{"title":"A spatiotemporal lifecycle atlas decodes spatial coordination in rice.","authors":"Yi Jing, Qiong Chen, Yifan Chen, Wei Yan, Yuejing Gui, Yicheng Zhong, Mumu Qin, Han Zhang, James Whelan, Chuanxiu Li, Shiyu Chen, Chunyan Xu, Weiming He, Zhiyao Lv, Feng Yang, Rouxi Chen, Jing Zhang, Zongan Wang, Zhenyu Xiong, Xun Liao, Keke Xia, Tong Wei, Longjiang Fan, Tao Yang, Yinqi Bai, Jiwei Xu, Ying Dai, Fang Zhang, Shenhui Yang, Yanting Qiao, Shengwu Xiong, Yi Rong, Cunman He, Huixia Shou, Lei Wang, Qian Wang, Xueqing Xia, Xiongbo Peng, Kaiting Sun, Yongzhong Xing, Lin Du, Rui Han, Chao Qin, Likun Jiang, Xinsen Yang, Jun'e Jiang, Xinle Yu, Jiantao Wu, Rui Li, Yinru Yan, Yizhou Wang, Ying Gu, Jian Wang, Pengfei Jia, Xiaodong Fang, Peng Zhao, Zhen Yue, Hongwei Guo, Yidan Ouyang, Xun Xu, Fan Chen","doi":"10.1016/j.cell.2026.09.023","DOIUrl":"10.1016/j.cell.2026.09.023","url":null,"abstract":"<p><p>How gene expression programs are coordinated across space and time to build a complete plant remains poorly understood. Here, we combine high-resolution spatial transcriptomics, single-nucleus RNA sequencing, and a gap-free reference genome to build a 3D spatiotemporal atlas of rice, spanning 10 organs and 61 stages from seed to seed. Our datasets profile 851,725 nuclei and 347,640 spatial bins, defining 119 cell types and 133 subtypes across the rice lifecycle. Through multimodal integration, we reconstruct an inferred developmental trajectory graph that links cell states from the proembryo to mature organs and identifies trajectory-associated regulators. We further implicate the pleiotropic regulator OsARF1 in distinct spatial gene programs across developmental contexts. We also uncover widespread axis-associated transcriptional asymmetry, including dorsoventral endosperm programs that partition starch and protein accumulation. Collectively, this high-resolution atlas provides a spatiotemporal framework for understanding rice development and guiding future crop improvement.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":""},"PeriodicalIF":45.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-06DOI: 10.1016/j.cell.2026.09.021
Niklas A Schmacke, Sophia C Mädler, Georg Wallmann, Andreas Metousis, Varvara Varlamova, Sophia Steigerwald, Sarah B Christ, Marleen Bérouti, Hartmann Harz, Heinrich Leonhardt, Fabian J Theis, Matthias Mann, Veit Hornung
{"title":"SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.","authors":"Niklas A Schmacke, Sophia C Mädler, Georg Wallmann, Andreas Metousis, Varvara Varlamova, Sophia Steigerwald, Sarah B Christ, Marleen Bérouti, Hartmann Harz, Heinrich Leonhardt, Fabian J Theis, Matthias Mann, Veit Hornung","doi":"10.1016/j.cell.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.cell.2026.09.021","url":null,"abstract":"<p><p>Forward genetic screening links genotype to phenotype by introducing random genetic perturbations and identifying phenotype-altering mutations. Although genome-scale screens are routine for simple phenotypes in cultured cells, extending them to complex image-based phenotypes remains challenging. Here, we present spatially resolved CRISPR screening (SPARCS), a microscopy-based platform for forward genetic screening on single-cell images. SPARCS physically isolates mutants in situ by automated laser microdissection, enabling image-based screening at unprecedented scale with multimodal hit phenotyping. We demonstrate SPARCS in genome-wide CRISPR knockout screens of autophagosome formation and activation of the immune sensor STING across 70 million cells. Via machine learning-based image analysis, SPARCS recovered most macroautophagy genes and identified GPHR as a pH-dependent regulator of STING. Mass spectrometry-based proteomics of isolated hit cells revealed endoplasmic reticulum (ER)/Golgi disruption and nominated additional STING regulators via in silico perturbation modeling. These results establish SPARCS as a scalable platform for genome-wide genetic screening of complex cellular phenotypes with a proteome-level readout.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":""},"PeriodicalIF":45.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01DOI: 10.1016/j.cell.2026.08.056
