Cancer CellPub Date : 2025-07-24DOI: 10.1016/j.ccell.2025.07.017
Sonia A. Melo, Catia Moutinho, Santiago Ropero, George A. Calin, Simona Rossi, Riccardo Spizzo, Agustin F. Fernandez, Veronica Davalos, Alberto Villanueva, Guillermo Montoya, Hiroyuki Yamamoto, Simo Schwartz, Manel Esteller
{"title":"A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells","authors":"Sonia A. Melo, Catia Moutinho, Santiago Ropero, George A. Calin, Simona Rossi, Riccardo Spizzo, Agustin F. Fernandez, Veronica Davalos, Alberto Villanueva, Guillermo Montoya, Hiroyuki Yamamoto, Simo Schwartz, Manel Esteller","doi":"10.1016/j.ccell.2025.07.017","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.07.017","url":null,"abstract":"No Abstract","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"20 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors","authors":"Zhi-Ying Wu, Qi-Wen Wu, Yi Han, Shu-Jing Xiang, Ying-Nan Wang, Wen-Wei Wu, Yan-Xing Chen, Zi-Qing Feng, Yi-Yu Wang, Ze-Gong Xu, Huan-Chun He, Jun-Jie He, Jia-Qi Chen, Hui Sheng, Qi-Hua Zhang, Zi-Xian Wang, Kun Liao, Qi Zhao, Wei-Jian Mei, Pei-Rong Ding, Rui-Hua Xu","doi":"10.1016/j.ccell.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.07.002","url":null,"abstract":"The emergence of immunotherapy has revolutionized cancer therapy. However, immunotherapeutic resistance remains a major obstacle for broader clinical application. Recent studies highlight that gut microbiota enhances immunotherapy by modulating anti-tumor immunity. In our investigation, we identify that <em>Alistipes finegoldii</em> (<em>A. finegoldii</em>) is associated with superior immunotherapy efficacy across multiple cohorts. Subsequent <em>in vitro</em> and <em>in vivo</em> experiments reveal that <em>A. finegoldii</em> enhances CD8<sup>+</sup> T cell chemotaxis via the CXCL16-CXCR6 axis, enhancing immunotherapy efficacy. Mechanistically, a lipoprotein derived from <em>A. finegoldii</em> (LIPOAF) activates the nuclear factor kappa B (NF-κB) signaling pathway to augment CXCL16 expression in CCR7<sup>+</sup> conventional dendritic cells through binding with the Toll-like receptor 2. Released CXCL16 subsequently facilitates the recruitment of CXCR6<sup>+</sup>CD8<sup>+</sup> T cells into the tumor microenvironment, effectively curbing tumor growth. Our findings suggest a promising strategy for treating solid tumors by combining <em>A. finegoldii</em> with immunotherapy.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"34 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-17DOI: 10.1016/j.ccell.2025.06.019
Lasse Meyer, Hartland W. Jackson, Nils Eling, Shan Zhao, Genki Usui, Haithem Dakhli, Peter Schraml, Susanne Dettwiler, Constanze Elfgen, Zsuzsanna Varga, Holger Moch, Natalie de Souza, Bernd Bodenmiller
{"title":"A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture","authors":"Lasse Meyer, Hartland W. Jackson, Nils Eling, Shan Zhao, Genki Usui, Haithem Dakhli, Peter Schraml, Susanne Dettwiler, Constanze Elfgen, Zsuzsanna Varga, Holger Moch, Natalie de Souza, Bernd Bodenmiller","doi":"10.1016/j.ccell.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.019","url":null,"abstract":"Rapid recurrence is common in triple-negative breast cancer (TNBC). To better understand drivers of recurrence, we use imaging mass cytometry to characterize the tumor phenotype landscapes of 215 TNBC patients. We observe high intertumor heterogeneity with eleven tumor cell phenotypes, each of which dominates in an individual patient, and identify a tumor cell phenotype with reduced basoluminal lineage fidelity and stem-like traits that is correlated with rapid disease recurrence. Scoring of tumor-CD8<sup>+</sup> T cell interactions identifies patients with inflamed tumors and high HLADR expression. We combine these features in multi-omics analyses of 8 cohorts with 3737 patients across all molecular subtypes to propose five prognostic breast cancer subtypes distinguished by tumor cytokeratin expression profiles and CD8<sup>+</sup> T cell spatial patterns. This stratification scheme has direct clinical implications: inflamed tumors show good prognosis and high immunotherapy response rates, whereas patients dominated by basoluminal tumor cells have poor prognosis.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"2 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-17DOI: 10.1016/j.ccell.2025.06.017
