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{"title":"Statistical analysis and uncertainty risk assessment of large-scale fatal gas explosions based on Chinese coal mine accidents.","authors":"Wei Zhang, Deming Wang","doi":"10.1007/s11356-025-36703-x","DOIUrl":"https://doi.org/10.1007/s11356-025-36703-x","url":null,"abstract":"<p><p>Large-scale fatal gas explosions (LSFGEs) are primary accidents in coalmines owing to complicated formation and coupling paths of the causative factors. Therefore, space-time distributions of 282 LSFGEs from 2000 to 2022 in Chinese coalmines were analyzed. A cause-chain inference model of gas explosion was proposed using the Delphi method and Bayesian network (BN). The results showed that working-excavating faces and winter were the main sites and seasons of gas explosions respectively, accounting for 67% and 32.3%. These statistics suggested the ignition sources of 14.5% of LSFGEs were fuzzy, including coal spontaneous combustion and friction sparks. Moreover, instantaneous gas overruns were attributed to periodic roof caving and coal-rock dynamic disasters, accounting for 11.0%. The change in roof pressures and concealment of the enclosed areas were key risk factors of a gas explosion. A comprehensive analysis of cause-chains with expert knowledge and probabilistic inference reduced the epistemic uncertainty of fuzzy causes. The sensitivity analysis highlighted electric sparks and the absence of wind or breeze as the primary causes of gas explosion accidents and its percentage of exceeded 20%. This study aimed to elucidate key causative factors and their interrelationships in gas explosions, providing valuable guidance for daily risk management and accident investigations.</p>","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFKM Promotes the Progression of Gastric Cancer by Up-regulating CNTN1 Expression Through H3K18la Modification.","authors":"Xin Shen, Hai Shi, Lei Liu, Shujing Chong, Junwei Han, Yuping Gu","doi":"10.1007/s12010-025-05319-9","DOIUrl":"https://doi.org/10.1007/s12010-025-05319-9","url":null,"abstract":"<p><p>Gastric cancer (GC) stands as one of the most common malignancies globally, characterized by significant incidence rates. Phosphofructokinase muscle isoform (PFKM), a critical rate-limiting enzyme in glycolysis, has its expression modulated by lactate production in tumor cells. The objective of this study is to elucidate the underlying molecular mechanisms by which PFKM contributes to the pathogenesis of GC. The viability, migration, and invasion of GC cells were analyzed by CCK-8 and transwell assays. Each condition was repeated three times. The regulation of H3K18la on transcription activity of CNTNl was evaluated by·dua-luciferase reporter assay. Animal experiment was performed using nude mice with six mice in each group, and tumor growth was evaluated. Statistical analysis was performed using GraphPad Prism software with t-test, one-way or two-way ANOVA. We found that PFKM was over-expressed in GC. Downregulated PFKM restrained the viability, migration, invasion, glucose uptake, and lactate production of GC cells. Mechanically, PFKM interacted with CNTN1 and facilitated the enrichment of H3K18la at the CNTN1 promoter region. Overexpression of CNTN1 reversed the inhibitory effects of PFKM knockdown on GC progression. Our research showed that increasing PFKM levels accelerated GC development by regulating CNTN1 expression through mechanisms involving histone lactylation, which could potentially contribute to novel approaches in diagnosing and treating GC.</p>","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black carbon characterization and its association with meteorological phenomena using network data.","authors":"Vivek Kumar, Panuganti C S Devara, Vijay K Soni","doi":"10.1007/s10661-025-14216-x","DOIUrl":"https://doi.org/10.1007/s10661-025-14216-x","url":null,"abstract":"<p><p>Studies related to the impact of Black Carbon (BC) aerosols on weather phenomena like monsoon breaks, winter fog events, and pre-monsoon heatwaves are sparse in India. This study fills the gap of observational information of BC aerosols and their relationship with meteorological phenomena. We examined the interaction between BC aerosols and precipitation during the monsoon's active-break cycle, a critical period for agriculture, water resources, and weather patterns. Data from stations in rural and urban areas provided contrasting seasonal and diurnal variation. The diurnal pattern is closely linked to