Jonathan A Stefely, Felicia G Deng, Michael Z Chen, Khanh Nguyen, Bridget E Luce, Michelle Y Fry, Xiaoyan A Guo, Konstantinos Maliaris, Keith D Rivera, Malvina Papanastasiou, Tiana M Issa, Bharath Kanakapura Sundararaj, Sophia L Y Root, D R Mani, Luke H Chao, Sarah E Calvo, Namrata D Udeshi, John Samuelson, Vamsi K Mootha
{"title":"Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen.","authors":"Jonathan A Stefely, Felicia G Deng, Michael Z Chen, Khanh Nguyen, Bridget E Luce, Michelle Y Fry, Xiaoyan A Guo, Konstantinos Maliaris, Keith D Rivera, Malvina Papanastasiou, Tiana M Issa, Bharath Kanakapura Sundararaj, Sophia L Y Root, D R Mani, Luke H Chao, Sarah E Calvo, Namrata D Udeshi, John Samuelson, Vamsi K Mootha","doi":"10.1016/j.cell.2026.08.056","DOIUrl":"https://doi.org/10.1016/j.cell.2026.08.056","url":null,"abstract":"<p><p>Acanthamoeba castellanii causes infectious blindness and resides in a key evolutionary outgroup to humans and fungi. Its divergent mitochondria are of outstanding interest due to their predicted aerobic and anaerobic functions with potential for drug targeting. However, a detailed delineation of its bioenergetic machinery, its activities, and their regulation remains lacking. Here, we integrate mitochondrial immunoprecipitation, density gradient purification, mass spectrometry, protein correlation profiling, and microscopy to generate a high-confidence inventory of the Acanthamoeba mitoproteome. The resulting AcMitoCarta contains 1,122 proteins, including 381 lacking readily identifiable homologs in human and yeast mitochondria. Complexome analysis highlights 20 macromolecular assemblies. Complementary proteomic and transcriptomic profiling reveals extensive rewiring of the organelle's bioenergetic machinery by oxygen, including induction of an anaerobic pyruvate:ferredoxin oxidoreductase-to-hydrogenase pathway under anoxia. We experimentally demonstrate that Acanthamoeba can produce H<sub>2</sub> gas under anoxic conditions via a mitochondria-localized, oxygen-labile hydrogenase. AcMitoCarta establishes a framework for dissecting the interplay between aerobic and anaerobic energy metabolism.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"189 20","pages":"6246-6266.e19"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01DOI: 10.1016/j.cell.2026.09.003
Courtney W Stairs, Ryan M R Gawryluk
{"title":"Mitochondria before we knew them.","authors":"Courtney W Stairs, Ryan M R Gawryluk","doi":"10.1016/j.cell.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.cell.2026.09.003","url":null,"abstract":"<p><p>In this issue of Cell, Chen et al. chart mitochondrial proteome diversity across eukaryotes, revealing an unexpectedly complex ancestral proteome alongside extensive lineage-specific innovation. Their broad phylogenetic reconstruction provides new insights into the mitochondrial proteome of the last eukaryotic common ancestor while unearthing a wealth of unexplored mitochondrial biology outside of traditional model systems.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"189 20","pages":"6214-6216"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01DOI: 10.1016/j.cell.2026.09.006
Yin-Wei Kuo, Sherman Foo, Buzz Baum
{"title":"Taking the heat: Breaking the temperature limits of eukaryotic life.","authors":"Yin-Wei Kuo, Sherman Foo, Buzz Baum","doi":"10.1016/j.cell.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.cell.2026.09.006","url":null,"abstract":"<p><p>What's the highest temperature at which complex life can grow? It's an old question. Here, Rappaport and colleagues describe a thermophilic amoeba that breaks the previous record, which was set at ∼60°C, and suggest the beginnings of an answer to what innovations enable this organism to take the heat.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"189 20","pages":"6212-6213"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01DOI: 10.1016/j.cell.2026.09.002
Lingyan Shi
{"title":"Glioma margins gain a third dimension before surgery ends.","authors":"Lingyan Shi","doi":"10.1016/j.cell.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.cell.2026.09.002","url":null,"abstract":"<p><p>In this issue of Cell, Liu et al. introduce ULTRA, which combines rapid tissue clearing, single-channel stimulated Raman scattering microscopy, and AI to generate cell-resolved three-dimensional virtual histology of intact glioma specimens in about 30 minutes-fast enough to expose depth-dependent infiltration before surgery ends.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"189 20","pages":"6209-6211"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01Epub Date: 2026-08-10DOI: 10.1016/j.cell.2026.07.027
