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Repurposing Drugs for Cancer Prevention: Targeting Mechanisms Common to Chronic Diseases. 预防癌症的药物再利用：针对慢性疾病的共同机制。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000746
Nirmal Choradia, Eva Szabo
{"title":"Repurposing Drugs for Cancer Prevention: Targeting Mechanisms Common to Chronic Diseases.","authors":"Nirmal Choradia, Eva Szabo","doi":"10.1097/PPO.0000000000000746","DOIUrl":"10.1097/PPO.0000000000000746","url":null,"abstract":"<p><strong>Abstract: </strong>The development of agents for cancer prevention is a lengthy process requiring a delicate balance between the safety and tolerability of potential interventions and effectiveness in preventing future cancer. Individuals at risk for a specific cancer are frequently at risk for multiple types of cancer as well as other chronic diseases, especially ones associated with aging. Shared environmental exposures, genetic predisposition, metabolic factors, and commonalities in pathogenesis suggest opportunities for combined targeting of cancer and other chronic diseases. Examples discussed here include mechanisms shared between various cancers and obesity, diabetes, and cardiovascular disease.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"345-351"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in Understanding and Preventing Obesity-Related Colon Cancer. 了解和预防肥胖相关结肠癌的进展。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000744
Christine Shieh, Henry J Thompson, Eric McLaughlin, Chien-Wei Chiang, Hisham Hussan
{"title":"Advancements in Understanding and Preventing Obesity-Related Colon Cancer.","authors":"Christine Shieh, Henry J Thompson, Eric McLaughlin, Chien-Wei Chiang, Hisham Hussan","doi":"10.1097/PPO.0000000000000744","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000744","url":null,"abstract":"<p><strong>Abstract: </strong>Obesity and colorectal cancer are global public health issues, with the prevalence of both conditions increasing over the last 4 decades. In the United States alone, the prevalence of obesity is greater than 40%, and this percentage is projected to increase past 50% by 2030. This review focuses on understanding the association between obesity and the risk of colorectal cancer while also highlighting hypotheses about molecular mechanisms underlying the link between these disease processes. We also consider whether those linkages can be disrupted via weight loss therapies, including lifestyle modifications, pharmacotherapy, bariatric surgery, and endobariatrics.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"357-369"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ecosystemic Approach to Understanding Gut Microbiome-Mediated Prevention of Colorectal Cancer. 以生态系统方法了解肠道微生物介导的结直肠癌预防。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000743
Tymofiy Lutsiv, Hisham Hussan, Henry J Thompson
{"title":"Ecosystemic Approach to Understanding Gut Microbiome-Mediated Prevention of Colorectal Cancer.","authors":"Tymofiy Lutsiv, Hisham Hussan, Henry J Thompson","doi":"10.1097/PPO.0000000000000743","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000743","url":null,"abstract":"<p><p>Humans and their associated microorganisms coexist in complex symbiotic relationships. Continuously advancing research is demonstrating the crucial role of host-associated microbiota in the pathophysiology and etiology of disease and in mediating the prevention thereof. As an exemplar, the gut microbiota, especially colonic bacteria, have been extensively studied in colorectal cancer (CRC), and the growing body of evidence establishes new oncomicrobes and their oncometabolites associated with the initiation and promotion of carcinogenesis. Herein, we discuss the importance of approaching the gut microbiome as an ecosystem rather than an assortment of individual factors, especially in the context of cancer prevention. Furthermore, we argue that a dietary pattern effectively drives multiple nodes of the gut microbial ecosystem toward disease- or health-promoting qualities. In the modern circumstances of excessive consumption of ultraprocessed and animal-based foods and concomitant escalation of chronic disease burden worldwide, we focus on whole food-derived dietary fiber as a key to establishing a health-promoting eubiosis in the gut.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"329-344"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What to Eat for Cancer Prevention: The Total Dietary Pattern as a Combination Treatment for Prevention. 吃什么预防癌症？作为预防综合疗法的总体膳食模式。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000741
Yiwen Zhang, Edward L Giovannucci
{"title":"What to Eat for Cancer Prevention: The Total Dietary Pattern as a Combination Treatment for Prevention.","authors":"Yiwen Zhang, Edward L Giovannucci","doi":"10.1097/PPO.0000000000000741","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000741","url":null,"abstract":"<p><strong>Abstract: </strong>Over the past 2 decades, the search for dietary factors for developing cancer prevention guidelines has led to a significant expansion in the study of dietary patterns and their relation to cancer. Dietary patterns, which consider the types, amounts, variety, and combination of consumed foods, may encompass additive, synergistic, or interactive effects on human health, compared with individual nutrients or foods. In this review, we discuss the history and methodologies of dietary pattern research, describe common dietary indices used in cancer research, and summarize the existing evidence on dietary patterns and cancer risk. Current evidence supports the beneficial role of dietary patterns that are rich in vegetables, legumes, whole fruit, and whole grains and limited in added sugars, refined grains, processed foods, and red and processed meat in preventing various cancers, including breast, colorectal, and prostate cancers. Additionally, emerging evidence suggests that dietary patterns based on biological mechanisms, such as hyperinsulinemic diet and inflammatory diet, hold promise and may be priority areas for future research.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"307-312"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telemedicine and cancer care: Barriers and strategies to optimize delivery: Erratum. 远程医疗和癌症护理：远程医疗与癌症护理：优化服务的障碍与策略：勘误。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000748
