精确肿瘤学和遗传祖先：基于人群的癌症差异背后的科学

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-04-14 DOI:10.1016/j.ccell.2025.03.022

Melissa Boneta Davis, Rachel Martini

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引用次数: 0

摘要

精确肿瘤学已经改变了癌症治疗，但几乎没有使不同血统的患者受益。从历史上看，自我报告的种族/民族已被用作生物学差异的替代品，但遗传血统为理解癌症差异的遗传驱动因素提供了更精确的框架，包括血统与肿瘤亚型之间的关联，以及影响药物代谢和治疗反应的遗传变异。为了提高所有患者的肿瘤学精确性并减少癌症差异，我们建议扩大包括祖先在内的基因组数据，重新评估祖先不同队列中的疾病相关变异，并标准化数据共享实践。

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Precision oncology and genetic ancestry: The science behind population-based cancer disparities

Precision oncology has transformed cancer care but has barely benefited patients of diverse ancestry. Historically, self-reported race/ethnicity has served as a surrogate for biological differences, but genetic ancestry provides a more precise framework for understanding genetic drivers of cancer disparities, including associations between ancestry and tumor subtypes, and genetic variants affecting drug metabolism and treatment response. To improve precision oncology for all patients and reduce cancer disparities, we propose expanding ancestry-inclusive genomic data, reevaluating disease-associated variants within ancestrally diverse cohorts, and standardizing data-sharing practices.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.