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Cellular reprogramming最新文献

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Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential. 倒带以确定重编程潜能的内在决定因素。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-08-01 Epub Date: 2024-08-08 DOI: 10.1089/cell.2024.0035
Kate E Galloway
{"title":"Rewinding the Tape to Identify Intrinsic Determinants of Reprogramming Potential.","authors":"Kate E Galloway","doi":"10.1089/cell.2024.0035","DOIUrl":"10.1089/cell.2024.0035","url":null,"abstract":"<p><p>Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain memory of over several rounds of cell division. Moreover, they show that extrinsic factors change the number of primed cells, suggesting that there exist diverse paths of reprogramming and states of priming.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning. 基因组规模分析揭示克隆猴的障碍
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-08-01 DOI: 10.1089/cell.2024.0048
Marcelo Tigre Moura
{"title":"Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning.","authors":"Marcelo Tigre Moura","doi":"10.1089/cell.2024.0048","DOIUrl":"10.1089/cell.2024.0048","url":null,"abstract":"<p><p>Cloning by somatic cell nuclear transfer (SCNT) remained challenging for Rhesus monkeys, mostly due to its low efficiency and neonatal death. Genome-scale analyses revealed that monkey SCNT embryos displayed widespread DNA methylation and transcriptional alterations, thus including loss of genomic imprinting that correlated with placental dysfunction. The transfer of inner cell masses (ICM) from cloned blastocysts into ICM-depleted fertilized embryos rescued placental insufficiency and gave rise to a cloned Rhesus monkey that reached adulthood without noticeable abnormalities.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-07-05 DOI: 10.1089/cell.2024.0041
José C R Silva, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva.","authors":"José C R Silva, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.0041","DOIUrl":"https://doi.org/10.1089/cell.2024.0041","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.26895.jcrs
José C R Silva, Carlos-Filipe Pereira
{"title":"Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva.","authors":"José C R Silva, Carlos-Filipe Pereira","doi":"10.1089/cell.2024.26895.jcrs","DOIUrl":"https://doi.org/10.1089/cell.2024.26895.jcrs","url":null,"abstract":"","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Senescent Cells on Limb Regeneration. 衰老细胞对肢体再生的影响
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1089/cell.2024.0021
Marlene J Oesterle, Nicholas D Leigh
{"title":"The Impact of Senescent Cells on Limb Regeneration.","authors":"Marlene J Oesterle, Nicholas D Leigh","doi":"10.1089/cell.2024.0021","DOIUrl":"10.1089/cell.2024.0021","url":null,"abstract":"<p><p>Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial role during limb development. However, whether the process of limb regeneration also relies on senescent cells remains unclear. Creation of a novel targeted depletion strategy that can eliminate senescent cells in the regenerating limb has now demonstrated an important role for senescent cells in limb regeneration. This role is linked to senescent cell-derived Wnt signaling. These findings reveal a previously unknown role for senescent cells during limb regeneration through Wnt signaling.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy. 间充质干细胞恶性转化的分子前瞻：细胞疗法中的一个问题。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.0026
Maryam Kaviani, Saeede Soleimanian, Somayeh Keshtkar, Negar Azarpira, Zahra Asvar, Sara Pakbaz
