{"title":"Adaptive radiation and social evolution of the ants","authors":"Joel Vizueta, Zijun Xiong, Guo Ding, Rasmus S. Larsen, Hao Ran, Qionghua Gao, Josefin Stiller, Wei Dai, Wei Jiang, Jie Zhao, Chunxue Guo, Xiafang Zhang, Dashuang Zuo, Wenjiang Zhong, Morten Schiøtt, Chengyuan Liu, Hailin Zhang, Xueqin Dai, Ignasi Andreu, Yue Shi, Guojie Zhang","doi":"10.1016/j.cell.2025.05.030","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.030","url":null,"abstract":"Ants originated over 150 million years ago through an irreversible transition to superorganismal colony life. Comparative analyses of 163 ant genomes, including newly generated whole-genome sequences of 145 ant species, reveal extensive genome rearrangements correlated with speciation rates. Meanwhile, conserved syntenic blocks are enriched with co-expressed genes involved in basal metabolism and caste differentiation. Gene families related to digestion, endocrine signaling, cuticular hydrocarbon synthesis, and chemoreception expanded in the ant ancestor, while many caste-associated genes underwent positive selection in the formicoid ancestor. Elaborations and reductions of queen-worker dimorphism and other social traits left convergent signatures of intensified or relaxed selection in conserved signaling and metabolic pathways, suggesting that a core gene set was used to diversify organizational complexity. Previously uncharacterized genetic regulators of caste development were confirmed by functional experiments. This study reconstructs the genetic underpinning of social traits and their integration within gene-regulatory networks shaping caste phenotypes.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"22 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-13DOI: 10.1016/j.cell.2025.05.026
Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Elizabeth Hood, Tea Shuvaeva, Michael Zaleski, Damodar Gullipalli, Emily Wolfe, Carolann Espy, Evguenia Arguiri, Jichuan Wu, Yufei Wang, Oscar A. Marcos-Contreras, Wenchao Song, Vladimir R. Muzykantov, Jinglin Fu, Ravi Radhakrishnan, Jacob W. Myerson, Jacob S. Brenner
{"title":"A percolation phase transition controls complement protein coating of surfaces","authors":"Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Elizabeth Hood, Tea Shuvaeva, Michael Zaleski, Damodar Gullipalli, Emily Wolfe, Carolann Espy, Evguenia Arguiri, Jichuan Wu, Yufei Wang, Oscar A. Marcos-Contreras, Wenchao Song, Vladimir R. Muzykantov, Jinglin Fu, Ravi Radhakrishnan, Jacob W. Myerson, Jacob S. Brenner","doi":"10.1016/j.cell.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.026","url":null,"abstract":"When a material enters the body, it is immediately attacked by hundreds of proteins, organized into complex networks of binding interactions and reactions. How do such complex systems interact with a material, “deciding” whether to attack? We focus on the complement system of ∼40 blood proteins that bind microbes, nanoparticles, and medical devices, initiating inflammation. We show a sharp threshold for complement activation upon varying a fundamental material parameter, the surface density of potential complement attachment points. This sharp threshold manifests at scales spanning single nanoparticles to macroscale pathologies, shown here for diverse engineered and living materials. Computational models show these behaviors arise from a minimal subnetwork of complement, manifesting percolation-type critical transitions in the complement response. This criticality switch explains the “decision” of a complex signaling network to interact with a material.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"26 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Senescence-resistant human mesenchymal progenitor cells counter aging in primates","authors":"Jinghui Lei, Zijuan Xin, Ning Liu, Taixin Ning, Ying Jing, Yicheng Qiao, Zan He, Mengmeng Jiang, Yuanhan Yang, Zhiyi Zhang, Liyun Zhao, Jingyi Li, Dongliang Lv, Yupeng Yan, Hui Zhang, Lingling Xiao, Baohu Zhang, Haoyan Huang, Shuhui Sun, Fangshuo Zheng, Guang-Hui Liu","doi":"10.1016/j.cell.