CEN Case Reports最新文献

Subclinical acute tubular necrosis potentially associated with red yeast rice consumption unexpectedly detected in a patient with membranous nephropathy. 在一名膜性肾病患者身上意外发现可能与食用红曲米有关的亚临床急性肾小管坏死。

IF 1

CEN Case Reports Pub Date : 2024-11-19 DOI: 10.1007/s13730-024-00946-3

Narumichi Iwamura, Kanako Tsutsumi, Shunsuke Yamada, Noriko Uesugi, Takafumi Hamashoji, Yui Arita, Takashi Deguchi, Toshiaki Nakano

{"title":"Subclinical acute tubular necrosis potentially associated with red yeast rice consumption unexpectedly detected in a patient with membranous nephropathy.","authors":"Narumichi Iwamura, Kanako Tsutsumi, Shunsuke Yamada, Noriko Uesugi, Takafumi Hamashoji, Yui Arita, Takashi Deguchi, Toshiaki Nakano","doi":"10.1007/s13730-024-00946-3","DOIUrl":"10.1007/s13730-024-00946-3","url":null,"abstract":"In March 2024, a significant public health issue involving red yeast rice supplements emerged in Japan, which may have been associated with several health problems, including kidney dysfunction. A 74-year-old man without a history of urinary abnormalities developed nephrotic syndrome 10 weeks after starting \"Beni-Koji Choleste Help®,\" a red yeast rice supplement. Electron microscopy showed subepithelial and intramembranous dense deposits with abnormality of the glomerular basement membrane, which led to the diagnosis of long-standing membranous nephropathy. The diagnosis of phospholipase A2 receptor (PLA2R)-positive primary membranous nephropathy was confirmed via PLA2R-positive immunostaining. Furthermore, there were findings of focal tubular necrosis without unexplained cellular infiltration. Based on previous reports, it was suggested that red yeast rice-related products have triggered the acute tubular necrosis in the patient. His nephrotic syndrome reached partial remission with oral administration of prednisolone at an initial dose of 40 mg/day. This case indicates that membranous nephropathy was coincidentally accompanied by acute tubular necrosis that was potentially associated with red yeast rice-related health foods. It may be reasonable to state that individuals consuming red yeast rice-related health products may develop subclinical focal tubular necrosis even in the absence of overt clinical symptoms or laboratory abnormalities. The currently recognized health issues associated with red yeast rice-related health foods may only represent a small portion of the overall risks.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapsing peritoneal dialysis-associated peritonitis caused by Corynebacterium striatum: a case report. 由纹状体棒状杆菌引起的复发性腹膜透析相关性腹膜炎：病例报告。

IF 1

CEN Case Reports Pub Date : 2024-11-19 DOI: 10.1007/s13730-024-00947-2

Tomohisa Tsuyuki, Shinichi Abe, Emiko Otsuka, Kiyokazu Tsuji, Kenta Torigoe, Ayuko Yamashita, Kumiko Muta, Yasushi Mochizuki, Hiroshi Mukae, Tomoya Nishino

{"title":"Relapsing peritoneal dialysis-associated peritonitis caused by Corynebacterium striatum: a case report.","authors":"Tomohisa Tsuyuki, Shinichi Abe, Emiko Otsuka, Kiyokazu Tsuji, Kenta Torigoe, Ayuko Yamashita, Kumiko Muta, Yasushi Mochizuki, Hiroshi Mukae, Tomoya Nishino","doi":"10.1007/s13730-024-00947-2","DOIUrl":"10.1007/s13730-024-00947-2","url":null,"abstract":"Peritoneal dialysis (PD)-associated peritonitis is a serious complication of PD, and its prevention and treatment are important for reducing patient morbidity and mortality. Reports of PD-associated peritonitis caused by Corynebacterium spp. are limited, and PD-associated peritonitis caused by Corynebacterium striatum (C. striatum) is rare. Only two case reports are available, wherein improvement was only achieved after intraperitoneal administration of antibiotics. Here, we report a case of relapsing PD-associated peritonitis caused by C. striatum that did not improve with antibiotic therapy. In this case, the patient started PD due to end-stage renal failure with immunoglobulin A nephropathy. In addition, he had been diagnosed with bronchiectasis and was prescribed clarithromycin. Four days after PD induction, the patient developed culture-negative PD-associated peritonitis. Ceftazidime and cefazolin were subsequently administered intraperitoneally for a total of 14 days, resulting in improvement in his condition. However, 3 and 5 months after PD induction, he developed PD-associated peritonitis again, and C. striatum was detected in each culture. He was treated with intraperitoneal vancomycin for a total of 14 days and improved; however, he developed PD-associated culture-negative peritonitis again 7 months later. We diagnosed relapsing PD-associated peritonitis caused by C. striatum. PD catheter removal and reinsertion were performed, and he has not relapsed since. In conclusion, PD-associated peritonitis caused by C. striatum may have a poor prognosis; therefore, PD catheter removal is recommended, especially in patients with a history of repeated PD-related peritonitis due to C. striatum.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal calciphylaxis: a rare and devastating complication in end-stage kidney disease. 胃肠道钙化症：终末期肾病罕见的破坏性并发症。

