperuricemia Facilitates Uric Acid-Mediated Vascular Endothelial Cell Damage by Inhibiting Mitophagy. 高尿酸血症通过抑制有丝分裂促进尿酸引起的血管内皮细胞损伤

IF 1.8 4区生物学

Cell Biochemistry and Biophysics Pub Date : 2025-03-01 Epub Date: 2024-09-28 DOI: 10.1007/s12013-024-01512-5

Gang Wu, Jun Liu, Guirong Ma, Qiuyu Wei, Xinghui Song

{"title":"Hyperuricemia Facilitates Uric Acid-Mediated Vascular Endothelial Cell Damage by Inhibiting Mitophagy.","authors":"Gang Wu, Jun Liu, Guirong Ma, Qiuyu Wei, Xinghui Song","doi":"10.1007/s12013-024-01512-5","DOIUrl":"10.1007/s12013-024-01512-5","url":null,"abstract":"Hyperuricemia remains an elusive factor in the pathogenesis of vascular endothelial injury. This study elucidates the role of hydroxychloroquine (HCQ) in the context of uric acid (UA)-induced vascular endothelial cell damage. Human umbilical vein endothelial cells (HUVECs) were exposed to varying UA concentrations (6 mg/dL to 50 mg/dL) for 48 h, or to 50 mg/dL UA for different time points (6 to 72 h). We observed a concentration- and time-dependent inhibition of cell proliferation, particularly at 40 mg/dL and 50 mg/dL UA. The autophagy marker LC3 exhibited reduced fluorescence intensity post-UA treatment, along with decreased expression of LC3-II/LC3I, beclin1, and p62, indicating impaired autophagy. The mechanistic exploration revealed that HCQ, in conjunction with the mitochondrial autophagy inhibitor Cyclosporine A (CsA), exacerbated the inhibitory effects of UA on HUVEC autophagy. This was evidenced by a further reduction in mitochondrial autophagy-related proteins and diminished fluorescence of LC3-II/LC3-I and Parkin, culminating in suppressed cell proliferation and accelerated cell senescence and apoptosis. Conversely, the co-treatment with the mitochondrial autophagy inducer carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and HCQ mitigated the detrimental effects of UA on HUVEC autophagy. This intervention led to increased expression of PINK1, Parkin, Bnip3, and Nix, along with enhanced fluorescence of LC3-II/LC3-I and Parkin, effectively inhibiting cell senescence and apoptosis while promoting cell proliferation. In conclusion, our findings underscore the pivotal role of HCQ in modulating UA-mediated vascular endothelial cell damage through the inhibition of mitophagy, providing novel insights into the therapeutic potential of targeting HCQ in the management of hyperuricemia-associated vascular complications.","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":"811-821"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, DFT study, in silico ADMET evaluation, molecular docking, and QSAR analysis of new anti-tuberculosis drugs derived from 2-hydroxybenzohydrazide derivatives.

IF 3.9 2区化学

Molecular Diversity Pub Date : 2025-03-01 DOI: 10.1007/s11030-025-11130-9

Alaa E Hassanien, Ghada Elsherbiny, Gamal M Abdelfattah, Marwa M Abdel-Aziz, Eman A El-Hagrassey

{"title":"Synthesis, DFT study, in silico ADMET evaluation, molecular docking, and QSAR analysis of new anti-tuberculosis drugs derived from 2-hydroxybenzohydrazide derivatives.","authors":"Alaa E Hassanien, Ghada Elsherbiny, Gamal M Abdelfattah, Marwa M Abdel-Aziz, Eman A El-Hagrassey","doi":"10.1007/s11030-025-11130-9","DOIUrl":"https://doi.org/10.1007/s11030-025-11130-9","url":null,"abstract":"This study investigates the potential of novel thiazole and hydroxybenzohydrazide derivatives as antitubercular agents. Using molecular docking and density functional theory (DFT) calculations, the binding affinities of these derivatives to the enoyl-acyl carrier protein reductase (InhA) enzyme of M. tb were assessed. InhA is crucial for the mycobacterial fatty acid synthase II (FAS-II) pathway, making it a prime target for drug development. QSAR analysis was employed to relate molecular descriptors to biological activity, and ADMET descriptors evaluated the pharmacokinetics and toxicity of the compounds. Experimental synthesis of the compounds and their characterization via IR and NMR spectroscopy confirmed their structures. DFT calculations revealed multiple conformers for each compound, with specific isomers showing enhanced stability and favorable binding interactions with InhA. These findings suggest that the synthesized derivatives have potential as new antitubercular agents, offering a basis for future drug development strategies against multidrug-resistant TB.","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0