Cell and Tissue Research最新文献_第2页

Attenuation of intestinal peristalsis with age is attributed to decreased sensitivity of receptors in the enteric nervous system. 随着年龄的增长，肠蠕动的衰减是由于肠神经系统中受体的敏感性降低。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-06-01 Epub Date: 2025-03-27 DOI: 10.1007/s00441-025-03969-z

Tsukasa Kobayashi, Yuko Takeba, Masanori Ootaki, Yuki Ohta, Keisuke Kida, Taroh Iiri, Naoki Matsumoto

{"title":"Attenuation of intestinal peristalsis with age is attributed to decreased sensitivity of receptors in the enteric nervous system.","authors":"Tsukasa Kobayashi, Yuko Takeba, Masanori Ootaki, Yuki Ohta, Keisuke Kida, Taroh Iiri, Naoki Matsumoto","doi":"10.1007/s00441-025-03969-z","DOIUrl":"10.1007/s00441-025-03969-z","url":null,"abstract":"Constipation and other digestive disorders are common in older adults. The autonomic nervous system plays a critical role in regulating digestive motility in the intestinal tract. However, studies on age-related changes in autonomic function and receptor expression in the intestinal tract are limited. In this study, we examined the expression of neurotransmitter receptors in the autonomic nervous system and the effects of acetylcholine and β-agonists on intestinal contraction and relaxation in the jejunum of aged rats. Jejunal sections collected from male and female Wistar/ST rats aged 4, 11, and 18 months were analyzed. Immunohistochemical staining and enzyme-linked immunosorbent assay were used to measure the expression of muscarinic acetylcholine receptors (CHRM2 and CHRM3) and β-adrenergic receptors (β2-ADR and β3-ADR). The effects of acetylcholine, isoproterenol, and mirabegron were assessed in the isolated jejunum for each age group. There was no significant difference in CHRM2 receptor expression among the age groups; however, CHRM3 receptor expression decreased with age. Additionally, the sensitivity to acetylcholine-induced contractile responses decreased with age. Although β2-ADR receptor expression did not differ among the age groups, β3-ADR receptor expression increased with age. Despite this, the relaxation response to isoproterenol and mirabegron decreased with age. Our study revealed an age-related decrease in CHRM3 expression and the contractile response to acetylcholine in the small intestine of rats. Although β-ADR expression, particularly β3-ADR, increased with age, the relaxation response to β-adrenergic agonists gradually decreased.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"303-317"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity-driven musculotendinous remodeling impairs tissue resilience to mechanical damage. 肥胖驱动的肌肉肌腱重塑损害组织对机械损伤的恢复力。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.1007/s00441-025-03967-1

Cesanelli L, Minderis P, Balnyte I, Ratkevicius A, Degens H, Satkunskiene D

{"title":"Obesity-driven musculotendinous remodeling impairs tissue resilience to mechanical damage.","authors":"Cesanelli L, Minderis P, Balnyte I, Ratkevicius A, Degens H, Satkunskiene D","doi":"10.1007/s00441-025-03967-1","DOIUrl":"10.1007/s00441-025-03967-1","url":null,"abstract":"Obesity has been associated with lower muscle strength-to-body mass ratio. Here, we evaluated the effects of diet-induced obesity on the mechano-structural properties of isolated muscles and tendons. Thirty 10-week-old male C57BL/6 J mice were randomly assigned to either an obesogenic high-fat diet group (OB) for 24 weeks or a control group (CN) maintained on a standard chow diet. Soleus muscle (SOL) and Achilles tendon (AT) specimens were isolated and subjected either to failure testing, 300 cycles of passive stretch-destretch, or isometric twitch contractions. Morpho-structural and protein expression analyses were conducted to assess collagen and adipose tissue accumulation, concentrations of cross-linking factors, and any alterations in the POSTN-TGFβ1-Akt signaling pathway. OB SOL and AT tissues were more fragile than those from CN (p < 0.05). A piecewise linear regression model revealed a tendency for OB tissues to exhibit steeper mechanical property changes within the first 20 cycles compared to CN, followed by a similar plateau phase in both groups. OB SOL-AT complexes showed a slower twitch-contraction-relaxation pattern than CN (p < 0.05). OB tendons and muscles were larger than those of the CN, with muscles featuring bigger fibers, and higher collagen area fraction (p < 0.05). Elevated TGFβ1 and POSTN concentrations were observed in OB tissues (p < 0.05), alongside increased P-Akt and P-4EBP1 expression (p < 0.05). These findings highlight the detrimental effects of obesity on the structural integrity of muscle and tendon tissues and suggest a significant role of POSTN-TGFβ1-Akt signaling in obesity-associated musculotendinous remodeling.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"287-302"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Microtubule organization and tubulin post‑translational modifications in intact tissues and during regeneration in calcareous sponges. 对完整组织和钙质海绵再生过程中微管组织和微管蛋白翻译后修饰的修正。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-06-01 DOI: 10.1007/s00441-025-03964-4

