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Transcatheter renal arterial embolization for intractable urinary fistula occurring after robot-assisted partial nephrectomy: a case report. 经导管肾动脉栓塞治疗机器人辅助肾部分切除术后发生的顽固性尿瘘:病例报告。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-03-19 DOI: 10.1007/s13730-024-00866-2
Yoshiaki Kawamura, Takato Uchida, Tatsuo Kano, Tatsuya Umemoto, Nobuyuki Nakajima, Masahiro Nitta, Masanori Hasegawa, Sunao Shoji, Akira Miyajima
{"title":"Transcatheter renal arterial embolization for intractable urinary fistula occurring after robot-assisted partial nephrectomy: a case report.","authors":"Yoshiaki Kawamura, Takato Uchida, Tatsuo Kano, Tatsuya Umemoto, Nobuyuki Nakajima, Masahiro Nitta, Masanori Hasegawa, Sunao Shoji, Akira Miyajima","doi":"10.1007/s13730-024-00866-2","DOIUrl":"10.1007/s13730-024-00866-2","url":null,"abstract":"<p><p>Partial nephrectomy is the standard surgical procedure for small renal tumors. Since the advent of robot-assisted partial nephrectomy (RAPN), the number of cases of renal tumors undergoing the procedure has increased exponentially. Urinary fistula is a complication of partial nephrectomy. Conservative management using ureteral stents is useful in most cases of urinary fistulas. However, some patients develop intractable urinary fistulas. Herein, we report a case in which vascular embolization was useful for treating an infected and intractable urinary fistula that developed after RAPN. A 59-year-old man was accidentally found to have a right renal tumor (approximately 3 cm in diameter) during a physical examination. Pathology was clear cell carcinoma. RAPN was performed owing to the small size of the renal tumor; however, postoperatively, an intractable urinary fistula with an isolated calyx developed, which was successfully treated with transcatheter renal arterial embolization (TAE). We encountered a rare case of infected refractory urinary fistula with an isolated calyx in which TAE was successful. TAE seems useful in treating intractable urinary fistulas with an isolated calyx occurring after RAPN.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"425-428"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140173783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary liver-type fatty acid-binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria. 尿液肝T型脂肪酸结合蛋白水平作为严重恶性疟原虫疟疾继发急性肾损伤的预后指标。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1007/s13730-024-00886-y
Yuri Katayama, Keiki Shimada, Daisuke Katagiri, Kanako Terakawa, Emi Sakamoto, Takahito Niikura, Minami Suzuki, Yuki Yoshizaki, Lubna Sato, Gen Yamada, Yutaro Akiyama, Sekiko Taneda, Hideki Takano
{"title":"Urinary liver-type fatty acid-binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria.","authors":"Yuri Katayama, Keiki Shimada, Daisuke Katagiri, Kanako Terakawa, Emi Sakamoto, Takahito Niikura, Minami Suzuki, Yuki Yoshizaki, Lubna Sato, Gen Yamada, Yutaro Akiyama, Sekiko Taneda, Hideki Takano","doi":"10.1007/s13730-024-00886-y","DOIUrl":"10.1007/s13730-024-00886-y","url":null,"abstract":"<p><p>Acute kidney injury (AKI) secondary to severe falciparum malaria possesses a high mortality rate; however, a prognostic marker of renal dysfunction has not yet been identified. Thus, we reported a case of a patient with AKI secondary to falciparum malaria who underwent hemodialysis and a renal biopsy due to prolonged renal dysfunction. The male patient, in his 50 s, presented to our hospital with vomiting, diarrhea, fever, and decreased level of consciousness. The Giemsa-stained peripheral blood film revealed approximately 5% parasitemia, and a rapid diagnostic test was positive for Plasmodium falciparum. He was diagnosed with severe falciparum malaria and was started on quinine hydrochloride. Hemodialysis was initiated due to the decreased urine output and fluid retention. Subsequently, he was weaned off hemodialysis. The histopathological analysis of a renal biopsy revealed interstitial fibrosis, tubular atrophy, and chronic inflammatory cell infiltration; thus, malarial nephropathy was diagnosed. Thereafter, his renal function stabilized, and he was discharged from the hospital. The urinary liver-type fatty acid-binding protein (L-FABP) level decreased before renal function improved. Our report highlighted that long-term follow-up is essential for severe AKI secondary to malaria. The urinary L-FABP level may be a useful prognostic indicator of AKI secondary to severe falciparum malaria.