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.021","url":null,"abstract":"Aging is characterized by a deterioration of stem cell function, but the feasibility of replenishing these cells to counteract aging remains poorly defined. Our study addresses this gap by developing senescence (seno)-resistant human mesenchymal progenitor cells (SRCs), genetically fortified to enhance cellular resilience. In a 44-week trial, we intravenously delivered SRCs to aged macaques, noting a systemic reduction in aging indicators, such as cellular senescence, chronic inflammation, and tissue degeneration, without any detected adverse effects. Notably, SRC treatment enhanced brain architecture and cognitive function and alleviated the reproductive system decline. The restorative effects of SRCs are partly attributed to their exosomes, which combat cellular senescence. This study provides initial evidence that genetically modified human mesenchymal progenitors can slow primate aging, highlighting the therapeutic potential of regenerative approaches in combating age-related health decline.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"609 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fragmented replay of very large environments in the hippocampus of bats","authors":"Tamir Eliav, Shir R. Maimon, Ayelet Sarel, Shaked Palgi, Liora Las, Nachum Ulanovsky","doi":"10.1016/j.cell.2025.05.024","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.024","url":null,"abstract":"The hippocampus is crucial for memory. Memory consolidation is thought to be subserved by hippocampal “replays” of previously experienced trajectories. However, it is unknown how the brain replays long spatial trajectories in very large, naturalistic environments. Here, we investigated this in the hippocampus of bats that were flying prolonged flights in a 200-m-long tunnel. We found many time-compressed replay sequences during sleep and during awake pauses between flights, similar to rodents exploring small environments. Individual neurons fired multiple times per replay, according to their multiple place fields. Surprisingly, replays were highly fragmented, depicting short trajectory pieces covering only ∼6% of the environment size—unlike replays in small setups, which cover most of the environment. This fragmented replay may reflect biophysical or network constraints on replay distance and may facilitate memory chunking for hippocampal-neocortical communication. Overall, hippocampal replay in very large environments is radically different from classical notions of memory reactivation—carrying important implications for hippocampal network mechanisms in naturalistic, real-world environments.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"42 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-12DOI: 10.1016/j.cell.2025.04.031
Meghan B. Ward, Giedre Krenciute
{"title":"The neurological toll of CAR T cell therapy","authors":"Meghan B. Ward, Giedre Krenciute","doi":"10.1016/j.cell.2025.04.031","DOIUrl":"https://doi.org/10.1016/j.cell.2025.04.031","url":null,"abstract":"Understanding acute and long-term adverse events following CAR T cell therapy for cancer remains a crucial area of investigation as CAR T cells become more prominent in the clinic. In this issue of <em>Cell</em>, Geraghty and Acosta-Alvarez et al. investigate the mechanisms underlying cognitive decline in animal models following CAR T cell therapy for hematological, solid, and CNS malignancies.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"46 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-12DOI: 10.1016/j.cell.2025.04.029
Murukarthick Jayakodi, Preethi Purushotham, Nils Stein
{"title":"Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics","authors":"Murukarthick Jayakodi, Preethi Purushotham, Nils Stein","doi":"10.1016/j.cell.2025.04.029","DOIUrl":"https://doi.org/10.1016/j.cell.2025.04.029","url":null,"abstract":"Using modern genomic tools, Feng et al. revisited Mendel’s seven pea traits in a recent <em>Nature</em> study, uncovering the molecular genetic basis of all of them, including the three unresolved ones: pod color, pod shape, and flower position. Their work highlights the level of complexity provided by structural variation that could impact genes and their regulatory regions and thus influence the expression of plant traits. The authors demonstrate how revisiting foundational experiments with contemporary tools can manifest novel biological insights and also guide future crop improvement.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"19 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-12DOI: 10.1016/j.cell.2025.05.022
