Cell and Tissue Research最新文献_第10页

Phagocytic hemocytes, independent of pericardial cells, modulate cellular immune responses on the dorsal vessel of mosquitoes, including the infection-induced reduction of the heart rate. 独立于心包细胞的吞噬血细胞调节蚊子背血管上的细胞免疫反应，包括感染引起的心率降低。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.1007/s00441-025-04011-y

Cole J Meier, Shabbir Ahmed, Tania Y Estévez-Lao, Julián F Hillyer

{"title":"Phagocytic hemocytes, independent of pericardial cells, modulate cellular immune responses on the dorsal vessel of mosquitoes, including the infection-induced reduction of the heart rate.","authors":"Cole J Meier, Shabbir Ahmed, Tania Y Estévez-Lao, Julián F Hillyer","doi":"10.1007/s00441-025-04011-y","DOIUrl":"10.1007/s00441-025-04011-y","url":null,"abstract":"Infection induces the aggregation of hemocytes on the dorsal vessel of mosquitoes. These hemocytes, called periostial hemocytes, phagocytose pathogens and produce immune factors on the abdominal portion of the dorsal vessel, called the heart. One of these immune factors, nitric oxide, is a pleiotropic free radical that is an antimicrobial and a heartbeat reducer. But nitric oxide is not just produced by hemocytes. It is also synthesized by pericardial cells that flank the heart, and other tissues. To determine whether it is the periostial hemocytes or the pericardial cells that modulate the heart following infection, we chemically ablated the hemocytes using clodronate liposomes and measured immune responses and heart physiology. We demonstrate that clodronate liposomes ablate the sessile hemocytes, including the periostial hemocytes, while leaving the pericardial cells and heart integrity unaffected. Moreover, ablating hemocytes abolishes the phagocytosis of bacteria, alters the deposition of melanized bacteria, and decreases nitric oxide synthase activity on the heart. Importantly, hemocyte ablation eliminates the infection induced reduction of the heart rate, mainly by modifying the anterograde heart rate. Therefore, periostial hemocytes drive immune responses on the heart and infection-induced changes to circulatory physiology.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"173-188"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12594744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note to: Overexpression of miR-429 impairs intestinal barrier function in diabetic mice by down-regulating occludin expression. 注：过表达miR-429通过下调occludin表达损害糖尿病小鼠肠道屏障功能。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 DOI: 10.1007/s00441-025-04009-6

Tao Yu, Xi-Ji Lu, Jie-Yao Li, Ti-Dong Shan, Can-Ze Huang, Hui Ouyang, Hong-Sheng Yang, Ji-Hao Xu, Wa Zhong, Zhong-Sheng Xia, Qi-Kui Chen

引用次数: 0

MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells. MicroRNA-29b靶向ADAM12和adam19调控筛板细胞的细胞外基质。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI: 10.1007/s00441-025-04006-9

Aoife Smyth, Breedge Callaghan, Mustapha Irnaten, Darrell Andrews, Colin E Willoughby, Colm O'Brien

{"title":"MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells.","authors":"Aoife Smyth, Breedge Callaghan, Mustapha Irnaten, Darrell Andrews, Colin E Willoughby, Colm O'Brien","doi":"10.1007/s00441-025-04006-9","DOIUrl":"10.1007/s00441-025-04006-9","url":null,"abstract":"Glaucoma remains the leading cause of irreversible blindness worldwide, with elevated intraocular pressure (IOP) being the only modifiable risk factor in primary open-angle glaucoma (POAG). Despite adequate IOP control, many patients continue to progress to irreversible optic neuropathy, emphasising the need for alternate treatments. Transforming growth factor-beta (TGF-β) promotes extracellular matrix (ECM) production and fibrosis at the optic nerve head (ONH) in glaucoma. A disintegrin and metalloprotease-12 and metalloprotease-19 (ADAM12 and ADAM19) are implicated in fibrosis. Recent studies have explored miRNA-based manipulation of the TGF-β signalling pathway as a potential therapeutic strategy in fibrosis. This study investigates whether miR-29b modulation affects ADAM12, ADAM19, and ECM gene expression in human lamina cribrosa (LC) cells. Primary human normal lamina cribrosa (NLC) and glaucoma LC (GLC) cells were treated with TGF-β1 and transfected with either a miR-29b mimic or control. Gene expression levels of ADAM12, ADAM19, miR-29b, and several ECM genes were quantified using real-time RT-qPCR, and protein expression levels by Western blotting. ADAM12 and ADAM19 expression was elevated in untreated GLC cells, and treatment with TGF-β1 in both NLC and GLC cells increased ADAM12 and ADAM19 expression. The expression of miR-29b was significantly reduced in both GLC- and TGF-β1-treated NLC and GLC cells. Transfection with miR-29b resulted in a marked reduction in ADAM12 and ADAM19 mRNA expression in TGF-β1-treated NLC and GLC cells. Additionally, miR-29b transfection reduced ECM gene expression in both NLC and GLC under TGF-β1 stimulation. Our results demonstrate that miR-29b plays a crucial role in fibrotic remodelling at the LC by antagonising the effects of TGF-β1 on ADAM and ECM gene expression, representing a novel therapeutic target in glaucoma.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"201-214"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus. 家族性神经垂体性尿崩症小鼠模型中抗利尿激素神经元的吞噬细胞起源于内质网膜。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-10-04 DOI: 10.1007/s00441-025-04013-w

