CellPub Date : 2024-07-11Epub Date: 2024-05-29DOI: 10.1016/j.cell.2024.05.045
Joseph R Knoedler, Sayaka Inoue, Daniel W Bayless, Taehong Yang, Adarsh Tantry, Chung-Ha Davis, Nicole Y Leung, Srinivas Parthasarathy, Grace Wang, Maricruz Alvarado, Abbas H Rizvi, Lief E Fenno, Charu Ramakrishnan, Karl Deisseroth, Nirao M Shah
{"title":"A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.","authors":"Joseph R Knoedler, Sayaka Inoue, Daniel W Bayless, Taehong Yang, Adarsh Tantry, Chung-Ha Davis, Nicole Y Leung, Srinivas Parthasarathy, Grace Wang, Maricruz Alvarado, Abbas H Rizvi, Lief E Fenno, Charu Ramakrishnan, Karl Deisseroth, Nirao M Shah","doi":"10.1016/j.cell.2024.05.045","DOIUrl":"10.1016/j.cell.2024.05.045","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"3781"},"PeriodicalIF":45.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-06-20Epub Date: 2024-05-21DOI: 10.1016/j.cell.2024.05.021
Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Michael Fayon, François Galode, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bogunovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, Jacinta Bustamante
{"title":"Human inherited CCR2 deficiency underlies progressive polycystic lung disease.","authors":"Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Michael Fayon, François Galode, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bogunovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, Jacinta Bustamante","doi":"10.1016/j.cell.2024.05.021","DOIUrl":"10.1016/j.cell.2024.05.021","url":null,"abstract":"","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"3460"},"PeriodicalIF":45.5,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-06-06Epub Date: 2024-05-21DOI: 10.1016/j.cell.2024.04.016
Juan Diaz-Colunga, Abigail Skwara, Jean C C Vila, Djordje Bajic, Alvaro Sanchez
{"title":"Global epistasis and the emergence of function in microbial consortia.","authors":"Juan Diaz-Colunga, Abigail Skwara, Jean C C Vila, Djordje Bajic, Alvaro Sanchez","doi":"10.1016/j.cell.2024.04.016","DOIUrl":"10.1016/j.cell.2024.04.016","url":null,"abstract":"<p><p>The many functions of microbial communities emerge from a complex web of interactions between organisms and their environment. This poses a significant obstacle to engineering microbial consortia, hindering our ability to harness the potential of microorganisms for biotechnological applications. In this study, we demonstrate that the collective effect of ecological interactions between microbes in a community can be captured by simple statistical models that predict how adding a new species to a community will affect its function. These predictive models mirror the patterns of global epistasis reported in genetics, and they can be quantitatively interpreted in terms of pairwise interactions between community members. Our results illuminate an unexplored path to quantitatively predicting the function of microbial consortia from their composition, paving the way to optimizing desirable community properties and bringing the tasks of predicting biological function at the genetic, organismal, and ecological scales under the same quantitative formalism.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"3108-3119.e30"},"PeriodicalIF":64.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-06-06Epub Date: 2024-05-21DOI: 10.1016/j.cell.2024.04.043
Qiulong Yan, Shenghui Li, Qingsong Yan, Xiaokui Huo, Chao Wang, Xifan Wang, Yan Sun, Wenyu Zhao, Zhenlong Yu, Yue Zhang, Ruochun Guo, Qingbo Lv, Xin He, Changliang Yao, Zhiming Li, Fang Chen, Qianru Ji, Aiqin Zhang, Hao Jin, Guangyang Wang, Xiaoying Feng, Lei Feng, Fan Wu, Jing Ning, Sa Deng, Yue An, De-An Guo, Francis M Martin, Xiaochi Ma
{"title":"A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases.","authors":"Qiulong Yan, Shenghui Li, Qingsong Yan, Xiaokui Huo, Chao Wang, Xifan Wang, Yan Sun, Wenyu Zhao, Zhenlong Yu, Yue Zhang, Ruochun Guo, Qingbo Lv, Xin He, Changliang Yao, Zhiming Li, Fang Chen, Qianru Ji, Aiqin Zhang, Hao Jin, Guangyang Wang, Xiaoying Feng, Lei Feng, Fan Wu, Jing Ning, Sa Deng, Yue An, De-An Guo, Francis M Martin, Xiaochi Ma","doi":"10.1016/j.cell.2024.04.043","DOIUrl":"10.1016/j.cell.2024.04.043","url":null,"abstract":"<p><p>The gut fungal community represents an essential element of human health, yet its functional and metabolic potential remains insufficiently elucidated, largely due to the limited availability of reference genomes. To address this gap, we presented the cultivated gut fungi (CGF) catalog, encompassing 760 fungal genomes derived from the feces of healthy individuals. This catalog comprises 206 species spanning 48 families, including 69 species previously unidentified. We explored the functional and metabolic attributes of the CGF species and utilized this catalog to construct a phylogenetic representation of the gut mycobiome by analyzing over 11,000 fecal metagenomes from Chinese and non-Chinese populations. Moreover, we identified significant common disease-related variations in gut mycobiome composition and corroborated the associations between fungal signatures and inflammatory bowel disease (IBD) through animal experimentation. These resources and findings substantially enrich our understanding of the biological diversity and disease relevance of the human gut mycobiome.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"2969-2989.e24"},"PeriodicalIF":64.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-04-25Epub Date: 2024-03-28DOI: 10.1016/j.cell.2024.02.034
Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H Eric Xu, Jianjun Cheng, Sheng Wang
{"title":"Flexible scaffold-based cheminformatics approach for polypharmacological drug design.","authors":"Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H Eric Xu, Jianjun Cheng, Sheng Wang","doi":"10.1016/j.cell.2024.02.034","DOIUrl":"10.1016/j.cell.2024.02.034","url":null,"abstract":"<p><p>Effective treatments for complex central nervous system (CNS) disorders require drugs with polypharmacology and multifunctionality, yet designing such drugs remains a challenge. Here, we present a flexible scaffold-based cheminformatics approach (FSCA) for the rational design of polypharmacological drugs. FSCA involves fitting a flexible scaffold to different receptors using different binding poses, as exemplified by IHCH-7179, which adopted a \"bending-down\" binding pose at 5-HT<sub>2A</sub>R to act as an antagonist and a \"stretching-up\" binding pose at 5-HT<sub>1A</sub>R to function as an agonist. IHCH-7179 demonstrated promising results in alleviating cognitive deficits and psychoactive symptoms in mice by blocking 5-HT<sub>2A</sub>R for psychoactive symptoms and activating 5-HT<sub>1A</sub>R to alleviate cognitive deficits. By analyzing aminergic receptor structures, we identified two featured motifs, the \"agonist filter\" and \"conformation shaper,\" which determine ligand binding pose and predict activity at aminergic receptors. With these motifs, FSCA can be applied to the design of polypharmacological ligands at other receptors.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"2194-2208.e22"},"PeriodicalIF":64.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-04-25Epub Date: 2024-03-29DOI: 10.1016/j.cell.2024.03.002
Vidhya Krishnamoorthy, Martina Foglizzo, Robert L Dilley, Angela Wu, Arindam Datta, Parul Dutta, Lisa J Campbell, Oksana Degtjarik, Laura J Musgrove, Antonio N Calabrese, Elton Zeqiraj, Roger A Greenberg
{"title":"The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.","authors":"Vidhya Krishnamoorthy, Martina Foglizzo, Robert L Dilley, Angela Wu, Arindam Datta, Parul Dutta, Lisa J Campbell, Oksana Degtjarik, Laura J Musgrove, Antonio N Calabrese, Elton Zeqiraj, Roger A Greenberg","doi":"10.1016/j.cell.2024.03.002","DOIUrl":"10.1016/j.cell.2024.03.002","url":null,"abstract":"<p><p>Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication protein turnover. Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. Deficiency in the 55LCC complex elicited ubiquitin-independent proteotoxicity, replication stress, and severe chromosome instability. 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. These findings define 55LCC-mediated proteostasis as critical for replication fork progression and genome stability and provide a rationale for pathogenic variants seen in associated human neurodevelopmental disorders.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"2250-2268.e31"},"PeriodicalIF":64.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Short-distance vesicle transport via phase separation.","authors":"Hua Qiu, Xiandeng Wu, Xiaoli Ma, Shulin Li, Qixu Cai, Marcelo Ganzella, Liang Ge, Hong Zhang, Mingjie Zhang","doi":"10.1016/j.cell.2024.03.003","DOIUrl":"10.1016/j.cell.2024.03.003","url":null,"abstract":"<p><p>In addition to long-distance molecular motor-mediated transport, cellular vesicles also need to be moved at short distances with defined directions to meet functional needs in subcellular compartments but with unknown mechanisms. Such short-distance vesicle transport does not involve molecular motors. Here, we demonstrate, using synaptic vesicle (SV) transport as a paradigm, that phase separation of synaptic proteins with vesicles can facilitate regulated, directional vesicle transport between different presynaptic bouton sub-compartments. Specifically, a large coiled-coil scaffold protein Piccolo, in response to Ca<sup>2+</sup> and via its C2A domain-mediated Ca<sup>2+</sup> sensing, can extract SVs from the synapsin-clustered reserve pool condensate and deposit the extracted SVs onto the surface of the active zone protein condensate. We further show that the Trk-fused gene, TFG, also participates in COPII vesicle trafficking from ER to the ER-Golgi intermediate compartment via phase separation. Thus, phase separation may play a general role in short-distance, directional vesicle transport in cells.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"2175-2193.e21"},"PeriodicalIF":64.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-04-11Epub Date: 2024-03-18DOI: 10.1016/j.cell.2024.02.029
