CEN Case Reports最新文献_第6页

A case of mucormycosis caused by Rhizopus microsporus in a renal transplant patient. 肾移植患者小孢子根霉引起毛霉病1例。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2025-01-20 DOI: 10.1007/s13730-025-00969-4

Miruzato Fukuda, Takayoshi Yokoyama, Morota Marie, Katsuyuki Miki, Masayuki Yamanouchi, Hiroki Mizuno, Yuki Oba, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Eiko Hasegawa, Tatsuya Suwabe, Takehiko Wada, Kei Kono, Kenichi Ohashi, Yutaka Yamaguchi, Sho Ogura, Naoki Sawa, Yuki Nakamura, Yasuo Ishii, Yoshifumi Ubara

{"title":"A case of mucormycosis caused by Rhizopus microsporus in a renal transplant patient.","authors":"Miruzato Fukuda, Takayoshi Yokoyama, Morota Marie, Katsuyuki Miki, Masayuki Yamanouchi, Hiroki Mizuno, Yuki Oba, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Eiko Hasegawa, Tatsuya Suwabe, Takehiko Wada, Kei Kono, Kenichi Ohashi, Yutaka Yamaguchi, Sho Ogura, Naoki Sawa, Yuki Nakamura, Yasuo Ishii, Yoshifumi Ubara","doi":"10.1007/s13730-025-00969-4","DOIUrl":"10.1007/s13730-025-00969-4","url":null,"abstract":"A 54-year-old man who had been on the kidney donor register for 32 years received a kidney from a 9-year-old boy who had died of fulminant myocarditis. The post-operative course was poor, and hemodialysis was still needed after surgery. A kidney biopsy one hour after surgery showed a neutrophil-predominant inflammatory cell infiltrate localized to the peritubular capillaries (PTC) and acute tubular necrosis of the proximal tubule. Rhizopus species was detected in a perirenal white exudate taken 29 days postoperatively, and the transplanted kidney was removed on postoperative day 45. The removed kidney showed fungal collection formation localized in the arteries and endotheliitis and embolization of the arteries. Renal damage caused by mucormycosis due to Rhizopus microspores was diagnosed. Mucormycosis is a fungal infection with a strong vascular affinity that develops along the vascular wall but does not extend beyond it. The infection leads to arterial infarction and organ failure. This report presents a rare case in which mucormycosis, which had been nested within the peritubular capillaries of the donor kidney, proliferated under immunosuppressive treatment but did so only in the artery, leading to infarction of the kidney. Neutrophilic collections within the PTC on one hour biopsy may be helpful in the early diagnosis of fungal infections.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"580-586"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritoneal lymphomatosis as a rare entity of post-transplant lymphoproliferative disorder after kidney transplantation: a case report. 腹膜淋巴瘤病是肾移植后少见的淋巴细胞增生性疾病：1例报告。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2025-02-19 DOI: 10.1007/s13730-025-00976-5

Kana Shirai, Masatomo Ogata, Marie Murata-Hasegawa, Masataka Miyauchi, Yuko Sakurai, Kazunobu Shinoda, Junki Koike, Yugo Shibagaki, Masahiko Yazawa

{"title":"Peritoneal lymphomatosis as a rare entity of post-transplant lymphoproliferative disorder after kidney transplantation: a case report.","authors":"Kana Shirai, Masatomo Ogata, Marie Murata-Hasegawa, Masataka Miyauchi, Yuko Sakurai, Kazunobu Shinoda, Junki Koike, Yugo Shibagaki, Masahiko Yazawa","doi":"10.1007/s13730-025-00976-5","DOIUrl":"10.1007/s13730-025-00976-5","url":null,"abstract":"Post-transplant lymphoproliferative disorder (PTLD) is a severe complication of solid organ transplantation, and its manifestation as peritoneal lymphomatosis (PL) is extremely rare. This report describes the case of a 65-year-old kidney transplant recipient who presented with massive ascites as the initial symptom of PTLD 8 years post-transplantation. The patient experienced a sudden onset of ascites, and both his serum and ascitic fluid showed elevated lactate dehydrogenase (LDH) levels along with characteristic computed tomography (CT) findings, both of which raised the suspicion of lymphoma. The cytology of the ascitic fluid confirmed the diagnosis of peritoneal primary diffuse large B-cell lymphoma, leading to an early diagnosis of PL and management strategies. Although the patient developed tumor lysis syndrome soon after chemotherapy, prompt management led to complete remission. When ascites is observed in post-transplant recipients, it is essential to consider PTLD, recognize the diagnostic value of LDH levels and CT imaging, and emphasize the importance of early intervention to achieve favorable outcomes. To the best of our knowledge, this is the first reported case of PL in a kidney transplant recipient.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"604-611"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of lupus nephritis with masked polyclonal IgG presenting as severe AKI, successfully treated and withdrawn from hemodialysis: a case report. 狼疮性肾炎伴隐匿多克隆IgG表现为严重AKI，成功治疗并退出血液透析：1例报告。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2025-03-28 DOI: 10.1007/s13730-025-00988-1