{"title":"Molecular Prospective on Malignant Transformation of Mesenchymal Stem Cells: An Issue in Cell Therapy.","authors":"Maryam Kaviani, Saeede Soleimanian, Somayeh Keshtkar, Negar Azarpira, Zahra Asvar, Sara Pakbaz","doi":"10.1089/cell.2024.0026","DOIUrl":"https://doi.org/10.1089/cell.2024.0026","url":null,"abstract":"<p><p>Mesenchymal stem cell (MSCs) therapy, as a rapidly developing area of medicine, holds great promise for the treatment of a variety of medical conditions. MSCs are multipotent stem cells that can be isolated from various tissues and could self-renew and differentiate. They secrete cytokines and trophic factors that create a regenerative microenvironment and have immunomodulatory properties. Although clinical trials have been conducted with MSCs in various diseases, concerns regarding the possibility of malignant transformation of these cells have been raised. The studies showed a higher rate of hematological malignancy and carcinogenesis in experimental models after MSC transplantation. The mechanisms underlying malignant transformation of MSCs are complex and not fully understood, but they are believed to involve the presence of special signaling molecules and alterations in cell behavior regulation pathways. Possible pathways that lead to MSCs' oncogenic transformation occur through two mechanisms: spontaneous and stimulated malignant transformation, including cell fusion, fusion proteins, and the tumor microenvironment. MSC-based therapies have the potential to revolutionize medicine, and addressing the issue of malignancy is crucial to ensure their safety and efficacy. Therefore, the purpose of the present review is to summarize the potential mechanisms of the malignant transformation of MSCs. [Figure: see text].</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly Defined Induced Pluripotent Stem Cell Lines Mimic Donor Red Blood Cell Antigen Profiles for Therapeutic and Diagnostic Use. 高度定义的诱导多能干细胞系模拟供体红细胞抗原谱，用于治疗和诊断。
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.0018
Lucas Ferioli Catelli, Péricles Natan Mendes da Costa, Felipe Augusto Rós, Evandra Strazza Rodrigues, Fernanda Ferreira Ursoli, Flávia Leite Souza Santos, Mayra Dorigan, Lílian Maria de Castilho, Dimas Tadeu Covas, Simone Kashima
{"title":"Highly Defined Induced Pluripotent Stem Cell Lines Mimic Donor Red Blood Cell Antigen Profiles for Therapeutic and Diagnostic Use.","authors":"Lucas Ferioli Catelli, Péricles Natan Mendes da Costa, Felipe Augusto Rós, Evandra Strazza Rodrigues, Fernanda Ferreira Ursoli, Flávia Leite Souza Santos, Mayra Dorigan, Lílian Maria de Castilho, Dimas Tadeu Covas, Simone Kashima","doi":"10.1089/cell.2024.0018","DOIUrl":"https://doi.org/10.1089/cell.2024.0018","url":null,"abstract":"<p><p>Our group generated two induced pluripotent stem cell (iPSC) lines for <i>in vitro</i> red blood cell (RBC) production from blood donors with extensively known erythrocyte antigen profiles. One line was intended to give rise to RBCs for transfusions in patients with sickle cell disease (SCD), while the other was developed to create RBC panel reagents. Two blood donors were selected based on their RBC phenotypes, further complemented by high-throughput DNA array analysis to obtain a more comprehensive erythrocyte antigen profile. Enriched erythroblast populations from the donors' peripheral blood mononuclear cells were reprogrammed into iPSCs using nonintegrative plasmid vectors. The iPSC lines were characterized and subsequently subjected to hematopoietic differentiation. iPSC PB02 and iPSC PB12 demonstrated <i>in vitro</i> and <i>in vivo</i> iPSC features and retained the genotype of each blood donor's RBC antigen profile. Colony-forming cell assays confirmed that iPSC PB02 and iPSC PB12 generated hematopoietic progenitors. These two iPSC lines were generated with defined erythrocyte antigen profiles, self-renewal capacity, and hematopoietic differentiation potential. With improvements in hematopoietic differentiation, these cells could potentially be more efficiently differentiated into RBCs in the future. They could serve as a complementary approach for obtaining donor-independent RBCs and addressing specific demands for blood transfusions.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revitalizing the Aging Immune System Through Selective Stem Cell Targeting. 通过选择性干细胞靶向激活老化的免疫系统
IF 1.2 4区 医学
Cellular reprogramming Pub Date : 2024-06-01 DOI: 10.1089/cell.2024.0029
Anna Konturek-Ciesla, David Bryder
