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{"title":"Determination of Mixing Efficiency in Various Laboratory-Scale Semi-Solid Formulation Techniques Through Computational Fluid Dynamics and Finite Volume Simulations","authors":"Emiliano Frenquelli,&nbsp;Juan P. Real,&nbsp;Juan M. Llabot,&nbsp;Liliana Pierella,&nbsp;Santiago D. Palma,&nbsp;Daniel A. Real","doi":"10.1007/s12247-025-09963-w","DOIUrl":"10.1007/s12247-025-09963-w","url":null,"abstract":"<div><h3>Objective</h3><p>This study evaluated various mixing, homogenization, and dosing techniques for laboratory-scale semi-solid formulations, focusing on parameters such as volume, rpm, container morphology, and paddle design to determine efficiency and efficacy.</p><h3>Methods</h3><p>Three three-dimensional vessels were analyzed: mortar and pestle, blender, and a custom-designed conical reactor. Simulations using computational fluid dynamics (CFD) and the finite volume method were conducted to study particle trajectories and the homogenization process during the mixing, agitation, and emptying phases. Additionally, experimental validation was performed in parallel with the simulations, using similar operational conditions for each system.</p><h3>Results</h3><p>The CFD simulations revealed that the conical reactor was the most efficient under all conditions (high and low volumes and revolutions). Further evaluations showed that the helical (screw) paddle inside the reactor provided the highest efficiency in mixing and significantly accelerated the complete emptying of the reactor. Experimental validation corroborated the simulation results, showing a high degree of agreement between both methods and demonstrating the reliability of CFD simulations under real operational conditions.</p><h3>Conclusions</h3><p>The results demonstrate the relevance of the conical reactor and its helical screw paddle for improving the efficiency of mixing and dosing in semi-solid formulations, offering valuable insights for pharmacists involved in therapy customization. The findings emphasize the need for further research to refine these systems and enhance their efficiency in pharmaceutical applications.\u0000</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic salvation: HIIT and herbal allies reverse NAFLD damage in rats","authors":"Ehsan Arabzadeh,&nbsp;Amir Sarshin,&nbsp;Foad Feizolahi,&nbsp;Majid Mohabbat,&nbsp;Mohammad-Ali Soleiman-Fallah,&nbsp;Alireza Rahimi,&nbsp;Anatoli Petridou,&nbsp;Zahra Emami,&nbsp;Helena Tajik,&nbsp;Reza Bozorg Omid,&nbsp;Amir Maleki,&nbsp;Hamid Ekrami Ogholbag,&nbsp;Ali Khademi,&nbsp;Mehdi Zargani","doi":"10.1007/s10735-025-10413-7","DOIUrl":"10.1007/s10735-025-10413-7","url":null,"abstract":"<div><p>Fatty liver disease is a build-up of fats in the liver that can damage the organ and lead to serious complications. This study aimed to investigate the effects of exercise training and supplementation (milk thistle, chicory and cumin) on liver metabolites related to its function and health in rats with non-alcoholic fatty liver disease (NAFLD). Forty adult male Wistar rats with an average weight of 215 ± 10 g were divided into a control group fed on the basal diet and four experimental groups fed with high-fat diet (HFD) for 6 weeks to induce non-alcoholic fatty liver disease (NAFLD). The 4 NAFLD groups were subdivided and treated with (a) plain HFD, (b) high-intensity interval training (HIIT), (c) supplement (milk thistle, chicory, and cumin), and (d) combined HIIT and supplementation for 4 weeks. The induction of NAFLD through HFD yielded dyslipidemia, liver tissue damage, increased malondialdehyde, uncoupling protein 2 (UCP2), and phosphatidylinositol-3 kinase (PI3K), as well as decreased superoxide dismutase (SOD) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) in liver tissue (<i>p</i> &lt; 0.05). The 4 weeks intervention with either HIIT, supplement or especially the combined application of both, reversed these factors (<i>p</i> &lt; 0.05) through changes in their concentrations in a direction indicative of enhanced liver health and function. HIIT beside supplementation (milk thistle, chicory, and cumin) improved indices related to oxidative stress, lipid profile, and the expression of PI3K, UCP2, PGC-1α genes expression and PGC-1α protein content, making it potentially promising in the treatment of liver damage caused by HFD.</p></div>","PeriodicalId":650,"journal":{"name":"Journal of Molecular Histology","volume":"56 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10735-025-10413-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local quantum fisher information and quantum phase transitions in the XY spin-1/2 chain","authors":"Xiao-Dong Tan,&nbsp;Yu Shi,&nbsp;Ru Hou","doi":"10.1007/s11128-025-04726-5","DOIUrl":"10.1007/s11128-025-04726-5","url":null,"abstract":"<div><p>We study the local quantum Fisher information (LQFI) of arbitrary two-qubit states for the anisotropic XY spin-1/2 chain in a transverse field <i>h</i> at finite temperature <i>T.