Kazuhiro Takeuchi, Kasumi Sato, Hideaki Kuno, Emi Sakamoto, Naomi Kuwahara, Yasuo Takeuchi, Akira Shimizu, Mitsuko Iwazaki

{"title":"A case of lupus nephritis with masked polyclonal IgG presenting as severe AKI, successfully treated and withdrawn from hemodialysis: a case report.","authors":"Kazuhiro Takeuchi, Kasumi Sato, Hideaki Kuno, Emi Sakamoto, Naomi Kuwahara, Yasuo Takeuchi, Akira Shimizu, Mitsuko Iwazaki","doi":"10.1007/s13730-025-00988-1","DOIUrl":"10.1007/s13730-025-00988-1","url":null,"abstract":"Lupus nephritis (LN) is well-known as an immune-mediated glomerulonephritis characterized by the full-house pattern of immunoglobulin (Ig) and complement deposition. The \"masked IgG\" is a recently recognized concept in which IgG appears negative on standard frozen sections but becomes positive on formalin-fixed paraffin-embedded (FFPE) tissue sections treated with pronase. Typically, monoclonal IgGκ deposition is observed in such cases. We report a unique case of LN in a 69-year-old male with urinary abnormalities and renal dysfunction. Kidney biopsy revealed necrotizing glomerulonephritis and crescent formation with massive subepithelial and mild subendothelial electron-dense deposits, consistent with Class III(A/C) + V LN. However, immunofluorescence using a frozen sample showed pauci-immune features. In contrast, FFPE with pronase digestion showed strong positive for IgG and light chain-kappa and lambda indicating \"masked polyclonal IgG\". The patient developed AKI, which progressed to ESRD, necessitating the initiation of hemodialysis. Notably, 5 months after the initiation of treatment with steroids and mycophenolate mofetil, the patient experienced an improvement in renal function and ultimately achieved withdrawal from hemodialysis. A repeat kidney biopsy revealed progression to Class IV(A/C) + V lupus nephritis and Ig and complements were detected in normal immunofluorescence using a frozen sample. Further, mass spectrometry analysis of glomeruli in both biopsies identified a \"high-temperature requirement A serine peptidase 1\", HTRA1. In conclusion, this was a pathologically extremely rare case of lupus nephritis (LN) with masked polyclonal IgG, in which HTRA1 was detected in the kidney biopsy.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"618-625"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An adolescent presenting with IgA nephropathy and persistent decreased kidney function after COVID-19 vaccination during follow-up for asymptomatic hematuria: a clinicopathological study. 一名青少年在无症状血尿随访期间接种COVID-19疫苗后出现IgA肾病并持续肾功能下降：临床病理研究

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2025-04-13 DOI: 10.1007/s13730-025-00989-0

Kazumi Morisawa, Tsutomu Takahashi, Kentaro Matsuoka, Akinori Hashiguchi, Mariko Yamanaka, Riku Hamada, Masataka Honda

{"title":"An adolescent presenting with IgA nephropathy and persistent decreased kidney function after COVID-19 vaccination during follow-up for asymptomatic hematuria: a clinicopathological study.","authors":"Kazumi Morisawa, Tsutomu Takahashi, Kentaro Matsuoka, Akinori Hashiguchi, Mariko Yamanaka, Riku Hamada, Masataka Honda","doi":"10.1007/s13730-025-00989-0","DOIUrl":"10.1007/s13730-025-00989-0","url":null,"abstract":"Although the coronavirus disease 2019 (COVID-19) vaccine has been proven to be effective and safe in most adults and children, various diseases, including IgA nephropathy, sometimes occur as an adverse effect. We herein describe a case of IgA nephropathy in a 16-year-old, male patient with persistent kidney dysfunction following COVID-19 vaccination and present the clinicopathological course of the disease. The patient presented to the outpatient clinic with a history of gross hematuria 6 days after receiving the COVID-19 vaccine. Prior to the current presentation, he was being examined regularly at an outpatient clinic for asymptomatic hematuria. His mother had received a diagnosis of IgA nephropathy, and his younger brother had received a diagnosis of asymptomatic hematuria. A blood test of this patient demonstrated elevated serum creatinine, and IgA nephropathy was pathologically diagnosed (Oxford classification M0E1S1T0C1). Prednisolone and immunosuppressants were administered promptly to treat the decreased kidney function and the pathology. Nevertheless, the failure of his kidney function to recover to the state it was in prior to this episode may have led to the formation of chronic lesions, causing irreversible kidney tissue damage. Some patients with IgA nephropathy, asymptomatic hematuria or a family history of kidney-related symptoms may experience kidney dysfunction after COVID-19 vaccination and require prednisolone or immunosuppressive therapy to stem the progressive deterioration of their kidney function. Prior to receiving the COVID-19 vaccine, patients with any of these conditions should be provided with an appropriate explanation of the risks and be asked for their consent to be vaccinated.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"635-640"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe hypokalemia through urinary retention: a case report of a patient with sigmoid neobladder replacement. 重度低钾血症伴尿潴留：乙状结肠新膀胱置换术1例报告。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1007/s13730-025-01002-4

