Ceskoslovenska patologie最新文献_第9页

Comparative analysis of two almost identical traffic accidents. 两起几乎完全相同的交通事故的比较分析。

Ceskoslovenska patologie Pub Date : 2021-01-01

Martina Kostíková, Kateřina Bucsuházy, Pavlína Moravcová, Michal Zelený, Teťana Makarčuková, Eva Matuchová, Roman Mikulec

引用次数: 0

Case report: Gaucher disease in trepanobiopsy of 16yo woman examined for suspected myelodysplastic syndrome. 病例报告:16岁女性梅毒穿刺检查疑似骨髓增生异常综合征的戈谢病。

Ceskoslovenska patologie Pub Date : 2021-01-01

Vladimír Židlík, Tomáš Kuhn, Pavel Hurník, Mária Wozniaková, Barbora Mičulková, Dušan Žiak, Marie Sporková, Patricie Delongová, Jaroslav Horáček, Jiří Ehrmann

{"title":"Case report: Gaucher disease in trepanobiopsy of 16yo woman examined for suspected myelodysplastic syndrome.","authors":"Vladimír Židlík, Tomáš Kuhn, Pavel Hurník, Mária Wozniaková, Barbora Mičulková, Dušan Žiak, Marie Sporková, Patricie Delongová, Jaroslav Horáček, Jiří Ehrmann","doi":"","DOIUrl":"","url":null,"abstract":"Gaucher disease is an autosomal recessive disease belonging to the so-called storage diseases. More than 300 mutations of the GBA1 gene encoding the β-glucocerebrosidase enzyme are known. It is a very rare disease in the Czech Republic. Currently 35 patients are treated. In our case report, we present the case of a 16 year old female patient attending the Clinic of Pediatric Medicine at the University Hospital in Ostrava. Since 2007, the patient has suffered prolonged thrombocytopenia, at the time with progression, and splenomegaly, which has not been further investigated. Trepanobiopsy was sent to the Department of Pathology with suspicion of myelodysplastic syndrome in May of 2018. In the biopsy examination, the individual bloodline did not show dysplastic features and the number of blasts was not increased. The marrow interstitium was 70% permeated with gaucher cells with intraplasmatic fibrous material. Cells were in the appearance of „crumpled paper“ and expressed CD68 in immunohistochemical stain and in histochemical examination of PAS and iron (Fe) staining. Based on a morphological finding, Gauchers disease was suspected. Repeated bone marrow aspirates were subsequently captured by gaucher cells, and a next biochemical examination showed a β-glucocerebrosidase enzyme decrease of activity. Gaucher disease is a progressive disease that requires early diagnosis with the onset of therapy.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 2","pages":"105-108"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear Cell Chondrosarcoma 透明细胞软骨肉瘤

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/7oiymo

引用次数: 21

Desmoplastic ameloblastoma. 多造釉细胞瘤。

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/0e9xwl

M. Ludvíkoyá, M. Michal, M. Zamecnik, R. Houba, P. Sedlacek, E. Csillagi, M. Sivak

引用次数: 1

[Giant cell angiofibroma]. 巨细胞血管纤维瘤。

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/0mn7yx

M. Švajdler, M. Michal, Z. Kinkor

引用次数: 0

Secretory Meningioma 分泌脑膜瘤

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/v4op8p

引用次数: 6

Desmoplastic Fibroblastoma 多见成纤维细胞瘤

Ceskoslovenska patologie Pub Date : 2020-02-07 DOI: 10.32388/9xhujg

引用次数: 0

Intestinal T-Cell Lymphoma 肠t细胞淋巴瘤

Ceskoslovenska patologie Pub Date : 2020-02-02 DOI: 10.32388/c9dyev

引用次数: 0

Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article. 免疫组织化学和分子遗传学在睾丸肿瘤中应用的实践建议。评论文章。

Ceskoslovenska patologie Pub Date : 2020-01-01

Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal

{"title":"Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article.","authors":"Květoslava Michalová, Michael Michal, Milan Hora, Ondřej Hes, Michal Michal","doi":"","DOIUrl":"","url":null,"abstract":"The great majority of testicular tumors can be diagnosed on the basis of morphology, while immunohistochemistry and molecular genetics assist in only a small proportion of cases. Similar to other areas of pathology, ancillary diagnostic methods have to be used responsibly and assessed in correlation with morphological, serological and clinical findings. Prior to their effective use, a limited differential diagnosis based on morphology is required.The significance of germ cell tumors is underscored by the fact that they represent the most frequent solid neoplasms occurring in men between 20-30 years and if diagnosed correctly and in early stage, they have excellent prognosis. From the molecular genetic standpoint, germ cell tumors stand apart from the current trend of tumor stratification based on molecular profiles. It is mainly due to the low mutational load, since the main genetic abnormality are chromosomal aneuploidies. Given the frequency of germ cell tumors among testicular neoplasms and since morphology is usually diagnostically most valuable, this review article is focused mainly on germ cell tumors, emphasizing the morphological features. Sertoli cell tumor, NOS is the only sex-cord stromal tumor included in this review as its diagnosis can be challenging. For practical purposes, this reviewis focused on differential diagnosis, including only entities where misdiagnosis would have impact on clinical outcome.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 3","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38506223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report. 隆突性皮肤纤维肉瘤伴纤维肉瘤转化1例。

Ceskoslovenska patologie Pub Date : 2020-01-01

Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor

{"title":"Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report.","authors":"Jan Hrudka, Martin Charvát, Petr Grossmann, Zdeněk Kinkor","doi":"","DOIUrl":"","url":null,"abstract":"Dermatofibrosarcoma protuberans is a quite rare local aggressive tumor of dermis and subcutis, revealing characteristic morphology and chromosomal translocation (17; 22)(q21;q13) with gene fusion COL1A1-PDGFB. The tumour almost never metastasizes and complete excision signs an excellent prognosis. Approximately in 10% of cases, dermatofibrosarcoma undergoes a fibrosarcomatous transformation associated with metastatic disease and worse prognosis. In this paper, we refer a case of a male patient with subcutaneous tumor in back region, in which the small biopsy lead to diagnosis of a spindle cell sarcoma. However, only the histopathological examination of the entire tumor in the material from the radical surgery detected the dermatofibrosarcoma protuberans with fibrosarcomatous transformation. Both components of the tumor showed the characteristic genetic alteration. Identification of fibrosarcomatous component within the DFSP matters in prognosis. Distinction between fibrosarcoma arising within the dermatofibrosarcoma protuberans and fibrosarcoma arising de novo is of therapeutic consequence: the patients with metastatic or inoperable DFSP with fibrosarcomatous transformation may profit form imatinib treatment.","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"56 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38004773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0