Kseniia V Skorentseva, Fyodor V Bolshakov, Aleena A Saidova, Andrey I Lavrov

引用次数: 0

Correction to: Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA‑145a‑5p that targets SIRT1 in late‑onset hypogonadism. 更正：长链非编码RNA XIST抑制通过作为microRNA - 145a - 5p的竞争内源性RNA促进间质细胞凋亡，microRNA - 145a - 5p在晚发性性腺功能减退中靶向SIRT1。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-06-01 DOI: 10.1007/s00441-025-03963-5

Jing Wang, Yiqiong Yang, Yang Xu, Zhipeng Xu, Xiaozhi Zhao, Ruipeng Jia, Yutian Dai

引用次数: 0

Tissue-specific differences impacts therapeutic outcomes of mitochondrial transplantation through regulation of bioenergetics in metabolic syndrome. 组织特异性差异通过调节代谢综合征的生物能量学影响线粒体移植的治疗结果。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-26 DOI: 10.1007/s00441-025-03977-z

Jyotsna Pareek, Pallavi Mudgal, Nitika Sindhu, Vaibhav Tiwari, Dinesh Mani Tripathi, Swati Paliwal

{"title":"Tissue-specific differences impacts therapeutic outcomes of mitochondrial transplantation through regulation of bioenergetics in metabolic syndrome.","authors":"Jyotsna Pareek, Pallavi Mudgal, Nitika Sindhu, Vaibhav Tiwari, Dinesh Mani Tripathi, Swati Paliwal","doi":"10.1007/s00441-025-03977-z","DOIUrl":"https://doi.org/10.1007/s00441-025-03977-z","url":null,"abstract":"Mitochondria transplantation is an emerging therapeutic strategy with remarkable potential in treating various diseases associated with mitochondrial dysfunction. Despite the known differences in tissue-specific mitochondria, the therapeutic outcomes of mitochondria isolated from various sources, after their transplantation in a specific disease model has remained elusive. In this study, we investigated the tissue-dependent therapeutic differences after transplantation of mitochondria isolated from heart, muscle, and liver tissues in a high-fat diet and streptozotocin, 35 mg/Kg (HFD + STZ) induced metabolic syndrome (MetS) in Wistar rats. We found striking differences in lowering of blood glucose levels, blood pressure, cholesterol, ALT, and AST levels in MetS after transplantation of mitochondria obtained from heart, muscle, and liver tissues (P < 0.01). Liver mitochondria transplantation demonstrated the most effective upregulation of mitochondrial complex activities, enhanced anti-oxidant enzyme levels in recipient liver tissues (P < 0.01). It also upregulated gene expression of genes associated with mitochondrial biogenesis and bioenergetics and reduced apoptosis and inflammation associated genes in HFD + STZ rats. In addition, GC-MS metabolite analysis revealed differential blood serum concentrations of key tri-carboxylic acid metabolites such as succinic acid, malic acid, alpha-ketoglutarate, citric acid, and pyruvate after mitochondrial transplantation in HFD + STZ rats. This study supports the idea that mitochondria source tissue should be considered to provide better clinical outcomes for mitochondrial transplantation.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization management of acute phase increases healing ligament strength. 急性期的固定治疗可增加愈合韧带的强度。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-23 DOI: 10.1007/s00441-025-03983-1

Chiharu Takasu, Sora Kawabata, Hidenobu Terada, Takuma Kojima, Yuri Morishita, Yuichiro Oka, Kiyomi Takayanagi, Naohiko Kanemura, Kenji Murata

