CEN Case Reports最新文献

Acute tubulointerstitial nephritis following a coronavirus disease 2019 vaccine booster dose: a pediatric case report. 2019冠状病毒病疫苗加强剂后急性肾小管间质性肾炎：一份儿科病例报告

IF 0.7

CEN Case Reports Pub Date : 2026-05-08 DOI: 10.1007/s13730-026-01126-1

Haruhide Sakaguchi, Daishi Hirano, Yoichi Takemasa, Yuna Hiwatari, Shiho Yoshizawa, Yosuke Shoji, Aya Saito, Chisato Umeda, Saori Miwa, Akira Ito, Kimihiko Oishi

{"title":"Acute tubulointerstitial nephritis following a coronavirus disease 2019 vaccine booster dose: a pediatric case report.","authors":"Haruhide Sakaguchi, Daishi Hirano, Yoichi Takemasa, Yuna Hiwatari, Shiho Yoshizawa, Yosuke Shoji, Aya Saito, Chisato Umeda, Saori Miwa, Akira Ito, Kimihiko Oishi","doi":"10.1007/s13730-026-01126-1","DOIUrl":"https://doi.org/10.1007/s13730-026-01126-1","url":null,"abstract":"Messenger ribonucleic acid vaccines against coronavirus disease 2019 (COVID-19) have been temporally associated with various renal adverse events, including acute tubulointerstitial nephritis (ATIN). Herein, we present the case of a 14-year-old male who developed biopsy-confirmed ATIN following a booster dose of the BNT162b2 (Pfizer-BioNTech) severe acute respiratory syndrome coronavirus 2 vaccine. Ten days after vaccination, the patient presented with fever, fatigue, and nausea and was referred to our hospital because of impaired kidney function. Kidney biopsy demonstrated diffuse tubulointerstitial inflammation consistent with ATIN, and gallium-67 scintigraphy showed diffuse bilateral kidney uptake. The lymphocyte transformation test (LTT) showed a stronger positive response to the BNT162b2 vaccine than to concomitant medications, suggesting a possible association with vaccination. Corticosteroid therapy led to rapid improvement in kidney function and normalization of tubular injury markers. This case demonstrated that ATIN may rarely occur after booster vaccination, and highlights the potential role of the LTT as a useful tool when multiple possible triggers are present.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":"15 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis treated with living-donor kidney transplantation: case report. 活体肾移植治疗家族性低镁血症伴高钙尿和肾钙质沉着症1例。

IF 0.7

CEN Case Reports Pub Date : 2026-05-07 DOI: 10.1007/s13730-026-01103-8

Akari Kaba, Keizo Kaku, Kodai Shingaki, Shinsuke Kubo, Yu Hisadome, Hiroshi Noguchi, Kei Nishiyama, Yasuhiro Okabe, Masafumi Nakamura

{"title":"Familial hypomagnesemia with hypercalciuria and nephrocalcinosis treated with living-donor kidney transplantation: case report.","authors":"Akari Kaba, Keizo Kaku, Kodai Shingaki, Shinsuke Kubo, Yu Hisadome, Hiroshi Noguchi, Kei Nishiyama, Yasuhiro Okabe, Masafumi Nakamura","doi":"10.1007/s13730-026-01103-8","DOIUrl":"10.1007/s13730-026-01103-8","url":null,"abstract":"Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare genetic disorder characterized by renal magnesium wasting, hypercalciuria, and progressive renal function decline, often culminating in end-stage renal disease (ESRD). This report presents the case of a successful living-donor kidney transplantation from a mother to her 22-year-old son, who was diagnosed with FHHNC. The patient initially exhibited hematuria at age two years, progressing to recurrent nephrolithiasis and hypercalciuria. Genetic analysis at age nine years confirmed FHHNC because of a CLDN-16 gene mutation. The CLDN-16 gene, which codes for claudin-16, is a crucial protein involved in renal magnesium and calcium reabsorption. While both parents and one sibling were identified as heterozygous carriers of the mutation, only the patient experienced severe symptoms. As his renal function progressively declined, ultimately reaching ESRD, a living-donor transplant was deemed necessary. His mother, with normal renal function and no history of nephrolithiasis, was evaluated as a suitable donor. Post-transplantation, the patient demonstrated rapid improvement in renal function, with magnesium levels stabilizing to baseline without supplementation, indicating effective graft function. This case underscores the complexities of managing FHHNC, particularly regarding kidney transplantation options and outcomes. Given the rarity of FHHNC, this report highlights the critical role of genetic diagnosis, family screening, and timely intervention. Additionally, it contributes to the limited literature on post-transplant outcomes in FHHNC, emphasizing the potential for living-donor transplantation to restore renal function and enhance quality of life in affected patients.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":"15 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute esophageal necrosis in end-stage renal disease. 终末期肾病的急性食管坏死。