Amalia Villagran Suarez, Kathryn S Hatch, Tatyana Bodrug, Wei Gai, Katherine J Surridge, Elizabeth Moussikhina, Kendrick H V Nguyen, Marta Sanz-Murillo, Robert Callahan, Erica Xiong, Delisa Ramos, Lawrence Zhu, Verena Dederer, Sebastian Mathea, Janet Iwasa, Stefan Knapp, Kevan M Shokat, Samara L Reck-Peterson, Andres E Leschziner
{"title":"The structural basis for LRRK2's activation and autoinhibition.","authors":"Amalia Villagran Suarez, Kathryn S Hatch, Tatyana Bodrug, Wei Gai, Katherine J Surridge, Elizabeth Moussikhina, Kendrick H V Nguyen, Marta Sanz-Murillo, Robert Callahan, Erica Xiong, Delisa Ramos, Lawrence Zhu, Verena Dederer, Sebastian Mathea, Janet Iwasa, Stefan Knapp, Kevan M Shokat, Samara L Reck-Peterson, Andres E Leschziner","doi":"10.1016/j.cell.2026.07.027","DOIUrl":"10.1016/j.cell.2026.07.027","url":null,"abstract":"<p><p>Mutations in leucine-rich repeat kinase 2 (LRRK2) are the second most common cause of autosomal-dominant Parkinson's disease (PD), and increased LRRK2 kinase activity is also observed in idiopathic PD, making LRRK2 a major actionable therapeutic target. LRRK2 is a 286-kDa multidomain enzyme containing a Ras-like GTPase (ROC) and a kinase domain. Using cryo-electron microscopy (cryo-EM), biochemical reconstitution, and cell-based assays, we show that the ROC GTPase governs switching between autoinhibited and active states: GTP binding promotes activation, whereas GDP binding enforces autoinhibition. Two common PD-linked mutations, G2019S and R1441C/G/H, activate LRRK2 through distinct structural mechanisms, revealing genotype-specific routes to dysregulation. These findings provide a unified framework for understanding LRRK2 regulation with broad therapeutic implications. Stabilizing the guanosine diphosphate (GDP)-bound state may inhibit LRRK2 by maintaining autoinhibition, whereas promoting the GTP-bound state could be advantageous in specific cellular contexts, such as the lung, where increased LRRK2 kinase activity may play protective or regulatory roles.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"6460-6473.e7"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01Epub Date: 2026-08-11DOI: 10.1016/j.cell.2026.07.029
Christopher J Giuliano, Chinmay A Kalluraya, Joachim Kloehn, Megan A Sloan, Molly E Bunkofske, Christopher A Hunter, Dominique Soldati-Favre, Clare R Harding, Sebastian Lourido
{"title":"Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma.","authors":"Christopher J Giuliano, Chinmay A Kalluraya, Joachim Kloehn, Megan A Sloan, Molly E Bunkofske, Christopher A Hunter, Dominique Soldati-Favre, Clare R Harding, Sebastian Lourido","doi":"10.1016/j.cell.2026.07.029","DOIUrl":"10.1016/j.cell.2026.07.029","url":null,"abstract":"<p><p>Diverse organisms adjust metabolic gene expression during crowding as they encounter nutrient scarcity, oxidative stress, and waste accumulation. Apicomplexan parasites experience these stresses during intracellular growth within host cells yet lack known regulators of metabolic adaptation. We screened the apicomplexan parasite Toxoplasma gondii to identify genes that support parasite fitness during crowding. Nicotinamide adenine dinucleotide (NAD)(P)<sup>+</sup> biosynthesis was required at high parasite density, along with several parasite-specific factors, including an RNA-binding protein we named \"T. gondii parasite response to oxidation\" (TgPRO). TgPRO loss elevated reactive oxygen species under ambient conditions, which was rescued by growth at low oxygen levels. TgPRO regulates the expression of transcripts involved in carbon metabolism and iron-sulfur cluster assembly. Regulation of the iron-sulfur cluster assembly protein ISCU relies on TgPRO binding to the transcript's 3' UTR. Through convergent evolution, TgPRO performs a role analogous to that of known metabolic regulators from other species, representing the first dedicated regulator of metabolic gene expression in apicomplexans.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"6338-6355.e10"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01Epub Date: 2026-08-31DOI: 10.1016/j.cell.2026.07.058