anthropogenic activities and meteorological factors. The study examines significant diurnal and seasonal variation in relation to local and regional meteorological variation. BC concentrations show distinct bimodal diurnal patterns, with major peak in the evening, between 2000 to 2300 h IST and secondary peak in the morning between 0700 to 0900 h IST. Seasonal variations show the lowest BC levels during the monsoon due to efficient wet scavenging, while the highest levels occur during the post-monsoon, primarily from agricultural burning. Meteorological factors like temperature, humidity, rainfall, and wind speed significantly influence BC dynamics. Higher temperatures and lower humidity increase BC levels, while rainfall reduces them, and wind disperses BC aerosols, affecting their concentration and distribution. Analysis of pre-monsoon heatwaves, winter fog events, and monsoon conditions reveals the complex interplay between BC aerosols and weather patterns. Local meteorological factors such as temperature inversions and wind patterns significantly influence the BC impact on weather phenomena. This research enhances the understanding of BC pollution and its diverse effects on weather and climate, emphasizing the importance of integrating meteorological factors into air quality management and policymaking. It lays the groundwork for developing targeted strategies to mitigate BC's adverse effects on health and the environment in India.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 8","pages":"852"},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic contamination in vertical water columns and fish: a comparative study between the Buriganga River and the Bay of Bengal in Bangladesh.","authors":"Ashiqur Rahman Tamim, Md Abdullah Yousuf Al Harun, Md Atikul Islam, Md Mezbaul Bahar, Md Shaharuf Islam, Mahadi Hasan","doi":"10.1007/s10661-025-14328-4","DOIUrl":"https://doi.org/10.1007/s10661-025-14328-4","url":null,"abstract":"<p><p>This study investigated microplastic (MP) contamination in freshwater and marine ecosystems in Bangladesh, focusing on the Buriganga River and the Bay of Bengal. Water and fish samples were collected, digested with H₂O₂, and analyzed using microscopy and micro-Fourier transform infrared spectroscopy for visual inspection and MP characterization. Microplastics were significantly more prevalent in the freshwater system and its fish compared to the marine environment (p ≤ 0.05), with variations observed across different depths. Fish, particularly those in the benthopelagic zone, showed substantial MPs contamination, predominantly in the form of fibers, fragments, and foam. Transparent MPs dominated in water samples, while colored MPs are more prevalent in fish. Polycarbonate, nitrile, and polypropylene were the major polymers identified in the water and fish samples. A significant positive correlation (r = 0.65, p ≤ 0.05) between MPs in water and fish suggests ingestion of MPs from their habitat.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 8","pages":"851"},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication, characterization, and modification of a novel polyethersulfone (PES) mix matrix membrane via BiFeO3 as a hydrophilic additive to improve permeability and antifouling features.","authors":"Shahad K Jawad, Khalid T Rashid, Manal Afham Toma, Adnan A AbdulRazak, Alaa Dhari Jawad Al-Bayati, Zaidoon M Shakor, Aqeel S A Aljadiri, Qusay F Alsalhy, Mohammed Ahmed Shehab","doi":"10.1007/s11356-025-36711-x","DOIUrl":"https://doi.org/10.1007/s11356-025-36711-x","url":null,"abstract":"<p><p>In the present study, the synthesis of a novel polyethersulfone (PES/BiFeO3NPs) ultrafiltration membrane was achieved through a phase inversion method. For the first time, different concentrations of BiFeO3NPs were added to the casting solution in order to better understand how they affect the properties and performance of modified PES membranes: weight percents of 0, 0.1, 0.2, 0.3, and 0.4. The neat and modified PES membranes were characterized comprehensively via field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), porosity, and contact angle (CA) techniques. The modified membranes demonstrated a substantially higher level of purified water flow and a high rejection of MB dye and BSA solutions when compared to the pristine PES membrane, in addition to increasing the membrane fouling resistance. An increase of about 65% over the bare PES membrane (20.2 kg/h.m²) was seen in the pure water flux, which reached a peak of 52.5 kg/h.m² at a BiFeO₃ concentration of 0.3 wt.