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"522-527"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary adrenal insufficiency developed 22 years after the diagnosis of light and heavy chain deposition disease: a case report. 轻链和重链沉积症确诊 22 年后出现的原发性肾上腺功能不全:病例报告。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-20 DOI: 10.1007/s13730-024-00893-z
Eriko Eguchi
{"title":"Primary adrenal insufficiency developed 22 years after the diagnosis of light and heavy chain deposition disease: a case report.","authors":"Eriko Eguchi","doi":"10.1007/s13730-024-00893-z","DOIUrl":"10.1007/s13730-024-00893-z","url":null,"abstract":"<p><p>Monoclonal immunoglobulin deposition diseases (MIDDs), including light and heavy chain deposition disease (LHCDD), are rare and heterogeneous disorders associated with underlying B-cell clonal disorders. Adrenal involvement is a potential extrarenal manifestation of MIDDs; however, limited data are available regarding its prevalence and clinical presentation. Herein, the present report describes, for the first time, a case of primary adrenal insufficiency that developed twenty-two years after a diagnosis of LHCDD had been made. A 69 year-old woman with a 10 year history of hemodialysis suddenly became bedridden after falling down stairs in the absence of focal neurological deficits. Subsequently, she experienced appetite loss, nausea, vomiting, a fever of unknown origin, and unexplained hypotension. Several months later, primary adrenal insufficiency and normal pressure hydrocephalus were diagnosed and successfully managed. The long-term clinical prognosis of MIDDs has not been fully elucidated despite recent advances in the management of the disorders. This report may contribute to improving our understanding of the disease course.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"545-551"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Daratumumab therapy in a pediatric case of C3 nephritic factor-positive proliferative glomerulonephritis with monoclonal IgG deposits. 达拉单抗治疗一例C3肾炎因子阳性伴单克隆IgG沉积的增生性肾小球肾炎儿科病例。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI: 10.1007/s13730-024-00868-0
Sophia Giang, Anurag K Agrawal, Aris Oates
{"title":"Daratumumab therapy in a pediatric case of C3 nephritic factor-positive proliferative glomerulonephritis with monoclonal IgG deposits.","authors":"Sophia Giang, Anurag K Agrawal, Aris Oates","doi":"10.1007/s13730-024-00868-0","DOIUrl":"10.1007/s13730-024-00868-0","url":null,"abstract":"<p><p>Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is an exceedingly rare cause of glomerulonephritis among children for which prognosis is generally poor, with low incidence of remission and high rates of recurrence after transplant. While there are more cases reported in the adult literature, substantial differences in pediatric vs. adult PGNMID render it essential that we further characterize pediatric cases to optimize management. We report the case of a 12-year-old male presenting initially with edema and hypertension who was subsequently diagnosed with IgG3/Kappa-dominant PGNMID. In the absence of any proven therapy and though without a detectable clone, he was empirically treated with daratumumab with positive effect to date. This is the first reported case of daratumumab monotherapy in pediatric PGNMID, as well as the first PGNMID case to detect presence of C3 nephritic factor.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"429-433"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tubulointerstitial nephritis with IgG4-positive plasma cell infiltration and tertiary lymphoid tissue in a patient with cryoglobulinemic vasculitis: a case report. 一名冷球蛋白血症血管炎患者伴有 IgG4 阳性浆细胞浸润和三级淋巴组织的肾小管间质性肾炎:病例报告。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-15 DOI: 10.1007/s13730-024-00884-0
Yoshikuni Nagayama, Sakurako Yoshioka, Ayana Ichikura-Iida, Takashi Inoue, Koki Maeda, Masako Otani, Shigeki Iwasaki
