机械力调节ADSCs的旁分泌功能，通过调节血管生成和炎症反应促进AAM的脂肪再生作用

IF 5.9 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-04-27 DOI:10.1111/cpr.70045

Yining Wang, Luyu Zhang, Jiaxuan Liu, Yuchao Yang, Zhenyu Bi, Jun Ouyang

{"title":"机械力调节ADSCs的旁分泌功能，通过调节血管生成和炎症反应促进AAM的脂肪再生作用","authors":"Yining Wang, Luyu Zhang, Jiaxuan Liu, Yuchao Yang, Zhenyu Bi, Jun Ouyang","doi":"10.1111/cpr.70045","DOIUrl":null,"url":null,"abstract":"<p>Conditioned medium (CM), obtained by mechanical regulation of the paracrine activity of ADSCs, was fused with acellular adipose matrix (AAM) and methyl cellulose (MC) to synthesize a composite hydrogel which was grafted onto nude mice. The composite hydrogel could promote soft tissue regeneration by regulating the level of vascular regeneration and inflammation.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":"58 6","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.70045","citationCount":"0","resultStr":"{\"title\":\"Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose-Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response\",\"authors\":\"Yining Wang, Luyu Zhang, Jiaxuan Liu, Yuchao Yang, Zhenyu Bi, Jun Ouyang\",\"doi\":\"10.1111/cpr.70045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Conditioned medium (CM), obtained by mechanical regulation of the paracrine activity of ADSCs, was fused with acellular adipose matrix (AAM) and methyl cellulose (MC) to synthesize a composite hydrogel which was grafted onto nude mice. The composite hydrogel could promote soft tissue regeneration by regulating the level of vascular regeneration and inflammation.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":9760,\"journal\":{\"name\":\"Cell Proliferation\",\"volume\":\"58 6\",\"pages\":\"\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.70045\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Proliferation\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cpr.70045\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Proliferation","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cpr.70045","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

通过机械调节ADSCs旁分泌活性获得条件培养基（CM），与脱细胞脂肪基质（AAM）和甲基纤维素（MC）融合合成复合水凝胶，并移植到裸鼠身上。复合水凝胶可以通过调节血管再生和炎症水平来促进软组织再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose-Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response

查看原文本刊更多论文

Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose-Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response

Conditioned medium (CM), obtained by mechanical regulation of the paracrine activity of ADSCs, was fused with acellular adipose matrix (AAM) and methyl cellulose (MC) to synthesize a composite hydrogel which was grafted onto nude mice. The composite hydrogel could promote soft tissue regeneration by regulating the level of vascular regeneration and inflammation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.