IMPDH2在细胞生长和疾病中的核心作用：一个潜在的治疗靶点。

IF 5.9 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-04-19 DOI:10.1111/cpr.70031

Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu

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引用次数: 0

摘要

IMPDH2是鸟嘌呤核苷酸生物合成中的限速酶。它在核苷酸代谢、炎症、免疫功能、核糖体应激等各种生理病理过程中发挥着不同的作用。IMPDH2的结构或调控改变与重大的健康问题有关，并且与疾病进展具有关键相关性。我们的目标是强调IMPDH2作为临床应用的有希望的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target.

IMPDH2 is a rate-limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We aim to underscore the potential of IMPDH2 as a promising therapeutic target for clinical applications.

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.