Midori Kobayashi, Katsuyuki Nagatoya, Masafumi Wada, Maho Tokuchi, Soichiro Misegawa, Rina Saito, Hiroki Nomi, Ryota Haga, Daisuke Mori, Atsushi Yamauchi

{"title":"Severe hypokalemia through urinary retention: a case report of a patient with sigmoid neobladder replacement.","authors":"Midori Kobayashi, Katsuyuki Nagatoya, Masafumi Wada, Maho Tokuchi, Soichiro Misegawa, Rina Saito, Hiroki Nomi, Ryota Haga, Daisuke Mori, Atsushi Yamauchi","doi":"10.1007/s13730-025-01002-4","DOIUrl":"10.1007/s13730-025-01002-4","url":null,"abstract":"Severe hypokalemia with respiratory distress is rarely caused by intestinal potassium (K) excretion from the intestinal tract because most of the ingested K is excreted in the urine and the kidney primarily maintains K balance. However, we recently experienced a rare case in which severe hypokalemia may have been caused by K excretion from a portion of the intestinal tract used as a neobladder. This case was characterized by the massive dilatation of the sigmoid neobladder estimated to hold 2-3 L of urine, due to urinary retention. The patient developed respiratory distress and required K dosages in excess of 300 mEq per day. Recent studies have demonstrated that the physical stimulus of membrane stretch increases the probability of opening the BK channel, a type of K channel expressed on the luminal side of the colon's wall. Therefore, we presumed that, in our case, much potassium was excreted through the urine in the sigmoid neobladder due to colonic wall extension. Additionally, immunostaining of the sigmoid colon tissue of his bladder demonstrated a higher level of expression of BK channel protein than the patient with normal renal function. We speculated that BK channel upregulation also contributed to severe hypokalemia.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"674-678"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapsing peritoneal dialysis-associated peritonitis caused by Corynebacterium striatum: a case report. 由纹状体棒状杆菌引起的复发性腹膜透析相关性腹膜炎：病例报告。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2024-11-19 DOI: 10.1007/s13730-024-00947-2

Tomohisa Tsuyuki, Shinichi Abe, Emiko Otsuka, Kiyokazu Tsuji, Kenta Torigoe, Ayuko Yamashita, Kumiko Muta, Yasushi Mochizuki, Hiroshi Mukae, Tomoya Nishino

