Complexity of insulin resistance in early-onset colorectal cancer

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-04-17 DOI:10.1016/j.ccell.2025.03.033

Samson Mathews Samuel, Elizabeth Varghese, Dietrich Büsselberg

引用次数: 0

Abstract

Early-life exposure to lifestyle-associated metabolic alterations could be a key contributor to early-onset colorectal cancer (EOCRC). Notably, insulin resistance (InsR)-linked hyperinsulinemia, elevated levels of insulin-like growth factors, and chronic inflammation could trigger EOCRC by modulating gene expression/pathways that support carcinogenesis/anti-apoptosis. Here, we discuss how InsR could be the trigger that offsets metabolic homeostasis in young individuals, leading to EOCRC. Furthermore, we emphasize the need for lifestyle interventions, early detection, and targeted therapeutic interventions to mitigate this growing health concern.

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早发性结直肠癌胰岛素抵抗的复杂性

早期生活暴露于与生活方式相关的代谢改变可能是早发性结直肠癌（EOCRC）的关键因素。值得注意的是，胰岛素抵抗（InsR）相关的高胰岛素血症、胰岛素样生长因子水平升高和慢性炎症可通过调节支持致癌/抗凋亡的基因表达/途径触发EOCRC。在这里，我们讨论了InsR如何在年轻人中成为抵消代谢稳态的触发因素，从而导致EOCRC。此外，我们强调生活方式干预、早期发现和有针对性的治疗干预的必要性，以减轻这一日益增长的健康问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.