IF 1

CEN Case Reports Pub Date : 2024-11-14 DOI: 10.1007/s13730-024-00944-5

Amirhossein Aarabi, Karthik Kumar

{"title":"Gastrointestinal calciphylaxis: a rare and devastating complication in end-stage kidney disease.","authors":"Amirhossein Aarabi, Karthik Kumar","doi":"10.1007/s13730-024-00944-5","DOIUrl":"https://doi.org/10.1007/s13730-024-00944-5","url":null,"abstract":"Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare and severe condition that predominantly affects individuals with end-stage kidney disease (ESKD). It manifests through vascular calcifications that precipitate tissue necrosis, with cutaneous manifestations being common. However, gastrointestinal involvement is an infrequent but gravely serious occurrence. In this report, we present an atypical case of gastrointestinal (GI) calciphylaxis in a 66-year-old woman undergoing peritoneal dialysis. The patient's initial symptoms of abdominal pain and turbid peritoneal fluid raised suspicions of bacterial peritonitis. Despite therapeutic interventions, the patient's condition deteriorated. Computed tomography (CT) imaging revealed a perforation in the caecal wall, necessitating emergency surgical intervention. Histopathology post-surgery confirmed the diagnosis of GI calciphylaxis. The patient's postoperative trajectory was fraught with complications, ultimately leading to a fatal outcome. This case highlights the importance of vigilance for calciphylaxis in the differential diagnosis when abdominal pain develops in patients with ESKD, regardless of the presence of typical skin symptoms. Prompt detection and an integrated care approach are essential for improved prognosis. Further research is needed to find more efficacious treatments for this devastating illness.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of mitochondrial dysfunction in a case of Fanconi syndrome with normoglycemic MODY1. 一例范可尼综合征合并血糖正常的 MODY1 患者存在线粒体功能障碍。

IF 1

CEN Case Reports Pub Date : 2024-11-11 DOI: 10.1007/s13730-024-00948-1

Yuko Fujii, Hideki Matsumura, Kei Murayama, Yasushi Okazaki, Akira Ashida

{"title":"Presence of mitochondrial dysfunction in a case of Fanconi syndrome with normoglycemic MODY1.","authors":"Yuko Fujii, Hideki Matsumura, Kei Murayama, Yasushi Okazaki, Akira Ashida","doi":"10.1007/s13730-024-00948-1","DOIUrl":"https://doi.org/10.1007/s13730-024-00948-1","url":null,"abstract":"Maturity-onset diabetes of the young 1 (MODY1) is characterized by macrosomia and transient hypoglycemia in neonates, in addition to diabetes mellitus (DM). Only patients with MODY1 harboring a pathogenic variant (c.187C > T; p.R63W) in HNF4A are sure to develop Fanconi syndrome (FS). Here we report the successful diagnosis of MODY1 in a patient harboring p.R63W before confirmation of DM-related hyperglycemia after being alerted to the presence of abnormal mitochondria in a kidney-biopsy specimen revealed by electron microscopy. The patient was born at 39 weeks of gestation with macrosomia, elevated levels of liver enzymes, and transient hypoglycemia. At three years of age, proteinuria was found by chance, and further laboratory investigations revealed metabolic acidosis, mild renal dysfunction, hypouricemia, proteinuria, aminoaciduria, and glycosuria. On this basis, we diagnosed the patient as having FS and performed percutaneous renal biopsy. Light microscopy revealed no evidence of proximal tubule disorder, but electron microscopy demonstrated mitochondria with disordered cristae in glomerular podocytes and giant mitochondria in proximal tubules. Mitochondrial nephropathy was suspected, and skin fibroblasts from the patient grown on galactose medium showed decreased oxygen consumption suggestive of mitochondrial dysfunction. Therefore, genetic testing was performed and a pathogenic variant (c.187C > T; p.R63W) in HNF4A was detected. Mitochondrial dysfunction in a Drosophila and murine model of patients with both MODY1 and FS has already been reported, and we detected it in this human MODY1/FS patient on the basis of functional tests and imaging. We believe mitochondrial dysfunction may be involved in the pathogenesis of MODY1/FS.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of PLA2R-positive membranous nephropathy with subsequent development of IgG4-related disease. 一例 PLA2R 阳性膜性肾病，随后发展为 IgG4 相关疾病。