</i> The results show that LQFI for the states of the nearest-neighbor and the next-nearest-neighbor spin pairs can clearly spotlight the critical point (CP)<span>(gamma)</span> = 0 of a quantum phase transition (QPT) in this model even at finite<i> T</i>, due to the discontinuity of the first derivative of LQFI at <span>(gamma)</span> = 0 (<span>(gamma)</span> is the anisotropy parameter). Moreover, LQFI can successfully detect another QPT point <i>h</i> = 1 at <i>T</i> = 0, due to the divergence of the first derivative of LQFI at <i>h</i> = 1 if <span>(left| gamma right| ne 1)</span>. When <span>(left| gamma right| = 1)</span>, the CP <i>h</i> = 1 can be also clearly detected by LQFI at <i>T</i> &gt; 0. Besides, LQFI can pick out the special points (not the CPs), where LQFI always displays a cusp-like behavior. At some proper values of <span>(gamma)</span> and <i> h</i>, LQFI can increase with increasing <i>T</i> as well. These remarkable properties suggest that LQFI could serve as an useful tool for experimentally detecting the CPs of QPTs in spin systems at finite <i>T</i>.</p></div>","PeriodicalId":746,"journal":{"name":"Quantum Information Processing","volume":"24 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Continuum Gas Flows to Second Order in Knudsen Number with Arbitrary Surface Accommodation","authors":"Nitay Ben-Shachar,&nbsp;Joseph T. Johnson,&nbsp;Douglas R. Brumley,&nbsp;Jason Nassios,&nbsp;John E. Sader","doi":"10.1007/s10955-025-03417-w","DOIUrl":"10.1007/s10955-025-03417-w","url":null,"abstract":"<div><p>Asymptotic analyses of the Boltzmann equation for near-continuum low-Mach-number gas flows predominantly assume diffuse scattering from solid surfaces, i.e., complete surface accommodation, despite gas scattering often deviating from this idealized behavior in practice. While some results for arbitrary surface accommodation exist to second order in small Knudsen number, the full theory to this order is yet to be reported. Here, we present a matched asymptotic expansion of the linearized Boltzmann–BGK equation that generalizes existing theories to Maxwell-type boundary conditions with arbitrary accommodation at solid surfaces. This is performed to second order in small Knudsen number for smooth solid surfaces, and holds for steady and unsteady flow at oscillatory frequencies far smaller than the molecular collision frequency. In contrast to diffuse scattering, we find that the second-order Knudsen layer functions vary as <span>(eta log ^2eta )</span> for incomplete but arbitrary accommodation at a curved surface, where <span>(eta )</span> is the dimensionless normal coordinate. A modified refined moment method is developed to numerically handle this spatial dependency. Analytical formulas for all velocity slip and temperature jump coefficients for the Hilbert region are reported that exhibit accuracies greater than 99.9%. This resolves conflicting literature reports on the second-order velocity slip and temperature jump coefficients.</p></div>","PeriodicalId":667,"journal":{"name":"Journal of Statistical Physics","volume":"192 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistics for the Triangle Density in ERGM and Its Mean-Field Approximation","authors":"Elena Magnanini,&nbsp;Giacomo Passuello","doi":"10.1007/s10955-025-03430-z","DOIUrl":"10.1007/s10955-025-03430-z","url":null,"abstract":"<div><p>We consider the edge-triangle model (also known as the Strauss model) and its mean-field approximation, within the region of parameters called replica symmetric regime. While our motivation stems from analyzing the asymptotic behavior of the triangle density in the edge-triangle model, a significant part of our work is devoted to studying an approximation of this observable in the mean-field setting, where explicit computations are possible. More specifically, for the first model, we prove that the triangle density concentrates with high probability in a neighborhood of its typical values. For the second model we can go further and prove, for the approximated triangle density, a standard and non-standard central limit theorem at the critical point, still not known for the edge-triangle model. Additionally, we obtain many concentration results derived via large deviations and statistical mechanics techniques. Although a rigorous comparison between these two models is still lacking, we believe that they are asymptotically equivalent in many respects. To support this conjectured behavior, we complement the analysis with simulations related to the central limit theorem for the edge-triangle model.