Takashi Miyata, Daisuke Hagiwara, Ryosei Ashida, Satoshi Naito, Yohei Kawaguchi, Tomoko Handa, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Mami Matsumoto, Hidetoshi Urakubo, Nobuhiko Ohno, Hiroshi Arima

{"title":"Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus.","authors":"Takashi Miyata, Daisuke Hagiwara, Ryosei Ashida, Satoshi Naito, Yohei Kawaguchi, Tomoko Handa, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Mami Matsumoto, Hidetoshi Urakubo, Nobuhiko Ohno, Hiroshi Arima","doi":"10.1007/s00441-025-04013-w","DOIUrl":"10.1007/s00441-025-04013-w","url":null,"abstract":"Familial neurohypophysial diabetes insipidus (FNDI) is an autosomal dominant disorder caused by mutations in the arginine vasopressin (AVP) gene. In AVP neurons in a mouse model of FNDI, aggregates of mutant AVP precursors accumulate within a specific compartment of the endoplasmic reticulum (ER). However, as FNDI mice aged, or were exposed to repeated water deprivation, the ER lumen dilated and mutant aggregates dispersed throughout the ER. Meanwhile, autophagic isolation membranes, known as phagophores, emerged to envelop ER containing these aggregates, indicating induction of ER-phagy. Previous in vitro studies showed that phagophores originate from ER membranes, but the structural relationship between phagophores and the ER membrane in vivo remains unknown. In this study, we used serial block-face scanning electron microscopy to investigate the structural relationship between phagophores, ER membranes, and protein aggregates within dilated ER of AVP neurons from FNDI mice subjected to intermittent water deprivation for 4 weeks. Three-dimensional analysis revealed that phagophores enveloped aggregates located within the dilated ER. Serial imaging further demonstrated a physical connection between these phagophores and intact ER membranes. This study provides the first in vivo evidence of the structural continuity between phagophores and the ER membrane in AVP neurons in a mouse model of FNDI.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"139-144"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12594716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parvin is essential for indirect flight muscle (IFM) performance and Zasp52 localisation to the Z-disc in Drosophila melanogaster. Parvin对于果蝇的间接飞行肌肉（IFM）表现和Zasp52在z盘的定位至关重要。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-09-03 DOI: 10.1007/s00441-025-04007-8

Ushashi Ain, Benazir Fatma, Hena Firdaus

{"title":"Parvin is essential for indirect flight muscle (IFM) performance and Zasp52 localisation to the Z-disc in Drosophila melanogaster.","authors":"Ushashi Ain, Benazir Fatma, Hena Firdaus","doi":"10.1007/s00441-025-04007-8","DOIUrl":"10.1007/s00441-025-04007-8","url":null,"abstract":"The integrin-associated proteins (IAPs) function in a tightly regulated and coordinated manner to maintain the complex cytoarchitecture at the myotendinous junctions (MTJs) of Drosophila indirect flight muscles (IFMs). Parvin, a conserved but less explored IAP, forms a ternary complex with ILK and PINCH (the IPP complex). Although the IPP complex is functionally conserved, playing a central role in integrin-mediated adhesion, its individual components may also exert independent roles. The present study investigates parvin as a critical regulator of IFM function and sarcomeric integrity. Downregulation of parvin in IFM leads to altered sarcomere organisation and lowered accumulation of essential thin filament genes, including Act88F, wupA, up, TpnC4, and TM2 transcripts. Furthermore, Z-disc-associated proteins such as Zasp52 and its binding partner α-actinin, which are vital for myofibril stability, showed markedly reduced expression in parvin-deficient muscles. Notably, Zasp52 failed to localise to the Z-discs in IFMs, despite being detectable in leg muscles, suggesting tissue-specific mislocalisation. The expression of sallimus, a titin orthologue contributing to muscle elasticity, remained unchanged. Our findings underscore parvin's essential role in preserving IFM ultrastructure and function. We also emphasise the importance of maintaining the stoichiometric balance within the IPP complex-including its extended member Ras suppressor 1 (RSU1)-for proper muscle performance. Additionally, perturbation of parvin expression in a tissue-specific manner revealed its broader role in fly viability and muscle-driven behaviours, including larval locomotion and leg muscle function. Collectively, this study positions parvin as a pivotal component in maintaining muscle integrity across multiple muscle types in Drosophila.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"157-171"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental changes in the Aedes aegypti mosquito endocrine gland complex. 埃及伊蚊内分泌腺复合体的发育变化。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI: 10.1007/s00441-025-04012-x

