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Reprogramming Stars #18: Engineering Cell Fates and Preventing Disease by Repressing Unwanted Plasticity-An Interview with Dr. Moritz Mall. 重编程之星 #18：通过抑制不必要的可塑性来改造细胞命运和预防疾病--莫里茨-马尔博士访谈录。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-10-01 DOI: 10.1089/cell.2024.36789.mor
Moritz Mall, Mariana Lopes, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #18: Engineering Cell Fates and Preventing Disease by Repressing Unwanted Plasticity-An Interview with Dr. Moritz Mall.","authors":"Moritz Mall, Mariana Lopes, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.36789.mor","DOIUrl":"https://doi.org/10.1089/cell.2024.36789.mor","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Sertoli Cell Signaling Pathway with Protein-Protein Interaction, Single-Cell Sequencing, and Gene Ontology. 利用蛋白质-蛋白质相互作用、单细胞测序和基因本体解密Sertoli细胞信号通路
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-10-01 DOI: 10.1089/cell.2024.0059
Danial Hashemi Karoii, Gohar Javadzadeh, Hossein Azizi, Fadhil Farhood M Al-Joborae, Mehdi Amirian
{"title":"Deciphering the Sertoli Cell Signaling Pathway with Protein-Protein Interaction, Single-Cell Sequencing, and Gene Ontology.","authors":"Danial Hashemi Karoii, Gohar Javadzadeh, Hossein Azizi, Fadhil Farhood M Al-Joborae, Mehdi Amirian","doi":"10.1089/cell.2024.0059","DOIUrl":"https://doi.org/10.1089/cell.2024.0059","url":null,"abstract":"<p><p>Spermatogenesis constitutes a complex and intricate cascade of differentiation, indispensable for the male reproductive competence. The intercellular communication conduits of Sertoli cells (SCs) are pivotal in orchestrating this cascade ensuring sustenance and development of germ cells. Single cells and bioinformatics recently demonstrated articles are used for the regulatory modalities through which SCs modulate spermatogenesis, specifically <i>via</i> androgen receptors (ARs), the transforming growth factor-beta/Smad axis, mitogen-activated protein kinases, cAMP/protein kinase A (PKA), phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3k)/AKT serine threonine kinase (Akt), AMP-activated protein kinase, and AR pathways. Within this framework, homeostasis of gap junction dynamics, cryptic sites and the activities at tight junctions and adherens junctions, with the integrity of the testicular barrier, glucose assimilation, lactate distribution, being governed also along with SC maturation. Disruptions in activities or abnormal concentration in derangements in AR, cAMP/PKA, and PI3k/Akt pathways, and as well as the molecules that comprise them, would present male infertility.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Frontier in Tumor Eradication: Harnessing In Vivo Cellular Reprogramming for Durable Cancer Immunotherapy. 根除肿瘤的新前沿：利用体内细胞重编程实现持久的癌症免疫疗法。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.1089/cell.2024.0077
Constantinos Chronis
{"title":"A New Frontier in Tumor Eradication: Harnessing <i>In Vivo</i> Cellular Reprogramming for Durable Cancer Immunotherapy.","authors":"Constantinos Chronis","doi":"10.1089/cell.2024.0077","DOIUrl":"10.1089/cell.2024.0077","url":null,"abstract":"<p><p>Tumors evade immune detection by downregulating antigen presentation and hindering immune responses. Type 1 conventional dendritic cells (cDC1s) are vital in stimulating cytotoxic T cells against tumors. Ascic et al. are now demonstrating the <i>in situ</i> ability of PU.1, IRF8, and BATF3 (PIB) transcription factors to directly reprogram a plethora of tumors bypassing the suppressive effects of the tumor microenvironment, and leading to overall tumor regression while eliciting a systemic immune response that can protect from secondary tumor induction.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential. 倒带以确定重编程潜能的内在决定因素。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-08-01 Epub Date: 2024-08-08 DOI: 10.1089/cell.2024.0035
Kate E Galloway
{"title":"Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential.","authors":"Kate E Galloway","doi":"10.1089/cell.2024.0035","DOIUrl":"10.1089/cell.2024.0035","url":null,"abstract":"<p><p>Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain memory of over several rounds of cell division. Moreover, they show that extrinsic factors change the number of primed cells, suggesting that there exist diverse paths of reprogramming and states of priming.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning. 基因组规模分析揭示克隆猴的障碍
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-08-01 DOI: 10.1089/cell.2024.0048
Marcelo Tigre Moura
{"title":"Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning.","authors":"Marcelo Tigre Moura","doi":"10.1089/cell.2024.0048","DOIUrl":"10.1089/cell.2024.0048","url":null,"abstract":"<p><p>Cloning by somatic cell nuclear transfer (SCNT) remained challenging for Rhesus monkeys, mostly due to its low efficiency and neonatal death. Genome-scale analyses revealed that monkey SCNT embryos displayed widespread DNA methylation and transcriptional alterations, thus including loss of genomic imprinting that correlated with placental dysfunction. The transfer of inner cell masses (ICM) from cloned blastocysts into ICM-depleted fertilized embryos rescued placental insufficiency and gave rise to a cloned Rhesus monkey that reached adulthood without noticeable abnormalities.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-07-05 DOI: 10.1089/cell.2024.0041
José C R Silva, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva.","authors":"José C R Silva, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.0041","DOIUrl":"https://doi.org/10.1089/cell.2024.0041","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.26895.jcrs