IF 1

CEN Case Reports Pub Date : 2024-11-08 DOI: 10.1007/s13730-024-00941-8

Fumiaki Tanemoto, Imari Mimura, Hiroyuki Abe, Masaomi Nangaku

{"title":"A case of PLA2R-positive membranous nephropathy with subsequent development of IgG4-related disease.","authors":"Fumiaki Tanemoto, Imari Mimura, Hiroyuki Abe, Masaomi Nangaku","doi":"10.1007/s13730-024-00941-8","DOIUrl":"https://doi.org/10.1007/s13730-024-00941-8","url":null,"abstract":"Membranous nephropathy (MN) is a common cause of adult-onset nephrotic syndrome. It is also known as a minor but established renal manifestation of Immunoglobulin G4-related disease (IgG4-RD). Previous reports suggest that MN can also be an initial manifestation of IgG4-RD, all of which are phospholipase A2 receptor (PLA2R)-negative MN. We describe a case of PLA2R-positive MN that subsequently developed other manifestations of IgG4-RD. A 60-year-old male with nephrotic syndrome was diagnosed as primary MN with positive staining for PLA2R on the initial renal biopsy, which remained in partial remission with supportive therapy using angiotensin II receptor blocker (ARB) without steroid. About 1 year later, a renal mass was detected during an annual checkup, and contrast-enhanced computed tomography revealed low-density masses in bilateral kidneys and the head of the pancreas. The findings of endoscopic biopsy of the pancreatic mass were consistent with autoimmune pancreatitis (AIP) and the second renal biopsy showed the findings of MN with tubulointerstitial nephritis, both of which led to a diagnosis of IgG4-RD. The second renal biopsy also showed positive PLA2R. The patient received oral glucocorticoid therapy for IgG4-RD, which improved IgG4-related AIP and renal masses and also resulted in complete remission of MN. To our knowledge, this is the first reported case of PLA2R-positive MN with subsequent development of IgG4-RD. It is sometimes difficult to determine whether PLA2R-positive MN occurring with IgG4-RD is primary MN or secondary MN associated with IgG4-RD. The possibility of developing IgG4-RD should be considered even when preceding MN is PLA2R-positive, suggesting of primary MN.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing malignant hypertension with renal TMA: a case for caution in blood-pressure reduction. 用肾脏 TMA 治疗恶性高血压：降压需谨慎。

IF 1

CEN Case Reports Pub Date : 2024-11-07 DOI: 10.1007/s13730-024-00933-8

Narumichi Iwamura, Yuta Matsukuma, Eisuke Katafuchi, Yoshiko Nakano, Kanako Tsutsumi, Yuki Ueno, Yasuhisa Tamura, Toshiaki Nakano

{"title":"Managing malignant hypertension with renal TMA: a case for caution in blood-pressure reduction.","authors":"Narumichi Iwamura, Yuta Matsukuma, Eisuke Katafuchi, Yoshiko Nakano, Kanako Tsutsumi, Yuki Ueno, Yasuhisa Tamura, Toshiaki Nakano","doi":"10.1007/s13730-024-00933-8","DOIUrl":"https://doi.org/10.1007/s13730-024-00933-8","url":null,"abstract":"Malignant hypertension with renal thrombotic microangiopathy is a rare yet serious cause of acute kidney injury (AKI). Patients are often treated with antihypertensive therapy; however, managing their blood pressure is complex, with targets for initial treatment unclear. We report on a 55-year-old male with severe hypertension (blood pressure 210/140 mmHg), AKI (serum creatinine 9.27 mg/dL), anemia (hemoglobin 7.6 g/dL), thrombocytopenia (platelets 113 k/μL), and renal biopsy confirming malignant arteriolar nephrosclerosis and thrombotic microangiopathy. Previously prescribed 20-mg azilsartan daily, he lost consciousness the next day and was urgently admitted with a blood pressure of 118 mmHg and increased serum creatinine from 1.28 to 9.27 mg/dL over 6 months. Azilsartan was stopped; blood pressure managed with 12.5 mg of losartan daily, targeting systolic pressure between 150 and 160 mmHg. His creatinine peaked on day 14; however, treatment with 12.5 - 50 mg/day of losartan and 5 - 10 mg/day of amlodipine gradually improved renal function to 4.48 mg/dL by month ten without hemodialysis or further syncope. Our case suggests a gradual approach to blood-pressure management to avoid ischemic risks.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report. 一名克罗恩病患者因英夫利西单抗治疗引发的急性肾小管间质性肾炎：病例报告。

