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A case of recurrent peritoneal dialysis-related peritonitis caused by Stenotrophomonas maltophilia during ongoing antibiotic treatment for Enterococcus faecalis-induced peritonitis. 一例在对粪肠球菌诱发的腹膜炎进行抗生素治疗期间,由嗜麦芽单胞菌引起的腹膜透析相关腹膜炎复发病例。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-07-02 DOI: 10.1007/s13730-024-00909-8
Jun Takami, Yuta Nakano, Eriko Harada, Shota Nakakuma, Ryosuke Kawamoto, Kayoko Matsukawa
{"title":"A case of recurrent peritoneal dialysis-related peritonitis caused by Stenotrophomonas maltophilia during ongoing antibiotic treatment for Enterococcus faecalis-induced peritonitis.","authors":"Jun Takami, Yuta Nakano, Eriko Harada, Shota Nakakuma, Ryosuke Kawamoto, Kayoko Matsukawa","doi":"10.1007/s13730-024-00909-8","DOIUrl":"10.1007/s13730-024-00909-8","url":null,"abstract":"<p><p>Recurrent peritonitis is a serious complication of peritoneal dialysis (PD), which could result in PD withdrawal and mortality. However, cases of recurrent peritonitis occurring during ongoing antimicrobial therapy are rarely reported. Herein, we present a 71-year-old man who experienced initial peritonitis due to Enterococcus faecalis. Despite effective antimicrobial therapy, he developed recurrent peritonitis while on antimicrobial therapy. PD fluid culture analysis yielded Stenotrophomonas maltophilia (S. maltophilia). He was treated with multiple antimicrobials, and the peritoneal catheter was removed. To the best of our knowledge, this is the first case of recurrent peritonitis caused by S. maltophilia, which was developed during antimicrobial treatment. Our report findings suggest the importance of considering S. maltophilia infection in an atypical case of very early recurrent peritonitis.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"81-84"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Fanconi syndrome with karyomegalic interstitial nephritis after ifosfamide treatment for osteosarcoma: a case report. Correction to:骨肉瘤伊佛酰胺治疗后伴巨核细胞间质性肾炎的范可尼综合征:病例报告。
IF 1
CEN Case Reports Pub Date : 2025-02-01 DOI: 10.1007/s13730-024-00916-9
Yohei Kita, Sayuri Shirai, Teppei Koyama, Ryuichiro Makinouchi, Shinji Machida, Katsuomi Matsui, Junki Koike, Naohiko Imai
{"title":"Correction to: Fanconi syndrome with karyomegalic interstitial nephritis after ifosfamide treatment for osteosarcoma: a case report.","authors":"Yohei Kita, Sayuri Shirai, Teppei Koyama, Ryuichiro Makinouchi, Shinji Machida, Katsuomi Matsui, Junki Koike, Naohiko Imai","doi":"10.1007/s13730-024-00916-9","DOIUrl":"10.1007/s13730-024-00916-9","url":null,"abstract":"","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"71"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report. 肠系膜上动脉血栓形成导致肠坏死的腹膜透析相关性腹膜炎:病例报告。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-06-02 DOI: 10.1007/s13730-024-00894-y
Yosuke Osaki, Yujiro Maeoka, Mai Sami, Akira Takahashi, Naoki Ishiuchi, Kensuke Sasaki, Takao Masaki
{"title":"Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report.","authors":"Yosuke Osaki, Yujiro Maeoka, Mai Sami, Akira Takahashi, Naoki Ishiuchi, Kensuke Sasaki, Takao Masaki","doi":"10.1007/s13730-024-00894-y","DOIUrl":"10.1007/s13730-024-00894-y","url":null,"abstract":"<p><p>Peritoneal dialysis (PD)-associated peritonitis is a common complication of PD. Enteric peritonitis is defined as peritonitis arising from an intestinal or intra-abdominal organ source. The delay in the diagnosis or treatment of enteric peritonitis has been reported to increase mortality. Therefore, the early consideration of enteric peritonitis, particularly in cases of culture-negative peritonitis, is imperative. A 67-year-old Japanese man who had been undergoing PD for 3 years, was admitted to our hospital with a diagnosis of PD-associated peritonitis. A month previously, he experienced a bleeding gastric ulcer, which led to severe anemia (hemoglobin 6.3 mg/dL), followed by thrombocytosis. On admission, peritoneal fluid analysis showed a high white blood cell count (WBC: 8,570 /µL), with neutrophils predominating (74.5%). Cultures of both his dialysis effluent and blood were negative. After admission, the WBC count of the dialysis effluent gradually decreased alongside antibiotic therapy, but the patient's abdominal pain did not improve. After 4 days, enhanced computed tomography showed superior mesenteric artery (SMA) thrombosis and intestinal necrosis. Therefore, emergency intestinal resection and PD catheter removal were performed, and then antithrombosis therapy was initiated. Because the patient's abdominal pain was improved and platelet count and D-dimer concentration were reduced by these treatments, he was discharged from the hospital after 47 days. Thus, we report a rare case of culture-negative PD-associated peritonitis, which was caused by SMA thrombosis and intestinal necrosis. It is likely that combination of severe calcification of SMA and prolonged thrombocytosis secondary to the severe anemia contributed to the thrombosis.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: A case of acute kidney injury and Fanconi syndrome while taking multiple supplements, including Red Yeast Rice Cholesterol Help®. 更正:一例在服用包括红麴胆固醇帮助®在内的多种营养补充剂时出现急性肾损伤和范可尼综合征的病例。