{"title":"Immobilization management of acute phase increases healing ligament strength.","authors":"Chiharu Takasu, Sora Kawabata, Hidenobu Terada, Takuma Kojima, Yuri Morishita, Yuichiro Oka, Kiyomi Takayanagi, Naohiko Kanemura, Kenji Murata","doi":"10.1007/s00441-025-03983-1","DOIUrl":"https://doi.org/10.1007/s00441-025-03983-1","url":null,"abstract":"Conservative treatment of the anterior cruciate ligament (ACL) is important for restoring functional activity and preventing secondary degeneration. However, the molecular mechanisms underlying ligament immobilization and its precise role in the healing process remain poorly understood. In this study, we investigated the effect of immobilization on the strength of the healed ACL during acute management. We performed surgery to heal the ACL of rats and immobilized the knees using Kirschner wires. The group in which only the surgery to promote ACL healing was performed was designated as the controlled anterior tibial instability group, whereas the group that underwent both surgery and immobilization was designated as the immobilization (IMM) group. After 1-2 weeks of immobilization, histological analyses using hematoxylin-eosin staining and immunohistochemical evaluation of collagen types I and III expression were performed. A comprehensive genetic analysis in the acute phase was performed via RNA sequencing. Furthermore, fibroblasts derived from rat ACL were used to recapitulate inflammation with interleukin-1β, and its effect on elongation stress (110%) was investigated using polymerase chain reaction. Joint immobilization for 2 weeks postoperatively increased the mechanical strength of the conservatively connected ligaments. Stretch stimulation of fibroblasts with interleukin-1β also decreased the expression of the extracellular matrix. Furthermore, bioinformatics analyses identified differentially expressed genes associated with the healing process in fixed versus unfixed ligaments. The results demonstrate that acute-phase immobilization, defined as fixation for 2 weeks following injury, enhances ligament strength by promoting extracellular matrix synthesis and organized regeneration, providing novel insights into optimizing conservative ACL therapy.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of the sex difference in calbindin D-28K neurons and the role of calbindin D-28K in clustering neurons of the preoptic area in mice. calbindin D-28K神经元性别差异的出现及calbindin D-28K在小鼠视前区聚类神经元中的作用。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-21 DOI: 10.1007/s00441-025-03981-3

Ryoma Koiso, Chihiro Kushida, Moeko Kanaya, Shinji Tsukahara

{"title":"Emergence of the sex difference in calbindin D-28K neurons and the role of calbindin D-28K in clustering neurons of the preoptic area in mice.","authors":"Ryoma Koiso, Chihiro Kushida, Moeko Kanaya, Shinji Tsukahara","doi":"10.1007/s00441-025-03981-3","DOIUrl":"https://doi.org/10.1007/s00441-025-03981-3","url":null,"abstract":"Neurons expressing Calb1 that encodes calbindin D-28K (Calb), a calcium-binding protein, are significant components of the sexually dimorphic nucleus (SDN) of the preoptic area in mice. Calb is therefore used as a marker to study the SDN. The number of Calb neurons in the SDN is greater in males than in females, and this sex difference emerges before puberty. However, the timing of emergence of this difference and the role of Calb1 in the SDN remain unclear. In this study, we investigated when the sex difference in Calb neurons appears and whether Calb1 is required for organizing the SDN. Profiling the temporal changes in Calb neurons revealed that these neurons dramatically increased in the SDN during postnatal days 15 to 20 in males but not in females, resulting in a significant difference between sexes. However, the Calb1 mRNA in the SDN remained unchanged during the late postnatal period and did not differ between sexes. Calb1 knockdown (KD) was performed by injecting an adeno-associated virus vector into the preoptic area of neonatal mice. The analysis of postnatal Calb1-KD mice revealed that Calb1 KD reduced not only Calb1 expression but also the number of neurons comprising the SDN. These findings suggest that compared with the female SDN, more Calb neurons migrate to and are incorporated into the male SDN, thereby yielding the sex difference in the number of Calb neurons at the late postnatal period, and that Calb1 plays a significant role in clustering neurons in the SDN.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folliculogenesis and follicular growth in the endangered fish Brycon opalinus, with emphasis on ovarian matrix remodeling. 濒危鱼类卵泡发生和卵泡生长，重点是卵巢基质重塑。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-19 DOI: 10.1007/s00441-025-03982-2

Camila Ferreira Sales, Bruna Aquino Araújo, Sarah Morais de Souza, Elizete Rizzo, Rafael Magno Costa Melo

{"title":"Folliculogenesis and follicular growth in the endangered fish Brycon opalinus, with emphasis on ovarian matrix remodeling.","authors":"Camila Ferreira Sales, Bruna Aquino Araújo, Sarah Morais de Souza, Elizete Rizzo, Rafael Magno Costa Melo","doi":"10.1007/s00441-025-03982-2","DOIUrl":"https://doi.org/10.1007/s00441-025-03982-2","url":null,"abstract":"Ovarian development of fishes involves significant functional and structural changes during the process of mature egg formation. In this study, we report the folliculogenesis and follicular growth in the endangered species Brycon opalinus as well as the dynamics of the proteins Foxl2, Col4 and MMP-9 during ovarian maturation. Seventeen females were collected in the Doce River basin and their ovaries were subjected to histological techniques, electron microscopy, immunohistochemistry and Western blotting. In ovaries of B. opalinus, isolated oogonia and oogonia grouped in niches were identified, both surrounded by prefollicle cells. Primary growth initiated when the ovarian follicle was formed by the oocyte and follicle cells, in addition to the formation of zona radiata. Secondary growth was characterized by the incorporation of yolk into the oocyte and development of the zona radiata and follicle cells. Proportion of oogonia, perinucleolar follicles, and ovarian stroma was higher during resting stage, while previtellogenic and vitellogenic follicles were more frequent in the early and advanced maturation stages. Foxl2 was expressed mainly in prefollicle cells in oogonia and follicle cells in young follicles during reproductive resting. Col4 was expressed in basement membrane and extracellular matrix, primarily during resting and early maturation of ovaries. MMP-9 showed discrete labeling in ovarian matrix, but theca cells and zona radiata of secondary growth follicles, as well as granulocytes in matrix, showed significant immunolabeling during advanced maturation. We conclude that during ovarian development of B. opalinus there is intense participation and interaction of Foxl2, Col4 and MMP-9 with matrix components, somatic and germ cells for formation and follicular growth.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes. 在中隔细胞向周细胞分化过程中，ETS1促进Ctsb和Mmp13的表达。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-19 DOI: 10.1007/s00441-025-03979-x

