Cell Proliferation最新文献_第5页

The heterogeneity of cellular metabolism in the tumour microenvironment of hepatocellular carcinoma with portal vein tumour thrombus. 伴有门静脉瘤栓的肝癌肿瘤微环境中细胞代谢的异质性。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-27 DOI: 10.1111/cpr.13738

Xiu-Ping Zhang, Wen-Bo Zou, Zhen-Qi Li, Ze-Tao Yu, Shao-Bo Yu, Zhao-Yi Lin, Fei-Fan Wu, Peng-Jiong Liu, Ming-Gen Hu, Rong Liu, Yu-Zhen Gao

{"title":"The heterogeneity of cellular metabolism in the tumour microenvironment of hepatocellular carcinoma with portal vein tumour thrombus.","authors":"Xiu-Ping Zhang, Wen-Bo Zou, Zhen-Qi Li, Ze-Tao Yu, Shao-Bo Yu, Zhao-Yi Lin, Fei-Fan Wu, Peng-Jiong Liu, Ming-Gen Hu, Rong Liu, Yu-Zhen Gao","doi":"10.1111/cpr.13738","DOIUrl":"https://doi.org/10.1111/cpr.13738","url":null,"abstract":"Given the growing interest in the metabolic heterogeneity of hepatocellular carcinoma (HCC) and portal vein tumour thrombus (PVTT). This study comprehensively analysed the metabolic heterogeneity of HCC, PVTT, and normal liver samples using multi-omics combinations. A single-cell RNA sequencing dataset encompassing six major cell types was obtained for integrated analysis. The optimal subtypes were identified using cluster stratification and validated using spatial transcriptomics and fluorescent multiplex immunohistochemistry. Then, a combined index based meta-cluster was calculated to verify its prognostic significance using multi-omics data from public cohorts. Our study first depicted the metabolic heterogeneity landscape of non-malignant cells in HCC and PVTT at multiomics levels. The optimal subtypes interpret the metabolic characteristics of PVTT formation and development. The combined index provided effective predictions of prognosis and immunotherapy responses. Patients with a higher combined index had a relatively poor prognosis (p <0.001). We also found metabolism of polyamines was a key metabolic pathway involved in conversion of metabolic heterogeneity in HCC and PVTT, and identified ODC1 was significantly higher expressed in PVTT compared to normal tissue (p =0.03). Our findings revealed both consistency and heterogeneity in the metabolism of non-malignant cells in HCC and PVTT. The risk stratification based on cancer-associated fibroblasts and myeloid cells conduce to predict prognosis and guide treatment. This offers new directions for understanding disease development and immunotherapy responses.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13738"},"PeriodicalIF":5.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intellectual base and research fronts of IL-18: A bibliometric review of the literature from WoSCC (2012–2022) IL-18 的知识基础和研究前沿：对 WoSCC（2012-2022 年）文献的文献计量学回顾。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-26 DOI: 10.1111/cpr.13684

Zhongzhi Wang

{"title":"The intellectual base and research fronts of IL-18: A bibliometric review of the literature from WoSCC (2012–2022)","authors":"Zhongzhi Wang","doi":"10.1111/cpr.13684","DOIUrl":"10.1111/cpr.13684","url":null,"abstract":"Interleukin-18 (IL-18) is a vital pro-inflammatory cytokine crucial for immune regulation. Despite its significance, bibliometric analysis in this field is lacking. This study aims to quantitatively and qualitatively assess IL-18 research to construct its intellectual base and predict future hotspots. We conducted a thorough search on the Web of Science Core Collection for relevant publications between 1 January 2012 and 31 December 2022. English-language articles and reviews were included. Visual analysis was performed using various tools including VOSviewer, Citespace, and Microsoft Excel. Our analysis covers interleukin-18 (IL-18) literature from 2012 to 2022, exploring research trends comprehensively. Key institutions like Yale University and Shanghai Jiao Tong University emerged as significant contributors. Prolific authors such as Kanneganti and Dinarello made notable contributions. Main focus areas included biology, medicine, and immunology. Co-citation analysis highlighted influential works like Jianjin Shi. Hotspot keyword frequency cluster analysis revealed emerging themes like pyroptosis and psoriasis. Gene co-occurrence clustering identified genes associated with immune regulation and inflammation. GO and KEGG pathway enrichment analysis provided insights into IL-18-related biological processes and pathways. Protein–protein interaction networks identified core proteins such as IL10 and TNF. Association disease analysis linked IL-18 to various inflammatory, autoimmune, and metabolic disorders. This bibliometric review offers insights into IL-18 research trends over the past decade, guiding future investigations and serving as a reference for researchers in this field.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":"57 11","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.13684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment. 用于有效治疗胶质母细胞瘤的新型四面体框架核酸衍生化学动力疗法制剂。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-24 DOI: 10.1111/cpr.13736