IF 1
CEN Case Reports Pub Date : 2025-02-01 DOI: 10.1007/s13730-024-00911-0
Keiko Oda, Tomohiro Murata, Fumika Tanaka, Hidemasa Oda, Kayo Tsujimoto, Ayumi Fukumori, Masahiro Yamawaki, Ryosuke Saiki, Yasuo Suzuki, Kan Katayama, Kaoru Dohi
{"title":"Correction to: A case of acute kidney injury and Fanconi syndrome while taking multiple supplements, including Red Yeast Rice Cholesterol Help<sup>®</sup>.","authors":"Keiko Oda, Tomohiro Murata, Fumika Tanaka, Hidemasa Oda, Kayo Tsujimoto, Ayumi Fukumori, Masahiro Yamawaki, Ryosuke Saiki, Yasuo Suzuki, Kan Katayama, Kaoru Dohi","doi":"10.1007/s13730-024-00911-0","DOIUrl":"10.1007/s13730-024-00911-0","url":null,"abstract":"","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"52"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Report of renal allograft tuberculosis a decade after transplant: challenges in diagnosis and management. 移植十年后的肾移植结核病报告:诊断和管理方面的挑战。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-06-26 DOI: 10.1007/s13730-024-00904-z
Joy Kumar, Shankar Prasad Nagaraju, Kavitha Saravu, Dharshan Rangaswamy
{"title":"Report of renal allograft tuberculosis a decade after transplant: challenges in diagnosis and management.","authors":"Joy Kumar, Shankar Prasad Nagaraju, Kavitha Saravu, Dharshan Rangaswamy","doi":"10.1007/s13730-024-00904-z","DOIUrl":"10.1007/s13730-024-00904-z","url":null,"abstract":"<p><p>Post-transplant infections constitute an important cause of morbidity and mortality in renal transplant recipients worldwide. Tuberculosis (TB) contributes significantly to this burden in endemic countries, such as India. We report a case of renal allograft TB, 10 years post-transplantation, diagnosed during a routine outpatient visit. An asymptomatic rise in serum creatinine level and a 6 month history of immunosuppressive drug non-compliance prompted evaluation of graft dysfunction. Biopsy of the renal allograft tissue suggested chronic active antibody mediated rejection with epithelioid granulomas in the interstitium. Guided by kidney biopsy, further testing with urine acid fast bacilli and urinary GeneXpert yielded positive results for TB. Treatment of TB was further complicated by the development of anti-tubercular therapy induced hepatitis and immune reconstitution inflammatory syndrome, which were managed with the reintroduction regimen and escalation of steroid dose, respectively. Our case highlights the atypical presentation and challenges in managing patients with TB in a post-renal transplant setting.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"61-64"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of renal limited myeloperoxidase anti-neutrophil cytoplasmic antibody-positive vasculitis treated with maintenance avacopan monotherapy. 一例肾局限性髓过氧化物酶抗中性粒细胞胞浆抗体阳性血管炎患者接受阿伐潘单药维持治疗。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-07-02 DOI: 10.1007/s13730-024-00910-1
Yoshifumi Ubara, Yuki Oba, Shigekazu Kurihara, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Kei Kono, Kenichi Ohashi, Takehiko Wada, Naoki Sawa
{"title":"A case of renal limited myeloperoxidase anti-neutrophil cytoplasmic antibody-positive vasculitis treated with maintenance avacopan monotherapy.","authors":"Yoshifumi Ubara, Yuki Oba, Shigekazu Kurihara, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Kei Kono, Kenichi Ohashi, Takehiko Wada, Naoki Sawa","doi":"10.1007/s13730-024-00910-1","DOIUrl":"10.1007/s13730-024-00910-1","url":null,"abstract":"<p><p>A 76-year-old woman was admitted with progressive renal function decline. A kidney biopsy was performed because of myeloperoxidase anti-neutrophil cytoplasmic antibody (ANCA; 333 IU/mL), proteinuria (1.21 g/d), and urinary erythrocyte sediment (10-19/high-power field). Renal-limited ANCA-positive vasculitis with pauci-immune necrotizing crescentic glomerulonephritis (ANCA-associated vasculitis, AAV) was diagnosed. Glucocorticoid therapy was