Lenka Rouhová, Gabriela Krejčová, Ana Beatriz Barletta Ferreira, Houda Ouns Maaroufi, Fernando G Noriega, Carolina Barillas-Mury, Hana Sehadová, Marcela Nouzova

{"title":"Developmental changes in the Aedes aegypti mosquito endocrine gland complex.","authors":"Lenka Rouhová, Gabriela Krejčová, Ana Beatriz Barletta Ferreira, Houda Ouns Maaroufi, Fernando G Noriega, Carolina Barillas-Mury, Hana Sehadová, Marcela Nouzova","doi":"10.1007/s00441-025-04012-x","DOIUrl":"10.1007/s00441-025-04012-x","url":null,"abstract":"In the larvae of the mosquito Aedes aegypti, the three most important endocrine glands, the corpora allata (CA), the corpora cardiaca (CC), and the prothoracic gland (PG), together form the glandular complexes (GC). Using confocal laser scanning microscopy in combination with immunohistochemistry, in situ hybridization, ultrastructural expansion microscopy, and apoptosis studies, we were able to identify the different cell types of the GC and follow their fate during metamorphosis. Our studies revealed that the CC is not a well-defined organ but consists of individual cells randomly distributed within the GC and CA-CC complexes. Furthermore, imaging and in situ hybridization show that the CA is a compact organ composed of a single cell type. We observed that CA and CC survive during the larval-to-adult transition, while PG undergoes apoptosis and disappears within the first 24 h of adult life. This study lays the foundation for a more detailed understanding of the structure and changes in the major endocrine organs of mosquitoes, which are vectors of several important infectious diseases.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"145-155"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the antiangiogenic effects of Phospholipases A₂ from Bothrops diporus venom. 探讨双翅虫毒液磷脂酶A2的抗血管生成作用。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-11-01 Epub Date: 2025-09-10 DOI: 10.1007/s00441-025-04008-7

Daniela J Sasovsky, Gabriela B Olea, Gonzalo Ojeda, Angélica M Cesario, Franco J Gonzalez, Bruno Lomonte, Daniel Lombardo, Soledad Bustillo

{"title":"Exploring the antiangiogenic effects of Phospholipases A2 from Bothrops diporus venom.","authors":"Daniela J Sasovsky, Gabriela B Olea, Gonzalo Ojeda, Angélica M Cesario, Franco J Gonzalez, Bruno Lomonte, Daniel Lombardo, Soledad Bustillo","doi":"10.1007/s00441-025-04008-7","DOIUrl":"10.1007/s00441-025-04008-7","url":null,"abstract":"Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a crucial process in both physiological and pathological contexts, including cancer. Phospholipases A2 (PLA2s), enzymes found in snake venoms, have attracted attention due to their potential antiangiogenic properties. In this study, we explored the antiangiogenic effects of PLA2 isoforms isolated from Bothrops diporus venom using a combination of in vivo and ex vivo models. The chorioallantoic membrane (CAM) assay revealed a significant reduction in vascular density and branching following PLA2s treatment, with histological analysis confirming vascular regression, including vessel wall thinning and luminal collapse. Moreover, PLA2s induced endothelial cell apoptosis, as shown by TUNEL staining, and reduced VEGF expression. The filter paper disc variant of the CAM assay further supported these findings, demonstrating inhibited neovascularization while preserving mature vessels. Additionally, the CAM explant assay showed a marked decrease in vascular complexity and branching. These results demonstrate the antiangiogenic effect of PLA2 isoforms from B. diporus and suggest that these enzymes may modulate key angiogenic pathways. Based on our previous findings, this modulation may involve interference with integrin-mediated signaling, which could underlie the vascular effects observed. Thus, this work provides compelling evidence for the potential role of snake venom-derived PLA2s in modulating angiogenesis and highlights the need for further research into their mechanisms and possible biomedical applications.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"189-199"},"PeriodicalIF":2.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonizing bacteria around aggregated lymphoid tissue of the rat ascending colon change diurnally and affect the host local transcriptome. 大鼠升结肠聚集淋巴组织周围的定殖细菌每天都在变化，并影响宿主的局部转录组。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-10-01 Epub Date: 2025-08-26 DOI: 10.1007/s00441-025-04000-1

Asaka Shimada, Naoto Kubota, Sika Zheng, Rinako Morishita, Toshifumi Yokoyama, Nobuhiko Hoshi, Youhei Mantani

