Cell death, IL-1 cytokines, and tumor progression

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-04-17 DOI:10.1016/j.ccell.2025.03.030

Long Cheng, Ying Zhang

引用次数: 0

Abstract

Tumor cell death shapes tumorigenesis and antitumor immunity in complex ways. Recently, Hänggi et al. revealed that necrotic-like death releases interleukin-1α (IL-1α), driving myeloid-mediated immunosuppression. Lamorte et al. demonstrated that medullary sinus macrophage (MSM) efferocytosis of apoptotic tumor cells activates the IL-33-regulatory T cell (Treg) axis, accelerating tumor growth. Blocking these pathways enhances the efficacy of cancer immunotherapy.

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细胞死亡、IL-1细胞因子与肿瘤进展

肿瘤细胞死亡以复杂的方式影响肿瘤发生和抗肿瘤免疫。最近，Hänggi等人发现坏死样死亡释放白细胞介素-1α (IL-1α)，驱动髓细胞介导的免疫抑制。Lamorte等人证实肿瘤细胞凋亡的髓窦巨噬细胞（MSM） efferocytosis激活il -33调节性T细胞（Treg）轴，加速肿瘤生长。阻断这些途径可以提高癌症免疫治疗的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.