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Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers. 林奇综合征携带者结直肠癌的免疫预防策略。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000738
Charles M Bowen, Krishna M Sinha, Eduardo Vilar
{"title":"Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers.","authors":"Charles M Bowen, Krishna M Sinha, Eduardo Vilar","doi":"10.1097/PPO.0000000000000738","DOIUrl":"10.1097/PPO.0000000000000738","url":null,"abstract":"<p><strong>Abstract: </strong>The immune revolution that swept the field of oncology in the mid-2010s with the advent of checkpoint inhibitors has led to a paradigm shift in approaches toward adapting new cancer prevention modalities. Cancer vaccines have emerged from this era with astounding potential as a durable intervention to prevent cancers especially for patients with hereditary susceptibilities such as Lynch syndrome carriers. This review covers new insights in the immunoprevention landscape for patients living with Lynch syndrome including highlights ranging from clinical trials exploring the use of chemoprevention agents to boost immune cellularity to investigative studies using novel vaccine approaches to induce long-term antitumor immunity.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"352-356"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targets for Cancer Prevention: Evolving Methodologies in Basic and Epidemiological Sciences Identify Interrelated Pathways and the Need for Holistic Approaches. 癌症预防目标：基础科学和流行病学中不断发展的方法确定了相互关联的途径和整体方法的必要性。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000747
Zora Djuric
{"title":"Targets for Cancer Prevention: Evolving Methodologies in Basic and Epidemiological Sciences Identify Interrelated Pathways and the Need for Holistic Approaches.","authors":"Zora Djuric","doi":"10.1097/PPO.0000000000000747","DOIUrl":"10.1097/PPO.0000000000000747","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"299-300"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Natural Products for Cancer Prevention. 发现预防癌症的天然产品。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000745
Peter J Blanco Carcache, Steven K Clinton, A Douglas Kinghorn
{"title":"Discovery of Natural Products for Cancer Prevention.","authors":"Peter J Blanco Carcache, Steven K Clinton, A Douglas Kinghorn","doi":"10.1097/PPO.0000000000000745","DOIUrl":"10.1097/PPO.0000000000000745","url":null,"abstract":"<p><strong>Abstract: </strong>\"Cancer chemoprevention\" is a term referring to the slowing or reversal of this disease, using nontoxic natural or synthetic compounds. For about 50 years, there has been a strong scientific interest in discovering plant-derived compounds to prevent cancer, and strategies for this purpose using a concerted series of in vitro, ex vivo, and in vivo laboratory bioassays have been developed. Five examples of the more thoroughly investigated agents of this type are described herein, which are each supported by detailed literature reports, inclusive of ellagic acid, isoliquiritigenin, lycopene, trans-resveratrol, and sulforaphane. In addition, extracts of the plants avocado (Persea americana), noni (Morinda citrifolia), açai (Euterpe oleracea), and mangosteen (Garcinia mangostana) have all shown inhibitory activity in an in vivo or ex vivo bioassay using a carcinogen and germane to cancer chemoprevention, and selected in vitro-active constituents are described for each of these 4 species.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"313-319"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overexpression of glyoxalase system enzymes in human kidney tumor: Erratum. 人类肾脏肿瘤中乙二醛酶系统酶的过度表达：勘误。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000739
{"title":"Overexpression of glyoxalase system enzymes in human kidney tumor: Erratum.","authors":"","doi":"10.1097/PPO.0000000000000739","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000739","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"297"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer: Challenges and Opportunities. 循环肿瘤 DNA 在直肠癌患者管理中的作用：挑战与机遇
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000731
Ibrahim Halil Sahin, Rami Yanes, Turcin Saridogan, Jennifer Holder-Murray, Arvind N Dasari
{"title":"The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer: Challenges and Opportunities.","authors":"Ibrahim Halil Sahin, Rami Yanes, Turcin Saridogan, Jennifer Holder-Murray, Arvind N Dasari","doi":"10.1097/PPO.0000000000000731","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000731","url":null,"abstract":"<p><strong>Abstract: </strong>Recently, organ preservation with total neoadjuvant therapy resulted in substantial progress in the management of locally advanced rectal cancer (LARC). The PROSPECT trial showed noninferiority of de-escalation of radiotherapy for patients with low-risk LARC who do not need abdominoperineal resection. Although these escalation and de-escalation approaches offer more personalized therapeutic approaches, the current state of care for patients with rectal cancer is far from individualized management. Circulating tumor DNA (ctDNA) is known to be one of the most powerful prognostic factors for early relapse and has been investigated in several interventional clinical trials to offer more precise treatment algorithms. In this review article, we discuss recent updates from studies examining the role of ctDNA for the prediction of treatment response and recurrence for patients with rectal cancer. We also elaborate on the future potential use of ctDNA in treatment escalation and de-escalation approaches for more personalized therapeutic interventions.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"290-296"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal Cancer-The Only Constant Is Change. 直肠癌--唯一不变的是变化。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000733