{"title":"Telemedicine and cancer care: Barriers and strategies to optimize delivery: Erratum.","authors":"","doi":"10.1097/PPO.0000000000000748","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000748","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"370"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers. 林奇综合征携带者结直肠癌的免疫预防策略。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000738
Charles M Bowen, Krishna M Sinha, Eduardo Vilar
{"title":"Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers.","authors":"Charles M Bowen, Krishna M Sinha, Eduardo Vilar","doi":"10.1097/PPO.0000000000000738","DOIUrl":"10.1097/PPO.0000000000000738","url":null,"abstract":"<p><strong>Abstract: </strong>The immune revolution that swept the field of oncology in the mid-2010s with the advent of checkpoint inhibitors has led to a paradigm shift in approaches toward adapting new cancer prevention modalities. Cancer vaccines have emerged from this era with astounding potential as a durable intervention to prevent cancers especially for patients with hereditary susceptibilities such as Lynch syndrome carriers. This review covers new insights in the immunoprevention landscape for patients living with Lynch syndrome including highlights ranging from clinical trials exploring the use of chemoprevention agents to boost immune cellularity to investigative studies using novel vaccine approaches to induce long-term antitumor immunity.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"352-356"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targets for Cancer Prevention: Evolving Methodologies in Basic and Epidemiological Sciences Identify Interrelated Pathways and the Need for Holistic Approaches. 癌症预防目标：基础科学和流行病学中不断发展的方法确定了相互关联的途径和整体方法的必要性。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000747
Zora Djuric
{"title":"Targets for Cancer Prevention: Evolving Methodologies in Basic and Epidemiological Sciences Identify Interrelated Pathways and the Need for Holistic Approaches.","authors":"Zora Djuric","doi":"10.1097/PPO.0000000000000747","DOIUrl":"10.1097/PPO.0000000000000747","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"299-300"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Natural Products for Cancer Prevention. 发现预防癌症的天然产品。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000745
Peter J Blanco Carcache, Steven K Clinton, A Douglas Kinghorn
{"title":"Discovery of Natural Products for Cancer Prevention.","authors":"Peter J Blanco Carcache, Steven K Clinton, A Douglas Kinghorn","doi":"10.1097/PPO.0000000000000745","DOIUrl":"10.1097/PPO.0000000000000745","url":null,"abstract":"<p><strong>Abstract: </strong>\"Cancer chemoprevention\" is a term referring to the slowing or reversal of this disease, using nontoxic natural or synthetic compounds. For about 50 years, there has been a strong scientific interest in discovering plant-derived compounds to prevent cancer, and strategies for this purpose using a concerted series of in vitro, ex vivo, and in vivo laboratory bioassays have been developed. Five examples of the more thoroughly investigated agents of this type are described herein, which are each supported by detailed literature reports, inclusive of ellagic acid, isoliquiritigenin, lycopene, trans-resveratrol, and sulforaphane. In addition, extracts of the plants avocado (Persea americana), noni (Morinda citrifolia), açai (Euterpe oleracea), and mangosteen (Garcinia mangostana) have all shown inhibitory activity in an in vivo or ex vivo bioassay using a carcinogen and germane to cancer chemoprevention, and selected in vitro-active constituents are described for each of these 4 species.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"313-319"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overexpression of glyoxalase system enzymes in human kidney tumor: Erratum. 人类肾脏肿瘤中乙二醛酶系统酶的过度表达：勘误。
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000739
{"title":"Overexpression of glyoxalase system enzymes in human kidney tumor: Erratum.","authors":"","doi":"10.1097/PPO.0000000000000739","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000739","url":null,"abstract":"","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"297"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer: Challenges and Opportunities. 循环肿瘤 DNA 在直肠癌患者管理中的作用：挑战与机遇
IF 2.6 4区 医学
Cancer journal Pub Date : 2024-07-01 DOI: 10.1097/PPO.0000000000000731
Ibrahim Halil Sahin, Rami Yanes, Turcin Saridogan, Jennifer Holder-Murray, Arvind N Dasari
{"title":"The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer: Challenges and Opportunities.","authors":"Ibrahim Halil Sahin, Rami Yanes, Turcin Saridogan, Jennifer Holder-Murray, Arvind N Dasari","doi":"10.1097/PPO.0000000000000731","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000731","url":null,"abstract":"<p><strong>Abstract: </strong>Recently, organ preservation with total neoadjuvant therapy resulted in substantial progress in the management of locally advanced rectal cancer (LARC). The PROSPECT trial showed noninferiority of de-escalation of radiotherapy for patients with low-risk LARC who do not need abdominoperineal resection. Although these escalation and de-escalation approaches offer more personalized therapeutic approaches, the current state of care for patients with rectal cancer is far from individualized management. Circulating tumor DNA (ctDNA) is known to be one of the most powerful prognostic factors for early relapse and has been investigated in several interventional clinical trials to offer more precise treatment algorithms. In this review article, we discuss recent updates from studies examining the role of ctDNA for the prediction of treatment response and recurrence for patients with rectal cancer. We also elaborate on the future potential use of ctDNA in treatment escalation and de-escalation approaches for more personalized therapeutic interventions.</p>","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 4","pages":"290-296"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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