Reuben A. Saunders, William E. Allen, Xingjie Pan, Jaspreet Sandhu, Jiaqi Lu, Thomas K. Lau, Karina Smolyar, Zuri A. Sullivan, Catherine Dulac, Jonathan S. Weissman, Xiaowei Zhuang
{"title":"Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue","authors":"Reuben A. Saunders, William E. Allen, Xingjie Pan, Jaspreet Sandhu, Jiaqi Lu, Thomas K. Lau, Karina Smolyar, Zuri A. Sullivan, Catherine Dulac, Jonathan S. Weissman, Xiaowei Zhuang","doi":"10.1016/j.cell.2025.05.022","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.022","url":null,"abstract":"Metazoan life requires the coordinated activities of thousands of genes in spatially organized cell types. Understanding the basis of tissue function requires approaches to dissect the genetic control of diverse cellular and tissue phenotypes <em>in vivo</em>. Here, we present Perturb-Multimodal (Perturb-Multi), a paired imaging and sequencing method to construct large-scale, multimodal genotype-phenotype maps in tissues with pooled genetic perturbations. Using imaging, we identify perturbations in individual cells while simultaneously measuring their gene expression profiles and subcellular morphology. Using single-cell sequencing, we measure full transcriptomic responses to the same perturbations. We apply Perturb-Multi to study hundreds of genetic perturbations in the mouse liver. Our data suggest the genetic regulators and mechanisms underlying the dynamic control of hepatocyte zonation, the unfolded protein response, and steatosis. Perturb-Multi accelerates discoveries of the genetic basis of complex cell and tissue physiology and provides critical training data for emerging machine learning models of cellular function.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"3 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-11DOI: 10.1016/j.cell.2025.05.025
Samuel Liebana, Aeron Laffere, Chiara Toschi, Louisa Schilling, Jessica Moretti, Jacek Podlaski, Matthias Fritsche, Peter Zatka-Haas, Yulong Li, Rafal Bogacz, Andrew Saxe, Armin Lak
{"title":"Dopamine encodes deep network teaching signals for individual learning trajectories","authors":"Samuel Liebana, Aeron Laffere, Chiara Toschi, Louisa Schilling, Jessica Moretti, Jacek Podlaski, Matthias Fritsche, Peter Zatka-Haas, Yulong Li, Rafal Bogacz, Andrew Saxe, Armin Lak","doi":"10.1016/j.cell.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.025","url":null,"abstract":"Striatal dopamine plays fundamental roles in fine-tuning learned decisions. However, when learning from naive to expert, individuals often exhibit diverse learning trajectories, defying understanding of its underlying dopaminergic mechanisms. Here, we longitudinally measure and manipulate dorsal striatal dopamine signals in mice learning a decision task from naive to expert. Mice learning trajectories transitioned through sequences of strategies, showing substantial individual diversity. Remarkably, the transitions were systematic; each mouse’s early strategy determined its strategy weeks later. Dopamine signals reflected strategies each animal transitioned through, encoding a subset of stimulus-choice associations. Optogenetic manipulations selectively updated these associations, leading to learning effects distinct from that of reward. A deep neural network using heterogeneous teaching signals, each updating a subset of network association weights, captured our results. Analyzing the model’s fixed points explained learning diversity and systematicity. Altogether, this work provides insights into the biological and mathematical principles underlying individual long-term learning trajectories.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"37 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-11DOI: 10.1016/j.cell.2025.05.017