Yasuhiko Bando, Kenjiro Bandow, Koji Sakiyama, Arata Nagasaka, Kaito Suzuki, Miyuki Toda-Fujii, Yuji Owada, Osamu Amano

{"title":"ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes.","authors":"Yasuhiko Bando, Kenjiro Bandow, Koji Sakiyama, Arata Nagasaka, Kaito Suzuki, Miyuki Toda-Fujii, Yuji Owada, Osamu Amano","doi":"10.1007/s00441-025-03979-x","DOIUrl":"https://doi.org/10.1007/s00441-025-03979-x","url":null,"abstract":"Septoclasts (SCs), which express both fatty acid-binding protein 5 and platelet-derived growth factor beta, are mononuclear cartilage-resorbing cells predominantly located at the chondro-osseous junction of the growth plate (GP). These cells originate from pericytes (PCs). Cathepsin B (CTSB) and matrix metalloproteinase-13 (MMP13), expressed in SCs, participate in the degradation of collagen and other cartilage matrices. This study aimed to investigate the involvement of the ETS proto-oncogene 1 (ETS1) in the transcription of Ctsb and Mmp13 during the differentiation of SCs from PCs. ETS1 was localized in SCs and a small number of PCs during development and postnatal stages. Upregulation of Ets1, Mmp13, Ctsb, and the Ets1-related genes, specificity protein 1 (Sp-1), jun proto-oncogene (c-Jun), and cAMP response element-binding protein-binding protein (Crebbp) in SCs compared with those in PCs was shown by RNA-seq analysis of samples isolated from the tibiae of 3-week-old postnatal mice. The Ets1-related proteins were localized ubiquitously in SCs and PCs in the GP. In primary SC cultures, the expression levels of Ctsb and Mmp13 were significantly reduced following treatment with Ets1 siRNA. Thus, our results revealed that ETS1 promoted the expression of Ctsb and Mmp13 in SCs during the differentiation of SCs from PCs.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of macromolecular crowders on deposition of extracellular matrix in astrocyte cultures. 大分子添加剂对星形胶质细胞细胞外基质沉积的影响。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2025-05-19 DOI: 10.1007/s00441-025-03980-4

Sorour Nemati, Michelle Kilcoyne, Dimitrios Zeugolis, Siobhan S McMahon

{"title":"The effect of macromolecular crowders on deposition of extracellular matrix in astrocyte cultures.","authors":"Sorour Nemati, Michelle Kilcoyne, Dimitrios Zeugolis, Siobhan S McMahon","doi":"10.1007/s00441-025-03980-4","DOIUrl":"https://doi.org/10.1007/s00441-025-03980-4","url":null,"abstract":"Macromolecular crowding (MMC) is a biophysical phenomenon that has proven effective in enhancing extracellular matrix (ECM) deposition in vitro. However, MMCs potential in neuroglial cell cultures remains underexplored. This study investigates the effects of three distinct MMC agents [carrageenan (CR), dextran sulphate (DxS) and FicollⓇ cocktail (FC)] on ECM deposition and cell behaviour of Neu7 and primary astrocytes. While the viability and metabolic activity of Neu7 astrocytes were unaffected by any of the crowding agents, primary astrocytes exhibited a significant decrease in viability and metabolic activity in the presence of CR and DxS. The addition of CR, DxS, and FC resulted in a significant increase in deposition of fibronectin, collagen IV, collagen I, GFAP and CS56 in Neu7 astrocytes. In primary astrocytes, FC significantly enhanced the expression of astrocytic markers and increased the deposition of ECM proteins, including fibronectin and collagen IV. This study highlights the advantages of using FC as a MMC agent for enhancing ECM deposition in astrocytes. The method demonstrates potential for developing fast and more physiologically relevant in vitro models and improving drug screening processes for future studies. The observed benefits underscore the utility of FC in creating advanced cellular models that better mimic the native neural environment.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0