锁定命运：PROX1如何抑制可塑性和肝癌。

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2025-03-26 DOI:10.1089/cell.2025.0013

Seung-Won Lee, Jungsun Kim

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引用次数: 0

摘要

沃丁顿景观中的转录脊。1957年提出的Waddington景观模型为理解细胞命运决定提供了一个强有力的框架（Waddington, 1957）。随着发育的进展，细胞被限制到不同的命运，被阻止身份转换的高“脊”分开。《自然遗传学》杂志最近的一项研究揭示了肝细胞谱系规范中的这种差异（Lim et al., 2025）。Lim等人报道，prospero homobox蛋白1 （PROX1）作为肝细胞特异性保护抑制因子，通过积极抑制替代细胞命运和预防胆管癌的发展来确保谱系稳定性。

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Locking the Fate: How PROX1 Represses Plasticity and Liver Cancer.

A Transcriptional Ridge in the Waddington Landscape. The Waddington landscape model, proposed in 1957, provides a powerful framework for understanding cell fate determination (Waddington, 1957). As development progresses, cells become restricted to distinct fates, separated by high "ridges" that prevent identity switching. A recent study in Nature Genetics uncovers such a ridge in hepatocyte lineage specification (Lim et al., 2025). Lim et al. report that prospero homeobox protein 1 (PROX1) acts as a hepatocyte-specific safeguard repressor, ensuring lineage stability by actively suppressing alternative cell fates and preventing cholangiocarcinoma development.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.