Michael J. Boucher, Sanjita Banerjee, Meenakshi B. Joshi, Angela L. Wei, Matthew J. Nalley, Manning Y. Huang, Susan Lei, Massimiliano Ciranni, Andrew Condon, Andreas Langen, Thomas D. Goddard, Ippolito Caradonna, Alexi I. Goranov, Christina M. Homer, Yasaman Mortensen, Sarah Petnic, Morgann C. Reilly, Ying Xiong, Katherine J. Susa, Vito Paolo Pastore, Hiten D. Madhani
{"title":"Phenotypic landscape of an invasive fungal pathogen reveals its unique biology","authors":"Michael J. Boucher, Sanjita Banerjee, Meenakshi B. Joshi, Angela L. Wei, Matthew J. Nalley, Manning Y. Huang, Susan Lei, Massimiliano Ciranni, Andrew Condon, Andreas Langen, Thomas D. Goddard, Ippolito Caradonna, Alexi I. Goranov, Christina M. Homer, Yasaman Mortensen, Sarah Petnic, Morgann C. Reilly, Ying Xiong, Katherine J. Susa, Vito Paolo Pastore, Hiten D. Madhani","doi":"10.1016/j.cell.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.017","url":null,"abstract":"<em>Cryptococcus neoformans</em> is the most common cause of fungal meningitis and the top-ranking WHO fungal priority pathogen. Only distantly related to model fungi, <em>C. neoformans</em> is also a powerful experimental system for exploring conserved eukaryotic mechanisms lost from specialist model yeast lineages. To decipher its biology globally, we constructed 4,328 gene deletions and measured—with exceptional precision—the fitness of each mutant under 141 diverse growth-limiting <em>in vitro</em> conditions and during murine infection. We defined functional modules by clustering genes based on their phenotypic signatures. In-depth studies leveraged these data in two ways. First, we defined and investigated new components of key signaling pathways, which revealed metazoan-like cellular machinery not present in model yeasts. Second, we identified environmental adaptation mechanisms repurposed to promote mammalian virulence by <em>C. neoformans</em>, which lacks a known animal reservoir. Our work provides an unprecedented resource for deciphering a deadly human pathogen.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"173 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2025-06-11DOI: 10.1016/j.cell.2025.05.023
Michael B. Gilbert, Karl M. Glastad, Maxxum Fioriti, Matan Sorek, Tierney Scarpa, Freddy S. Purnell, Daniel Xu, Lindsay K. Pino, Anatoly Korotkov, Ali Biashad, Josue Baeza, Richard Lauman, Anastasiia Filippova, Balint Z. Kacsoh, Roberto Bonasio, Mackenzie W. Mathis, Benjamin A. Garcia, Andrei Seluanov, Vera Gorbunova, Shelley L. Berger
{"title":"Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes","authors":"Michael B. Gilbert, Karl M. Glastad, Maxxum Fioriti, Matan Sorek, Tierney Scarpa, Freddy S. Purnell, Daniel Xu, Lindsay K. Pino, Anatoly Korotkov, Ali Biashad, Josue Baeza, Richard Lauman, Anastasiia Filippova, Balint Z. Kacsoh, Roberto Bonasio, Mackenzie W. Mathis, Benjamin A. Garcia, Andrei Seluanov, Vera Gorbunova, Shelley L. Berger","doi":"10.1016/j.cell.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.cell.2025.05.023","url":null,"abstract":"Social insects offer powerful models to investigate mechanisms of elaborate individual behaviors comprising a cooperative community. Workers of the leafcutter ant genus <em>Atta</em> are extreme examples of behavioral segregation among phenotypically distinct worker types. We utilize this worker system to test the molecular underpinnings of behavioral programming and the extent of plasticity to reprogramming. We identify specific neuropeptides mediating worker division of labor in <em>A. cephalotes</em>, finding two neuropeptides associated with characteristic behaviors of leaf cutting and of brood care. Genetic knockdown or injection of these neuropeptides led to a stark gain or loss of each behavior and to transcriptomic shifts toward gene pathways expressed in the natural castes. We also reveal global similarities between worker transcriptomes of the eusocial mammal, the naked mole-rat <em>H. g</em><em>l</em><em>aber</em>, with orthologous <em>A. cephalotes</em> workers. This work underscores the essential function of neuropeptides in establishing complex social behavior and a remarkable plasticity among individual behavioral types.","PeriodicalId":9656,"journal":{"name":"Cell","volume":"585 1","pages":""},"PeriodicalIF":64.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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