Xiaodie Li, Lei Li, Xin Fu, Shiqian Huang, Yuhao Wang, Yuepeng Yang, Shuqin Zhou, Zhaowei Zou, Qing Peng, Chao Zhang

{"title":"A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment.","authors":"Xiaodie Li, Lei Li, Xin Fu, Shiqian Huang, Yuhao Wang, Yuepeng Yang, Shuqin Zhou, Zhaowei Zou, Qing Peng, Chao Zhang","doi":"10.1111/cpr.13736","DOIUrl":"https://doi.org/10.1111/cpr.13736","url":null,"abstract":"Chemodynamic therapy (CDT) has garnered significant attention for treating diverse malignant tumours due to its minimally invasive nature, reduced damage to healthy tissues, and potential mitigation of side effects. However, its application in glioblastoma (GBM) is hindered by the diminished capacity of CDT agents to traverse the blood-brain barrier (BBB), inadequate tumour targeting efficiency, and restricted availability of H2O2 within the tumour microenvironment (TME). To address these challenges, we devised a novel CDT agent (Fe@tFNAs-ANG-3AT) based on a tetrahedral framework nucleic acids (tFNAs). Fe@tFNAs-ANG-3AT was constructed by anchoring iron ions (Fe3+) onto the dual appendages-modified tFNAs. Specifically, one appendage, Angiopep-2 (ANG, a penetrating peptide), facilitates Fe@tFNAs-ANG-3AT penetration across the BBB and selective targeting of tumour cells. Simultaneously, the second appendage, 3-Amino-1,2,4-triazole (3AT, a H2O2 enzyme inhibitor), augments the H2O2 levels required for effective CDT treatment. Upon tumour cell internalization, the loaded Fe3+ in Fe@tFNAs-ANG-3AT is reduced to Fe2+ by the overexpressed glutathione (GSH) in the TME, catalysing the generation of cytotoxic hydroxyl radicals (·OH) and inducing tumour cell death via elevated oxidative stress levels within tumour cells. It is anticipated that Fe@tFNAs-ANG-3AT holds promise as a transformative treatment strategy for GBM.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13736"},"PeriodicalIF":5.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small molecule valproic acid enhances ventral patterning of human neural tube organoids by regulating Wnt and Shh signalling. 小分子丙戊酸通过调节Wnt和Shh信号增强人类神经管器官组织的腹侧模式。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-20 DOI: 10.1111/cpr.13737

Yuanyuan Zheng, Fangrong Zhang, Haifeng Nie, Xinyu Li, Jiali Xun, Jianping Fu, Lijun Wu