{"title":"Tubulointerstitial nephritis with IgG4-positive plasma cell infiltration and tertiary lymphoid tissue in a patient with cryoglobulinemic vasculitis: a case report.","authors":"Yoshikuni Nagayama, Sakurako Yoshioka, Ayana Ichikura-Iida, Takashi Inoue, Koki Maeda, Masako Otani, Shigeki Iwasaki","doi":"10.1007/s13730-024-00884-0","DOIUrl":"10.1007/s13730-024-00884-0","url":null,"abstract":"<p><p>Tertiary lymphoid tissue (TLT) develops at sites of chronic immune stimulation, including infection, autoimmune disease, transplant rejection, and cancer. Recently, TLT has been focused on an indicator for poor renal prognosis in various kidney diseases. In cryoglobulinemic vasculitis (CV), specific glomerular and vascular lesions are seen; however, tubulointerstitial lesions are usually nonspecific. We herein report the case of a 74-year-old man with idiopathic CV with rare tubulointerstitial lesions, such as tubulointerstitial nephritis (TIN) with IgG4-positive plasma cell infiltration and TLT. To our knowledge, this is the first report identifying TLT in the kidney biopsy in a patient with CV. Glucocorticoid improved the renal outcome. The association between CV and TIN with TLT remains unknown.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"534-544"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper deficiency anemia due to zinc supplementation in a chronic hemodialysis patient. 慢性血液透析患者因补锌导致的缺铜性贫血。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-03-23 DOI: 10.1007/s13730-024-00862-6
Tomoka Watanabe, Satomi Yonemoto, Yoshihiro Ikeda, Kiyotaka Kawaguchi, Tatsuo Tsukamoto
{"title":"Copper deficiency anemia due to zinc supplementation in a chronic hemodialysis patient.","authors":"Tomoka Watanabe, Satomi Yonemoto, Yoshihiro Ikeda, Kiyotaka Kawaguchi, Tatsuo Tsukamoto","doi":"10.1007/s13730-024-00862-6","DOIUrl":"10.1007/s13730-024-00862-6","url":null,"abstract":"<p><p>Zinc deficiency causes dysgeusia and dermatitis as well as anemia. As approximately half of dialysis patients have zinc deficiency, zinc supplementation should be considered in case of erythropoiesis-stimulating agent (ESA)-hyporesponsive anemia. We report a case of a chronic dialysis patient with copper deficiency anemia caused by standard-dose zinc supplementation. The patient was a 70-year-old woman who had received maintenance hemodialysis for 8 years due to diabetic nephropathy. She had been treated with weekly administration of darbepoetin 30 μg for renal anemia, which resulted in Hb 12 to 14 g/dL. She had no dysgeusia. When zinc deficiency (44 μg/dL) had been identified 4 months earlier, 50 mg daily zinc acetate hydrate (Nobelzin®), which is the standard dose, was started. Unexpectedly, her anemia progressed slowly with macrocytosis together with granulocytopenia. Her platelet count did not decrease at that time. Laboratory tests revealed a marked decrease of serum copper (< 4 μg/dL) and ceruloplasmin (< 2 mg/dL), although serum zinc was within the normal limit (125 μg/dL). We discontinued zinc acetate and started copper supplementation including cocoa for 1 month. Her anemia and granulocytopenia were dramatically restored coincident with the increase in both serum copper and ceruloplasmin. Copper supplementation also improved her iron status as assessed by transferrin saturation and ferritin. Clinicians should monitor both zinc and copper status in anemic dialysis patients during zinc supplementation, as both are important to drive normal hematopoiesis.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"440-444"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of a peritoneal dialysis patient with left pleuroperitoneal communication caused by a pericardial defect after coronary artery bypass surgery. 一例腹膜透析患者在冠状动脉搭桥手术后因心包缺损导致左侧胸膜腹腔相通。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-03-31 DOI: 10.1007/s13730-024-00867-1
Eisuke Nakamura, Tadashi Sofue, Masato Higashitani, Koichi Saiki, Tamae Yamamoto, Takafumi Shiga, Yuhei Aoki, Aiko Shiraishi, Yasushi Kunisho, Keisuke Onishi, Ayumu Kato, Tetsuo Minamino