{"title":"Colonizing bacteria around aggregated lymphoid tissue of the rat ascending colon change diurnally and affect the host local transcriptome.","authors":"Asaka Shimada, Naoto Kubota, Sika Zheng, Rinako Morishita, Toshifumi Yokoyama, Nobuhiko Hoshi, Youhei Mantani","doi":"10.1007/s00441-025-04000-1","DOIUrl":"10.1007/s00441-025-04000-1","url":null,"abstract":"The settlement levels of indigenous bacteria show circadian rhythms in various regions of the rat alimentary tract. Numerous bacteria colonize between the mucosal folds of the ascending colon in rodents; however, the rhythm of bacteria colonizing the ascending colon remains to be clarified. Therefore, we first aimed to examine the diurnal changes in bacteria colonizing in the rat ascending colon. The settlement levels of indigenous bacteria were significantly higher at zeitgeber time (ZT) 18 (dark phase) than at ZT6 (light phase) in the region encompassing the aggregated lymphoid tissue in the ascending colon (ALT-AC). The bacterial composition around the ALT-AC was dominated by the phylum Firmicutes and the family Lachnospiraceae, displaying notable distinctions from the compositions found in cecal contents and feces. The relative abundance of some bacterial species around the ALT-AC, such as Mucispirillum schaedleri, changed significantly between ZT6 and ZT18. Furthermore, we explored the effect of bacterial expansion on gene expression in the ALT-AC at ZT18 by administrating antibiotics for 1 day to inhibit bacterial growth. The antibiotic-treated group exhibited significant downregulation of multiple genes, including those associated with cell proliferation (Plk3), differentiation into goblet cells (Spdef, Atoh1, Bhlha15), and Golgi organization (Gorasp2). These results suggested that indigenous bacteria around the rat ALT-AC undergo diurnal changes in both settlement levels, peaking at the dark phase, and bacterial composition. In addition, bacterial expansion during the dark phase can induce changes in the expression of diverse genes, including genes associated with goblet cell differentiation.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"97-108"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary cilium disappearance in podocytes during vertebrate phylogeny revealed by array tomography. 阵列断层扫描揭示脊椎动物系统发育过程中足细胞初级纤毛的消失。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI: 10.1007/s00441-025-04002-z

Takayuki Miyaki, Jingyuan Xu, Makoto Sugiura, Hisako Kaneda, Juan Alejandro Oliva Trejo, Yuto Kawasaki, Takuya Omotehara, Takako Negishi-Koga, Muneaki Ishijima, Junji Yamaguchi, Soichiro Kakuta, Koichiro Ichimura

{"title":"Primary cilium disappearance in podocytes during vertebrate phylogeny revealed by array tomography.","authors":"Takayuki Miyaki, Jingyuan Xu, Makoto Sugiura, Hisako Kaneda, Juan Alejandro Oliva Trejo, Yuto Kawasaki, Takuya Omotehara, Takako Negishi-Koga, Muneaki Ishijima, Junji Yamaguchi, Soichiro Kakuta, Koichiro Ichimura","doi":"10.1007/s00441-025-04002-z","DOIUrl":"10.1007/s00441-025-04002-z","url":null,"abstract":"Podocytes are a type of epithelial cells that form the kidney nephron and are essential for ultrafiltration in the glomerulus. The majority of nephron constituent cells have primary cilia, which play an important role in the maintenance of normal tubular architecture of nephron. However, whether podocytes have primary cilia was only partially understood. In general, immunohistochemistry with an anti-acetylated α-tubulin antibody is often used to visualize primary cilia. α-Tubulin is highly acetylated throughout podocytes, and this antibody is not suitable to determine the presence or absence of primary cilia in podocytes, which is one reason why the presence of primary cilia in podocytes has remained unclear. In the present study, we determined the presence or absence of primary cilia in mature podocytes of six vertebrate species using a recently reported array tomography workflow optimized for whole glomerulus analysis. The proportion of podocytes with primary cilia tended to decrease with evolution as follows: 89.6% in river lampreys (Agnatha), 42.1% in zebrafish (Osteichthyes), 43.3% in African clawed frogs (Amphibia), 17.3% in Reeves' turtles (Reptilia), 10.4% in common quails (Aves), and 0.0% in Wistar rats (Mammalia). Our previous study has reported that, in rats, primary cilia are present in podocytes during development and disappear in mature podocytes. In other words, primary cilia disappear from podocytes during both phylogeny and ontogeny in vertebrates. We discuss the triggers and significance of primary cilium disappearance from vertebrate podocytes.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"51-63"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical relevance of the compartments and lymphocyte subsets in the human spleen. 人脾细胞间室和淋巴细胞亚群的临床相关性。

IF 2.9 3区生物学

Cell and Tissue Research Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI: 10.1007/s00441-025-04001-0

Reinhard Pabst

引用次数: 0