CEN Case Reports最新文献_第9页

Concurrent emphysematous cystitis and emphysematous pyelonephritis in a patient with extrarenal pelvis. 一名肾盂外患者同时患有气肿性膀胱炎和气肿性肾盂肾炎。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-09-07 DOI: 10.1007/s13730-023-00816-4

Elham Barahimi, Ayoub Basham, Ebrahim Evazi, Mehdi Hassaniazad, Behnoush Heidari, Mostafa Mazaheri

{"title":"Concurrent emphysematous cystitis and emphysematous pyelonephritis in a patient with extrarenal pelvis.","authors":"Elham Barahimi, Ayoub Basham, Ebrahim Evazi, Mehdi Hassaniazad, Behnoush Heidari, Mostafa Mazaheri","doi":"10.1007/s13730-023-00816-4","DOIUrl":"10.1007/s13730-023-00816-4","url":null,"abstract":"We report co-occurrence of emphysematous cystitis and emphysematous pyelonephritis (EC/EPN) in a 64-year-old female with poor-controlled diabetes mellitus (DM) that presented with flank pain, fever, and hematuria that turned out to have a bilateral extrarenal pelvis. On examination, she was feverish, and the costovertebral angle was tender. By considering herhemoglobin A1C, her DM was out of control. Inflammatory markers elevated. Renal function tests were impaired. Urine culture was positive for extended-spectrum beta-lactamase Escherichia coli. Computed tomography scans (CT) confirmed the presence of air in the bladder and renal pelvis in favor of EC and unilateral EPN. We planned to use conservative treatments. Promptly intravenous antibiotics started; thereafter, the renal pelvis was drained via percutaneous catheter, and the bladder was drained via foley catheter, as well. After 14 days of hospitalization, clinical status improved, urine culture got negative, and emphysema in follow-up CT images wholly regressed. To our knowledge, co-occurrence of emphysematous cystitis (EC) and emphysematous pyelonephritis (EPN) in a patient with an extra renal pelvis never happened. We tend to convey messages, including (1) the extrarenal pelvis may contribute to predisposing the patient to pyelonephritis if it is considerably large; (2) the conservative plan and observation was a successful experience in treating extrarenal pelvis patients with EC/EPN.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10174049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of relapsing anti-GBM disease secondary to alemtuzumab therapy. 一例阿仑单抗治疗后复发的抗GBM疾病。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-11-09 DOI: 10.1007/s13730-023-00822-6

Saskia M Leibowitz, Valli Manickam, Vikas Srivastava, George Kan

引用次数: 0

Neural epidermal growth factor-like 1 protein (NELL1)-associated membranous nephropathy with heterogeneous underlying diseases: a case report. 神经表皮生长因子样1蛋白（NELL1）相关膜性肾病伴异质性基础疾病：一例报告。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-10-28 DOI: 10.1007/s13730-023-00826-2

Reina Miyazaki, Hiroyuki Ueda, Masahiro Okabe, Akihiro Shimizu, Kensuke Joh, Nobuo Tsuboi, Takashi Yokoo

{"title":"Neural epidermal growth factor-like 1 protein (NELL1)-associated membranous nephropathy with heterogeneous underlying diseases: a case report.","authors":"Reina Miyazaki, Hiroyuki Ueda, Masahiro Okabe, Akihiro Shimizu, Kensuke Joh, Nobuo Tsuboi, Takashi Yokoo","doi":"10.1007/s13730-023-00826-2","DOIUrl":"10.1007/s13730-023-00826-2","url":null,"abstract":"Neural epidermal growth factor-like 1 protein (NELL1) is a target antigen of membranous nephropathy (MN). NELL1-associated MN (NELL1-MN) was originally described as a primary form but has subsequently been associated with other diseases, including malignancies, pre-exposure to certain drugs, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, and rheumatoid arthritis (RA). We present a case of a 78-year-old woman with long-standing RA who developed persistent proteinuria and was diagnosed with MN. Evaluation of the underlying cause revealed chronic active HCV infection and past HBV infection. The underlying cause was less likely to be drug-related; however, there was no evidence of malignancy. The patient was diagnosed with HCV-associated MN. At 4 years after the diagnosis of MN, the patient died of breast cancer with multiple metastases. Subsequent immunohistological analysis revealed that she had NELL1-MN, and her breast cancer tissue stained positive for NELL1. Our case illustrates the difficulty in establishing the underlying cause of NELL1-MN, even after diagnosis. However, the incidence of malignancies, particularly breast and prostate cancers, is higher in NELL1-MN than in MN with other target antigens. Therefore, malignancies are considered a priority for investigation because of their frequency and prognosis among patients with NELL1-MN.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial focal segmental glomerulosclerosis with Alport-like glomerular basement changes caused by paired box protein 2 gene variant. 配对盒蛋白2基因变异引起家族性局灶性节段性肾小球硬化伴Alport样肾小球基底改变。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-10-28 DOI: 10.1007/s13730-023-00830-6