Yi-Fan Zhou, Ding Ma, Zhi-Ming Shao
{"title":"TNBC’s compass: Navigating prognosis with a cellular map","authors":"Yi-Fan Zhou, Ding Ma, Zhi-Ming Shao","doi":"10.1016/j.ccell.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.017","url":null,"abstract":"In this issue of <em>Cancer Cell</em>, Meyer et al. use imaging mass cytometry and identify a stem-like basoluminal tumor cell linked to poor prognosis in triple-negative breast cancer (TNBC). They integrate this finding with T cell spatial architecture to establish a five-subtype classification for predicting prognosis and guiding therapy.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"676 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-17DOI: 10.1016/j.ccell.2025.06.018
Jason E. Chan, Tuomas Tammela
{"title":"Decoding subclonal anti-tumor immunity","authors":"Jason E. Chan, Tuomas Tammela","doi":"10.1016/j.ccell.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.018","url":null,"abstract":"Subclonal evolution allows tumors to evade the immune system. In this issue of <em>Cancer Cell</em>, Dijkstra et al. combine the TRACERx cohort with co-cultures of autologous tumors and immune cells to functionally profile subclonal immune escape at the single-clone resolution. This work highlights cancer-intrinsic immune-escape mechanisms that can be interrogated on a co-culture platform.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"109 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-17DOI: 10.1016/j.ccell.2025.06.020
Min-Min Chen, Qinhang Gao, Huiheng Ning, Kang Chen, Yang Gao, Min Yu, Chao-Qun Liu, Wei Zhou, Jieying Pan, Lusheng Wei, Wenxian Dou, Dingwen Zhang, Linnan Zhu, Qingling Zhang, Rufu Chen, Zemin Zhang
{"title":"Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer","authors":"Min-Min Chen, Qinhang Gao, Huiheng Ning, Kang Chen, Yang Gao, Min Yu, Chao-Qun Liu, Wei Zhou, Jieying Pan, Lusheng Wei, Wenxian Dou, Dingwen Zhang, Linnan Zhu, Qingling Zhang, Rufu Chen, Zemin Zhang","doi":"10.1016/j.ccell.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.020","url":null,"abstract":"Nerves are integral to tumor biology, yet the peri- and intra-neural microenvironment and their roles in cancer-neural invasion (NI) remain underexplored. Here, we perform single-cell/single-nucleus RNA sequencing (sc/snRNA-seq) and spatial transcriptomics on 62 samples from 25 pancreatic ductal adenocarcinoma (PDAC) patients, mapping cellular composition, lineage dynamics, and spatial organization across varying NI statuses. Tertiary lymphoid structures are abundant in low-NI tumor tissues and co-localize with non-invaded nerves, while NLRP3<sup>+</sup> macrophages and cancer-associated myofibroblasts surround invaded nerves in high-NI tissues. We identify a unique endoneurial NRP2<sup>+</sup> fibroblast population and characterize three distinct Schwann cell subsets. TGFBI<sup>+</sup> Schwann cells locate at the leading edge of NI, can be induced by transforming growth factor β (TGF-β) signaling, promote tumor cell migration, and correlate with poor survival. We also identify basal-like and neural-reactive malignant subpopulations with distinct morphologies and heightened NI potential. This landscape depicting tumor-associated nerves highlights critical cancer-immune-neural interactions <em>in situ</em> and enlightens treatment development targeting NI.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"11 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-14Epub Date: 2025-07-03DOI: 10.1016/j.ccell.2025.06.009
Tracy O'Connor, Xiaolan Zhou, Jan Kosla, Arlind Adili, Maria Garcia Beccaria, Elena Kotsiliti, Dominik Pfister, Anna-Lena Johlke, Ankit Sinha, Roman Sankowski, Markus Schick, Richard Lewis, Nikolaos Dokalis, Bastian Seubert, Bastian Höchst, Donato Inverso, Danijela Heide, Wenlong Zhang, Petra Weihrich, Katrin Manske, Dirk Wohlleber, Martina Anton, Alexander Hoellein, Gitta Seleznik, Juliane Bremer, Sabine Bleul, Hellmut G Augustin, Florian Scherer, Uwe Koedel, Achim Weber, Ulrike Protzer, Reinhold Förster, Thomas Wirth, Adriano Aguzzi, Felix Meissner, Marco Prinz, Bernd Baumann, Uta E Höpken, Percy A Knolle, Louisa von Baumgarten, Ulrich Keller, Mathias Heikenwalder
