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IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-08-01 DOI: 10.1111/cpr.13726

Changling Xu, Liyan Zhang, Yinyi Zhou, Haoliang Du, Jieyu Qi, Fangzhi Tan, Li Peng, Xingliang Gu, Nianci Li, Qiuhan Sun, Ziyu Zhang, Yicheng Lu, Xiaoyun Qian, Busheng Tong, Jiaqiang Sun, Renjie Chai, Yi Shi

引用次数: 0

Therapeutic effects of tetrahedral framework nucleic acids and tFNAs-miR22 on retinal ischemia/reperfusion injury 四面体框架核酸和 tFNAs-miR22 对视网膜缺血再灌注损伤的治疗作用

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-31 DOI: 10.1111/cpr.13695

Xiaoxiao Xu, Yanyan Fu, Delun Luo, Lina Zhang, Xi Huang, Yingying Chen, Chunyan Lei, Jinnan Liu, Shiqi Li, Zhouyuan Yu, Yunfeng Lin, Meixia Zhang

{"title":"Therapeutic effects of tetrahedral framework nucleic acids and tFNAs-miR22 on retinal ischemia/reperfusion injury","authors":"Xiaoxiao Xu, Yanyan Fu, Delun Luo, Lina Zhang, Xi Huang, Yingying Chen, Chunyan Lei, Jinnan Liu, Shiqi Li, Zhouyuan Yu, Yunfeng Lin, Meixia Zhang","doi":"10.1111/cpr.13695","DOIUrl":"10.1111/cpr.13695","url":null,"abstract":"Retinal ischemia/reperfusion injury (RI/R) is a common pathological process in ophthalmic diseases, which can cause severe visual impairment. The mechanisms underlying RI/R damage and repair are still unclear. Scholars are actively exploring effective intervention strategies to restore impaired visual function. With the development of nucleic acid nanomaterials, tetrahedral framework nucleic acids (tFNAs) have shown promising therapeutic potential in various fields such as stem cells, biosensors, and tumour treatment due to their excellent biological properties. Besides, miRNA-22-3p (miR-22), as an important regulatory factor in neural tissue, has been proven to have positive effects in various neurodegenerative diseases. By stably constructing a complex of tetrahedral framework nucleic acids miR22 (tFNAs-miR22), we observed that tFNAs-miR22 had a positive effect on the repair of RI/R injury in retinal neural tissue. Previous studies have shown that tFNAs can effectively deliver miR-22 into damaged retinal neurons, subsequently exerting neuroprotective effects. Interestingly, we found that there was a certain synergistic effect between tFNAs and miR-22. tFNAs-miR22 can selectively activated the ERK1/2 signalling pathway to reduce neuronal apoptosis, accelerate cell proliferation, and restore synaptic functional activity. In this study, we established a simple yet effective small molecule drug for RI/R treatment which may become a promising neuroprotectant for treating this type of vision impairment disease in the future.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":"57 11","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.13695","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in gut–brain organ chips 肠脑器官芯片的进展。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-31 DOI: 10.1111/cpr.13724

Yu Zhang, Si-Ming Lu, Jian-Jian Zhuang, Li-Guo Liang

{"title":"Advances in gut–brain organ chips","authors":"Yu Zhang, Si-Ming Lu, Jian-Jian Zhuang, Li-Guo Liang","doi":"10.1111/cpr.13724","DOIUrl":"10.1111/cpr.13724","url":null,"abstract":"The brain and gut are sensory organs responsible for sensing, transmitting, integrating, and responding to signals from the internal and external environment. In-depth analysis of brain–gut axis interactions is important for human health and disease prevention. Current research on the brain–gut axis primarily relies on animal models. However, animal models make it difficult to study disease mechanisms due to inherent species differences, and the reproducibility of experiments is poor because of individual animal variations, which leads to a significant limitation of real-time sensory responses. Organ-on-a-chip platforms provide an innovative approach for disease treatment and personalized research by replicating brain and gut ecosystems in vitro. This enables a precise understanding of their biological functions and physiological responses. In this article, we examine the history and most current developments in brain, gut, and gut–brain chips. The importance of these systems for understanding pathophysiology and developing new drugs is emphasized throughout the review. This article also addresses future directions and present issues with the advancement and application of gut–brain-on-a-chip technologies.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":"57 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.13724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TGFβ-mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound-induced skin fibrosis. TGFβ 介导的真皮下脂肪细胞祖细胞分化抑制可促进伤口诱导的皮肤纤维化。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-29 DOI: 10.1111/cpr.13722