IF 1

CEN Case Reports Pub Date : 2024-11-02 DOI: 10.1007/s13730-024-00943-6

Naif Alghamdi, Fahad Alshehri, Sultan Alhazza, Fahad Bhutto, Azhari Alhassan, Mohammed Kechrid, Dhafer Alshehri, Kadi Alshammari, Talal Assiri, Ohoud Assiri, Emad Darewsh, Mohammed Ali, Ruba Qadri, Yasser Alahmadi

引用次数: 0

Acute tubulointerstitial nephritis following coronavirus disease 2019 mRNA vaccination: a pediatric case report. 接种冠状病毒 2019 mRNA 疫苗后出现急性肾小管间质性肾炎：一例儿科病例报告。

IF 1

CEN Case Reports Pub Date : 2024-10-31 DOI: 10.1007/s13730-024-00945-4

Gakushi Eguchi, Miki Murakoshi, Futaba Miyaoka, Asami Shimbo, Hitoshi Irabu, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaki Shimizu

{"title":"Acute tubulointerstitial nephritis following coronavirus disease 2019 mRNA vaccination: a pediatric case report.","authors":"Gakushi Eguchi, Miki Murakoshi, Futaba Miyaoka, Asami Shimbo, Hitoshi Irabu, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaki Shimizu","doi":"10.1007/s13730-024-00945-4","DOIUrl":"10.1007/s13730-024-00945-4","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) mRNA vaccines have been linked to various kidney adverse events including acute tubulointerstitial nephritis (ATIN). This report describes a 15-year-old female who developed persistent fever and fatigue 54 days after receiving her second dose of the BNT162b2 2 SARS-CoV-2 vaccine. She presented with elevated serum creatinine and urinary β2-microglobulin (β2MG) levels. Kidney biopsy revealed mononuclear infiltrate with some eosinophils, confirming the diagnosis of ATIN. Repeatedly positive lymphocyte transformation test results for the vaccine suggested a relationship between the vaccine and interstitial nephritis. Initially, treatment with prednisolone was effective. However, an increase in urinary β2MG level was observed 7 months later, and the introduction of mycophenolate mofetil (MMF) allowed for the gradual reduction and eventual cessation of prednisolone. This case represents one of the rare pediatric instances of ATIN following COVID-19 vaccination. MMF can be an effective alternative in corticosteroid-dependent cases.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubulointerstitial nephritis with IgM-positive plasma cells complicated by liver failure. IgM阳性浆细胞并发肝衰竭的肾小管间质性肾炎。

IF 1

CEN Case Reports Pub Date : 2024-10-23 DOI: 10.1007/s13730-024-00932-9

Takashi Kudo, Daigo Nakazawa, Saori Nishio, Fumihiko Hattanda, Yusho Ueda, Junpei Yoshikawa, Satoka Shiratori-Aso, Sari Iwasaki, Takahiro Tsuji, Yasuni Nakanuma, Goki Suda, Koji Ogawa, Naoya Sakamoto, Tatsuya Atsumi

{"title":"Tubulointerstitial nephritis with IgM-positive plasma cells complicated by liver failure.","authors":"Takashi Kudo, Daigo Nakazawa, Saori Nishio, Fumihiko Hattanda, Yusho Ueda, Junpei Yoshikawa, Satoka Shiratori-Aso, Sari Iwasaki, Takahiro Tsuji, Yasuni Nakanuma, Goki Suda, Koji Ogawa, Naoya Sakamoto, Tatsuya Atsumi","doi":"10.1007/s13730-024-00932-9","DOIUrl":"https://doi.org/10.1007/s13730-024-00932-9","url":null,"abstract":"Tubulointerstitial nephritis (TIN) is characterized by inflammation of the renal interstitium with the infiltration of immune cells, mainly consisting of T cells. Recently, patients with TIN with the predominant infiltration of immunoglobulin M (IgM)-positive plasma cells were reported, coined IgMPC-TIN. Here we report the case of a 70-year-old woman diagnosed with Fanconi syndrome and renal tubular acidosis. Renal biopsy revealed IgMPC-TIN. Her renal dysfunction and clinical findings improved after corticosteroid therapy. However, the patient died of progressive liver failure and spontaneous bacterial peritonitis. In laboratory tests, viral hepatitis was excluded, and autoantibodies associated with liver diseases were negative. Generally, IgMPC-TIN is often complicated by primary biliary cholangitis (PBC), whereas her autopsy revealed the local infiltration of IgM-positive plasma cells, obliterative portal venopathy, and nodular regenerative hyperplasia in liver. This case is the first demonstration that IgMPC-TIN is also seen in liver disease with nodular regenerative hyperplasia, although IgMPC-TIN is more common in anti-M2 antibody-positive disease.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

List of referees. 推荐人名单。

IF 1

CEN Case Reports Pub Date : 2024-10-19 DOI: 10.1007/s13730-024-00938-3

引用次数: 0