started, and the patient responded well. About 1 year later, avacopan treatment was started and glucocorticoid therapy was discontinued. Avacopan did not normalize ANCA levels and did not make urinary findings negative. However, further progression of renal function decline is prevented. Factors attributed to the development of AAV in this case were investigated; AAV developed after the second dose of the COVID-19 vaccine and ANCA levels re-elevated after the fifth dose. This suggests that the COVID-19 vaccine may have contributed to the development of AAV in this elderly patient. Avacopan monotherapy has been shown to be effective as maintenance therapy to control the progression of renal failure although not sufficient for complete remission of AAV.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"85-89"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of hyperviscosity syndrome associated with Waldenström macroglobulinemia treated with membrane plasma exchange without predilution. 一例与瓦尔登斯特伦巨球蛋白血症有关的高粘滞性综合征患者,在未进行预稀释的情况下接受了膜等离子交换治疗。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI: 10.1007/s13730-024-00912-z
Koichi Saiki, Tadashi Sofue, Chikako Higashiyama, Takafumi Shiga, Yuhei Aoki, Aiko Shiraishi, Yasushi Kunisho, Keisuke Onishi, Eisuke Nakamura, Tomoya Ishida, Tetsuo Minamino
{"title":"A case of hyperviscosity syndrome associated with Waldenström macroglobulinemia treated with membrane plasma exchange without predilution.","authors":"Koichi Saiki, Tadashi Sofue, Chikako Higashiyama, Takafumi Shiga, Yuhei Aoki, Aiko Shiraishi, Yasushi Kunisho, Keisuke Onishi, Eisuke Nakamura, Tomoya Ishida, Tetsuo Minamino","doi":"10.1007/s13730-024-00912-z","DOIUrl":"10.1007/s13730-024-00912-z","url":null,"abstract":"<p><p>A 75-year-old man with blurred vision and nasal bleeding was diagnosed with hyperviscosity syndrome and central retinal vein occlusion secondary to Waldenström macroglobulinemia. Serum total protein and IgM levels were undetectable. Because of the severe symptoms, we determined that immediate plasma-exchange treatment was required to decrease the blood viscosity. The initial plasma exchange was performed using the membrane isolation method with a predilution standby. A saline predilution replacement was prepared to decrease the total membrane pressure (TMP); however, the predilution protocol was not used because the planned treatment volume could be achieved without increasing the TMP. After two consecutive days of membrane plasma exchange, all serum biochemical tests were measurable, and IgM was below 4000 mg/dL. After chemotherapy, his visual symptoms improved, and he was discharged. Since it is difficult to assess the risk of elevated TMP prior to initial plasma exchange, membrane plasma exchange with a predilution standby may be a useful strategy for initial plasma exchange for hyperviscosity syndrome in terms of safety and efficiency.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"90-94"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of membranous nephropathy complicated by Cronkhite-Canada syndrome successfully treated with mizoribine. 一例膜性肾病并发克朗凯特-加拿大综合征的病例,用米佐利宾治疗成功。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-07-02 DOI: 10.1007/s13730-024-00908-9
Hiroyuki Nakanoh, Kenji Tsuji, Shiho Morimoto, Kazuhiko Fukushima, Masaya Iwamuro, Haruhito A Uchida, Jun Wada
{"title":"A case of membranous nephropathy complicated by Cronkhite-Canada syndrome successfully treated with mizoribine.","authors":"Hiroyuki Nakanoh, Kenji Tsuji, Shiho Morimoto, Kazuhiko Fukushima, Masaya Iwamuro, Haruhito A Uchida, Jun Wada","doi":"10.1007/s13730-024-00908-9","DOIUrl":"10.1007/s13730-024-00908-9","url":null,"abstract":"<p><p>Cronkhite-Canada syndrome (CCS) is a non-hereditary disorder characterized by non-neoplastic hamartomatous gastrointestinal polyposis, hair loss, nail atrophy, hyperpigmentation, and diarrhea. While the relationship between CCS and nephritis remains unclear, seven cases of nephritis complicated by CCS have been reported to date, all of which were membranous nephropathy (MN). A 57-year-old man presented with taste disturbance, hair loss, nail plate atrophy, skin pigmentation, and frequent diarrhea. Endoscopic findings showed multiple polyposis of the stomach and large intestine. Given the above, he was diagnosed with CCS. The symptoms gradually improved with prednisolone treatment, although urinary protein and hypoproteinemia appeared during the tapering of prednisolone. He was diagnosed with MN using a renal biopsy, and immunofluorescence microscopy with IgG subclass staining showed predominantly diffuse granular capillary wall staining of IgG4. The cause of secondary MN was not found, including malignant tumors. Nephrotic-range proteinuria persisted despite treatment with prednisolone and cyclosporine. Additional treatment with mizoribine resulted in incomplete remission type 1 of nephrotic syndrome, suggesting that mizoribine may be a treatment option for patients with CCS with steroid-resistant MN. Considering a high prevalence of hypoproteinemia due to chronic diarrhea and protein-losing enteropathy in patients with CCS, proteinuria might be overlooked; thus, follow-up urinalysis would be recommended in patients with CCS.