Matthew R King, Kiersten M Ruff, Andrew Z Lin, Avnika Pant, Mina Farag, Jared M Lalmansingh, Tingting Wu, Martin J Fossat, Wei Ouyang, Matthew D Lew, Emma Lundberg, Michael D Vahey, Rohit V Pappu
{"title":"Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient.","authors":"Matthew R King, Kiersten M Ruff, Andrew Z Lin, Avnika Pant, Mina Farag, Jared M Lalmansingh, Tingting Wu, Martin J Fossat, Wei Ouyang, Matthew D Lew, Emma Lundberg, Michael D Vahey, Rohit V Pappu","doi":"10.1016/j.cell.2024.02.029","DOIUrl":"10.1016/j.cell.2024.02.029","url":null,"abstract":"<p><p>Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nucleolar proteins. We show that the localization preferences of nucleolar proteins are determined by their IDRs and the types of RNA or DNA binding domains they encompass. In vitro reconstitutions and studies in cells showed how condensation, which combines binding and complex coacervation of nucleolar components, contributes to nucleolar organization. D/E tracts of nucleolar proteins contribute to lowering the pH of co-condensates formed with nucleolar RNAs in vitro. In cells, this sets up a pH gradient between nucleoli and the nucleoplasm. By contrast, juxta-nucleolar bodies, which have different macromolecular compositions, featuring protein IDRs with very different charge profiles, have pH values that are equivalent to or higher than the nucleoplasm. Our findings show that distinct compositional specificities generate distinct physicochemical properties for condensates.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"1889-1906.e24"},"PeriodicalIF":64.5,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140173860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-04-11Epub Date: 2024-03-20DOI: 10.1016/j.cell.2024.02.030
Petra Kukanja, Christoffer M Langseth, Leslie A Rubio Rodríguez-Kirby, Eneritz Agirre, Chao Zheng, Amitha Raman, Chika Yokota, Christophe Avenel, Katarina Tiklová, André O Guerreiro-Cacais, Tomas Olsson, Markus M Hilscher, Mats Nilsson, Gonçalo Castelo-Branco
{"title":"Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology.","authors":"Petra Kukanja, Christoffer M Langseth, Leslie A Rubio Rodríguez-Kirby, Eneritz Agirre, Chao Zheng, Amitha Raman, Chika Yokota, Christophe Avenel, Katarina Tiklová, André O Guerreiro-Cacais, Tomas Olsson, Markus M Hilscher, Mats Nilsson, Gonçalo Castelo-Branco","doi":"10.1016/j.cell.2024.02.030","DOIUrl":"10.1016/j.cell.2024.02.030","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single-cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly understood. We investigated the cellular dynamics of MS by modeling temporal and regional rates of disease progression in mouse experimental autoimmune encephalomyelitis (EAE). By performing single-cell spatial expression profiling using in situ sequencing (ISS), we annotated disease neighborhoods and found centrifugal evolution of active lesions. We demonstrated that disease-associated (DA)-glia arise independently of lesions and are dynamically induced and resolved over the disease course. Single-cell spatial mapping of human archival MS spinal cords confirmed the differential distribution of homeostatic and DA-glia, enabled deconvolution of active and inactive lesions into sub-compartments, and identified new lesion areas. By establishing a spatial resource of mouse and human MS neuropathology at a single-cell resolution, our study unveils the intricate cellular dynamics underlying MS.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"1990-2009.e19"},"PeriodicalIF":64.5,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2024-04-11Epub Date: 2024-03-29DOI: 10.1016/j.cell.2024.02.032
Selmaan N Chettih, Emily L Mackevicius, Stephanie Hale, Dmitriy Aronov
{"title":"Barcoding of episodic memories in the hippocampus of a food-caching bird.","authors":"Selmaan N Chettih, Emily L Mackevicius, Stephanie Hale, Dmitriy Aronov","doi":"10.1016/j.cell.2024.02.032","DOIUrl":"10.1016/j.cell.2024.02.032","url":null,"abstract":"<p><p>The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, we leveraged the specialized behavior of chickadees-food-caching birds that form memories at well-defined moments in time whenever they cache food for subsequent retrieval. Our recordings during caching revealed very sparse, transient barcode-like patterns of firing across hippocampal neurons. Each \"barcode\" uniquely represented a caching event and transiently reactivated during the retrieval of that specific cache. Barcodes co-occurred with the conventional activity of place cells but were uncorrelated even for nearby cache locations that had similar place codes. We propose that animals recall episodic memories by reactivating hippocampal barcodes. Similarly to computer hash codes, these patterns assign unique identifiers to different events and could be a mechanism for rapid formation and storage of many non-interfering memories.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"1922-1935.e20"},"PeriodicalIF":64.5,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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