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01123-4

Satoshi Ototake, Isao Aoyama

引用次数: 0

Single-dose rituximab as induction therapy in adult IgA vasculitis with rapidly progressive glomerulonephritis: a case report with peripheral blood CD19⁺ B-cell monitoring. 单剂量利妥昔单抗诱导治疗成人IgA血管炎伴快速进展性肾小球肾炎：外周血CD19 + b细胞监测1例

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01118-1

Naoko Kyoda, Rika Ago, Naoko Masuzawa, Masaki Yanamoto, Masaho Aizawa, Takao Masaki

{"title":"Single-dose rituximab as induction therapy in adult IgA vasculitis with rapidly progressive glomerulonephritis: a case report with peripheral blood CD19⁺ B-cell monitoring.","authors":"Naoko Kyoda, Rika Ago, Naoko Masuzawa, Masaki Yanamoto, Masaho Aizawa, Takao Masaki","doi":"10.1007/s13730-026-01118-1","DOIUrl":"10.1007/s13730-026-01118-1","url":null,"abstract":"Treatment for adult IgA vasculitis (IgAV), particularly severe cases, is not well established, although recent reports have suggested potential efficacy of rituximab (RTX). Here, we report a case highlighting the effectiveness of RTX based on pathophysiological and pathological considerations of IgAV, as well as a treatment protocol that has not been previously described. A 50-year-old man receiving glucocorticoids for cutaneous IgAV developed nephrotic syndrome and acute nephritic syndrome. Renal biopsy showed marked endocapillary and extracapillary proliferation with IgA deposition, consistent with severe IgAV nephritis. Despite glucocorticoid pulse therapy and intravenous cyclophosphamide, rapidly progressive glomerulonephritis ensued, prompting RTX initiation. With reference to peripheral blood CD19± B-cell monitoring, a single-dose RTX induction regimen was selected. Following RTX administration, the patient showed a favorable renal response. This case supports the potential efficacy of RTX in highly active IgAV with systemic symptoms. It suggests that a single-dose RTX induction approach may represent a feasible strategy to balance effective disease control with reduced infection risk in selected patients with severe adult IgAV, for which peripheral blood CD19+ B-cell monitoring may be helpful.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":"15 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute interstitial nephritis due to acute pyelonephritis in a young woman: diagnostic utility of CK7 and CD10 immunostaining. 1例年轻女性急性肾盂肾炎所致急性间质性肾炎：CK7和CD10免疫染色的诊断价值

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01115-4

Naoto Eriguchi, Keiki Shimada, Daisuke Katagiri, Hitomi Otani, Yuri Katayama, Kanako Terakawa, Mikako Koizumi, Harui Bamba, Tomonobu Kajio, Mariko Kawamura, Minami Suzuki, Hideki Miyazaki, Hideki Takano

引用次数: 0

IgA nephropathy with rheumatoid arthritis related to adalimumab. 与阿达木单抗相关的IgA肾病伴类风湿性关节炎。

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-025-01078-y

Büşra Tüfekçi, Rıza Can Kardaş, Betül Öğüt, Abdulsamet Erden

{"title":"IgA nephropathy with rheumatoid arthritis related to adalimumab.","authors":"Büşra Tüfekçi, Rıza Can Kardaş, Betül Öğüt, Abdulsamet Erden","doi":"10.1007/s13730-025-01078-y","DOIUrl":"10.1007/s13730-025-01078-y","url":null,"abstract":"The co-occurrence of rheumatoid arthritis (RA) and IgA nephropathy (IgAN) is rare, presenting diagnostic and therapeutic challenges, particularly regarding potential associations with therapies such as TNF inhibitors. We report the case of a 44-year-old man diagnosed with seronegative RA following evaluation for polyarthritis. His prior treatments included rituximab and etanercept, although specific details were unavailable. Adalimumab therapy, initiated in 2014, effectively controlled his RA symptoms for five years. However, in 2019, he developed progressive proteinuria (1 g/day), persistent microscopic hematuria, and low C3/C4 levels. A kidney biopsy revealed IgAN (Oxford classification M1, E0, S1, T1, C0). Suspecting a temporal association with adalimumab, the medication was discontinued, resulting in a significant decrease in proteinuria (to 0.1 g/day) and normalization of serum creatinine. Subsequent treatment with tofacitinib provided inadequate RA control. In 2021, certolizumab was initiated, leading to sustained improvement in RA symptoms (DAS28-CRP 2.6) and continued remission of IgAN (proteinuria 0.2 g/day). This case highlights the potential association between adalimumab use and the development of IgAN in patients with RA and underscores the importance of vigilant renal monitoring during TNF inhibitor therapy.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":"15 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon dioxide contrast angiography-and computed tomography-guided percutaneous embolization of the renal allograft artery in a patient with graft intolerance syndrome and iodinated contrast allergy: a case report. 二氧化碳造影剂血管造影和计算机断层扫描引导下经皮肾移植动脉栓塞治疗一例移植物不耐受综合征和碘造影剂过敏患者。