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"72-80"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of crystalglobulin-induced nephropathy wherein M protein was identified by mass spectrometry and immunoglobulin G subclass staining. 一例晶体球蛋白诱发的肾病,通过质谱分析和免疫球蛋白 G 亚类染色鉴定出了 M 蛋白。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-06-25 DOI: 10.1007/s13730-024-00906-x
Hibiki Mochida, Mizuki Kyoda, Yusuke Ushio, Taku Morito, Takahiro Kamiyama, Hideaki Oyagi, Akira Hirasawa, Naoki Hasegawa, Yukio Kakuta, Dedong Kang, Kazuho Honda, Sekiko Taneda, Michiyasu Hatano
{"title":"A case of crystalglobulin-induced nephropathy wherein M protein was identified by mass spectrometry and immunoglobulin G subclass staining.","authors":"Hibiki Mochida, Mizuki Kyoda, Yusuke Ushio, Taku Morito, Takahiro Kamiyama, Hideaki Oyagi, Akira Hirasawa, Naoki Hasegawa, Yukio Kakuta, Dedong Kang, Kazuho Honda, Sekiko Taneda, Michiyasu Hatano","doi":"10.1007/s13730-024-00906-x","DOIUrl":"10.1007/s13730-024-00906-x","url":null,"abstract":"<p><p>Crystalglobulin-induced nephropathy is a rare disease that causes the deposition of crystallized monoclonal immunoglobulins into the glomerular capillary and arteriole spaces. Here, we report the case of a patient who presented with skin ulcers, urinary protein, and renal dysfunction. The patient underwent renal and skin biopsies, and the biopsy tissue samples were subjected to mass spectrometry. The patient was diagnosed with crystalglobulin-induced nephropathy. A literature review suggested that pathological examinations using electron microscopy, mass spectrometry, and immunofluorescent staining of paraffin-embedded biopsy samples treated with pronase may be useful for the diagnosis of this condition.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"53-60"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp®, a supplement containing red yeast rice. 成功治疗急性肾小管间质性肾炎,这可能归功于含有红麴的保健品 Benikoji CholesteHelp®。
IF 1
CEN Case Reports Pub Date : 2025-02-01 Epub Date: 2024-06-17 DOI: 10.1007/s13730-024-00897-9
Masayuki Maiguma, Masao Kihara, Maki Hamaguchi, Takashi Kobayashi, Koshi Yamada, Miyuki Takagi, Harumi Saeki, Tomohito Gohda, Yusuke Suzuki
{"title":"Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp<sup>®</sup>, a supplement containing red yeast rice.","authors":"Masayuki Maiguma, Masao Kihara, Maki Hamaguchi, Takashi Kobayashi, Koshi Yamada, Miyuki Takagi, Harumi Saeki, Tomohito Gohda, Yusuke Suzuki","doi":"10.1007/s13730-024-00897-9","DOIUrl":"10.1007/s13730-024-00897-9","url":null,"abstract":"<p><p>Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have been many cases of kidney dysfunction in people who have taken certain supplements containing red yeast rice in Japan. We experienced a case of acute kidney injuries induced after taking a supplement containing red yeast rice. A 58-year-old woman was admitted to our hospital due to renal dysfunction suspected to be caused by taking the supplement Benikoji CholesteHelp<sup>®</sup>, which contains red yeast rice. With elevations of urinary tubular injury markers such as urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase, serum creatinine levels were elevated up to 2.75 mg/dL. A kidney biopsy revealed a diagnosis of tubulointerstitial nephritis with lymphocytic infiltration of the interstitium, tubular atrophy, and interstitial fibrotic changes. After discontinuation of the supplement and initiation of the prednisolone treatment, renal dysfunction rapidly improved. The course of this case suggests tubular damage caused by the supplements containing red yeast rice. For early diagnosis and treatment, it should be noted that even what are regarded as nutritional health supplements can cause renal dysfunction.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"24-28"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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