{"title":"Relapsing peritoneal dialysis-associated peritonitis caused by Corynebacterium striatum: a case report.","authors":"Tomohisa Tsuyuki, Shinichi Abe, Emiko Otsuka, Kiyokazu Tsuji, Kenta Torigoe, Ayuko Yamashita, Kumiko Muta, Yasushi Mochizuki, Hiroshi Mukae, Tomoya Nishino","doi":"10.1007/s13730-024-00947-2","DOIUrl":"10.1007/s13730-024-00947-2","url":null,"abstract":"Peritoneal dialysis (PD)-associated peritonitis is a serious complication of PD, and its prevention and treatment are important for reducing patient morbidity and mortality. Reports of PD-associated peritonitis caused by Corynebacterium spp. are limited, and PD-associated peritonitis caused by Corynebacterium striatum (C. striatum) is rare. Only two case reports are available, wherein improvement was only achieved after intraperitoneal administration of antibiotics. Here, we report a case of relapsing PD-associated peritonitis caused by C. striatum that did not improve with antibiotic therapy. In this case, the patient started PD due to end-stage renal failure with immunoglobulin A nephropathy. In addition, he had been diagnosed with bronchiectasis and was prescribed clarithromycin. Four days after PD induction, the patient developed culture-negative PD-associated peritonitis. Ceftazidime and cefazolin were subsequently administered intraperitoneally for a total of 14 days, resulting in improvement in his condition. However, 3 and 5 months after PD induction, he developed PD-associated peritonitis again, and C. striatum was detected in each culture. He was treated with intraperitoneal vancomycin for a total of 14 days and improved; however, he developed PD-associated culture-negative peritonitis again 7 months later. We diagnosed relapsing PD-associated peritonitis caused by C. striatum. PD catheter removal and reinsertion were performed, and he has not relapsed since. In conclusion, PD-associated peritonitis caused by C. striatum may have a poor prognosis; therefore, PD catheter removal is recommended, especially in patients with a history of repeated PD-related peritonitis due to C. striatum.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"521-526"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopic polyangiitis in pediatric systemic lupus erythematosus: a unique presentation of pulmonary-renal syndrome and case report of an overlap syndrome. 小儿系统性红斑狼疮的显微镜下多血管炎：肺肾综合征的独特表现和重叠综合征的病例报告。

IF 0.7

CEN Case Reports Pub Date : 2025-08-01 Epub Date: 2024-12-11 DOI: 10.1007/s13730-024-00949-0

Chen-Xing Zhang, Lei Yin, You-Ying Mao, Zheng-Yu Zhou, Wei Zhou

{"title":"Microscopic polyangiitis in pediatric systemic lupus erythematosus: a unique presentation of pulmonary-renal syndrome and case report of an overlap syndrome.","authors":"Chen-Xing Zhang, Lei Yin, You-Ying Mao, Zheng-Yu Zhou, Wei Zhou","doi":"10.1007/s13730-024-00949-0","DOIUrl":"10.1007/s13730-024-00949-0","url":null,"abstract":"Secondary vasculitis is encountered in about one-third of all cases of systemic lupus erythematosus (SLE). Skin is most commonly involved in lupus-related small vasculitis. Although antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is relatively uncommon, it can be the most dangerous manifestation associated with high mortality. SLE and AAV are separate diseases with different pathophysiologies and an overlap syndrome has only been reported a few times in previous literature. We present a unique case of a pediatric patient of pulmonary-renal syndrome, presenting with pulmonary alveolar hemorrhage and rapidly progressive glomerulonephritis. Serological and biopsy findings were suggestive of SLE and AAV occurring, simultaneously. Renal biopsy demonstrated necrotizing and crescentic glomerulonephritis, superimposed on diffuse segmental proliferative lupus glomerulonephritis class IV. The presentations of autoimmune diseases and vasculitis can be multi-systemic. Considering overlap syndromes, especially in patients with underlying connective tissue disease or systemic vasculitis, is vital for prompt therapy and prevention of morbidity in this population.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"534-541"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective combination of corticosteroid and cyclosporine A for immunoglobulin A nephropathy with membranoproliferative glomerulonephritis features: a case report. 皮质类固醇和环孢素A有效联合治疗免疫球蛋白A肾病伴膜增生性肾小球肾炎1例

IF 1

CEN Case Reports Pub Date : 2025-06-01 Epub Date: 2024-12-28 DOI: 10.1007/s13730-024-00961-4

Saeko Hatanaka, Go Kanzaki, Kentaro Koike, Hiroyuki Ueda, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi, Takashi Yokoo

{"title":"Effective combination of corticosteroid and cyclosporine A for immunoglobulin A nephropathy with membranoproliferative glomerulonephritis features: a case report.","authors":"Saeko Hatanaka, Go Kanzaki, Kentaro Koike, Hiroyuki Ueda, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi, Takashi Yokoo","doi":"10.1007/s13730-024-00961-4","DOIUrl":"10.1007/s13730-024-00961-4","url":null,"abstract":"Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide with heterogeneous histopathological phenotypes. Although IgAN with membranoproliferative glomerulonephritis (MPGN)-like features has been reported in children and adults, treatment strategies for this rare IgAN subtype have not been established. Here, we present the case of a 56-year-old man with no history of kidney disease who initially presented with nephrotic syndrome. Renal biopsy revealed MPGN-like features with a negative serological workup for secondary causes. Immunofluorescent staining was predominantly positive for IgA in the glomerular mesangial and capillary walls. Galactose-deficient IgA1 staining showed a distribution pattern similar to IgA staining. Electron microscopy revealed disorganized structural deposits in the mesangial and subendothelial regions. Based on clinical and histopathological findings, the patient was diagnosed with primary IgAN. The nephrotic syndrome resolved completely after six months of combined corticosteroids and cyclosporine A (CsA) therapy. Although corticosteroids and CsA were tapered off, hematuria and proteinuria remained in complete remission for years of follow-up. This case demonstrates the importance of recognizing IgAN with MPGN-like features as a histopathological subtype that may benefit from intensive immunosuppressive therapy.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"486-492"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission. 一例神经源性神经营养因子阳性，梅毒相关的膜性肾病实现自发缓解。

