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Cellular reprogramming最新文献

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Reprogramming Stars #28: Stem Cell-Based Approaches to Build Blood Vessels and Liver Tissue-An Interview with Dr. Lay Teng Ang. 重编程之星#28：基于干细胞的血管和肝组织构建方法——采访李腾昂博士。
IF 2.7 4区 医学
Cellular reprogramming Pub Date : 2026-08-01 Epub Date: 2026-05-26 DOI: 10.1177/21524971261449506
Lay Teng Ang, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #28: Stem Cell-Based Approaches to Build Blood Vessels and Liver Tissue-An Interview with Dr. Lay Teng Ang.","authors":"Lay Teng Ang, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1177/21524971261449506","DOIUrl":"10.1177/21524971261449506","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"101-106"},"PeriodicalIF":2.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Involvement of Gut Microbiota and Their Key Metabolites in Regulating Fetal Development via the Gut-Placental Axis. 肠道微生物群及其关键代谢物通过肠道-胎盘轴参与调节胎儿发育。
IF 2.7 4区 医学
Cellular reprogramming Pub Date : 2026-06-01 Epub Date: 2026-05-07 DOI: 10.1177/21524971261450000
Hao Zhang, Tingting Ni, Xia Zha, Mabrouk Elsabagh, Mengzhi Wang
{"title":"The Involvement of Gut Microbiota and Their Key Metabolites in Regulating Fetal Development via the Gut-Placental Axis.","authors":"Hao Zhang, Tingting Ni, Xia Zha, Mabrouk Elsabagh, Mengzhi Wang","doi":"10.1177/21524971261450000","DOIUrl":"10.1177/21524971261450000","url":null,"abstract":"<p><p>The gut is the organ with the largest number of microorganisms in the organism, and host-microbe interactions allow the host to shape the composition of the microbiome and thus its numbers and diversity. The gut microbiome is integral to the facilitation of vital host functions that have a direct impact on the overall health of the host. This paper aims to present a thorough overview of the composition and function of the gut microbiome and its main metabolites (such as lipopolysaccharides, short-chain fatty acids, and bile acids), as well as their key roles and mechanisms in fetal development. The theme highlights the significance of the gut microbiome in fetal development, and the paper aims to establish their relationship and importance in a systematic manner. In the latter portion of the article, an analysis is presented regarding the proposed mechanism of the gut-placental axis, with an effort to outline strategies for regulating maternal gut microbiology in order to enhance fetal growth and development. By delving into this subject matter extensively, we aim to enhance comprehension of the correlation between maternal gut microbes and fetal development. This can contribute to safeguarding the mother's health, enhancing the survival and well-being of the fetus, and carrying significance for both human and animal reproduction. Furthermore, it can provide valuable insights for future research and clinical practices.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"75-88"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of Buffalo (Bubalus bubalis) Theca Cells: A Comparison Among Three Protocols. 水牛（Bubalus bubalis）卵泡细胞的分离：三种方法的比较。
IF 2.7 4区 医学
Cellular reprogramming Pub Date : 2026-06-01 Epub Date: 2026-05-25 DOI: 10.1177/21524971261449712
Jun Zhang, Bing Hu, Junming Sun, Yiqiang Ouyang, Yu Zhang
{"title":"Isolation of Buffalo (<i>Bubalus bubalis</i>) Theca Cells: A Comparison Among Three Protocols.","authors":"Jun Zhang, Bing Hu, Junming Sun, Yiqiang Ouyang, Yu Zhang","doi":"10.1177/21524971261449712","DOIUrl":"10.1177/21524971261449712","url":null,"abstract":"<p><p>Theca cells (TCs) are one of the most important cell types in follicles and play an essential role during follicular development. However, the suitable isolation method for buffalo TCs remains unclear. In the present study, we compared three separation methods (collagenase II digestion, trypsin digestion, and tissue cultivation) to seek the best isolation method for buffalo TCs. The results showed that, compared with the method of trypsin digestion, the isolation methods of collagenase II digestion and tissue cultivation exerted a significantly higher cell viability of buffalo TCs. Furthermore, compared to the methods of trypsin digestion and tissue cultivation, the isolation method of collagenase II manifested a significantly higher cell purity of buffalo TCs. This study indicated that, with regards to cell viability and purity, the method of collagenase II digestion was the optimal choice to isolate buffalo TCs. Our study provides a basis for the procurement of high-quality buffalo TCs to further explore buffalo somatic cell nuclear transfer.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"89-93"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #27: Drawing Inspiration from Reprogramming to Guide Stem Cell Differentiation: An Interview with Dr. Kyle Loh. 重编程之星#27：从重编程中获得灵感以指导干细胞分化：对Kyle Loh博士的采访。
IF 1.7 4区 医学
Cellular reprogramming Pub Date : 2026-06-01 Epub Date: 2026-03-16 DOI: 10.1177/21524971261432386
Kyle M Loh, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #27: Drawing Inspiration from Reprogramming to Guide Stem Cell Differentiation: An Interview with Dr. Kyle Loh.","authors":"Kyle M Loh, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1177/21524971261432386","DOIUrl":"10.1177/21524971261432386","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"69-74"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Cardiac Reprogramming in the Omics Era: Advances, Mechanisms, and Applications. 组学时代的直接心脏重编程：进展、机制和应用。
IF 2.7 4区 医学
Cellular reprogramming Pub Date : 2026-04-01 Epub Date: 2026-03-02 DOI: 10.1177/21524971261427184
Chelsea Li, Li Qian
