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EGFR-targeting ADCs: From oncogene addiction to antigen-guided drug delivery egfr靶向adc：从癌基因成瘾到抗原引导药物递送
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-13 DOI: 10.1016/j.ccell.2026.07.006
Lihui Liu,Kailun Fei,Jie Wang
{"title":"EGFR-targeting ADCs: From oncogene addiction to antigen-guided drug delivery","authors":"Lihui Liu,Kailun Fei,Jie Wang","doi":"10.1016/j.ccell.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.006","url":null,"abstract":"In this issue of Cancer Cell, Li et al. report a first-in-human phase 1 study of SYS6010, an epidermal growth factor receptor (EGFR)-targeting antibody-drug conjugate, in advanced solid tumors. The study highlights how EGFR-directed therapy moves beyond kinase inhibition toward antigen-guided cytotoxic delivery in non-small cell lung cancer.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"159 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stressed bones and glioblastoma. 受压骨骼和胶质母细胞瘤。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-09 DOI: 10.1016/j.ccell.2026.06.007
Manuel Valiente
{"title":"Stressed bones and glioblastoma.","authors":"Manuel Valiente","doi":"10.1016/j.ccell.2026.06.007","DOIUrl":"10.1016/j.ccell.2026.06.007","url":null,"abstract":"<p><p>Chronic stress has long been associated with poor cancer outcomes, yet the mechanisms linking systemic stress responses to glioblastoma progression remain poorly understood. In this issue of Cancer Cell, Yang et al. identify a stress-induced brain-bone marrow axis that rewires monocyte differentiation toward pro-tumorigenic macrophages, revealing unexpected therapeutic opportunities in glioblastoma.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1542-1543"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From prediction to interpretation in computational pathology. 计算病理学从预测到解释。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-06-25 DOI: 10.1016/j.ccell.2026.06.003
Jialu Yao, Zhi Huang
{"title":"From prediction to interpretation in computational pathology.","authors":"Jialu Yao, Zhi Huang","doi":"10.1016/j.ccell.2026.06.003","DOIUrl":"10.1016/j.ccell.2026.06.003","url":null,"abstract":"<p><p>In this issue of Cancer Cell, Liang et al. report PathPrism, demonstrating how interpretable spatial representations of tissue organization can support biomarker discovery, clinical prediction, and hypothesis generation from routine histopathology slides. The framework highlights an emerging transition in computational pathology from black-box prediction toward biologically meaningful interpretation.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1536-1538"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysbiosis-associated bile acids slam the brakes on immune checkpoint therapy. 与生态失调相关的胆汁酸会对免疫检查点疗法踩刹车。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-29 DOI: 10.1016/j.ccell.2026.06.013
Chi Chun Wong, Jun Yu
{"title":"Dysbiosis-associated bile acids slam the brakes on immune checkpoint therapy.","authors":"Chi Chun Wong, Jun Yu","doi":"10.1016/j.ccell.2026.06.013","DOIUrl":"10.1016/j.ccell.2026.06.013","url":null,"abstract":"<p><p>Antibiotics compromise the efficacy of immune checkpoint inhibition (ICI) therapy in cancer, but the underlying mechanism remains unclear. In this issue of Cancer Cell, Mallard de La Varende et al. identify dysbiosis-associated tauro-conjugated bile acids as drivers of ICI non-response and γ-glutamyl transferase (γGT) as a predictive biomarker.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1547-1548"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms. 骨髓增殖性肿瘤中依赖menin的巨核细胞增殖和纤维化。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-09 DOI: 10.1016/j.ccell.2026.06.008
Jeremy Wen, Anitria Cotton, Rashid Mehmood, Man Mohan, Trent Hall, Amber L Broadhurst, Kevin Zhang, Yunusa Olufadi, Guolian Kang, Bridget Marcellino, John Mascarenhas, Ronald Hoffman, Laura J Janke, Sandeep Gurbuxani, Gerard M McGeehan, John D Crispino