{"title":"Small molecule valproic acid enhances ventral patterning of human neural tube organoids by regulating Wnt and Shh signalling.","authors":"Yuanyuan Zheng, Fangrong Zhang, Haifeng Nie, Xinyu Li, Jiali Xun, Jianping Fu, Lijun Wu","doi":"10.1111/cpr.13737","DOIUrl":"https://doi.org/10.1111/cpr.13737","url":null,"abstract":"Valproic acid (VPA), a clinically approved small molecule, has been reported to activate Wnt signalling that is critical for dorsal-ventral (DV) patterning of neural tube. However, little is known about the impact of VPA on DV patterning process. Here, we show that even though VPA has a negative impact on the early formation of human neural tube organoids (hNTOs), it significantly enhances the efficiency of ventrally patterned hNTOs, when VPA is added during the entire differentiation process. RNA sequencing and RT-qPCR analysis demonstrates VPA activates endogenous Wnt signalling in hNTOs. Surprisingly, transcriptome analysis also identifies upregulation of genes for degradation of GLI2 and GLI3 proteins, whose truncated fragment are transcriptional repressors of Shh signalling. The Western-blot analysis confirms the increase of GLI3R proteins after VPA treatment. Thus, VPA might enhance ventral patterning of hNTOs through both activating Wnt, which can antagonise Shh signalling by inducing GLI3 expression, and/or inhibiting Shh signalling by inducing GLI protein degradation. We further obtain results to show that VPA still increases patterning efficiency of hNTOs with a weak influence on their early formation when the initiation time of VPA is delayed and its duration is reduced. Taken together, this study demonstrates that VPA enhances the generation of more reproducible hNTOs with ventral patterning, opening the avenues for the applications of hNTOs in developmental biology and regenerative medicine.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13737"},"PeriodicalIF":5.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of dynamic caudal type homeobox 2 expression on the differentiation of human trophoblast lineage during implantation. 胚胎植入过程中尾状同源染色体 2 的动态表达对人类滋养细胞系分化的影响

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-19 DOI: 10.1111/cpr.13729

Lujuan Rong, Lifeng Xiang, Zongyong Ai, Baohua Niu, Yaqing Wang, Yu Yin, Chun Feng, Gaohui Shi, Tingwei Chen, Jie Yang, Xi Luo, Yun Bai, Xiaoting Zhou, Xiaoping Liu, Haishan Zheng, Yang Ke, Tianqing Li, Ze Wu

{"title":"The impact of dynamic caudal type homeobox 2 expression on the differentiation of human trophoblast lineage during implantation.","authors":"Lujuan Rong, Lifeng Xiang, Zongyong Ai, Baohua Niu, Yaqing Wang, Yu Yin, Chun Feng, Gaohui Shi, Tingwei Chen, Jie Yang, Xi Luo, Yun Bai, Xiaoting Zhou, Xiaoping Liu, Haishan Zheng, Yang Ke, Tianqing Li, Ze Wu","doi":"10.1111/cpr.13729","DOIUrl":"https://doi.org/10.1111/cpr.13729","url":null,"abstract":"The trophoblast lineage differentiation represents a rate-limiting step in successful embryo implantation. Adhesion, invasion and migration processes within the trophoblast are governed by several transcription factors. Among them, CDX2 is a critical regulator shaping the destiny of the trophoblast. While its altered expression is a linchpin initiating embryo implantation in mice, the precise influence of CDX2 on the functionality and lineage differentiation of early human trophoblast remains unclear. In this study, we employed well-established human trophoblast stem cell (hTSC) lines with CDX2 overexpression coupled with a 3D in vitro culture system for early human embryos. We revealed that the downregulation of CDX2 is a prerequisite for syncytialization during human embryo implantation based on immunofluorescence, transcriptome analysis, CUT-tag sequencing and the construction of 3D human trophoblast organoids. While CDX2 overexpression inhibited syncytialization, it propelled hTSC proliferation and invasive migration. CDX2 exerted its influence by interacting with CGA, PTGS2, GCM1, LEF1 and CDH2, thereby hindering premature differentiation of the syncytiotrophoblast. CDX2 overexpression enhanced the epithelial-mesenchymal transition of human trophoblast organoids. In summary, our study provides insights into the molecular characteristics of trophoblast differentiation and development in humans, laying a theoretical foundation for advancing research in embryo implantation.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13729"},"PeriodicalIF":5.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternating electric fields transform the intricate network of tumour vasculature into orderly parallel capillaries and enhance the anti-angiogenesis effect of bevacizumab. 交变电场将错综复杂的肿瘤血管网络转化为有序的平行毛细血管，增强了贝伐珠单抗的抗血管生成效果。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-19 DOI: 10.1111/cpr.13734