{"title":"Revitalizing the Aging Immune System Through Selective Stem Cell Targeting.","authors":"Anna Konturek-Ciesla, David Bryder","doi":"10.1089/cell.2024.0029","DOIUrl":"https://doi.org/10.1089/cell.2024.0029","url":null,"abstract":"<p><p>The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body's ability to combat infections and an increased risk of various diseases, underlining the importance of rejuvenating the immune system as a strategy for promoting healthier aging. In issue 628 of Nature (2024), Ross et al. present a compelling study that introduces a novel strategy for rejuvenating the aged immune system (Ross et al., 2024). By using antibodies to selectively eliminate \"aberrant\" hematopoietic stem cells (HSCs), this research opens new avenues for addressing age-related immune deterioration.</p>","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental Pulp Stem Cell-Derived Exosomes Promote Sciatic Nerve Regeneration via Optimizing Schwann Cell Function. 牙髓干细胞衍生的外泌体通过优化许旺细胞功能促进坐骨神经再生
IF 1.6 4区 医学
Cellular reprogramming Pub Date : 2024-04-10 DOI: 10.1089/cell.2023.0115
Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Chen
{"title":"Dental Pulp Stem Cell-Derived Exosomes Promote Sciatic Nerve Regeneration via Optimizing Schwann Cell Function.","authors":"Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Chen","doi":"10.1089/cell.2023.0115","DOIUrl":"https://doi.org/10.1089/cell.2023.0115","url":null,"abstract":"Repair strategies for injured peripheral nerve have achieved great progresses in recent years. However, the clinical outcomes remain unsatisfactory. Recent studies have found that exosomes secreted by dental pulp stem cells (DPSC-exos) have great potential for applications in nerve repair. In this study, we evaluated the effects of human DPSC-exos on improving peripheral nerve regeneration. Initially, we established a coculture system between DPSCs and Schwann cells (SCs) in vitro to assess the effect of DPSC-exos on the activity of embryonic dorsal root ganglion neurons (DRGs) growth in SCs. We extracted and labeled human DPSC-exos, which were subsequently utilized in uptake experiments in DRGs and SCs. Subsequently, we established a rat sciatic nerve injury model to evaluate the therapeutic potential of DPSC-exos in repairing sciatic nerve damage. Our findings revealed that DPSC-exos significantly promoted neurite elongation by enhancing the proliferation, migration, and secretion of neurotrophic factors by SCs. In vivo, DPSC-exos administration significantly improved the walking behavior, axon regeneration, and myelination in rats with sciatic nerve injuries. Our study underscores the vast potential of DPSC-exos as a therapeutic tool for tissue-engineered nerve construction.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Expression of ZFP42 Improves Early Development of Pig Embryos Produced by Handmade Cloning. 高表达 ZFP42 可改善手工克隆猪胚胎的早期发育。
IF 1.6 4区 医学
Cellular reprogramming Pub Date : 2024-04-10 DOI: 10.1089/cell.2023.0122
Tianbin Liu, Yan Wu, Lin Li, Tingting Zhang, Xingju Zhang, Yong Li
{"title":"High Expression of ZFP42 Improves Early Development of Pig Embryos Produced by Handmade Cloning.","authors":"Tianbin Liu, Yan Wu, Lin Li, Tingting Zhang, Xingju Zhang, Yong Li","doi":"10.1089/cell.2023.0122","DOIUrl":"https://doi.org/10.1089/cell.2023.0122","url":null,"abstract":"Handmade Cloning (HMC) is a pivotal technique for cloning pig embryos. Despite its significance, the low efficiency of this method hampers its widespread application. Although numerous factors and signaling pathways influencing embryo development have been studied, the mechanisms underlying low developmental capacity and insufficient reprogramming of cloned embryos remain elusive. In the present study, we sought to elucidate key regulatory factors involved in the development of pig HMC embryos by comparing and analyzing the gene expression profiles of HMC embryos with those of naturally fertilized (NF) embryos at the 4-cell, 8-cell, and 16-cell stages. The results showed that ZFP42 expression is markedly higher in NF embryos than in cloned counterparts. Subsequent experiments involving the injection of ZFP42 messenger RNA (mRNA) into HMC embryos showed that ZFP42 could enhance the blastocyst formation rate, upregulate pluripotent genes and metabolic pathways. This highlights the potential of ZFP42 as a critical factor in improving the development of pig HMC embryos.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140718159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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