Meimei Yin, Lixiang Sun, Shuai Wu, Jinhang Ma, Wenlu Zhang, Xiaoxuan Ji, Zhichong Tang, Xiaowei Zhang, Yichun Yang, Xinyuan Zhang, Jin-Wen Huang, Shaoluan Zheng, Wen-Jie Liu, Chao Ji, Ling-Juan Zhang

{"title":"TGFβ-mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound-induced skin fibrosis.","authors":"Meimei Yin, Lixiang Sun, Shuai Wu, Jinhang Ma, Wenlu Zhang, Xiaoxuan Ji, Zhichong Tang, Xiaowei Zhang, Yichun Yang, Xinyuan Zhang, Jin-Wen Huang, Shaoluan Zheng, Wen-Jie Liu, Chao Ji, Ling-Juan Zhang","doi":"10.1111/cpr.13722","DOIUrl":"https://doi.org/10.1111/cpr.13722","url":null,"abstract":"Aberrant activation of dermal fibroblasts during wound healing often leads to debilitating fibrotic changes in the skin, such as scleroderma and keloids. However, the underlying cellular and molecular mechanisms remain elusive. Here, we established a wound-induced skin fibrosis (WISF) mouse model in mature adult mice, characterised by excessive deposition of collagen bundles, loss of dermal adipocytes, and enrichment of DPP4+Ly6A+THY1+ hypodermal interstitial adipocyte progenitors (HI-APs) and pericytes, resembling human fibrotic skin diseases. This WISF model exhibited an age-dependent gain of fibrotic characteristics, contrasting with the wound-induced hair neogenesis observed in younger mice. Through comprehensive analyses of the WISF, we delineated a trajectory of fibroblast differentiation that originates from HI-APs. These progenitors highly expressed several extracellular matrix (ECM) genes and exhibited a TGFβ pathway signature. TGFβ was identified as the key signal to inhibit the adipogenic potential and maintain the fibrogenic potential of dermal APs. Additionally, administering a TGFβ receptor inhibitor to wound scar reduced the abundance of ECM-producing APs. Finally, analysis of human scleroderma skin tissues revealed a negative correlation between the expression of AP-, ECM-, and TGFβ pathway-related genes and PPARG. Overall, this study establishes a wound-induced skin fibrosis mouse model and demonstrates that TGFβ-mediated blockage of HI-AP differentiation is crucial for driving fibrotic pathology. Targeting HI-APs and adipogenesis may provide novel avenues for developing disease-modifying therapies for fibrotic skin diseases.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13722"},"PeriodicalIF":5.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction 用于制造工程血管单元和诱导血管生成的内皮祖细胞。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-25 DOI: 10.1111/cpr.13716

Somayyeh Rashidi, Ghasem Bagherpour, Zahra Abbasi-Malati, Nafiseh Didar Khosrowshahi, Sara Aghakhani Chegeni, Golbarg Roozbahani, Hamid Lotfimehr, Emel Sokullu, Reza Rahbarghazi

{"title":"Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction","authors":"Somayyeh Rashidi, Ghasem Bagherpour, Zahra Abbasi-Malati, Nafiseh Didar Khosrowshahi, Sara Aghakhani Chegeni, Golbarg Roozbahani, Hamid Lotfimehr, Emel Sokullu, Reza Rahbarghazi","doi":"10.1111/cpr.13716","DOIUrl":"10.1111/cpr.13716","url":null,"abstract":"The promotion of vascularization and angiogenesis in the grafts is a crucial phenomenon in the healing process and tissue engineering. It has been shown that stem cells, especially endothelial progenitor cells (EPCs), can stimulate blood vessel formation inside the engineered hydrogels after being transplanted into the target sites. The incorporation of EPCs into the hydrogel can last the retention time, long-term survival, on-target delivery effects, migration and differentiation into mature endothelial cells. Despite these advantages, further modifications are mandatory to increase the dynamic growth and angiogenesis potential of EPCs in in vitro and in vivo conditions. Chemical modifications of distinct composites with distinct physical properties can yield better regenerative potential and angiogenesis during several pathologies. Here, we aimed to collect recent findings related to the application of EPCs in engineered vascular grafts and/or hydrogels for improving vascularization in the grafts. Data from the present article can help us in the application of EPCs as valid cell sources in the tissue engineering of several ischemic tissues.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":"57 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpr.13716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premeiotic deletion of Eif2s2 causes oocyte arrest at the early diplotene stage and apoptosis in mice. 小鼠减数分裂前期缺失 Eif2s2 会导致卵母细胞停滞在早期二分裂期并发生凋亡。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-24 DOI: 10.1111/cpr.13718

