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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism MDMX作为一种普遍的白血病前期到急性髓性白血病的过渡机制
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-26 DOI: 10.1016/j.ccell.2026.08.014
Koki Ueda,Rajni Kumari,Emily Schwenger,Justin C. Wheat,Oliver Bohorquez,Swathi-Rao Narayanagari,Samuel J. Taylor,Luis A. Carvajal,Kith Pradhan,Boris Bartholdy,Tihomira I. Todorova,Hiroki Goto,Daqian Sun,Jiahao Chen,Jidong Shan,Yinghui Song,Cristina Montagna,Shunbin Xiong,Guillermina Lozano,Andrea Pellagatti,Jacqueline Boultwood,Amit Verma,Ulrich Steidl
{"title":"MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism","authors":"Koki Ueda,Rajni Kumari,Emily Schwenger,Justin C. Wheat,Oliver Bohorquez,Swathi-Rao Narayanagari,Samuel J. Taylor,Luis A. Carvajal,Kith Pradhan,Boris Bartholdy,Tihomira I. Todorova,Hiroki Goto,Daqian Sun,Jiahao Chen,Jidong Shan,Yinghui Song,Cristina Montagna,Shunbin Xiong,Guillermina Lozano,Andrea Pellagatti,Jacqueline Boultwood,Amit Verma,Ulrich Steidl","doi":"10.1016/j.ccell.2026.08.014","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.08.014","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"35 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148821587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteo-genomics-guided interpretation of somatic mutations in cancer genomes 癌症基因组中体细胞突变的蛋白质基因组学指导解释
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-21 DOI: 10.1016/j.ccell.2026.07.017
Do Young Hyeon,Yuxiang Zhou,Wendy K. Chung,Felix Dietlein
{"title":"Proteo-genomics-guided interpretation of somatic mutations in cancer genomes","authors":"Do Young Hyeon,Yuxiang Zhou,Wendy K. Chung,Felix Dietlein","doi":"10.1016/j.ccell.2026.07.017","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.017","url":null,"abstract":"Cancer genomes harbor hundreds of mutated genes, but their exact roles in tumorigenesis often remain incompletely understood. Here, by integrating protein structures with mutation data from 139,818 patients, we generate detailed, functional maps of mutations for 173 cancer genes in 18+ tumor types. In most cancer genes, oncogenic mutations accumulate in “significantly mutated regions” aligned with key functions, including DNA-binding domains in transcription factors (e.g., FOXA1), ligand-binding sites in receptors (e.g., ERBB2), catalytic domains in chromatin remodelers (e.g., EP300), substrate-recognition sites in ubiquitin-proteasome regulators (e.g., SPOP), and degradation signals in cell-cycle proteins (e.g., CCND1). In other cancer genes, mutations align more closely with constraints in three-dimensional protein structures, such as targeting the interior core (e.g., TP53) or a specific secondary structure (e.g., PTEN). Broadly, our study provides a proteo-genomic framework to characterize the effects of mutations in tumorigenesis and integrate them into workflows for clinical interpretation in precision medicine.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"348 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor cells recruit macrophage bodyguards to outlast chemotherapy 肿瘤细胞招募巨噬细胞保镖来度过化疗
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-20 DOI: 10.1016/j.ccell.2026.07.015
Yuzhao Wang,Zibin Chen,Zhuowei Liu,Zikun Ma
{"title":"Tumor cells recruit macrophage bodyguards to outlast chemotherapy","authors":"Yuzhao Wang,Zibin Chen,Zhuowei Liu,Zikun Ma","doi":"10.1016/j.ccell.2026.07.015","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.015","url":null,"abstract":"In Cell Press Blue, Carvalho et al. identify spatially organized tumor-macrophage niches, EMT-like CD44high cancer cells paired with SPP1/PARP14high macrophages, that drive chemoresistance in bladder cancer. PARP14 inhibition can flip this protective niche into an inflammatory, cisplatin-sensitizing state.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"6 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological aging and the hidden architecture of early-onset cancer risk 生物老化和早期癌症风险的隐藏结构