Lin Shen, Shuai Li, Yalin Wang, Yi Yin, Yiting Liu, Yunlei Zhang, Xuesheng Zheng

{"title":"Alternating electric fields transform the intricate network of tumour vasculature into orderly parallel capillaries and enhance the anti-angiogenesis effect of bevacizumab.","authors":"Lin Shen, Shuai Li, Yalin Wang, Yi Yin, Yiting Liu, Yunlei Zhang, Xuesheng Zheng","doi":"10.1111/cpr.13734","DOIUrl":"https://doi.org/10.1111/cpr.13734","url":null,"abstract":"The search for effective strategies to target tumour angiogenesis remains a critical goal of cancer research. We present a pioneering approach using alternating electric fields to inhibit tumour angiogenesis and enhance the therapeutic efficacy of bevacizumab. Chicken chorioallantoic membrane, cell viability and in vitro endothelial tube formation assays revealed that electric fields with a frequency of 1000 kHz and an electric intensity of 0.6 V/cm inhibited the growth of vascular endothelial cells and suppressed tumour-induced angiogenesis. In an animal U87MG glioma model, 1000 kHz electric fields inhibited tumour angiogenesis and suppressed tumour growth. As demonstrated by 3D vessel analysis, tumour vasculature in the control group was a stout, interwoven network. However, electric fields transformed it into slim, parallel capillaries that were strictly perpendicular to the electric field direction. This architectural transformation was accompanied by apoptosis of vascular endothelial cells and a notable reduction in tumour vessel number. Additionally, we found that the anti-angiogenesis and tumour-suppression effects of electric fields synergised with bevacizumab. The anti-angiogenic mechanisms of electric fields include disrupting spindle formation during endothelial cell division and downregulating environmental angiogenesis-related cytokines, such as interleukin-6, CXCL-1, 2, 3, 5 and 8, and matrix metalloproteinases. In summary, our findings demonstrate the potential of alternating electric fields (AEFs) as a therapeutic modality to impede angiogenesis and restrain cancer growth.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13734"},"PeriodicalIF":5.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical stress-induced autophagy is cytoskeleton dependent. 机械应力诱导的自噬依赖于细胞骨架。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-18 DOI: 10.1111/cpr.13728

Lin Liu, Wei Zheng, Yuhui Wei, Qian Li, Nan Chen, Qinglin Xia, Lihua Wang, Jun Hu, Xingfei Zhou, Yanhong Sun, Bin Li

引用次数: 0

HDAC3 in action: Expanding roles in inflammation and inflammatory diseases. HDAC3 在行动：扩大在炎症和炎症性疾病中的作用

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-14 DOI: 10.1111/cpr.13731

Ruyuan He, Zhuokun He, Tianyu Zhang, Bohao Liu, Minglang Gao, Ning Li, Qing Geng

引用次数: 0

Mesothelin CAR-engineered NK cells derived from human embryonic stem cells suppress the progression of human ovarian cancer in animals. 来源于人类胚胎干细胞的间皮素 CAR 工程化 NK 细胞可抑制动物体内人类卵巢癌的进展。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-13 DOI: 10.1111/cpr.13727

Yanhong Liu, Min Zhang, Xiaoyan Shen, Chengxiang Xia, Fangxiao Hu, Dehao Huang, Qitong Weng, Qi Zhang, Lijuan Liu, Yanping Zhu, Lei Wang, Jie Hao, Mengyun Zhang, Tongjie Wang, Jinyong Wang

