完全和部分葡萄胎的分子诊断。

Q4 Medicine
Ceskoslovenska patologie Pub Date : 2023-01-01
Martina Putzová, Šárka Hadravská, Magdaléna Daumová
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引用次数: 0

摘要

完全和部分葡萄胎是妊娠的异常产物,可以通过临床、超声、形态学、组织学和遗传学方法来鉴别。诊断通常只能通过组织学检查来证实。然而,基于形态学标准的准确诊断是困难的,一些研究表明,即使由经验丰富的病理学家进行分析,错误分类也是常见的。误诊可能意味着女性要么没有接受足够的β-hCG随访,有可能有葡萄胎发展为绒毛膜癌的风险,要么相反,被不必要地纳入随访。一种可靠的补充病理解释的方法可能是对胎儿进行遗传分析,通过区分非磨牙自然流产和葡萄胎并确定葡萄胎的类型来消除诊断困境。我们这篇短文的目的是向更广泛的临床病理学家介绍我们实验室使用的常规分子分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular diagnosis of complete and partial hydatidiform moles.

Complete and partial hydatidiform moles are abnormal products of conception that can be identified by clinical, ultrasonographic, morphologic, histologic, and genetic methods. The diagnosis is usually confirmed only by histological examination. However, accurate diagnosis based on morphological criteria is difficult and some studies have shown that misclassifications are common, even when analysed by highly experienced pathologists. Misdiagnosis may mean that women are either not included in adequate β-hCG follow-up with the risk that the hydatidiform mole progresses to choriocarcinoma or, conversely, are included in follow-up unnecessarily. A reliable complementary method to pathological interpretation may be genetic analysis of the conceptus to eliminate the diagnostic dilemma by distinguishing non-molar spontaneous abortions from hydatidiform moles and defining the type of hydatidiform mole. The aim of our short paper is to introduce the routine molecular analysis used in our laboratory to a wider range of clinical pathologists.

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来源期刊
Ceskoslovenska patologie
Ceskoslovenska patologie Medicine-Medicine (all)
CiteScore
0.40
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发文量
17
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