{"title":"Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms.","authors":"Jeremy Wen, Anitria Cotton, Rashid Mehmood, Man Mohan, Trent Hall, Amber L Broadhurst, Kevin Zhang, Yunusa Olufadi, Guolian Kang, Bridget Marcellino, John Mascarenhas, Ronald Hoffman, Laura J Janke, Sandeep Gurbuxani, Gerard M McGeehan, John D Crispino","doi":"10.1016/j.ccell.2026.06.008","DOIUrl":"10.1016/j.ccell.2026.06.008","url":null,"abstract":"<p><p>Menin inhibition, an approved therapy for KMT2A-rearranged and NPM1 mutant acute leukemia, is accompanied by decreased platelet counts in 15-20% of heavily pre-treated patients. While studying the mechanism underlying this effect, we discovered that menin inhibition reduced the numbers of megakaryocyte progenitors in human CD34<sup>+</sup> cultures and in mice. Because megakaryocytes are key drivers of myeloproliferative neoplasms (MPNs), we investigated the extent to which menin inhibition ameliorates MPN phenotypes. We found that the menin inhibitor revumenib has potent anti-tumor activity, synergizes with ruxolitinib, and shows only subtle effects on healthy mice. Moreover, revumenib suppressed megakaryopoiesis of primary MPN patient specimens in vitro and in vivo. Importantly, genetic knockout of MEN1 and its target MEF2C phenocopied the action of revumenib, confirming an on-target effect of the drug. Together, we reveal menin as a dependency in proliferative megakaryocytes and support further evaluation of menin inhibition as a potential therapy for MPNs.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1639-1652.e6"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial multi-omics landscape of colorectal cancer macro- and micrometastases. 结直肠癌宏观和微转移的空间多组学景观。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-09 DOI: 10.1016/j.ccell.2026.06.009
Yang Liu, Akshaya S Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Zhimin Tong, Tieling Zhou, Kangyu Lin, Baohua Sun, Mei Jiang, Sharia D Hernandez, Idania Carolina Lubo Julio, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Chu, Fuduan Peng, Khaja Khan, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Sean W Barnes, Ou Shi, Shreeya Indulkar, Alaa M T Mohamed, Natalie Wall Fowlkes, Timothy Newhook, Yun Shin Chun, Van K Morris, David Menter, Dadi Jiang, John Paul Shen, Ryan Sun, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M Solis Soto, Scott Kopetz, Linghua Wang, Dipen Maru
{"title":"Spatial multi-omics landscape of colorectal cancer macro- and micrometastases.","authors":"Yang Liu, Akshaya S Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Zhimin Tong, Tieling Zhou, Kangyu Lin, Baohua Sun, Mei Jiang, Sharia D Hernandez, Idania Carolina Lubo Julio, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Chu, Fuduan Peng, Khaja Khan, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Sean W Barnes, Ou Shi, Shreeya Indulkar, Alaa M T Mohamed, Natalie Wall Fowlkes, Timothy Newhook, Yun Shin Chun, Van K Morris, David Menter, Dadi Jiang, John Paul Shen, Ryan Sun, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M Solis Soto, Scott Kopetz, Linghua Wang, Dipen Maru","doi":"10.1016/j.ccell.2026.06.009","DOIUrl":"10.1016/j.ccell.2026.06.009","url":null,"abstract":"<p><p>Colorectal cancer (CRC) metastases frequently recur due to minimal residual disease (MRD) and persistent micrometastases after therapy. Here, we performed spatial multimodal profiling using spot-level and high-resolution spatial transcriptomics, multi-regional whole-genome sequencing following laser-capture microdissection, and high-plex protein imaging to map 49 tumors from 19 patients, encompassing paired primary CRC and matched liver (CLiM) and lung (CLuM) metastases. Phylogenetic reconstruction revealed that liver micrometastases (CLiMi) arose from early clonal divergences and harbored a stem-like, quiescent state consistent with metastatic dormancy. Spatially, we uncovered distinct stromal barriers: macrometastases were encapsulated by myofibroblasts, whereas micrometastases were surrounded by immunosuppressive niches characterized by T cell exhaustion and distinct ligand-receptor signaling networks. Notably, we identified a CLiMi-specific six-gene signature associated with MRD status, disease-free survival, and chemotherapy resistance across multiple independent cohorts. These findings elucidate the spatial evolutionary landscape of CRC metastases and provide tissue-based spatially validated biomarkers for surveillance and therapeutic targeting.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1568-1586.e11"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13390483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption. 血管RhoJ是肿瘤血管生成和血管破坏的有效和选择性靶点。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-06-30 DOI: 10.1016/j.ccell.2026.06.014
