Cellular reprogramming最新文献

The Involvement of Gut Microbiota and Their Key Metabolites in Regulating Fetal Development via the Gut-Placental Axis. 肠道微生物群及其关键代谢物通过肠道-胎盘轴参与调节胎儿发育。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-05-07 DOI: 10.1177/21524971261450000

Hao Zhang, Tingting Ni, Xia Zha, Mabrouk Elsabagh, Mengzhi Wang

{"title":"The Involvement of Gut Microbiota and Their Key Metabolites in Regulating Fetal Development via the Gut-Placental Axis.","authors":"Hao Zhang, Tingting Ni, Xia Zha, Mabrouk Elsabagh, Mengzhi Wang","doi":"10.1177/21524971261450000","DOIUrl":"https://doi.org/10.1177/21524971261450000","url":null,"abstract":"The gut is the organ with the largest number of microorganisms in the organism, and host-microbe interactions allow the host to shape the composition of the microbiome and thus its numbers and diversity. The gut microbiome is integral to the facilitation of vital host functions that have a direct impact on the overall health of the host. This paper aims to present a thorough overview of the composition and function of the gut microbiome and its main metabolites (such as lipopolysaccharides, short-chain fatty acids, and bile acids), as well as their key roles and mechanisms in fetal development. The theme highlights the significance of the gut microbiome in fetal development, and the paper aims to establish their relationship and importance in a systematic manner. In the latter portion of the article, an analysis is presented regarding the proposed mechanism of the gut-placental axis, with an effort to outline strategies for regulating maternal gut microbiology in order to enhance fetal growth and development. By delving into this subject matter extensively, we aim to enhance comprehension of the correlation between maternal gut microbes and fetal development. This can contribute to safeguarding the mother's health, enhancing the survival and well-being of the fetus, and carrying significance for both human and animal reproduction. Furthermore, it can provide valuable insights for future research and clinical practices.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"21524971261450000"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Cardiac Reprogramming in the Omics Era: Advances, Mechanisms, and Applications. 组学时代的直接心脏重编程：进展、机制和应用。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-04-01 Epub Date: 2026-03-02 DOI: 10.1177/21524971261427184

Chelsea Li, Li Qian

{"title":"Direct Cardiac Reprogramming in the Omics Era: Advances, Mechanisms, and Applications.","authors":"Chelsea Li, Li Qian","doi":"10.1177/21524971261427184","DOIUrl":"10.1177/21524971261427184","url":null,"abstract":"Cardiovascular disease remains the leading cause of death worldwide, with its disease burden continuing to rise. After cardiac injury, most commonly ischemia from myocardial infarction, irreversible loss of cardiomyocytes (CMs) occurs, and the damaged myocardium is replaced by fibroblast (Fib)-derived scar tissue. Because adult CMs have limited regenerative capacity, repair is limited, cardiac function progressively declines, and patients often develop heart failure. Direct cardiac reprogramming-converting Fibs into induced CM-like cells (iCMs)-has emerged as a promising strategy to restore contractile myocardium. Omics-based approaches have greatly advanced understanding of the mechanisms that enable or hinder iCM generation. Single-cell transcriptomics have delineated gene expression trajectories and intermediate cell states, while epigenomic studies have revealed how chromatin accessibility, histone modifications, and DNA methylation shape cell fate conversion. Post-transcriptional analyses further highlight the importance of RNA processing and translational control, and proteomic profiling has demonstrated rapid remodeling of protein networks and paracrine signaling during reprogramming. In parallel, metabolic studies have linked shifts in metabolite flux to iCM maturation. Together, these multi-omics investigations provide an integrated framework for defining both barriers and facilitators of Fib-to-iCM conversion. This review synthesizes recent omics-based insights into direct cardiac reprogramming and discusses future directions for advancing its clinical application.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"46-62"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming Stars #26: Understanding the Reprogramming Privilege-An Interview with Dr. Shangqin Guo. 重编程之星#26：理解重编程的特权——采访郭尚勤博士

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1177/21524971251407961

Shangqin Guo, Mariana Lopes, Carlos-Filipe Pereira

引用次数: 0

Reprogramming Stars #27: Drawing Inspiration from Reprogramming to Guide Stem Cell Differentiation: An Interview with Dr. Kyle Loh. 重编程之星#27：从重编程中获得灵感以指导干细胞分化：对Kyle Loh博士的采访。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-03-16 DOI: 10.1177/21524971261432386

Kyle M Loh, Mariana Lopes, Carlos-Filipe Pereira

引用次数: 0

Reprogramming Stars #17: Breaking Down the Barriers of Direct Reprogramming Using a Model Organism-An Interview with Dr. Baris Tursun. 重编程之星#17：使用模型生物打破直接重编程的障碍-对Baris Tursun博士的采访。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-03-11 DOI: 10.1089/cell.2024.54625