Raajaram Gowrishankar, Madelyn M Hjort, Abigail J Elerding, Sofia E Shirley, Pranav Senthilkumar, Josie Van Tilburg, David J Marcus, Khalid A Abrera, Dustin Sumarli, Marcelina Wezik, Kat Motovilov, Adam G Gordon, Zhe C Zhou, Chunyang Dong, Lin Tian, Garret D Stuber, Michael R Bruchas
{"title":"Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action.","authors":"Raajaram Gowrishankar, Madelyn M Hjort, Abigail J Elerding, Sofia E Shirley, Pranav Senthilkumar, Josie Van Tilburg, David J Marcus, Khalid A Abrera, Dustin Sumarli, Marcelina Wezik, Kat Motovilov, Adam G Gordon, Zhe C Zhou, Chunyang Dong, Lin Tian, Garret D Stuber, Michael R Bruchas","doi":"10.1016/j.cell.2026.07.058","DOIUrl":"10.1016/j.cell.2026.07.058","url":null,"abstract":"<p><p>Endogenous neuropeptides are uniquely poised to regulate neuronal activity and behavior across multiple timescales. Traditional studies ascribing neuropeptide contributions to behavior lack spatiotemporal precision. The endogenous opioid dynorphin is a neuropeptide highly enriched in the dorsal striatum, a region critical for goal-directed behavior. However, the functional role of endogenous dynorphin- kappa opioid receptor (KOR) signaling in goal-directed behavior is unknown. Here, we report that local, time-locked dynorphin release from dorsomedial striatum medium spiny neurons (MSNs) is necessary and sufficient for goal-directed behavior using a suite of modern approaches, including conditional deletions, neuropeptide biosensor detection, two-photon imaging, and time-locked optogenetic manipulations of neuropeptide release. We discovered that glutamatergic axon terminals from the basolateral amygdala evoke striatal dynorphin release, resulting in feed-forward retrograde presynaptic G protein-coupled receptor (GPCR) inhibition to promote behavior. Collectively, our findings isolate a causal role for endogenous neuropeptide release at rapid timescales and subsequent pre-synaptic Gi-GPCR activity for promoting goal-directed behavior.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":" ","pages":"6522-6542.e8"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CellPub Date : 2026-10-01DOI: 10.1016/j.cell.2026.08.057
Michelle Y Fry, Bridget E Luce, Jonathan A Stefely, Michael Z Chen, Felicia G Deng, Tiana M Issa, Sarah E Calvo, John Samuelson, Vamsi K Mootha, Luke H Chao
{"title":"Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS.","authors":"Michelle Y Fry, Bridget E Luce, Jonathan A Stefely, Michael Z Chen, Felicia G Deng, Tiana M Issa, Sarah E Calvo, John Samuelson, Vamsi K Mootha, Luke H Chao","doi":"10.1016/j.cell.2026.08.057","DOIUrl":"https://doi.org/10.1016/j.cell.2026.08.057","url":null,"abstract":"<p><p>Oxidative phosphorylation (OXPHOS) is a key metabolic process that couples redox energy to ATP production. While some core OXPHOS complex subunits are found across all domains of life, many have diverged or expanded across evolution-as seen in the protozoan pathogen Acanthamoeba castellanii. By integrating cryo-electron microscopy of unenriched mitochondrial lysate with mass spectrometry proteomics, we resolved the structures of endogenous mitochondrial ATP synthase (complex V), Hsp60, and respiratory complex III from Acanthamoeba. We capture Acanthamoeba ATP synthase in an IF1-inhibited state and reveal how Acanthamoeba-specific subunits and extensions stabilize the molecular machine, which includes a β subunit extension that interfaces with the peripheral stalk. Additionally, we characterize an active malate dehydrogenase (MDH) dimer structurally integrated within the ATP synthase peripheral stalk, thus revealing a direct protein tether between OXPHOS and the tricarboxylic acid cycle. Together, these findings provide structural insight into lineage-specific adaptations in Acanthamoeba that may tune protozoan metabolism.</p>","PeriodicalId":9656,"journal":{"name":"Cell","volume":"189 20","pages":"6307-6324.e7"},"PeriodicalIF":45.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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