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Endolymphatic sac tumour - a rare complication associated with von Hippel-Lindau disease. 内淋巴囊瘤-一种与希佩尔-林道病相关的罕见并发症。
Ceskoslovenska patologie Pub Date : 2023-01-01
Mária Wozniaková, Vladimír Židlík, Jozef Škarda
{"title":"Endolymphatic sac tumour - a rare complication associated with von Hippel-Lindau disease.","authors":"Mária Wozniaková,&nbsp;Vladimír Židlík,&nbsp;Jozef Škarda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a 42-year - old female with familiar form von Hippel-Lindau disease (VHL) and recurrent endolymphatic sac tumour (ELST), which was presented like non-homogenous, solid and cystic expansion of the left petrous temporal bone. Histologically, there was found lamellae of bone with adjacent ligament and with papillary projections with fibrovascular core. The papillae were lined by a single layer of cuboidal epithelium with hyperchromatic and lightly pleomorphic nuclei. Sporadically, small cystic formations with eosinophilic, PAS positive secretion were noted. Imunohistochemically, the cuboidal cells showed diffuse positivity for vimentin, epithelial membrane antigen (EMA), cytokeratin AE1/AE3 and S100 protein (weakly). Other markers examined, including TTF1, PAX8 and CD10, were negative. Endolymphatic sac tumour is rare low-grade malignant epithelial tumour arising from the endolymphatic sac in the temporal bone, which occurs in 1 out of 30 000 births, with just fewer than 300 cases reported in the literature. About one third of cases are associated with von Hippel- Lindau disease, an autosomal dominant familial cancer syndrome.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 1","pages":"32-35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9421123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current possibilities of histopathologic separation of idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis. How to do it? 目前特发性肺纤维化与纤维化性过敏性肺炎的组织病理学分离的可能性。怎么做呢?
Ceskoslovenska patologie Pub Date : 2023-01-01
Radoslav Matěj
{"title":"Current possibilities of histopathologic separation of idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis. How to do it?","authors":"Radoslav Matěj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histopathological pattern of progressive pulmonary fibrosis could be seen in many different fibrotic lung interstitial diseases. Exact diagnosis is crucial for precise therapy, moreover, different diseases have different prognosis. The most important disorders in this group are idiopatic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis, and their separation is crucial because of totally different treatment of the patients. The aim of this review is to sum up the most important characteristics of usual interstitial pneumonia, histopathological pattern of idiopatic pulmonary fibrosis, and fibrotic hypersensitivity pneumonitis and provide a practical work-up for precise diagnostics of these diseases in the frame of effectively cooperating multidisciplinary team.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 1","pages":"10-17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and histopathological aspects of the most common inflammatory non-infectious skin diseases. 最常见的炎症性非传染性皮肤病的临床和组织病理学方面。
Ceskoslovenska patologie Pub Date : 2023-01-01
Miroslav Důra, Eva Sticová, Andrea Felšöová, Jiří Štork
{"title":"Clinical and histopathological aspects of the most common inflammatory non-infectious skin diseases.","authors":"Miroslav Důra,&nbsp;Eva Sticová,&nbsp;Andrea Felšöová,&nbsp;Jiří Štork","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors present a didactic overview of the most common inflammatory non-infectious skin diseases. This overview is not exhaustive, but illustrative, especially when regarding the aspect of a systematic approach to the evaluation of skin biopsy with an initial evaluation of the morphological pattern of the inflammatory process. This will subsequently facilitate the diagnosis. Photodocumentation of typical primary skin manifestations is attached to the photomicrograph images. This enables the pathologist to make a basic clinical-pathological correlation, which is of fundamental importance in dermatopathology.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 3","pages":"104-123"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41129242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bleeding after childbirth / miscarriage - practical notes on the examination of biopsy material. 分娩/流产后出血-活检材料检查的实用注意事项。
Ceskoslovenska patologie Pub Date : 2023-01-01
Šárka Hadravská, Vladimír Korečko, Magdaléna Daumová