{"title":"Direct Cardiac Reprogramming in the Omics Era: Advances, Mechanisms, and Applications.","authors":"Chelsea Li, Li Qian","doi":"10.1177/21524971261427184","DOIUrl":"10.1177/21524971261427184","url":null,"abstract":"<p><p>Cardiovascular disease remains the leading cause of death worldwide, with its disease burden continuing to rise. After cardiac injury, most commonly ischemia from myocardial infarction, irreversible loss of cardiomyocytes (CMs) occurs, and the damaged myocardium is replaced by fibroblast (Fib)-derived scar tissue. Because adult CMs have limited regenerative capacity, repair is limited, cardiac function progressively declines, and patients often develop heart failure. Direct cardiac reprogramming-converting Fibs into induced CM-like cells (iCMs)-has emerged as a promising strategy to restore contractile myocardium. Omics-based approaches have greatly advanced understanding of the mechanisms that enable or hinder iCM generation. Single-cell transcriptomics have delineated gene expression trajectories and intermediate cell states, while epigenomic studies have revealed how chromatin accessibility, histone modifications, and DNA methylation shape cell fate conversion. Post-transcriptional analyses further highlight the importance of RNA processing and translational control, and proteomic profiling has demonstrated rapid remodeling of protein networks and paracrine signaling during reprogramming. In parallel, metabolic studies have linked shifts in metabolite flux to iCM maturation. Together, these multi-omics investigations provide an integrated framework for defining both barriers and facilitators of Fib-to-iCM conversion. This review synthesizes recent omics-based insights into direct cardiac reprogramming and discusses future directions for advancing its clinical application.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"46-62"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #26: Understanding the Reprogramming Privilege-An Interview with Dr. Shangqin Guo. 重编程之星#26：理解重编程的特权——采访郭尚勤博士
IF 1.7 4区 医学
Cellular reprogramming Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1177/21524971251407961
Shangqin Guo, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #26: Understanding the Reprogramming Privilege-An Interview with Dr. Shangqin Guo.","authors":"Shangqin Guo, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1177/21524971251407961","DOIUrl":"10.1177/21524971251407961","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"41-45"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #17: Breaking Down the Barriers of Direct Reprogramming Using a Model Organism-An Interview with Dr. Baris Tursun. 重编程之星#17：使用模型生物打破直接重编程的障碍-对Baris Tursun博士的采访。
IF 1.7 4区 医学
Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-03-11 DOI: 10.1089/cell.2024.54625
Baris Tursun, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #17: Breaking Down the Barriers of Direct Reprogramming Using a Model Organism-An Interview with Dr. Baris Tursun.","authors":"Baris Tursun, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.54625","DOIUrl":"10.1089/cell.2024.54625","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"12-20"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。
IF 1.7 4区 医学
Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-03-11 DOI: 10.1089/cell.2024.0041
José C R Silva, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva.","authors":"José C R Silva, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.0041","DOIUrl":"10.1089/cell.2024.0041","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"6-11"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural and Artificial Hematopoietic Cell Reprogramming. 自然和人工造血细胞重编程。
IF 2.7 4区 医学
Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-02-12 DOI: 10.1177/21524971261424117
Dong Yu, Wenpei Liu, Feng Liu, Lin Cheng
{"title":"Natural and Artificial Hematopoietic Cell Reprogramming.","authors":"Dong Yu, Wenpei Liu, Feng Liu, Lin Cheng","doi":"10.1177/21524971261424117","DOIUrl":"10.1177/21524971261424117","url":null,"abstract":"<p><p>Hematopoietic cell reprogramming, defined as the conversion from one hematopoietic or immune cell type into another, has been shown to hold transformative potential for advancing our understanding of hematopoiesis, disease mechanisms, and therapeutic innovation. This process occurs via transdifferentiation, dedifferentiation, or transitional plasticity, driven by transcriptional, epigenetic, and microenvironmental cues, which may be achieved by physiological or pathological stressors <i>in vivo</i>, or genetic or chemical strategies <i>in vitro</i>. Nevertheless, challenges persist, including low reprogramming efficiency, unstable phenotype, and safety concerns. Advancements in multi-omics, gene editing, and chemical biology are enhancing the efficacy of reprogramming protocols and facilitating clinical translatability. The integration of these strategies, in conjunction with artificial intelligence-driven screening and single-cell analytics, has the potential to facilitate the development of personalized cell therapies for cancers, immune disorders, and regenerative medicine. Additionally, the realization of this potential is contingent upon the resolution of challenges related to delivery, specificity, and long-term efficacy.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"21-35"},"PeriodicalIF":2.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #25: Modeling Brain Aging with Direct Reprogramming of Skin Cells into Neurons-An Interview with Dr. Jerome Mertens. 重编程之星#25：通过将皮肤细胞直接重编程为神经元来模拟大脑衰老——对Jerome Mertens博士的采访。
IF 1.7 4区 医学
Cellular reprogramming Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1177/21524971251398980
Jerome Mertens, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #25: Modeling Brain Aging with Direct Reprogramming of Skin Cells into Neurons-An Interview with Dr. Jerome Mertens.","authors":"Jerome Mertens, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1177/21524971251398980","DOIUrl":"10.1177/21524971251398980","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"207-212"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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