José C R Silva, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva.","authors":"José C R Silva, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.26895.jcrs","DOIUrl":"https://doi.org/10.1089/cell.2024.26895.jcrs","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Senescent Cells on Limb Regeneration. 衰老细胞对肢体再生的影响
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1089/cell.2024.0021
Marlene J Oesterle, Nicholas D Leigh
{"title":"The Impact of Senescent Cells on Limb Regeneration.","authors":"Marlene J Oesterle, Nicholas D Leigh","doi":"10.1089/cell.2024.0021","DOIUrl":"10.1089/cell.2024.0021","url":null,"abstract":"<p><p>Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial role during limb development. However, whether the process of limb regeneration also relies on senescent cells remains unclear. Creation of a novel targeted depletion strategy that can eliminate senescent cells in the regenerating limb has now demonstrated an important role for senescent cells in limb regeneration. This role is linked to senescent cell-derived Wnt signaling. These findings reveal a previously unknown role for senescent cells during limb regeneration through Wnt signaling.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy. 间充质干细胞恶性转化的分子前瞻：细胞疗法中的一个问题。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.0026
Maryam Kaviani, Saeede Soleimanian, Somayeh Keshtkar, Negar Azarpira, Zahra Asvar, Sara Pakbaz
{"title":"Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy.","authors":"Maryam Kaviani, Saeede Soleimanian, Somayeh Keshtkar, Negar Azarpira, Zahra Asvar, Sara Pakbaz","doi":"10.1089/cell.2024.0026","DOIUrl":"https://doi.org/10.1089/cell.2024.0026","url":null,"abstract":"<p><p>Mesenchymal stem cell (MSCs) therapy, as a rapidly developing area of medicine, holds great promise for the treatment of a variety of medical conditions. MSCs are multipotent stem cells that can be isolated from various tissues and could self-renew and differentiate. They secrete cytokines and trophic factors that create a regenerative microenvironment and have immunomodulatory properties. Although clinical trials have been conducted with MSCs in various diseases, concerns regarding the possibility of malignant transformation of these cells have been raised. The studies showed a higher rate of hematological malignancy and carcinogenesis in experimental models after MSC transplantation. The mechanisms underlying malignant transformation of MSCs are complex and not fully understood, but they are believed to involve the presence of special signaling molecules and alterations in cell behavior regulation pathways. Possible pathways that lead to MSCs' oncogenic transformation occur through two mechanisms: spontaneous and stimulated malignant transformation, including cell fusion, fusion proteins, and the tumor microenvironment. MSC-based therapies have the potential to revolutionize medicine, and addressing the issue of malignancy is crucial to ensure their safety and efficacy. Therefore, the purpose of the present review is to summarize the potential mechanisms of the malignant transformation of MSCs. [Figure: see text].</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly Defined Induced Pluripotent Stem Cell Lines Mimic Donor Red Blood Cell Antigen Profiles for Therapeutic and Diagnostic Use. 高度定义的诱导多能干细胞系模拟供体红细胞抗原谱，用于治疗和诊断。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.0018
Lucas Ferioli Catelli, Péricles Natan Mendes da Costa, Felipe Augusto Rós, Evandra Strazza Rodrigues, Fernanda Ferreira Ursoli, Flávia Leite Souza Santos, Mayra Dorigan, Lílian Maria de Castilho, Dimas Tadeu Covas, Simone Kashima
{"title":"Highly Defined Induced Pluripotent Stem Cell Lines Mimic Donor Red Blood Cell Antigen Profiles for Therapeutic and Diagnostic Use.","authors":"Lucas Ferioli Catelli, Péricles Natan Mendes da Costa, Felipe Augusto Rós, Evandra Strazza Rodrigues, Fernanda Ferreira Ursoli, Flávia Leite Souza Santos, Mayra Dorigan, Lílian Maria de Castilho, Dimas Tadeu Covas, Simone Kashima","doi":"10.1089/cell.2024.0018","DOIUrl":"https://doi.org/10.1089/cell.2024.0018","url":null,"abstract":"<p><p>Our group generated two induced pluripotent stem cell (iPSC) lines for <i>in vitro</i> red blood cell (RBC) production from blood donors with extensively known erythrocyte antigen profiles. One line was intended to give rise to RBCs for transfusions in patients with sickle cell disease (SCD), while the other was developed to create RBC panel reagents. Two blood donors were selected based on their RBC phenotypes, further complemented by high-throughput DNA array analysis to obtain a more comprehensive erythrocyte antigen profile. Enriched erythroblast populations from the donors' peripheral blood mononuclear cells were reprogrammed into iPSCs using nonintegrative plasmid vectors. The iPSC lines were characterized and subsequently subjected to hematopoietic differentiation. iPSC PB02 and iPSC PB12 demonstrated <i>in vitro</i> and <i>in vivo</i> iPSC features and retained the genotype of each blood donor's RBC antigen profile. Colony-forming cell assays confirmed that iPSC PB02 and iPSC PB12 generated hematopoietic progenitors. These two iPSC lines were generated with defined erythrocyte antigen profiles, self-renewal capacity, and hematopoietic differentiation potential. With improvements in hematopoietic differentiation, these cells could potentially be more efficiently differentiated into RBCs in the future. They could serve as a complementary approach for obtaining donor-independent RBCs and addressing specific demands for blood transfusions.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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