Wenjun Zhou, Biao Li, Zhijuan Wang, Shuang Liu, Weiyong Wang, Sihui He, Ye Chen, Xiaodan Zhang, Meijia Zhang

{"title":"Premeiotic deletion of Eif2s2 causes oocyte arrest at the early diplotene stage and apoptosis in mice.","authors":"Wenjun Zhou, Biao Li, Zhijuan Wang, Shuang Liu, Weiyong Wang, Sihui He, Ye Chen, Xiaodan Zhang, Meijia Zhang","doi":"10.1111/cpr.13718","DOIUrl":"https://doi.org/10.1111/cpr.13718","url":null,"abstract":"Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2), a subunit of the heterotrimeric G protein EIF2, is involved in the initiation of translation. Our findings demonstrate that the depletion of Eif2s2 in premeiotic germ cells causes oocyte arrest at the pachytene and early diplotene stages at 1 day postpartum (dpp) and 5 dpp, respectively, and eventually leads to oocyte apoptosis and failure of primordial follicle formation. Further studies reveal that Eif2s2 deletion downregulates homologous recombination-related and mitochondrial fission-related protein levels, and upregulates the integrated stress response-related proteins and mRNA levels. Consistently, Eif2s2 deletion significantly decreases the expression of dictyate genes and compromises mitochondrial function, characterized by elongated shapes, decreased ATP levels and mtDNA copy number, along with an excessive accumulation of reactive oxygen species (ROS) and mitochondrial superoxide. Furthermore, DNA damage response and proapoptotic protein levels increase, while anti-apoptotic protein levels decrease in Eif2s2-deleted mice. An increase in oocytes with positive cleaved-Caspase-3 and TUNEL signals, alongside reduced Lamin B1 intensity, further indicates oocyte apoptosis. Collectively, Eif2s2 deletion in premeiotic germ cells causes oocyte meiotic arrest at the early diplotene stage by impairing homologous recombination, and eventually leads to oocyte apoptosis mainly through the downregulation of mitochondrial fission-related proteins, ROS accumulation and subsequent DNA damage.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13718"},"PeriodicalIF":5.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. 核受体Rev-erbα通过招募NCoR-HDAC3共抑制因子和抑制NLRP3炎性体减轻椎间盘退变。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-24 DOI: 10.1111/cpr.13720

Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Sun

{"title":"Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome.","authors":"Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Sun","doi":"10.1111/cpr.13720","DOIUrl":"https://doi.org/10.1111/cpr.13720","url":null,"abstract":"Intervertebral discs (IVDs) are rhythmic tissues that experience daily low-load recovery. Notably, aging and abnormal mechanical stress predispose IVDs to degeneration due to dysrhythmia-induced disordered metabolism. Meanwhile, Rev-erbα acts as a transcriptional repressor in maintaining biorhythms and homeostasis; however, its function in IVD homeostasis and degeneration remains unclear. This study assessed the relationship between low Rev-erbα expression levels and IVD degeneration. Rev-erbα deficiency accelerated needle puncture or aging-induced IVD degeneration, characterized by increased extracellular matrix (ECM) catabolism and nucleus pulposus (NP) cell apoptosis. Mechanistically, Rev-erbα knockdown in NP cells aggravated rhIL1β-induced NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, exacerbating the imbalanced ECM and NP cell apoptosis. Meanwhile, blocking NLRP3 inflammasome activation mitigated Rev-erbα deficiency and needle puncture-induced IVD degeneration. Particularly, Rev-erbα mediated the transcriptional repression of the NLRP3 inflammasome via the ligand heme-binding of nuclear receptor co-repressor (NCoR) and histone deacetylase 3 (HDAC3) complex. Thus, the increased expression of Rev-erbα in NP cells following short-term rhIL1β treatment failed to inhibit NLRP3 transcription in vitro owing to heme depletion. Pharmacological activation of Rev-erbα in vivo and in vitro alleviated IVD degeneration by altering the NLRP3 inflammasome. Taken together, targeting Rev-erbα may be a potential therapeutic strategy for alleviating IVD degeneration and its related diseases.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13720"},"PeriodicalIF":5.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ imaging of intracellular miRNAs in tumour cells by branched hybridisation chain reaction. 利用分支杂交链反应对肿瘤细胞内的 miRNA 进行原位成像。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-22 DOI: 10.1111/cpr.13721