</p></div>","PeriodicalId":667,"journal":{"name":"Journal of Statistical Physics","volume":"192 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10955-025-03430-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel In-Situ Liquefying Carbonated SNEDDS Loaded with Atorvastatin Calcium: An Approach for Overcoming Dosage and Stability Challenges","authors":"Abdelrahman Y. Sherif,&nbsp;Mohamed Abbas Ibrahim","doi":"10.1007/s10876-025-02791-5","DOIUrl":"10.1007/s10876-025-02791-5","url":null,"abstract":"<div><p>Although self nanoemulsifying drug delivery system (SNEDDS) enhances atorvastatin calcium bioavailability, formulation leakage from capsules and drug degradation limits its pharmaceutical application. The traditional solidifying adsorption approach failed to overcome the instability issue and produced a powder with a high dosage. Combining in-situ liquefying (poloxamer 188) and pH-modifying agents (sodium bicarbonate) was invented to address these challenges while maintaining dissolution performance. Therefore, five formulations were prepared, namely: liquid SNEDDS (L-SNEDDS), solid SNEDDS (S-SNEDDS), carbonated SNEDDS (C-SNEDDS), in-situ liquefying SNEDDS (IL-SNEDDS), and in-situ liquefying carbonated SNEDDS (IL-C-SNEDDS). Oil and cosurfactant ingredients were selected based on the solubility of the drug and poloxamer 188, respectively, while surfactant was selected based on transmittance measurement. Moreover, the prepared formulations were characterized using a Zetasizer, pH meter, thermal behavior, SEM, FTIR, PXRD, and dissolution apparatus. Finally, the stability of prepared formulations was studied to assess the impact of formulation type on drug stability. Results showed that atorvastatin calcium exhibited the highest solubility in imwitor 308 (181.4 mg/g) among tested oils. The optimized SNEDDS formulation displayed a transmittance value of 98.62%, indicating excellent emulsification with a particle size of 10.5 nm. The optimized L-SNEDDS formulation comprises tween 80, propylene glycol, and imwitor 308 (2: 1: 1). The results showed that Syloid successfully adsorbed L-SNEDDS, which was present in an amorphous state. In vitro dissolution studies demonstrated that all SNEDDS formulations achieved &gt; 90% drug dissolution. However, notable drug degradation was observed with liquid and solid SNEDDS (&gt; 10%) compared to &lt; 5% in IL-C-SNEDDS. The present study demonstrates that IL-C-SNEDDS effectively addresses dosage and stability challenges without increasing the total dosage.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The miRNomics of antiretroviral therapy-induced obesity","authors":"Niska Majumdar,&nbsp;Bishwa R. Pokharel,&nbsp;Abigail Dickerson,&nbsp;Andreea Cruceanu,&nbsp;Smit Rajput,&nbsp;Lok R. Pokhrel,&nbsp;Paul P. Cook,&nbsp;Shaw M. Akula","doi":"10.1007/s10142-025-01585-2","DOIUrl":"10.1007/s10142-025-01585-2","url":null,"abstract":"<div><p>Human immunodeficiency virus (HIV) is a retrovirus that incorporates its genetic material into the host’s chromosome. The resulting diseases and related conditions constitute a global health problem as there are no treatments to eliminate HIV from an infected individual. However, the potent, complex, and active antiretroviral therapy (ART) strategies have been able to successfully inhibit HIV replication in patients. Unfortunately, obesity following ART is frequent among HIV-infected patients. The mechanism underlying ART-induced obesity is characterized based on expression of traditional markers such as genes and proteins. However, little is known about, yet another key component of molecular biology known as microRNAs (miRNAs). Micro-RNAs are ~ 22 base-long non-coding nucleotides capable of regulating more than 60% of all human protein-coding genes. The interest in miRNA molecules is increasing and their roles in HIV and obesity are beginning to be apparent. In this review, we provide an overview of HIV and its associated diseases, ART-induced obesity, and discuss the roles and plausible benefits of miRNAs in regulating obesity genes in HIV-infected patients. Understanding the roles of miRNAs in ART-induced obesity will aid in tracking the disease progression and designing beneficial therapeutic approaches.</p></div>","PeriodicalId":574,"journal":{"name":"Functional & Integrative Genomics","volume":"25 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10142-025-01585-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact bending strength and structural properties of hardwood: branch versus stem","authors":"Tobias Nenning,&nbsp;Johannes Konnerth,&nbsp;Wolfgang Gindl-Altmutter,&nbsp;Michael Grabner,&nbsp;Christian Hansmann,&nbsp;Lukas Eder,&nbsp;Sabine Bodner,&nbsp;Maximilian Pramreiter","doi":"10.1007/s00107-025-02247-7","DOIUrl":"10.1007/s00107-025-02247-7","url":null,"abstract":"<div><p>The branches of deciduous trees are optimised by nature to allow continuous adaptation and response to changing environmental conditions. As a result, the morphology and internal structure of the wood branches are often more variable than in the stem. Quantitatively, branches and stem tops represent 20–50% of the volume of the above-ground biomass of deciduous trees, which is currently under-utilized and mainly burned. To enable a higher-value application as a safe construction material, a comprehensive technological profile of branch wood is a prerequisite. Therefore, we performed single-blow impact pendulum tests in tangential wood direction on