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01125-2

Takahiro Shinzato, Akira Imaizumi, Shigeo Hara, Kojiro Nagai, Jiaowei Guo, Cong Xia, Takao Okawa, Kenta Ito, Masaaki Murakami, Ken Matsuo, Satoshi Tanaka, Kiyoshi Mori

引用次数: 0

Elevated hemoglobin levels associated with severe sleep-disordered breathing in hemodialysis patients not receiving erythropoiesis-stimulating agents: a case series. 血红蛋白水平升高与未接受促红细胞生成药物的血液透析患者的严重睡眠呼吸障碍相关：一个病例系列

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01124-3

Hiroshi Matsumoto, Seizo Murai

引用次数: 0

Acute kidney injury with interstitial hemorrhage in renal heavy chain amyloidosis: a clinicopathologic case report. 肾重链淀粉样变性急性肾损伤伴间质出血1例临床病理报告。

IF 0.7

CEN Case Reports Pub Date : 2026-04-29 DOI: 10.1007/s13730-026-01117-2

Nozomi Mori, Kayaho Maeda, Rie Ito, Yusuke Handa, Hibiki Tagawa, Suzuho Onagi, Fuyuki Kametani, Masahide Yazaki, Tomohiko Isaki, Asuka Kropp, Yusuke Kakizaki, Michiko Yamazaki, Tomoharu Watanabe

{"title":"Acute kidney injury with interstitial hemorrhage in renal heavy chain amyloidosis: a clinicopathologic case report.","authors":"Nozomi Mori, Kayaho Maeda, Rie Ito, Yusuke Handa, Hibiki Tagawa, Suzuho Onagi, Fuyuki Kametani, Masahide Yazaki, Tomohiko Isaki, Asuka Kropp, Yusuke Kakizaki, Michiko Yamazaki, Tomoharu Watanabe","doi":"10.1007/s13730-026-01117-2","DOIUrl":"10.1007/s13730-026-01117-2","url":null,"abstract":"Heavy chain (AH) amyloidosis is a rare subtype of immunoglobulin-derived amyloidosis, comprising less than 1% of all systemic cases. While kidney involvement is frequently observed in systemic amyloidosis, presentations dominated by acute kidney injury (AKI) with glomerular bleeding and interstitial hemorrhage are uncommon. We report the case of a Japanese man in his 50s who developed AKI requiring dialysis. He had a history of proteinuria noted during previous health checkups but no known underlying diseases. Renal biopsy revealed amorphous mesangial and capillary wall deposits with weak periodic acid-Schiff and negative periodic acid-methenamine silver staining, and positivity for Congo red and direct fast scarlet. Electron microscopy showed non-branching fibrils, and laser microdissection followed by liquid chromatography-tandem mass spectrometry confirmed a diagnosis of AH amyloidosis. Of note, the biopsy also revealed numerous intratubular red blood cells and patchy interstitial hemorrhage in the absence of crescents or necrotizing lesions. The patient was initially treated with corticosteroids under the presumption of rapidly progressive glomerulonephritis. After histologic diagnosis, clone-directed daratumumab-based chemotherapy was introduced. Renal function gradually recovered, and dialysis was discontinued within 3 weeks of admission. This case highlights a rare but important phenotype of AH amyloidosis characterized by disruption of the glomerular capillaries and interstitial hemorrhage leading to reversible AKI. Early biopsy and appropriate therapeutic intervention may allow renal function to recover, even in severe presentations.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":"15 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Mixed cryoglobulinaemia vasculitis secondary to marginal zone lymphoma in a patient with end‑stage renal failure on haemodialysis. 更正：血液透析终末期肾功能衰竭患者继发于边缘区淋巴瘤的混合性冷球蛋白血症血管炎。

IF 0.7

CEN Case Reports Pub Date : 2026-04-22 DOI: 10.1007/s13730-026-01109-2

Craig Peter Coorey, Amirhossein Aarabi, Karthik Kumar

引用次数: 0