Yuko Yamada, Hiroki Yokoyama, Ryo Kinoshita, Koichi Kitamoto, Yasuo Kawaba, Shinichi Okada, Takashi Horie, China Nagano, Kandai Nozu, Noriyuki Namba

{"title":"Familial focal segmental glomerulosclerosis with Alport-like glomerular basement changes caused by paired box protein 2 gene variant.","authors":"Yuko Yamada, Hiroki Yokoyama, Ryo Kinoshita, Koichi Kitamoto, Yasuo Kawaba, Shinichi Okada, Takashi Horie, China Nagano, Kandai Nozu, Noriyuki Namba","doi":"10.1007/s13730-023-00830-6","DOIUrl":"10.1007/s13730-023-00830-6","url":null,"abstract":"Paired box protein 2 (PAX2) gene variant causes renal coloboma syndrome (MIM#120330). Further, they are associated with focal segmental glomerulosclerosis and characterized by basement membrane changes similar to Alport syndrome.Herein, we report an 8-year-old boy who presented with proteinuria and decreased renal function. His paternal uncle has focal segmental glomerulosclerosis and renal failure, and his paternal grandmother has renal failure and is receiving peritoneal dialysis. Further, his father has stage 2 chronic kidney disease. At 3 years of age, his serum creatinine-estimated glomerular filtration rate was 40-50 mL/min/1.73 m2. At 8 years of age, his renal function further decreased and he had proteinuria (urinary protein/Cr 3.39 g/g Cr). Renal histopathology showed oligonephronia and focal segmental glomerulosclerosis. A partial basket-weave pattern, similar to Alport syndrome, was also observed on a transmission electron microscope, and low-vacuum scanning electron microscopy revealed coarse meshwork changes in the glomerular basement membrane. Genetic analysis revealed a PAX2 heterozygous variant (NM_003987.4:c.959C > G), a nonsense variant in which the serine at position 320 changes to a stop codon, in our patient and his father. PAX2 is a transcription factor that is important for the podocyte variant. However, podocytes with PAX2 gene variants may cause abnormal basement membrane production and repair, thereby resulting in Alport-like changes.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Anaphylaxis secondary to citric acid allergy in End Stage Renal Disease patient. 撤稿说明：终末期肾病患者继发于柠檬酸过敏的过敏性休克。

IF 1

CEN Case Reports Pub Date : 2024-06-01 DOI: 10.1007/s13730-024-00877-z

Hassaan Iftikhar, Maryam Saleem, Frank O'Brien

引用次数: 0

Membranous nephropathy after multiple Hymenoptera stings: a case report. 膜翅目昆虫多次蜇伤后膜性肾病1例。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-11-18 DOI: 10.1007/s13730-023-00834-2

Kenichi Morii, Toshiki Doi, Yoshio Yuba, Aiko Okubo, Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Kenichiro Shigemoto, Akira Shimizu, Takao Masaki

{"title":"Membranous nephropathy after multiple Hymenoptera stings: a case report.","authors":"Kenichi Morii, Toshiki Doi, Yoshio Yuba, Aiko Okubo, Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Kenichiro Shigemoto, Akira Shimizu, Takao Masaki","doi":"10.1007/s13730-023-00834-2","DOIUrl":"10.1007/s13730-023-00834-2","url":null,"abstract":"An association between Hymenoptera (bee and wasp) stings and nephrotic syndrome has been rarely reported. We report a case of nephrotic syndrome after multiple Hymenoptera stings, and membranous nephropathy was later diagnosed by a kidney biopsy. The patient was a 79-year-old woman who was stung by Hymenoptera at seven sites on her body. A weight gain of 3.7 kg was observed in the patient at 1 week after being stung, and she had considerable edema in both lower extremities. A urine protein concentration of 14.8 g/g creatinine and a serum albumin concentration of 1.7 g/dL led to the diagnosis of nephrotic syndrome. A percutaneous kidney biopsy 8 days after the Hymenoptera stings showed stage I membranous nephropathy. She was in complete remission 1 week after the administration of oral prednisolone 40 mg/day, which was started 14 days after Hymenoptera stings, and had no relapse of nephrotic syndrome. To the best of our knowledge, this is the first report of biopsy-proven membranous nephropathy caused by Hymenoptera stings.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome with recurrent acute cholecystitis: a case report. 产志贺毒素大肠杆菌相关溶血性尿毒症综合征伴复发性急性胆囊炎1例报告。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-11-14 DOI: 10.1007/s13730-023-00831-5