branch and stem wood samples of beech, oak, and poplar to investigate their relationship with wood density, macrostructural properties, fibre properties, and microfibril orientation of selected samples. Our results showed that the significant differences in mean impact bending strength between branch and stem for all species could not be explained by wood density. However, branch and stem wood with higher toughness are generally associated with longer fibres. Overall, branches showed higher MFA (microfibril angle) and lower fibre length compared to stems. We found that higher toughness in selected beech samples was associated with higher density and lower MFA. While oak also had a lower MFA, poplar had a higher MFA in high-toughness samples. Our empirical results provide insights into the species-specific structure-property relationships of hardwood branches, improving the understanding of their properties and variability, and potentially informing their use in structural applications.</p></div>","PeriodicalId":550,"journal":{"name":"European Journal of Wood and Wood Products","volume":"83 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00107-025-02247-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint identification of groundwater contaminant sources: an improved optimization algorithm","authors":"Zheng Guo,&nbsp;Boyan Sun,&nbsp;Saiju Li,&nbsp;Tongqing Shen,&nbsp;Pengpeng Ding,&nbsp;Lei Zhu","doi":"10.1007/s10661-025-13971-1","DOIUrl":"10.1007/s10661-025-13971-1","url":null,"abstract":"<div><p>Rapid identification of contaminant source information is critical for solving sudden groundwater contamination events. This paper constructs a combined EnKF-SPSO algorithm based on the ensemble Kalman filter (EnKF) and survival particle swarm optimization (SPSO) algorithms to groundwater contamination source identification, which includes determining the location of the source, initial concentration, and emission time. The proposed hybrid architecture improves upon conventional single-algorithm approaches by decoupling the identification process into two stages. First, the EnKF searches for the contaminant source’s location, thereby reducing the search space. Next, the SPSO estimates the initial concentration and emission time within the reduced domain. This two-stage process effectively mitigates the curse of dimensionality often encountered in standalone optimization methods. We set up two solute transport scenarios with different numbers of contaminant sources to examine the effectiveness of the algorithm and compare it with the EnKF, particle swarm optimization (PSO), and SPSO algorithms. The results show that the EnKF-SPSO algorithm can identify the contaminant characteristics more accurately without falling into a local optimum, and the average relative error is less than 1%. In addition, the EnKF-SPSO algorithm, for cases with measurement errors, is highly reliable. The combined algorithm can provide technical support for groundwater contamination remediations, risk assessments, and liability determinations.</p></div>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suitability of different Digital Elevation Models in the estimation of LS factor and soil loss","authors":"R. Akhila,&nbsp;S. K. Pramada","doi":"10.1007/s10661-025-13967-x","DOIUrl":"10.1007/s10661-025-13967-x","url":null,"abstract":"<div><p>Soil erosion is a global concern, and tons of fertile topsoil are lost worldwide. Topography significantly influences soil erosion patterns, shaping how soil loss varies across landscapes. In the Revised Universal Soil Loss Equation (RUSLE), the topographic factor (LS-factor) quantifies this impact, with Digital Elevation Models (DEMs) serving as key inputs for its derivation. The soil loss over Kerala, India, is estimated using different DEMs. The study also explored two methods for deriving the LS-factor, one based on flow accumulation and another based solely on the slope length. Among the approaches tested for LS factor estimation, the slope-based method proved more effective than one incorporating flow accumulation, as the study is for a region rather than a distinct hydrologic unit. Four freely available Digital Elevation Models, ALOS, ASTER, SRTM, and Cartosat-1 were selected for the study. The study showed that the general pattern of soil erosion can be captured by using any of these DEMs despite differences in individual elevation values. The mean potential soil loss estimated for the year 2020 was 215.91 t/ha/year, 205.70 t/ha/year, 203.99 t/ha/year, and 207.97 t/ha/year when using ASTER, ALOS, SRTM, and Cartosat-1, respectively. The ASTER DEM shows a slightly higher mean value but exhibited the least uncertainty, which was confirmed by bootstrap resampling uncertainty analysis. These findings emphasize the need for careful DEM selection based on terrain characteristics, enhancing the accuracy of soil erosion assessments and informing more effective land management strategies.</p></div>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}