Chan Kim, Hanseul Yang, Yoko Fukushima, Phei Er Saw, Junyeop Lee, Jin-Sung Park, Intae Park, Jinmyung Jung, Hiroshi Kataoka, Doheon Lee, Won Do Heo, Injune Kim, Sangyong Jon, Ralf H Adams, Shin-Ichi Nishikawa, Akiyoshi Uemura, Gou Young Koh
{"title":"Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.","authors":"Chan Kim, Hanseul Yang, Yoko Fukushima, Phei Er Saw, Junyeop Lee, Jin-Sung Park, Intae Park, Jinmyung Jung, Hiroshi Kataoka, Doheon Lee, Won Do Heo, Injune Kim, Sangyong Jon, Ralf H Adams, Shin-Ichi Nishikawa, Akiyoshi Uemura, Gou Young Koh","doi":"10.1016/j.ccell.2026.06.014","DOIUrl":"10.1016/j.ccell.2026.06.014","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1705-1709"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. 肝脏代谢的昼夜平衡抑制肝癌的发生。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-02 DOI: 10.1016/j.ccell.2026.06.019
Nicole M Kettner, Horatio Voicu, Milton J Finegold, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri, Chinenye A Katchy, Choogon Lee, David D Moore, Loning Fu
{"title":"Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.","authors":"Nicole M Kettner, Horatio Voicu, Milton J Finegold, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri, Chinenye A Katchy, Choogon Lee, David D Moore, Loning Fu","doi":"10.1016/j.ccell.2026.06.019","DOIUrl":"10.1016/j.ccell.2026.06.019","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1710-1711"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menin in normal and malignant megakaryopoiesis. Menin在正常和恶性巨核生成中的作用。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-09 DOI: 10.1016/j.ccell.2026.06.012
Justin C Wheat, Sheng F Cai
{"title":"Menin in normal and malignant megakaryopoiesis.","authors":"Justin C Wheat, Sheng F Cai","doi":"10.1016/j.ccell.2026.06.012","DOIUrl":"10.1016/j.ccell.2026.06.012","url":null,"abstract":"<p><p>Severe thrombocytopenia is a known complication of menin inhibitor therapy; however, the mechanism underlying this effect is unknown. In this issue of Cancer Cell, Wen et al. demonstrate that menin is a key component of normal megakaryopoiesis and establish menin as a therapeutic vulnerability in myeloproliferative neoplasms.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1544-1546"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond BCL-2: What drives venetoclax resistance in acute myeloid leukemia? 超越BCL-2：急性髓性白血病中venetoclax耐药的原因？
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 DOI: 10.1016/j.ccell.2026.07.004
Anna Skwarska, Marina Konopleva
{"title":"Beyond BCL-2: What drives venetoclax resistance in acute myeloid leukemia?","authors":"Anna Skwarska, Marina Konopleva","doi":"10.1016/j.ccell.2026.07.004","DOIUrl":"10.1016/j.ccell.2026.07.004","url":null,"abstract":"<p><p>The BCL-2 inhibitor venetoclax has transformed outcomes for older or frail patients with acute myeloid leukemia (AML), and its resistance mechanisms are becoming better defined, including compensatory and lineage-associated switches toward MCL-1 or BCL-xL dependence, oncogenic signaling activation, blast phenotype, and differentiation stage. Additional putative mechanisms-such as emerging BAX mutations, mitochondrial structure remodeling, integrated stress response, and metabolic adaptations, including enhanced amino acid uptake and fatty acid oxidation to sustain oxidative phosphorylation-require further validation.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"44 8","pages":"1525-1532"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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