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-18 DOI: 10.1016/j.ccell.2026.07.018
Ammal Abbasi, Ludmil B. Alexandrov
{"title":"Biological aging and the hidden architecture of early-onset cancer risk","authors":"Ammal Abbasi, Ludmil B. Alexandrov","doi":"10.1016/j.ccell.2026.07.018","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.018","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"2 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148755348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intratumoral Bacillus cereus orchestrates stem-like lymphoid niches to potentiate immunotherapy response in hepatocellular carcinoma 瘤内蜡样芽孢杆菌协调茎样淋巴细胞龛以增强肝癌的免疫治疗反应
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-17 DOI: 10.1016/j.ccell.2026.07.016
Chupeng Hu, Wenhua You, Yedi Huang, Yuhan Zhang, Jingying Lu, Jianzhou Yuan, Ruimin Shan, Songmao Li, Ran Li, Qing Li, Minghao Li, Yongqiang Gao, Gao-Jun Teng, Yun Chen
{"title":"Intratumoral Bacillus cereus orchestrates stem-like lymphoid niches to potentiate immunotherapy response in hepatocellular carcinoma","authors":"Chupeng Hu, Wenhua You, Yedi Huang, Yuhan Zhang, Jingying Lu, Jianzhou Yuan, Ruimin Shan, Songmao Li, Ran Li, Qing Li, Minghao Li, Yongqiang Gao, Gao-Jun Teng, Yun Chen","doi":"10.1016/j.ccell.2026.07.016","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.016","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"325 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148755382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SYS6010, epidermal growth factor receptor-targeting antibody-drug conjugate for advanced non-small cell lung cancer: A phase 1 trial SYS6010，表皮生长因子受体靶向抗体-药物偶联物治疗晚期非小细胞肺癌：1期试验
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-13 DOI: 10.1016/j.ccell.2026.07.012
Zi-Ming Li,Zhen Zhou,Zhi-Yong He,Liang Han,Jian Fang,Hong-Mei Sun,Hai-Feng Liu,Ming-Xia Wang,Yi-Bing Liu,Xiu-Juan Qu,Yu Yao,Yi Gong,Yan Yu,Hua-Qiu Shi,Yan Wang,Chun-Xia Su,Kun-Yu Yang,Yan-Hong Shang,Jian Ruan,Xiang-Lin Yuan,Ming-Jun Zhang,Hui Luo,Jiu-Wei Cui,Xiao-Yan Lin,Meng-Xia Li,Hai-Zhou Lou,Run-Xiang Yang,Hao Wu,Xi-Cheng Wang,Mo Dan,Li-Qiong Zhang,Yang-Zhi Su,Xue-Chao Wan,Kai Zou,Ying-Ying Yang,Shun Lu
{"title":"SYS6010, epidermal growth factor receptor-targeting antibody-drug conjugate for advanced non-small cell lung cancer: A phase 1 trial","authors":"Zi-Ming Li,Zhen Zhou,Zhi-Yong He,Liang Han,Jian Fang,Hong-Mei Sun,Hai-Feng Liu,Ming-Xia Wang,Yi-Bing Liu,Xiu-Juan Qu,Yu Yao,Yi Gong,Yan Yu,Hua-Qiu Shi,Yan Wang,Chun-Xia Su,Kun-Yu Yang,Yan-Hong Shang,Jian Ruan,Xiang-Lin Yuan,Ming-Jun Zhang,Hui Luo,Jiu-Wei Cui,Xiao-Yan Lin,Meng-Xia Li,Hai-Zhou Lou,Run-Xiang Yang,Hao Wu,Xi-Cheng Wang,Mo Dan,Li-Qiong Zhang,Yang-Zhi Su,Xue-Chao Wan,Kai Zou,Ying-Ying Yang,Shun Lu","doi":"10.1016/j.ccell.2026.07.012","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.012","url":null,"abstract":"SYS6010 is an antibody-drug conjugate targeting epidermal growth factor receptor (EGFR). We report the results of a phase 1 trial (ChiCTR2300072141) of SYS6010 in patients with non-small cell lung cancer (NSCLC). A total of 236 patients were treated. One dose-limiting toxicity occurred at 6.4 mg/kg; therefore, 4.2, 4.5, and 4.8 mg/kg were selected for cohort expansion. Treatment-related adverse events (TRAEs; any/grade ≥ 3) occurred in 99.6%/57.2% of patients. Common grade ≥3 TRAEs included neutropenia (30.9%), leukopenia (25.0%), and thrombocytopenia (17.4%). Objective response rate was 34.7% in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors (TKIs) and platinum chemotherapy, 45.7% in EGFR-mutant NSCLC treated with EGFR TKIs, 20.0% in EGFR wild-type squamous NSCLC, and 35.7% in EGFR wild-type non-squamous NSCLC. Median progression-free survival and overall survival were 7.6 and 19.4 months, respectively, in EGFR-mutant NSCLC treated with EGFR TKIs and platinum chemotherapy. Overall, SYS6010 shows a manageable safety profile and encouraging antitumor activity in previously treated, advanced NSCLC.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"15 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EGFR-targeting ADCs: From oncogene addiction to antigen-guided drug delivery egfr靶向adc：从癌基因成瘾到抗原引导药物递送