{"title":"A case of a peritoneal dialysis patient with left pleuroperitoneal communication caused by a pericardial defect after coronary artery bypass surgery.","authors":"Eisuke Nakamura, Tadashi Sofue, Masato Higashitani, Koichi Saiki, Tamae Yamamoto, Takafumi Shiga, Yuhei Aoki, Aiko Shiraishi, Yasushi Kunisho, Keisuke Onishi, Ayumu Kato, Tetsuo Minamino","doi":"10.1007/s13730-024-00867-1","DOIUrl":"10.1007/s13730-024-00867-1","url":null,"abstract":"<p><p>A 74-year-old woman with reduced kidney and cardiac function and a history of coronary artery bypass surgery involving the gastroepiploic artery to the right coronary artery and posterior descending artery #4 presented with dyspnea on exertion. Shortly after the induction of peritoneal dialysis (PD), an increase in the left pleural effusion was observed, and a diagnosis of left pleuroperitoneal communication was made by puncture drainage. The pleuroperitoneal communication hole was not detected under thoracoscopic observation; however, a 10 mm-sized hole in the pericardium was found, confirming leakage of ICG-loaded peritoneal dialysate fluid (PDF). CT peritoneography using PDF mixed with iodine contrast medium revealed that the gastroepiploic artery-to-right coronary artery pathway was defective on the abdominal side. We concluded that the left pleuroperitoneal communication was caused by a two-stage fistulous pathway between the abdominal and pleural cavities through the pericardial cavity after coronary artery bypass graft surgery. Although closure of the diaphragmatic hole around the gastroepiploic artery graft should have been performed to restart PD, the patient did not wish to undergo further invasive procedures. Identification of the fistulous pathway is extremely important for prompt diagnosis and treatment of pleuroperitoneal communication.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"457-462"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of non-traumatic rectus sheath hematoma in a post-kidney transplant patient undergoing catheter embolization during anticoagulation treatment for atrial fibrillation. 一例在抗凝治疗心房颤动期间接受导管栓塞术的肾移植术后患者的非外伤性直肠鞘血肿。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI: 10.1007/s13730-024-00890-2
Kumiko Fujieda, Shoji Saito, Akihito Tanaka, Kazuhiro Furuhashi, Takaya Ozeki, Yoshinari Yasuda, Yuta Sano, Shohei Ishida, Shoichi Maruyama
{"title":"A case of non-traumatic rectus sheath hematoma in a post-kidney transplant patient undergoing catheter embolization during anticoagulation treatment for atrial fibrillation.","authors":"Kumiko Fujieda, Shoji Saito, Akihito Tanaka, Kazuhiro Furuhashi, Takaya Ozeki, Yoshinari Yasuda, Yuta Sano, Shohei Ishida, Shoichi Maruyama","doi":"10.1007/s13730-024-00890-2","DOIUrl":"10.1007/s13730-024-00890-2","url":null,"abstract":"<p><p>A 65-year-old man, a post living donor kidney transplant patient, was admitted to the intensive care unit (ICU) with a severe bacterial infection. He also tested positive for coronavirus disease and had a cough. On admission, heparin was administered for atrial fibrillation. On the third day of hospitalization, his general condition had recovered, and he was discharged from the ICU to the general ward. On the fourth day of hospitalization, he experienced abdominal pain, and a hard mass was palpated in the left lower abdomen. On the fifth day of hospitalization, contrast-enhanced computed tomography showed an extensive rectus sheath hematoma (RSH) extending from the left lower abdominal wall to the left side of the bladder, with extravasation from a small branch of the left inferior epigastric artery. Heparin was discontinued, and transcatheter arterial embolization was performed to control the bleeding. RSH is a rare disease, and cases of extensive hematoma in post-kidney transplant patients occur even less frequently. Patients taking anticoagulants and those with chronic kidney disease are at high risk for RSH, so physicians should be cognizant of this disease when these patients develop abdominal pain.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"528-533"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case diagnosed with IgA nephropathy during a complete remission of minimal change nephrotic syndrome treated with rituximab. 一例在使用利妥昔单抗治疗极小变化肾病综合征完全缓解期间被诊断为 IgA 肾病的病例。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI: 10.1007/s13730-024-00885-z
