{"title":"Clear Cell Chondrosarcoma","authors":"","doi":"10.32388/7oiymo","DOIUrl":"https://doi.org/10.32388/7oiymo","url":null,"abstract":"A rare, usually low grade chondrosarcoma characterized by the presence of tumor cells with clear cytoplasm. It usually arises in the epiphyseal ends of long bones.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69625602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ludvíkoyá, M. Michal, M. Zamecnik, R. Houba, P. Sedlacek, E. Csillagi, M. Sivak
{"title":"Desmoplastic ameloblastoma.","authors":"M. Ludvíkoyá, M. Michal, M. Zamecnik, R. Houba, P. Sedlacek, E. Csillagi, M. Sivak","doi":"10.32388/0e9xwl","DOIUrl":"https://doi.org/10.32388/0e9xwl","url":null,"abstract":"Two cases of desmoplastic form of ameloblastoma are reported. This tumor shows marked stromal desmoplasia and often scattered osteoplasia. The majority of stromal elements is represented by myofibroblasts. The epithelial component of this tumor is often scanty and different from epithelial islands of classic ameloblastoma. Pathological, immunohistochemical and radiological findings are described and the differential diagnosis of this tumor is discussed.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"34 3 1","pages":"94-8"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43376227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal
{"title":"Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article.","authors":"Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The great majority of testicular tumors can be diagnosed on the basis of morphology, while immunohistochemistry and molecular genetics assist in only a small proportion of cases. Similar to other areas of pathology, ancillary diagnostic methods have to be used responsibly and assessed in correlation with morphological, serological and clinical findings. Prior to their effective use, a limited differential diagnosis based on morphology is required.The significance of germ cell tumors is underscored by the fact that they represent the most frequent solid neoplasms occurring in men between 20-30 years and if diagnosed correctly and in early stage, they have excellent prognosis. From the molecular genetic standpoint, germ cell tumors stand apart from the current trend of tumor stratification based on molecular profiles. It is mainly due to the low mutational load, since the main genetic abnormality are chromosomal aneuploidies. Given the frequency of germ cell tumors among testicular neoplasms and since morphology is usually diagnostically most valuable, this review article is focused mainly on germ cell tumors, emphasizing the morphological features. Sertoli cell tumor, NOS is the only sex-cord stromal tumor included in this review as its diagnosis can be challenging. For practical purposes, this reviewis focused on differential diagnosis, including only entities where misdiagnosis would have impact on clinical outcome.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 3","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38506223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor
{"title":"Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report.","authors":"Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dermatofibrosarcoma protuberans is a quite rare local aggressive tumor of dermis and subcutis, revealing characteristic morphology and chromosomal translocation (17; 22)(q21;q13) with gene fusion COL1A1-PDGFB. The tumour almost never metastasizes and complete excision signs an excellent prognosis. Approximately in 10% of cases, dermatofibrosarcoma undergoes a fibrosarcomatous transformation associated with metastatic disease and worse prognosis. In this paper, we refer a case of a male patient with subcutaneous tumor in back region, in which the small biopsy lead to diagnosis of a spindle cell sarcoma. However, only the histopathological examination of the entire tumor in the material from the radical surgery detected the dermatofibrosarcoma protuberans with fibrosarcomatous transformation. Both components of the tumor showed the characteristic genetic alteration. Identification of fibrosarcomatous component within the DFSP matters in prognosis. Distinction between fibrosarcoma arising within the dermatofibrosarcoma protuberans and fibrosarcoma arising de novo is of therapeutic consequence: the patients with metastatic or inoperable DFSP with fibrosarcomatous transformation may profit form imatinib treatment.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38004773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current nomenclature and histopathological criteria for assessment of the noninflammatory degenerative diseases of the aorta.","authors":"Ondřej Fabián","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A histopathological examination of the surgical specimen of the aorta usually follows a surgical reconstruction of the aortic aneurysm or dissection. Among the adults, the frequent cause of the aneurysm development is a severe atherosclerosis, while in children the aneurysm or dissection usually come as a complication of genetic syndromes. The common microscopical denominator of those diseases is a medial degeneration of variable degree. For a long time, a terminology of microscopical structural alterations used to be subjective and unsettled. In 2016, the first international guidelines for the histopathological assessment of the non-inflammatory degenerative diseases of the aorta were established. They introduced unified nomenclature, defined individual microscopic alterations and implemented a three-tier grading system. This work aims at practical aspects of the microscopical assessment and interpretation of the degenerative processes in the aorta with regards to the aforementioned consensus.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37923150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in histopathological classification of neuroendocrine tumors in 5th edition of WHO classification of gastrointestinal tract tumors (2019).","authors":"Tomáš Jirásek, Václav Mandys","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a brief review is presented a summary of news in the classification of neuroendocrine neoplasms of the digestive system, as they were introduced in the 5th edition of the WHO Classification of Digestive System Tumors published in summer 2019.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 4","pages":"207-211"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25492079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}