Learning the language of T cell receptors through large-scale screening

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-04-17 DOI:10.1016/j.ccell.2025.03.032

Živa Moravec, John B.A.G. Haanen, Ton N. Schumacher, Wouter Scheper

引用次数: 0

Abstract

T cells perform critical roles in orchestrating immunity in health and disease. However, decoding what individual T cells recognize has long been challenging due to the immense diversity of both T cell receptors (TCRs) and potential antigens. Recent advances in high-throughput TCR screening approaches now provide an opportunity to map the antigen specificity landscape of T cells with unprecedented depth. Here, we outline these recent developments in screening methodologies and discuss how these can help advance our fundamental understanding of T cell-based immunity.

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通过大规模筛选学习 T 细胞受体的语言

T细胞在协调健康和疾病中的免疫方面发挥着关键作用。然而，由于T细胞受体（tcr）和潜在抗原的巨大多样性，解码单个T细胞识别的内容长期以来一直具有挑战性。高通量TCR筛选方法的最新进展现在提供了前所未有的深度绘制T细胞抗原特异性景观的机会。在这里，我们概述了这些筛选方法的最新发展，并讨论了这些方法如何有助于促进我们对T细胞免疫的基本理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.