{"title":"Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.","authors":"Tracy O'Connor, Xiaolan Zhou, Jan Kosla, Arlind Adili, Maria Garcia Beccaria, Elena Kotsiliti, Dominik Pfister, Anna-Lena Johlke, Ankit Sinha, Roman Sankowski, Markus Schick, Richard Lewis, Nikolaos Dokalis, Bastian Seubert, Bastian Höchst, Donato Inverso, Danijela Heide, Wenlong Zhang, Petra Weihrich, Katrin Manske, Dirk Wohlleber, Martina Anton, Alexander Hoellein, Gitta Seleznik, Juliane Bremer, Sabine Bleul, Hellmut G Augustin, Florian Scherer, Uwe Koedel, Achim Weber, Ulrike Protzer, Reinhold Förster, Thomas Wirth, Adriano Aguzzi, Felix Meissner, Marco Prinz, Bernd Baumann, Uta E Höpken, Percy A Knolle, Louisa von Baumgarten, Ulrich Keller, Mathias Heikenwalder","doi":"10.1016/j.ccell.2025.06.009","DOIUrl":"10.1016/j.ccell.2025.06.009","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1377-1384"},"PeriodicalIF":48.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-10DOI: 10.1016/j.ccell.2025.06.016
Shin-Heng Chiou, Diane Tseng
{"title":"Blood TCRs go to town with early NPC detection","authors":"Shin-Heng Chiou, Diane Tseng","doi":"10.1016/j.ccell.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.016","url":null,"abstract":"In this issue of <em>Cancer Cell</em>, Zhang et al. report an innovative approach utilizing patients’ blood T cell receptor (TCR) sequences for the early detection of nasopharyngeal cancer. This study highlights the potential of harnessing highly public TCRs in the peripheral blood as biomarkers for virally associated malignancies.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"1 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer CellPub Date : 2025-07-10DOI: 10.1016/j.ccell.2025.06.015
Catalina Rozalén, Irene Sangrador, Silvia Avalle, Sandra Blasco-Benito, Panagiota Tzortzi, María Sanz-Flores, José Ángel Palomeque, Pau Torren-Duran, Mariona Dalmau, Helena Brunel, Albert Coll-Manzano, Iván Pérez-Núñez, Tamara Martos, Sonia Servitja, Sandra Pérez-Buira, José Ignacio Chacón, Ángel Guerrero-Zotano, Eduardo Martínez de Dueñas, Yolanda Guillén, Laura Comerma, Toni Celià-Terrassa
{"title":"TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak","authors":"Catalina Rozalén, Irene Sangrador, Silvia Avalle, Sandra Blasco-Benito, Panagiota Tzortzi, María Sanz-Flores, José Ángel Palomeque, Pau Torren-Duran, Mariona Dalmau, Helena Brunel, Albert Coll-Manzano, Iván Pérez-Núñez, Tamara Martos, Sonia Servitja, Sandra Pérez-Buira, José Ignacio Chacón, Ángel Guerrero-Zotano, Eduardo Martínez de Dueñas, Yolanda Guillén, Laura Comerma, Toni Celià-Terrassa","doi":"10.1016/j.ccell.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.06.015","url":null,"abstract":"In metastasis, the dynamics of tumor-immune interactions during micrometastasis remain unclear. Identifying the vulnerabilities of micrometastases before outbreaking into macrometastases can reveal therapeutic opportunities for metastasis. Here, we report a function of T cell immunoglobulin and mucin domain 3 (TIM3) in tumor cells during micrometastasis using breast cancer (BC) metastasis mouse models. TIM3 is highly upregulated in micrometastases, promoting survival, stemness, and immune escape. TIM3<sup>+</sup> tumor cells are specifically selected during early seeding of micrometastasis. Mechanistically, TIM3 increases β-catenin/interleukin-1β (IL-1β) signaling, leading to stemness and immune-evasion by inducing immunosuppressive γδ T cells and reducing CD8 T cells during micrometastasis. Clinical data confirm increased TIM3<sup>+</sup> tumor cells in BC metastasis and TIM3<sup>+</sup> tumor cells as a biomarker of poor outcome in BC patients. (Neo)adjuvant TIM3 blockade reduces the metastatic seeding and incidence in preclinical models. These findings unveil a specific mechanism of micrometastasis immune-evasion and the potential use of TIM3 blockade for subclinical metastasis.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"153 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