Baris Tursun, Mariana Lopes, Carlos-Filipe Pereira

引用次数: 0

Reprogramming Stars #16: Reprogramming, from Cells to Embryos-An Interview with Dr. José Silva. 重编程之星 #16：重编程，从细胞到胚胎--专访何塞-席尔瓦博士。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-03-11 DOI: 10.1089/cell.2024.0041

José C R Silva, Carlos-Filipe Pereira

引用次数: 0

Natural and Artificial Hematopoietic Cell Reprogramming. 自然和人工造血细胞重编程。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2026-02-01 Epub Date: 2026-02-12 DOI: 10.1177/21524971261424117

Dong Yu, Wenpei Liu, Feng Liu, Lin Cheng

{"title":"Natural and Artificial Hematopoietic Cell Reprogramming.","authors":"Dong Yu, Wenpei Liu, Feng Liu, Lin Cheng","doi":"10.1177/21524971261424117","DOIUrl":"10.1177/21524971261424117","url":null,"abstract":"Hematopoietic cell reprogramming, defined as the conversion from one hematopoietic or immune cell type into another, has been shown to hold transformative potential for advancing our understanding of hematopoiesis, disease mechanisms, and therapeutic innovation. This process occurs via transdifferentiation, dedifferentiation, or transitional plasticity, driven by transcriptional, epigenetic, and microenvironmental cues, which may be achieved by physiological or pathological stressors in vivo, or genetic or chemical strategies in vitro. Nevertheless, challenges persist, including low reprogramming efficiency, unstable phenotype, and safety concerns. Advancements in multi-omics, gene editing, and chemical biology are enhancing the efficacy of reprogramming protocols and facilitating clinical translatability. The integration of these strategies, in conjunction with artificial intelligence-driven screening and single-cell analytics, has the potential to facilitate the development of personalized cell therapies for cancers, immune disorders, and regenerative medicine. Additionally, the realization of this potential is contingent upon the resolution of challenges related to delivery, specificity, and long-term efficacy.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"21-35"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming Stars #25: Modeling Brain Aging with Direct Reprogramming of Skin Cells into Neurons-An Interview with Dr. Jerome Mertens. 重编程之星#25：通过将皮肤细胞直接重编程为神经元来模拟大脑衰老——对Jerome Mertens博士的采访。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1177/21524971251398980

Jerome Mertens, Mariana Lopes, Carlos-Filipe Pereira

引用次数: 0

In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming. 通过细胞重编程体外生成棕色和米色脂肪细胞。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2025-12-01 Epub Date: 2025-11-18 DOI: 10.1177/21524971251399164

Kurahashi Toshihiro, Yoshinori Harada, Ping Dai

{"title":"In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming.","authors":"Kurahashi Toshihiro, Yoshinori Harada, Ping Dai","doi":"10.1177/21524971251399164","DOIUrl":"10.1177/21524971251399164","url":null,"abstract":"The global prevalence of obesity continues to rise with no signs of slowing. Because obesity is a risk factor for numerous diseases, it diminishes both quality of life and life expectancy. Hence, developing effective strategies for obesity prevention and treatment is an urgent priority. Brown and beige adipocytes dissipate energy as heat via nonshivering thermogenesis, making them promising targets for treating metabolic disorders such as obesity. Since the 2009 discovery of metabolically active brown adipose tissue in adult humans, significant progress has been made in elucidating the developmental origins and physiological roles of brown and beige adipocytes. However, many aspects of their intrinsic biology remain poorly understood. In vitro analyses are indispensable for overcoming the limitations of in vivo studies, but isolating human brown adipocytes for culture is ethically and technically challenging. Therefore, just as in vitro models of white adipocytes have been invaluable for understanding adipose biology, establishing reliable in vitro systems for brown and beige adipocytes is crucial. This review summarizes current methodologies for generating brown and beige adipocytes in vitro-including cellular reprogramming approaches-a technological advance poised to accelerate future research on these thermogenic adipocytes.","PeriodicalId":9708,"journal":{"name":"Cellular reprogramming","volume":" ","pages":"216-227"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Nuclear Transplantation to Cellular Reprogramming-A Scientist Who Transformed Our View of Cell Identity. 从核移植到细胞重编程——一位科学家改变了我们对细胞身份的看法。

IF 1.7 4区医学

Cellular reprogramming Pub Date : 2025-12-01 Epub Date: 2025-11-18 DOI: 10.1177/21524971251398992

Filipe Pereira

引用次数: 0