IF 50.3 1区 医学
Cancer Cell Pub Date : 2026-08-13 DOI: 10.1016/j.ccell.2026.07.006
Lihui Liu,Kailun Fei,Jie Wang
{"title":"EGFR-targeting ADCs: From oncogene addiction to antigen-guided drug delivery","authors":"Lihui Liu,Kailun Fei,Jie Wang","doi":"10.1016/j.ccell.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.ccell.2026.07.006","url":null,"abstract":"In this issue of Cancer Cell, Li et al. report a first-in-human phase 1 study of SYS6010, an epidermal growth factor receptor (EGFR)-targeting antibody-drug conjugate, in advanced solid tumors. The study highlights how EGFR-directed therapy moves beyond kinase inhibition toward antigen-guided cytotoxic delivery in non-small cell lung cancer.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"159 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148717828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stressed bones and glioblastoma. 受压骨骼和胶质母细胞瘤。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-09 DOI: 10.1016/j.ccell.2026.06.007
Manuel Valiente
{"title":"Stressed bones and glioblastoma.","authors":"Manuel Valiente","doi":"10.1016/j.ccell.2026.06.007","DOIUrl":"10.1016/j.ccell.2026.06.007","url":null,"abstract":"<p><p>Chronic stress has long been associated with poor cancer outcomes, yet the mechanisms linking systemic stress responses to glioblastoma progression remain poorly understood. In this issue of Cancer Cell, Yang et al. identify a stress-induced brain-bone marrow axis that rewires monocyte differentiation toward pro-tumorigenic macrophages, revealing unexpected therapeutic opportunities in glioblastoma.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1542-1543"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From prediction to interpretation in computational pathology. 计算病理学从预测到解释。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-06-25 DOI: 10.1016/j.ccell.2026.06.003
Jialu Yao, Zhi Huang
{"title":"From prediction to interpretation in computational pathology.","authors":"Jialu Yao, Zhi Huang","doi":"10.1016/j.ccell.2026.06.003","DOIUrl":"10.1016/j.ccell.2026.06.003","url":null,"abstract":"<p><p>In this issue of Cancer Cell, Liang et al. report PathPrism, demonstrating how interpretable spatial representations of tissue organization can support biomarker discovery, clinical prediction, and hypothesis generation from routine histopathology slides. The framework highlights an emerging transition in computational pathology from black-box prediction toward biologically meaningful interpretation.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1536-1538"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysbiosis-associated bile acids slam the brakes on immune checkpoint therapy. 与生态失调相关的胆汁酸会对免疫检查点疗法踩刹车。
IF 56.1 1区 医学
Cancer Cell Pub Date : 2026-08-10 Epub Date: 2026-07-29 DOI: 10.1016/j.ccell.2026.06.013
Chi Chun Wong, Jun Yu
{"title":"Dysbiosis-associated bile acids slam the brakes on immune checkpoint therapy.","authors":"Chi Chun Wong, Jun Yu","doi":"10.1016/j.ccell.2026.06.013","DOIUrl":"10.1016/j.ccell.2026.06.013","url":null,"abstract":"<p><p>Antibiotics compromise the efficacy of immune checkpoint inhibition (ICI) therapy in cancer, but the underlying mechanism remains unclear. In this issue of Cancer Cell, Mallard de La Varende et al. identify dysbiosis-associated tauro-conjugated bile acids as drivers of ICI non-response and γ-glutamyl transferase (γGT) as a predictive biomarker.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":" ","pages":"1547-1548"},"PeriodicalIF":56.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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