% in the casting solution. The PES/BiFeO₃ membranes outperformed the neat PES in MB dye and BSA removal by a margin of over 99%. The membrane with the highest antifouling capability was the 0.3 wt.% BiFeO₃ (SM3) membrane, as determined by the fouling resistance of the membranes examined using methylene blue dye (MB) solution filtration. The results of this study indicate that BiFeO₃ is a promising nanoadditive with great potential for use in the production of UF membranes for wastewater treatment.</p>","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Immuno-Immobilization Mass-Spectrometry-Based Assay to Enable Structure-Activity Relationship Development of Emopamil Binding Protein (EBP) Inhibitors.","authors":"Ronghai Cheng, Paramasivam Murugan, Meiyi Zhang, Daniel Tekverk, Wanru Li, Katrina Ngyuen, Aram Chang, Rajesh Kumar, Karen S Conrad, Howard Jones, Martin Himmelbauer, Reza Nemati","doi":"10.1021/jasms.5c00121","DOIUrl":"https://doi.org/10.1021/jasms.5c00121","url":null,"abstract":"<p><p>Emopamil binding protein (EBP) is a transmembrane isomerase that catalyzes the conversion of 8,9-unsaturated sterols to 7,8-unsaturated sterols in the cholesterol biosynthesis pathway. Accumulation of 8,9-unsaturated sterols promotes oligodendrocyte progenitor cell (OPC) differentiation into new myelinating oligodendrocytes, making EBP inhibition a promising therapeutic strategy for neurodegenerative diseases such as multiple sclerosis. Structure-activity relationship (SAR)-driving assays are critical for advancing drug candidates through preclinical drug discovery. However, EBP is a challenging target due to low production yield and loss of enzymatic activity during the purification process. In addition, assay throughput is limited by chromatographic separation of EBP isomers. Here, we describe a robust functional assay to support SAR of EBP small molecule inhibitors. Immuno-mobilization of the active form of EBP, overexpressed in Expi293F cells, was coupled with liquid chromatography-atmospheric pressure chemical ionization multiple reaction monitoring MS (LC-APCI MRM MS) to quantify the potency of EBP inhibitors. This approach significantly enhanced EBP enzymatic activity at nanomolar concentrations compared to that of purified recombinant EBP (recEBP). Furthermore, automating sterol extraction and integrating a dual-arm high-speed LC autosampler further improved assay throughput. This approach showed excellent reproducibility and robustness suitable for SAR development. This was evidenced by high-quality individual concentration-response curves (CRCs) with confidence limit ratios (CLRs) below 5; a normal distribution of reference EBP inhibitor pIC₅₀ values with a two-standard deviation (2-SD) of 0.61 based on 72 independent measurements; and consistent IC₅₀ values for over 20 active EBP inhibitors spanning a broad potency range across two independent assay runs, with a mean pIC₅₀ difference between runs of -0.05 and a 2-SD interval of 0.24.</p>","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable chitosan/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications.","authors":"Abdelrhman Ragab, Nourhan El-Badry, Nouran Tamer, Ahmed Naas, Ahmed Hamdy, Samar H Tawakey, Abdelrahim H A Hassan, Alyaa I Salim","doi":"10.1186/s13065-025-01564-5","DOIUrl":"https://doi.org/10.1186/s13065-025-01564-5","url":null,"abstract":"<p><p>Chronic wounds pose significant healthcare challenges globally. The need for more effective strategies for wound healing applications has led to the exploration of numerous emerging technologies. The current study investigates the wound-healing potential of green synthesized silver nanoparticles (AgNPs) using Aloe Vera and green tea loaded on polyvinyl alcohol (PVA)/chitosan hydrogel. To this end, different hydrogel films incorporating various types of AgNPs were prepared. XRD, SEM, and EDX confirmed good integration of the crystallographic structure of the green synthesized nanomaterial and indicated smooth surface morphology of the films. The results of the biodegradability test showed that the Aloe Vera synthesized AgNPs hydrogel patch exhibited a high degradation rate with (22%) weight loss after 30 days. The results of in vitro antimicrobial testing and cytotoxicity assays revealed that Aloe Vera-synthesized AgNPs possess higher antibacterial activity against Escherichia coli and Staphylococcus aureus with high cell viability (82%). The in vitro release of AgNPs showed a gradual release of AgNPs with stabilization. The water vapor transmission rate was found to range between 1388.89 g/m2/day and a moisture content of 7.73%. The tensile stress and elongation at break were found to range between 69.14-67-13 MPa and 4.84%-4.34%, respectively, indicating significant mechanical properties of the films. Overall, the results proved that green synthesized AgNPs hydrogel patches, especially using Aloe Vera, provide the optimal properties for wound healing, combining good moisture utilization, stability, and holding potential as a biodegradable, antibacterial wound dressing.