{"title":"Mesothelin CAR-engineered NK cells derived from human embryonic stem cells suppress the progression of human ovarian cancer in animals.","authors":"Yanhong Liu, Min Zhang, Xiaoyan Shen, Chengxiang Xia, Fangxiao Hu, Dehao Huang, Qitong Weng, Qi Zhang, Lijuan Liu, Yanping Zhu, Lei Wang, Jie Hao, Mengyun Zhang, Tongjie Wang, Jinyong Wang","doi":"10.1111/cpr.13727","DOIUrl":"https://doi.org/10.1111/cpr.13727","url":null,"abstract":"CAR-NK cell therapy does not require HLA matching and has minimal side effects. However, traditional methods of engineering CARs into human tissue-derived NK cells exhibit heterogeneity, low transduction efficiency, and high manufacturing costs. Here, we provide a reliable approach for generating large-scale and cryopreserved mesothelin (MSLN) CAR-NK cells from human embryonic stem cells (hESCs) as an alternative cell source. We first constructed MSLN CAR-expressing hESCs to reduce CAR engineering costs and subsequently differentiated these stem cells into MSLN CAR-NK cells via an efficient organoid induction system. The MSLN CAR-NK cells exhibit the typical expression patterns of activating receptors, inhibitory receptors, and effector molecules of NK cells. In the presence of tumour cells, the MSLN CAR-NK cells show increased secretion of IFN-γ and TNF-α, as well as elevated CD107a expression level compared with induced NK cells. We cryopreserved the MSLN CAR-NK cells in liquid nitrogen using a clinical-grade freezing medium (CS10) for more than 6 months to mimic an off-the-shelf CAR-NK cell product. The thawed MSLN CAR-NK cells immediately recovered after 48-72-h culture and effectively eliminated ovarian tumour cells, including human primary ovarian tumour cells from patients. The thawed MSLN CAR-NK cells efficiently suppressed ovarian tumour development in vivo and prolonged the survival of tumour-bearing mice. Our study provides insights into the clinical translation of hESC-derived MSLN CAR-NK cells as a promising off-the-shelf cell product.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13727"},"PeriodicalIF":5.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive macro and micro views on immune cells in ischemic heart disease. 从宏观和微观角度全面审视缺血性心脏病中的免疫细胞。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-01 DOI: 10.1111/cpr.13725

Yongjian Zhao, Mingyue Tan, Yunfei Yin, Jun Zhang, Yiyi Song, Hang Li, Lin Yan, Yifeng Jin, Ziyue Wu, Tianke Yang, Tingbo Jiang, Hongxia Li

{"title":"Comprehensive macro and micro views on immune cells in ischemic heart disease.","authors":"Yongjian Zhao, Mingyue Tan, Yunfei Yin, Jun Zhang, Yiyi Song, Hang Li, Lin Yan, Yifeng Jin, Ziyue Wu, Tianke Yang, Tingbo Jiang, Hongxia Li","doi":"10.1111/cpr.13725","DOIUrl":"https://doi.org/10.1111/cpr.13725","url":null,"abstract":"Ischemic heart disease (IHD) is a prevalent cardiovascular condition that remains the primary cause of death due to its adverse ventricular remodelling and pathological changes in end-stage heart failure. As a complex pathologic condition, it involves intricate regulatory processes at the cellular and molecular levels. The immune system and cardiovascular system are closely interconnected, with immune cells playing a crucial role in maintaining cardiac health and influencing disease progression. Consequently, alterations in the cardiac microenvironment are influenced and controlled by various immune cells, such as macrophages, neutrophils, dendritic cells, eosinophils, and T-lymphocytes, along with the cytokines they produce. Furthermore, studies have revealed that Gata6+ pericardial cavity macrophages play a key role in regulating immune cell migration and subsequent myocardial tissue repair post IHD onset. This review outlines the role of immune cells in orchestrating inflammatory responses and facilitating myocardial repair following IHD, considering both macro and micro views. It also discusses innovative immune cell-based therapeutic strategies, offering new insights for further research on the pathophysiology of ischemic heart disease and immune cell-targeted therapy for IHD.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13725"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0