Ryuta Uwatoko, Nao Kani, Shuzo Makino, Tomoya Naka, Kazuhiro Okamoto, Hiromitsu Miyakawa, Nobuhiro Hashimoto, Rei Iio, Yoshiyasu Ueda, Terumasa Hayashi

{"title":"Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome with recurrent acute cholecystitis: a case report.","authors":"Ryuta Uwatoko, Nao Kani, Shuzo Makino, Tomoya Naka, Kazuhiro Okamoto, Hiromitsu Miyakawa, Nobuhiro Hashimoto, Rei Iio, Yoshiyasu Ueda, Terumasa Hayashi","doi":"10.1007/s13730-023-00831-5","DOIUrl":"10.1007/s13730-023-00831-5","url":null,"abstract":"Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) can induce life-threatening complications, including acute kidney injury, encephalopathy, and gastrointestinal complications. On the other hand, there have been few reports of cholecystitis associated with STEC-HUS. In this study, we report the case of an 83-year-old Japanese man who developed recurrent acute cholecystitis associated with STEC-HUS. Prior to establishing a definite diagnosis of STEC-HUS, plasma exchange and hemodialysis were initiated, which resulted in a rapid increase in the platelet count and decrease in lactate dehydrogenase levels. The patient presented an enlarged gallbladder detected by computed tomography during the course of treatment. Due to recurrent flare-ups, the patient had to undergo several rounds of endoscopic retrograde biliary drainage and, ultimately, cholecystectomy to prevent relapse of acute cholecystitis. Since cholecystitis was thought to have been caused by complex mechanisms in this case, we discussed those from multiple perspectives. This case report highlights the need for particular care to be given to the management of pre-existing diseases as well as STEC-HUS, especially in older patients.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A successful treatment for chronic active Epstein-Barr virus disease with Nephrotic Syndrome. 成功治疗伴有肾病综合征的慢性活动性 Epstein-Barr 病毒病。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-09-05 DOI: 10.1007/s13730-023-00815-5

Yasuhiro Inaba, Akinori Miyazono, Kenichi Imadome, Shinji Aratake, Yasuhiro Okamoto

{"title":"A successful treatment for chronic active Epstein-Barr virus disease with Nephrotic Syndrome.","authors":"Yasuhiro Inaba, Akinori Miyazono, Kenichi Imadome, Shinji Aratake, Yasuhiro Okamoto","doi":"10.1007/s13730-023-00815-5","DOIUrl":"10.1007/s13730-023-00815-5","url":null,"abstract":"Chronic active Epstein-Barr virus (CAEBV) disease is more likely to occur when a patient is on immunosuppressive therapy for any disease or is susceptible to infection, and the prognosis is poor without appropriate treatment, including hematopoietic stem cell transplantation (HSCT). In addition to HSCT, several other chemotherapy regimens have been reported, but all of them are difficult to maintain in remission. Without HSCT, survival rates have been reported to be 50% in 5 years and 25% in 15 years. This is a report of a 13-year-old boy who developed CAEBV disease during cyclosporine A (CyA) treatment for the steroid-dependent nephrotic syndrome (SDNS). Since SDNS precluded HSCT or chemotherapy, CyA was tapered off based on the belief that alleviating his immunosuppressed state would decrease the CAEBV disease. We decided to gradually reduce the CyA dose to activate T-cell immunity, while periodically monitoring the EBV viral load. Finally, we found an appropriate dose that could suppress both CAEBV disease and SDNS, and it lasted for more than 9 years. No case has been reported to date in which a patient developed CAEBV disease while receiving immunosuppressive drugs for the primary disease, and both diseases were controlled only by reducing the dose of immunosuppressive drugs. In this report, we show that dose reduction of immunosuppressive agents without chemotherapy or HSCT is an effective option for the treatment of CAEBV disease in patients receiving immunosuppressive agents.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10508814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed cryoglobulinaemia vasculitis secondary to marginal zone lymphoma in a patient with end-stage renal failure on haemodialysis. 一名接受血液透析的终末期肾功能衰竭患者继发于边缘区淋巴瘤的混合性冷球蛋白血症血管炎。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-10-06 DOI: 10.1007/s13730-023-00823-5