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"190"},"PeriodicalIF":4.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer in translation: cyanine carborane salts: a multifunctional theranostic approach to cancer treatment.","authors":"Simran Deep Kaur, Deepak N Kapoor","doi":"10.1186/s41181-025-00360-9","DOIUrl":"https://doi.org/10.1186/s41181-025-00360-9","url":null,"abstract":"","PeriodicalId":534,"journal":{"name":"EJNMMI Radiopharmacy and Chemistry","volume":"10 1","pages":"36"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug repurposing: a promising drug discovery strategy for the treatment of emerging epidemic infectious disease.","authors":"Simeng Zhang, Ruiqing Zhang, Lidan Zheng, Yang Liu, Qing Fan, Yingxu Liu, Xiangzhen Ning, Yanmin Zhang, Yadong Chen, Haichun Liu","doi":"10.1007/s11030-025-11247-x","DOIUrl":"https://doi.org/10.1007/s11030-025-11247-x","url":null,"abstract":"<p><p>Epidemic refers to a disease when the occurrence level exceeds expected standards (generating an epidemic phenomenon), in which infectious diseases pose a major challenge to global health. The concept of epidemiology arises with infectious diseases, which can infect many people within a certain period and lead to a pandemic. Especially in the face of sudden epidemics, time is of the essence. In such urgent scenarios, the time required for traditional drug discovery is often prohibitive, given its inherently long timelines, high costs, and frequent failures. Drug repurposing strategies, mainly divided into experimental and computational approaches,which involves identifying new therapeutic applications for already approved pharmaceuticals, have gained substantial attention as a time-efficient and cost-effective alternative. In light of this, the present review provides a comprehensive overview of the various approaches to drug repurposing for the treatment of emerging epidemic infectious diseases, the majority of which are sudden epidemics caused by viruses. In addition, we discuss the challenges faced by repurposing and propose innovative approaches to address these challenges to better achieve the successful translation of drug repurposing into clinical applications and maximize the therapeutic value of drugs.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling sources of fecal pollution in oligotrophic mountain waters: Integrating Escherichia coli enumeration, microbial source tracking, and eDNA analysis.","authors":"Sharon Maes, Martin Andersson-Li, Jessica Sjöstedt, Jon Hildahl, Daniel Yu, Norman Neumann, Monica Odlare, Anders Jonsson","doi":"10.1007/s10661-025-14298-7","DOIUrl":"10.1007/s10661-025-14298-7","url":null,"abstract":"<p><p>Aquatic ecosystems in mountainous regions are crucial for fulfilling natural and anthropogenic water demands around the world. This study integrates Escherichia coli (E. coli) enumeration, microbial source tracking (MST), and environmental DNA (eDNA) analysis to identify sources of fecal contamination in oligotrophic mountain waters. Conducted in an area with intense tourism and traditional reindeer herding, this research addresses the urgent need to identify fecal pollution sources to safeguard the water quality of these vital ecosystems. Our study reveals that E. coli levels vary significantly across different locations and times, suggesting varied sources of contamination from humans, wildlife, and livestock animals. MST techniques, alongside eDNA analysis, provided insights into the complex patterns of fecal pollution, allowing for the distinction between human and animal contributions to water contamination. Our findings highlight the importance of combining various analytical methods to track fecal pollution sources effectively, and to develop targeted strategies for water quality management.</p>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 8","pages":"849"},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}