Daniel T Chang
{"title":"Rectal Cancer-The Only Constant Is Change.","authors":"Daniel T Chang","doi":"10.1097/PPO.0000000000000733","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000733","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"225-226"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T3N0 Rectal Cancer: Radiation for All, None, or Some? T3N0 直肠癌：全部放疗、不放疗还是部分放疗？
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000726
Zachary R Chalmers, Hannah J Roberts, Jennifer Y Wo
{"title":"T3N0 Rectal Cancer: Radiation for All, None, or Some?","authors":"Zachary R Chalmers, Hannah J Roberts, Jennifer Y Wo","doi":"10.1097/PPO.0000000000000726","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000726","url":null,"abstract":"<p><strong>Abstract: </strong>The optimal management of T3N0 rectal cancer is an area of active debate that has withstood multiple decades of research. In this comprehensive review, we delve into the many nuances that come with treating T3N0 rectal cancer, particularly examining the role and evolution of radiation therapy. We review both the historical paradigms and latest advances in treatment and highlight the significance of precise preoperative staging. As the field continues to evolve, this review highlights a shift toward more tailored treatments, considering both patient goals and the desire for optimal oncologic outcomes. In the current era, clinical decision-making for T3N0 rectal cancer requires a patient-centric approach that balances effective therapy while minimizing undue side effects.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"232-237"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current State of Neoadjuvant Therapy for Locally Advanced Rectal Cancer. 局部晚期直肠癌新辅助疗法的现状。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000725
Sonal S Noticewala, Prajnan Das
{"title":"Current State of Neoadjuvant Therapy for Locally Advanced Rectal Cancer.","authors":"Sonal S Noticewala, Prajnan Das","doi":"10.1097/PPO.0000000000000725","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000725","url":null,"abstract":"<p><strong>Abstract: </strong>In locally advanced rectal cancer, neoadjuvant treatment has evolved from no preoperative treatment to the addition of radiation and systemic therapy and ultimately total neoadjuvant therapy. Total neoadjuvant therapy is the completion of preoperative radiation or chemoradiation and chemotherapy before surgery in order to maximize tumor response and improve survival outcomes. This review summarizes the literature of the neoadjuvant approaches related to locally advanced rectal cancer and highlights the nuances of selecting the appropriate treatment.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"227-231"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point/Counterpoint #2: Current Clinical Considerations With Nonoperative Management of Rectal Cancer. 观点/反方观点 2：直肠癌非手术治疗的当前临床考虑因素。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000732
Greeshma Rajeev-Kumar, Rohan R Katipally, Shen Li, Benjamin D Shogan, Kinga S Olortegui, Janet Chin, Blase N Polite, Stanley L Liauw
{"title":"Point/Counterpoint #2: Current Clinical Considerations With Nonoperative Management of Rectal Cancer.","authors":"Greeshma Rajeev-Kumar, Rohan R Katipally, Shen Li, Benjamin D Shogan, Kinga S Olortegui, Janet Chin, Blase N Polite, Stanley L Liauw","doi":"10.1097/PPO.0000000000000732","DOIUrl":"10.1097/PPO.0000000000000732","url":null,"abstract":"<p><strong>Abstract: </strong>Locally advanced rectal cancer has historically been treated with multimodal therapy consisting of radiation therapy, chemotherapy, and total mesorectal excision. However, recent prospective trials and registry studies have demonstrated similar disease outcomes with nonoperative management for patients who experience an excellent clinical response to radiation and chemotherapy. This article reviews data regarding nonoperative management for rectal cancer, and highlights current challenges and limitations in a point-counterpoint format, in the context of two clinical cases.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"256-263"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point/Counterpoint #1: Chemotherapy Alone Is a Sufficient Preoperative Treatment for Rectal cancer. 观点/反方观点 1：化疗是直肠癌术前治疗的充分手段。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000735
Abhishek Kumar, Manisha Palta, Jingquan Jia
{"title":"Point/Counterpoint #1: Chemotherapy Alone Is a Sufficient Preoperative Treatment for Rectal cancer.","authors":"Abhishek Kumar, Manisha Palta, Jingquan Jia","doi":"10.1097/PPO.0000000000000735","DOIUrl":"10.1097/PPO.0000000000000735","url":null,"abstract":"<p><strong>Abstract: </strong>For decades, the standard neoadjuvant therapy regimen for locally advanced rectal cancer consisted of chemoradiation, surgical resection, and consideration of adjuvant systemic therapy. Additional data have emerged suggesting neoadjuvant systemic therapy as a reasonable alternative to chemoradiation in selected patients. In addition, a total neoadjuvant therapy approach integrating both chemotherapy and chemoradiation results in superior cancer outcomes and the potential for consideration of nonoperative management in patients with a clinical complete response. Despite a multitude of therapeutic pathways for the management of rectal cancer, what is clear, however, is the importance of a multidisciplinary approach with shared patient and provider decision-making.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"251-255"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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