Mana Nishikawa, Noriaki Shimada, Motoyasu Kurahashi, Kentaro Watanabe, Motoko Kanzaki, Kosuke Fukuoka, Kenichiro Asano
{"title":"A case diagnosed with IgA nephropathy during a complete remission of minimal change nephrotic syndrome treated with rituximab.","authors":"Mana Nishikawa, Noriaki Shimada, Motoyasu Kurahashi, Kentaro Watanabe, Motoko Kanzaki, Kosuke Fukuoka, Kenichiro Asano","doi":"10.1007/s13730-024-00885-z","DOIUrl":"10.1007/s13730-024-00885-z","url":null,"abstract":"<p><p>We herein report a case of IgA nephropathy in a 20-year-old male who maintained a complete remission of minimal change nephrotic syndrome (MCNS) through the administration of rituximab (RTX). He was diagnosed with nephrotic syndrome at 4 years of age. After he relapsed frequently, he was diagnosed with MCNS at 8 years of age based on the findings of a kidney biopsy. At 13 years of age, RTX therapy was initiated to maintain a complete remission after steroid treatment. MCNS recurred twice, including the time in which the interval between the RTX administrations was long. Whenever he relapsed, remission induction was achieved using steroids, and remission maintenance was achieved using RTX. Five months after the 7th RTX administration, the serum IgA level started to increase. After the 9th RTX administration, he demonstrated microhematuria despite the urinary protein level indicating complete remission. At the 10th administration, the urinary protein and the red-blood cell casts were also observed. A renal biopsy was performed 84 months after the initial administration of RTX, and the patient was diagnosed with complications of IgA nephropathy. RTX is not considered to be a useful treatment for IgA nephropathy. The reasons for this are due to the fact that IgA1 does not decrease even following the administration of RTX, because B cells residing in the mucosa may not be deleted by RTX, and IgA production may also continue due to the presence of CD20<sup>-</sup> long-lived plasma cells. Even when administering RTX, if there are findings of glomerulonephritis on urine testing, the possibility of IgA nephropathy must be considered.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"561-564"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of immunoglobulin G4-related kidney disease manifesting after dipeptidyl peptidase-4 inhibitor treatment. 一例二肽基肽酶-4 抑制剂治疗后出现的免疫球蛋白 G4 相关肾病。
IF 1
CEN Case Reports Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1007/s13730-024-00889-9
Yoshifumi Ubara, Toshihiro Takeuchi, Eiko Hasegawa, Akinari Sekine, Noriko Inoue, Kiho Tanaka, Hiroki Mizuno, Yuki Oba, Masayuki Yamanouchi, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Naoki Sawa, Takehiko Wada
{"title":"A case of immunoglobulin G4-related kidney disease manifesting after dipeptidyl peptidase-4 inhibitor treatment.","authors":"Yoshifumi Ubara, Toshihiro Takeuchi, Eiko Hasegawa, Akinari Sekine, Noriko Inoue, Kiho Tanaka, Hiroki Mizuno, Yuki Oba, Masayuki Yamanouchi, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Naoki Sawa, Takehiko Wada","doi":"10.1007/s13730-024-00889-9","DOIUrl":"10.1007/s13730-024-00889-9","url":null,"abstract":"<p><p>A 68-year-old man with type 2 diabetes mellitus was admitted with decreased renal function. He had high IgG4 (1070 mg/dL) and hypocomplementemia (CH50, 25 U/mL). Kidney biopsy showed tubulointerstitial nephritis with IgG4-positive plasma cell infiltration. Four years later, a second kidney biopsy revealed a new manifestation of membranous nephropathy and tubulointerstitial nephritis with exacerbated fibrosis formation. Six years later, the patient developed bullous pemphigoid, which was thought to be caused by DPP4 inhibitors, so DPP4 inhibitor treatment was discontinued. The use of DPP4 inhibitors correlated with changes in renal function, and the patient was diagnosed with IgG4-related kidney disease related to DPP4 inhibitors.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"565-572"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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