{"title":"Bleeding after childbirth / miscarriage - practical notes on the examination of biopsy material.","authors":"Šárka Hadravská,&nbsp;Vladimír Korečko,&nbsp;Magdaléna Daumová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postpartum haemorrhage is a significant cause of maternal morbidity and mortality worldwide. The pathologist encounters only a limited spectrum of causes leading to postpartum haemorrhage. The most common causes are retained placenta and placental site subinvolution. Both of these lesions can be diagnosed from material obtained by uterine curettage. Morbidly adherent placenta (placenta accreta spectrum) is a less frequent subject of investigation, the diagnosis of which can be reliably established only on the basis of histological examination of uterine specimens after hysterectomy.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 2","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular diagnosis of complete and partial hydatidiform moles. 完全和部分葡萄胎的分子诊断。
Ceskoslovenska patologie Pub Date : 2023-01-01
Martina Putzová, Šárka Hadravská, Magdaléna Daumová
{"title":"Molecular diagnosis of complete and partial hydatidiform moles.","authors":"Martina Putzová,&nbsp;Šárka Hadravská,&nbsp;Magdaléna Daumová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Complete and partial hydatidiform moles are abnormal products of conception that can be identified by clinical, ultrasonographic, morphologic, histologic, and genetic methods. The diagnosis is usually confirmed only by histological examination. However, accurate diagnosis based on morphological criteria is difficult and some studies have shown that misclassifications are common, even when analysed by highly experienced pathologists. Misdiagnosis may mean that women are either not included in adequate β-hCG follow-up with the risk that the hydatidiform mole progresses to choriocarcinoma or, conversely, are included in follow-up unnecessarily. A reliable complementary method to pathological interpretation may be genetic analysis of the conceptus to eliminate the diagnostic dilemma by distinguishing non-molar spontaneous abortions from hydatidiform moles and defining the type of hydatidiform mole. The aim of our short paper is to introduce the routine molecular analysis used in our laboratory to a wider range of clinical pathologists.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 2","pages":"64-67"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tall cell carcinoma of the breast with reversed polarity - a report of three cases with a review of the literature. 极性颠倒的乳腺高细胞癌--三例病例报告及文献综述。
Ceskoslovenska patologie Pub Date : 2023-01-01
Karol Kajo, Mojmír Ducár, Ján Dzuracký, Katarína Kajová Macháleková, Miroslava Vallová, Csaba Biró, Lukáš Šebest, Tomáš Slamka, Regína Behulová Lohajová, Pavol Žúbor
{"title":"Tall cell carcinoma of the breast with reversed polarity - a report of three cases with a review of the literature.","authors":"Karol Kajo, Mojmír Ducár, Ján Dzuracký, Katarína Kajová Macháleková, Miroslava Vallová, Csaba Biró, Lukáš Šebest, Tomáš Slamka, Regína Behulová Lohajová, Pavol Žúbor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tall cell carcinoma with reverse polarity (TCCRP) is a rare special type of breast epithelial neoplasm presented by columnar cells with opposite nuclear polarity, solid and solid-papillary architecture, and frequent IDH2 gene alterations. Hereby, the authors present three cases of TCCRP in women aged 56, 66 and 67 years with maximum tumour sizes of 29 mm, 10 mm and 8 mm. Tumours showed histomorphological characteristics of TCCRP supported by immunohistochemical profile of tumour cells, in which positive expression of CK7, CK5/6, GCDFP15, mammaglobin, GATA3 and calretinin and negativity of CK14, p63, TTF1, thyroglobulin and neuroendocrine markers were demonstrated. Two tumours were triple negative, and in one tumour, only weak focal ER expression was noted along with PR and HER2 negativity. Pathogenic somatic variants in mutational hotspot region p.R172 in IDH2 gene were detected using NGS technology in all three tumours. Moreover, in two of these tumours, the most common pathogenic variants p.E545A and p.H1047R of PIK3CA were identified. TCCRP represents a rare breast neoplasm of low malignant potential, the incidence of which will probably increase due to the more clearly defined histomorphological, immunohistochemical and molecular-genetic characteristics, which were all responsible for including this entity into the 5th edition of WHO classification breast tumours.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 3","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydatidiform mole. 葡萄胎。
Ceskoslovenska patologie Pub Date : 2023-01-01
Magdaléna Daumová, Šárka Hadravská, Martina Putzová
{"title":"Hydatidiform mole.","authors":"Magdaléna Daumová,&nbsp;Šárka Hadravská,&nbsp;Martina Putzová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydatidiform mole is the most common form of gestational trophoblastic disease. It is an abnormally formed placental tissue with characteristic changes in karyotype, arising in fertilization disorders. The presence of abundant paternal genetic information plays a key role in the pathogenesis of complete and partial hydatidiform moles. These lesions are characterized by a relatively wide spectrum of morphological changes that may not be fully expressed, especially in the early stages of pregnancy. In addition, some changes can be observed in non-molar gravidities, which, unlike hydatidiform moles, lack any risk of malignant transformation. Although conventional histological examination still plays a key role in the diagnosis, it should be supplemented by other methods that reliably differentiate individual lesions. Accurate diagnosis of molar gravidities is important not only for determining the correct therapeutic approach, but the obtained data may also contribute to further research of these pathological entities.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 2","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9847651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral valve rheumatoid nodule complicated by infective endocarditis. 二尖瓣类风湿性结节并发感染性心内膜炎。