Ying Tang, Siwei Zhang, Xinyu Yang, Yao Chen, Sha Chen, Qiang Xi, Long Chao, Zhao Huang, Libo Nie

{"title":"In situ imaging of intracellular miRNAs in tumour cells by branched hybridisation chain reaction.","authors":"Ying Tang, Siwei Zhang, Xinyu Yang, Yao Chen, Sha Chen, Qiang Xi, Long Chao, Zhao Huang, Libo Nie","doi":"10.1111/cpr.13721","DOIUrl":"https://doi.org/10.1111/cpr.13721","url":null,"abstract":"The ability to visualise microRNA in situ is crucial for studying microRNAs, their microRNA-associated biological functions and disease diagnosis. Traditional fluorescence in situ hybridisation methods based on paraformaldehyde fixation of microRNAs suffer from release of microRNAs from cells, which limits the sensitivity of in situ hybridisation, making them unsuitable for the detection of small, low-abundance microRNAs. To reduce the loss, microRNAs were covalently cross-linked to proteins within cells by combining EDC and paraformaldehyde, and the target microRNA was used as the initiator chain for a branched hybridisation chain reaction to detect microRNA expression levels in situ. A simplified branched hybridisation chain reaction can be realised by coupling two hybridisation chain reaction circuits with a hairpin linker. Upon forming the primary hybridisation chain reaction product with extended sequence, this sequence reacts with the linker hairpin H3 to release the initiator sequence, resulting in the formation of numerous dendritic branched hybridisation chain reaction products. Imaging results show that this technique can detect microRNAs with high sensitivity and selectivity at both the single-cell and single-molecule levels. Compared with the traditional fluorescence in situ hybridisation technique, this method greatly improves the sensitivity and image resolution of in situ imaging detection. Therefore, we believe that the target-initiated branched hybridisation chain reaction based in situ detection method provides a reliable assay platform for analysing disease-related microRNA expression.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13721"},"PeriodicalIF":5.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipocalin-2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension. 脂联素-2 诱导的 LDHA 表达可促进肺动脉高压的血管重塑。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-18 DOI: 10.1111/cpr.13717

Guoliang Wang, Shenghua Liu, Xiaohui Kong, Hong Jiao, Feng Tong, Zhangke Guo, Meng Zhang, Xiaoxing Guan, Na Ren, Wanzhen Li, Lihua Qi, Yingjie Wei

引用次数: 0

Cellular senescence mediates retinal ganglion cell survival regulation post-optic nerve crush injury. 细胞衰老介导视神经挤压伤后视网膜神经节细胞存活调节。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-07-18 DOI: 10.1111/cpr.13719

Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang-Ling Yuan, Yingjie Cao, Tsz Kin Ng

{"title":"Cellular senescence mediates retinal ganglion cell survival regulation post-optic nerve crush injury.","authors":"Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang-Ling Yuan, Yingjie Cao, Tsz Kin Ng","doi":"10.1111/cpr.13719","DOIUrl":"https://doi.org/10.1111/cpr.13719","url":null,"abstract":"Traumatic optic neuropathy refers to optic nerve (ON) injury by trauma, including explosion and traffic accident. Retinal ganglion cell (RGC) death is the critical pathological cause of irreversible visual impairment and blindness in ON injury. We previously investigated the patterns of 11 modes of cell death in mouse retina post-ON injury. Here we aimed to identify additional signalling pathways regulating RGC survival in rodents post-ON injury. RNA sequencing analysis identified the upregulation of inflammation and cellular senescence-related genes in retina post-ON injury, which were confirmed by immunoblotting and immunofluorescence analyses. Increased expression of senescence-associated β-galactosidase (SA-βgal) in RGCs and activation of microglia were also found. Transforming growth factor-β receptor type II inhibitor (LY2109761) treatment suppressed p15Ink4b and p21Cip1 protein and SA-βgal expression and promoted RGC survival post-ON injury with decreasing the expression of cell death markers in retina. Consistently, senolytics (dasatinib and quercetin) treatments can promote RGC survival and alleviate the reduction of ganglion cell complex thickness and pattern electroretinography activity post-ON injury with reducing SA-βgal, p15Ink4b, p21Cip1, microglial activation and cell death marker expression. In summary, this study revealed the activation of cellular senescence in rodent retina post-ON injury and contribute to RGC survival regulation. Targeting cellular senescence can promote RGC survival after ON injury, suggesting a potential treatment strategy for traumatic optic neuropathy.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13719"},"PeriodicalIF":5.9,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0