Ceskoslovenska patologie最新文献_第10页

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/9xhujg

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Ceskoslovenska patologie Pub Date : 2020-02-02 DOI: 10.32388/c9dyev

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Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article. 免疫组织化学和分子遗传学在睾丸肿瘤中应用的实践建议。评论文章。

Ceskoslovenska patologie Pub Date : 2020-01-01

Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal

{"title":"Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article.","authors":"Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal","doi":"","DOIUrl":"","url":null,"abstract":"The great majority of testicular tumors can be diagnosed on the basis of morphology, while immunohistochemistry and molecular genetics assist in only a small proportion of cases. Similar to other areas of pathology, ancillary diagnostic methods have to be used responsibly and assessed in correlation with morphological, serological and clinical findings. Prior to their effective use, a limited differential diagnosis based on morphology is required.The significance of germ cell tumors is underscored by the fact that they represent the most frequent solid neoplasms occurring in men between 20-30 years and if diagnosed correctly and in early stage, they have excellent prognosis. From the molecular genetic standpoint, germ cell tumors stand apart from the current trend of tumor stratification based on molecular profiles. It is mainly due to the low mutational load, since the main genetic abnormality are chromosomal aneuploidies. Given the frequency of germ cell tumors among testicular neoplasms and since morphology is usually diagnostically most valuable, this review article is focused mainly on germ cell tumors, emphasizing the morphological features. Sertoli cell tumor, NOS is the only sex-cord stromal tumor included in this review as its diagnosis can be challenging. For practical purposes, this reviewis focused on differential diagnosis, including only entities where misdiagnosis would have impact on clinical outcome.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 3","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38506223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report. 隆突性皮肤纤维肉瘤伴纤维肉瘤转化1例。

Ceskoslovenska patologie Pub Date : 2020-01-01

Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor

{"title":"Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report.","authors":"Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor","doi":"","DOIUrl":"","url":null,"abstract":"Dermatofibrosarcoma protuberans is a quite rare local aggressive tumor of dermis and subcutis, revealing characteristic morphology and chromosomal translocation (17; 22)(q21;q13) with gene fusion COL1A1-PDGFB. The tumour almost never metastasizes and complete excision signs an excellent prognosis. Approximately in 10% of cases, dermatofibrosarcoma undergoes a fibrosarcomatous transformation associated with metastatic disease and worse prognosis. In this paper, we refer a case of a male patient with subcutaneous tumor in back region, in which the small biopsy lead to diagnosis of a spindle cell sarcoma. However, only the histopathological examination of the entire tumor in the material from the radical surgery detected the dermatofibrosarcoma protuberans with fibrosarcomatous transformation. Both components of the tumor showed the characteristic genetic alteration. Identification of fibrosarcomatous component within the DFSP matters in prognosis. Distinction between fibrosarcoma arising within the dermatofibrosarcoma protuberans and fibrosarcoma arising de novo is of therapeutic consequence: the patients with metastatic or inoperable DFSP with fibrosarcomatous transformation may profit form imatinib treatment.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38004773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Current nomenclature and histopathological criteria for assessment of the noninflammatory degenerative diseases of the aorta. 评估主动脉非炎性退行性疾病的现行命名法和组织病理学标准。

Ceskoslovenska patologie Pub Date : 2020-01-01

Ondřej Fabián

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Changes in histopathological classification of neuroendocrine tumors in 5th edition of WHO classification of gastrointestinal tract tumors (2019). 2019年第5版WHO胃肠道肿瘤分类中神经内分泌肿瘤组织病理分类的变化

Ceskoslovenska patologie Pub Date : 2020-01-01

Tomáš Jirásek, Václav Mandys

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A case of amoebic colitis with Crohn-like endoscopic and histopathological features. 具有克罗恩样内窥镜和组织病理学特征的阿米巴结肠炎1例。

Ceskoslovenska patologie Pub Date : 2020-01-01

Ondřej Fabián, Milan Trojánek, Lenka Richterová, František Stejskal, Kamila Dundrová, Markéta Roznetinská, Josef Zámečník

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Pathophysiology of ANCA-associated vasculitis. anca相关性血管炎的病理生理学。

Ceskoslovenska patologie Pub Date : 2020-01-01

Bartoňová Lenka, Hrušková Zdenka, Honsová Eva

{"title":"Pathophysiology of ANCA-associated vasculitis.","authors":"Bartoňová Lenka, Hrušková Zdenka, Honsová Eva","doi":"","DOIUrl":"","url":null,"abstract":"ANCA positive vasculitis (AAV) is a serious autoimmune disease mainly affecting small vessels in various organ systems, accompanied by the presence of ANCA antibodies in serum. AAV represents a group of the most common systemic vasculitis in adulthood, and based on clinical manifestations this disease entity includes 3 phenotypes, namely: granulomatosis with polyangiitis (formerly Wegeners granulomatosis), microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors, such as infections. The mechanisms by which ANCA antibodies cause vasculitis involves excessive neutrophil activation, that subsequently leads to release pro-inflammatory cytokines, reactive oxygen species and lytic enzymes. In addition, activated neutrophils induce the formation of neutrophil extracellular traps in a process called NETosis. The released neutrophil antigens are exposed to the immune system via antigen presenting cells, which further stimulates antibody production and creates a vicious circle with tissue destruction. Understanding the pathogenesis of AAV represents the key which provides not only optimal diagnosis and treatment, but also gives the pathologist a tool for deeper insight into the morphological features of disease progression, including the various stages of development and healing.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 2","pages":"65-67"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38005855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Echinococcus multilocularis: Diagnostic problem in a liver core biopsy. 多房棘球蚴:肝核心活检的诊断问题。

Ceskoslovenska patologie Pub Date : 2020-01-01

Alena Chlumská, Petr Mukenšnabl, Jana Němcová, Lenka Nedbalová, Petr Hrabal, Miroslav Ryska, Květa Michalová

{"title":"Echinococcus multilocularis: Diagnostic problem in a liver core biopsy.","authors":"Alena Chlumská, Petr Mukenšnabl, Jana Němcová, Lenka Nedbalová, Petr Hrabal, Miroslav Ryska, Květa Michalová","doi":"","DOIUrl":"","url":null,"abstract":"Echinococcus multilocularis causes an aggressive form of hydatidosis whose histomorphological picture is generally not well recognized. We report a case of 39-year-old women presenting with poorly circumscribed nodules in the right hepatic lobe. Owing to the clinical suspicion of focal nodular hyperplasia and hepatocellular adenoma, a core biopsy was performed. The histological findings of necrotic fibrous tissue infiltrated by narrow epithelial cords and small cysts containing cytokeratin positive material were in concordance with the diagnosis of cholangiocarcinoma. Subsequent examination of the surgically resected necrotic nodules with a vital tissue at the periphery corresponded to a reparative fibrosis accompanied by a striking ductular proliferation. Serological and molecular genetic work-up led to the diagnosis of Echinococcus multilocularis. The aim of this report is to point out the unusual histological features of the solid foci of alveolar hydatidosis, which consisted of necrotic fibrous tissue with ductular reaction. Such findings in a core biopsy may simulate regressively altered carcinoma.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 1","pages":"32-34"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37923151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Immunohistochemistry in hollow urinary tract. 空心尿路免疫组化。

Ceskoslovenska patologie Pub Date : 2020-01-01

Kristýna Pivovarčíková, Marián Švajdler, Ondřej Hes

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