近一个世纪的核转移研究：里程碑、应用和挑战。

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI:10.1089/cell.2024.0089

Yiren Qin

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引用次数: 0

摘要

从第一次克隆动物蝾螈到克隆灵长类动物猴子，核移植研究已经跨越了96年的漫长历史。在近一个世纪的过程中，它解决了基本的科学问题，并在广泛的实践领域找到了应用。这篇综述提供了一个全面的概述在其发展的关键里程碑，它的实际应用，并继续面临的挑战。

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Nearly a Century of Nuclear Transfer Research: Milestones, Applications, and Challenges.

From the first cloning of animals-salamanders-to the cloning of primates-monkeys-nuclear transfer research has spanned an extensive 96-year history. Over the course of nearly a century, it has addressed fundamental scientific questions and found applications across a wide range of practical fields. This review provides a comprehensive overview of the key milestones in its development, its practical applications, and the challenges it continues to face.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.