Ceskoslovenska patologie Pub Date : 2023-01-01
Monika Manethová, Václav Stejskal, Ivo Šteiner, Jiří Soukup
{"title":"Mitral valve rheumatoid nodule complicated by infective endocarditis.","authors":"Monika Manethová,&nbsp;Václav Stejskal,&nbsp;Ivo Šteiner,&nbsp;Jiří Soukup","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a case of a 73-year-old male with rheumatoid arthritis presenting with acute abdominal and back pain and rapidly developing multiorgan failure. A positive blood culture (Staphylococcus aureus, Candida species) followed by transoesophageal sonography established a diagnosis of mitral valve infective endocarditis. At the autopsy, the heart examination revealed fibrinous pericarditis and multiple small vegetations on the mitral valve. The mitral valve itself showed no significant damage. Surprisingly, the histological examination of the mitral valve showed granulomatous inflammation with central fibrinoid necrosis and peripheral palisade of histiocytes, with occasional giant cells and lymphocytic inflammatory infiltrate - findings consistent with a rheumatoid nodule. Infective vegetations were overlying the nodule. Due to its relative frequency, a possibility of cardiac involvement by rheumatoid arthritis and its potential infective complications should be considered in patients with appropriate history and clinical symptoms.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 3","pages":"129-131"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skeletal dysplasias of the fetus and infant: comprehensive review and our experience over a 10-year period. 胎儿和婴儿骨骼发育不良:综合回顾和我们10年来的经验。
Ceskoslovenska patologie Pub Date : 2023-01-01
Marta Ježová, Denisa Pavlovská, Ilga Grochová, Andrea Michenková, Pavel Vlašín
{"title":"Skeletal dysplasias of the fetus and infant: comprehensive review and our experience over a 10-year period.","authors":"Marta Ježová,&nbsp;Denisa Pavlovská,&nbsp;Ilga Grochová,&nbsp;Andrea Michenková,&nbsp;Pavel Vlašín","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a comprehensive review dealing with rare genetic skeletal disorders. More than 400 entities are included in the latest classification. The most severe or lethal phenotypes are identifiable in the prenatal period and the pregnancy can be terminated. Perinatal autopsy and posmortem X-rays are crucial in providing a definitive diagnosis. The number of cases confirmed by genetic testing is increasing. We report our own experience with genetic skeletal disorders based on 41 illustrative fetal and neonatal cases which we encountered over a 10-year period. Thanatophoric dysplasia and osteogenesis imperfecta represent approximately half of the cases coming to autopsy. Achondrogenesis type 2 and hypochondrogenesis, short-rib dysplasia, chondrodysplasia punctata, campomelic dysplasia and achondroplasia are less common. Skeletal dysplasias with autosomal recessive inheritance are the least frequent, e.g. perinatally lethal hypophophatasia, achondrogenesis type 1A, diastrophic dysplasia/atelosteogenesis type 2 or mucolipidosis type 2 (I cell disease).</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 2","pages":"68-79"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9834643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous abortion in the first trimester of pregnancy. 自然流产妊娠头三个月的自然流产
Ceskoslovenska patologie Pub Date : 2023-01-01
Magdaléna Daumová, Šárka Hadravská, Martina Putzová
{"title":"Spontaneous abortion in the first trimester of pregnancy.","authors":"Magdaléna Daumová,&nbsp;Šárka Hadravská,&nbsp;Martina Putzová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spontaneous abortions in the first trimester of gravidity represent a clinically significant problem that can affect up to 15% of recognized pregnancies. The causes of early pregnancy loss are very heterogeneous and include genetic, environmental and immunological factors. Although the pathologist's main task is to exclude molar pregnancy, in some cases conventional histological examination can also contribute to the elucidation of the cause of miscarriage and the management of subsequent pregnancies, especially in the case of lesions with a high risk of recurrence that may lead to habitual abortion.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"59 2","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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