Craig Peter Coorey, Amirhossein Aarabi, Karthik Kumar

{"title":"Mixed cryoglobulinaemia vasculitis secondary to marginal zone lymphoma in a patient with end-stage renal failure on haemodialysis.","authors":"Craig Peter Coorey, Amirhossein Aarabi, Karthik Kumar","doi":"10.1007/s13730-023-00823-5","DOIUrl":"10.1007/s13730-023-00823-5","url":null,"abstract":"Cryoglobulinaemia vasculitis can present with a variety of symptoms and there is limited data on the incidence and presentation of cryoglobulinaemia vasculitis in haemodialysis patients. We report a case of a 63-year-old male who had a series of presentations with rash, visual changes, abdominal pain, weight loss, fevers and digital ischaemia. This is on a background of a congenital single kidney with end-stage renal failure secondary to diabetes and hypertension, receiving haemodialysis for nearly 5 years. He initially experienced a leukocytoclastic vasculitis rash confirmed on skin biopsy, followed by multiple hospital presentations for undifferentiated abdominal pain and fever of unknown source. Jejunal biopsy revealed intestinal vasculitis. His peripheral blood flow cytometry and bone marrow biopsy were consistent with marginal zone lymphoma (indolent subtype, IgM kappa clone). Further testing revealed a type II cryoglobulinaemia consisting of an IgM kappa monoclonal band with polyclonal IgG (cryocrit 5%). A diagnosis of cryoglobulinaemia vasculitis was established and he was treated with pulsed methylprednisolone and rituximab therapy. However, after receiving three doses of rituximab the patient developed a presumed vasculitis-associated pulmonary haemorrhage for which he received treatment with five sessions of plasma exchange. His symptoms resolved and cryocrit reduced to < 1% after his final dose of rituximab. The clinical features of cryoglobulinaemia may be difficult to detect in chronic haemodialysis patients and vigilance is required.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41092816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal inflammatory myofibroblastic tumor coexisting with hemophilia A carrier: a case report and literature review. 肾炎性肌成纤维细胞肿瘤与血友病A携带者共存：病例报告和文献复习。

IF 1

CEN Case Reports Pub Date : 2024-06-01 Epub Date: 2023-10-28 DOI: 10.1007/s13730-023-00828-0

Zhenyu Zhang, Hai Wang, Ying Jiang, Zhongming Huang

{"title":"Renal inflammatory myofibroblastic tumor coexisting with hemophilia A carrier: a case report and literature review.","authors":"Zhenyu Zhang, Hai Wang, Ying Jiang, Zhongming Huang","doi":"10.1007/s13730-023-00828-0","DOIUrl":"10.1007/s13730-023-00828-0","url":null,"abstract":"Renal inflammatory myofibroblastic tumor (IMT) is an exceptionally uncommon occurrence. This report presented the first documented case of renal IMT coexisting with hemophilia A carrier status. A 52-year-old asymptomatic female was incidentally discovered to have a kidney mass during a routine computed tomography (CT) scan spanning a 5-month period. Ultrasonography and contrast-enhanced CT scan raised suspicion of a potential renal malignant tumor. Over 2 decades ago, the patient experienced significant bleeding during childbirth, and she possessed a 5-year history of rheumatoid arthritis. Following a radical surgical procedure, intravenous supplementation of factor VIII was administered during the perioperative period. Subsequent to strenuous defecation, the patient encountered hematuria. Continued coagulation factor supplementation led to alleviation of hematuria symptoms. The underlying causes and pathogenesis responsible for IMT remain unclear. IMT is often associated with rheumatoid arthritis, possibly suggesting a connection to its etiology. Surgical excision stands as the primary approach to treatment, with recurrence being an exceedingly rare event. In instances where hemophilia is a complicating factor, vigilant monitoring of coagulation function and appropriate coagulation factor supplementation is imperative.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0