IF 1

CEN Case Reports Pub Date : 2025-06-01 Epub Date: 2024-12-28 DOI: 10.1007/s13730-024-00960-5

Yuko Yoshida, Kenji Ueki, Yuta Matsukuma, Akihiro Tsuchimoto, Eri Ataka, Hirofumi Okamoto, Kumiko Torisu, Yuichirou Hara, Hirofumi Ikeda, Takanari Kitazono, Toshiaki Nakano

{"title":"A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission.","authors":"Yuko Yoshida, Kenji Ueki, Yuta Matsukuma, Akihiro Tsuchimoto, Eri Ataka, Hirofumi Okamoto, Kumiko Torisu, Yuichirou Hara, Hirofumi Ikeda, Takanari Kitazono, Toshiaki Nakano","doi":"10.1007/s13730-024-00960-5","DOIUrl":"10.1007/s13730-024-00960-5","url":null,"abstract":"Neuron-derived neurotrophic factor (NDNF) was discovered as a target antigen in membranous nephropathy (MN) caused by syphilis. However, there have been few reports of NDNF-positive MN in Japan. A 19-year-old female patient was admitted to our hospital with nephrotic syndrome and acute kidney injury. After admission, she presented with a skin rash and was serologically positive for syphilis. Kidney biopsy showed MN positive not only for immunoglobulin (Ig) G, but also for IgA and complement C1q. IgG subclass analysis revealed positivity for IgG1 and IgG3. Immunohistochemistry for glomerular NDNF was positive, and a diagnosis of syphilis-related MN was confirmed. Prior to treatment of the infection, her urinary protein decreased to achieve complete remission and her kidney function improved. Benzylpenicillin was administered, and no recurrence of nephrotic syndrome or kidney dysfunction was observed thereafter. This case illustrates the importance of considering syphilis infection when encountering a case of nephrotic syndrome with skin rash. In addition, urinalysis of syphilitic patients should be performed to avoid missing MN that may be in spontaneous remission. Further elucidation of the pathogenesis of NDNF-positive, syphilis-related MN in Japan is needed.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"318-323"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful outcome of a refractory IgA vasculitis nephritis in children treated with telitacicept. 替利他塞普治疗难治性IgA血管炎肾炎的成功结局。

IF 1

CEN Case Reports Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.1007/s13730-025-00983-6

Yanyan Jin, Aiqin Sheng, Qian Lin, Xue He, Haidong Fu, Jianhua Mao

{"title":"Successful outcome of a refractory IgA vasculitis nephritis in children treated with telitacicept.","authors":"Yanyan Jin, Aiqin Sheng, Qian Lin, Xue He, Haidong Fu, Jianhua Mao","doi":"10.1007/s13730-025-00983-6","DOIUrl":"10.1007/s13730-025-00983-6","url":null,"abstract":"IgA vasculitis (IgAV) is the most prevalent form of vasculitis in children. While most cases of IgAV present with mild clinical symptoms and generally have a favorable prognosis, some children with IgAV nephritis may experience persistent heavy proteinuria, which is at risk of progressing to end-stage renal disease. Despite the administration of various immunosuppressive agents, treatment outcomes for these children are often suboptimal. We report the case of an 8-year-and-four-month-old girl who initially presented with rashes on both lower limbs for a duration of four days and abdominal pain persisting for two days. Renal biopsy subsequently confirmed a diagnosis of IgAV nephritis, specifically type IIIb. Despite undergoing treatment with methylprednisolone sodium succinate, cyclophosphamide, mycophenolate mofetil, leflunomide, rituximab, dapagliflozin, and other medications for over two years, her urinary protein levels remained at least 1000 mg/24 h. One month after initiating treatment with telitacicept, the patient's urinary protein levels decreased, and two months later, they became negative. Notably, even after discontinuing immunosuppressants and glucocorticoids, the girl achieved sustained clinical remission. This case serves as a valuable clinical reference for the use of telitacicept in the treatment of refractory IgAV nephritis.","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"402-407"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0