肿瘤中的无膜细胞器和相分离:机制和前景。

IF 5.9 1区 生物学 Q2 CELL BIOLOGY
Hao Yang, Zhong Chu, Shuwen Han, Yuefen Pan
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引用次数: 0

摘要

无膜细胞器(MLOs)是近年来在真核生物中发现的一类亚细胞腔室结构。它们主要是通过细胞内蛋白质或核酸等大分子物质的液-液相分离(LLPS)和聚集形成的。当细胞受到刺激时,会启动一系列的应激反应,包括基因转录、RNA代谢、翻译、蛋白质修饰和信号转导,以维持体内平衡。这些细胞过程的失调是癌症发生和发展的关键事件。本文综述了无膜细胞器的结构、功能以及相分离的机制,总结肿瘤中相分离的最新研究进展。重点研究LLPS在肿瘤发生发展中的作用和分子机制,旨在为开发药物作用靶点和创新治疗策略提供新的理论参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects.

Membraneless organelles (MLOs) are a type of subcellular compartment structure discovered in eukaryotes in recent years. They are mainly formed through the liquid-liquid phase separation (LLPS) and aggregation of macromolecular substances such as proteins or nucleic acids in cells. When cells are stimulated, they initiate a series of stress responses including gene transcription, RNA metabolism, translation, protein modification and signal transduction to maintain homeostasis. The dysregulation of these cellular processes is a key event in the occurrence and development of cancer. This article provides an overview of the structure and function of membraneless organelles, as well as the mechanisms of phase separation, to summarise the latest research progress on phase separation in tumours. It focuses on the role and molecular mechanism of LLPS in the development of tumours, with the aim of providing new theoretical references for developing drug action targets and innovative treatment strategies.

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来源期刊
Cell Proliferation
Cell Proliferation 生物-细胞生物学
CiteScore
14.80
自引率
2.40%
发文量
198
审稿时长
1 months
期刊介绍: Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.
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