Cancer journal最新文献

Epigenetics of Dietary Phytochemicals in Cancer Prevention: Fact or Fiction. 膳食植物化学物质在癌症预防中的表观遗传学：事实或虚构。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000742

PoChung Jordan Chou, Rebecca Mary Peter, Ahmad Shannar, Yuxin Pan, Parv Dushyant Dave, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong

{"title":"Epigenetics of Dietary Phytochemicals in Cancer Prevention: Fact or Fiction.","authors":"PoChung Jordan Chou, Rebecca Mary Peter, Ahmad Shannar, Yuxin Pan, Parv Dushyant Dave, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong","doi":"10.1097/PPO.0000000000000742","DOIUrl":"10.1097/PPO.0000000000000742","url":null,"abstract":"Abstract: Cancer development takes 10 to 50 years, and epigenetics plays an important role. Recent evidence suggests that ~80% of human cancers are linked to environmental factors impinging upon genetics/epigenetics. Because advanced metastasized cancers are resistant to radiation/chemotherapeutic drugs, cancer prevention by relatively nontoxic \"epigenetic modifiers\" will be logical. Many dietary phytochemicals possess powerful antioxidant and anti-inflammatory properties that are hallmarks of cancer prevention. Dietary phytochemicals can regulate gene expression of the cellular genome via epigenetic mechanisms. In this review, we will summarize preclinical studies that demonstrate epigenetic mechanisms of dietary phytochemicals in skin, colorectal, and prostate cancer prevention. Key examples of the importance of epigenetic regulation in carcinogenesis include hypermethylation of the NRF2 promoter region in cancer cells, resulting in inhibition of NRF2-ARE signaling. Many dietary phytochemicals demethylate NRF2 promoter region and restore NRF2 signaling. Phytochemicals can also inhibit inflammatory responses via hypermethylation of inflammation-relevant genes to block gene expression. Altogether, dietary phytochemicals are excellent candidates for cancer prevention due to their low toxicity, potent antioxidant and anti-inflammatory properties, and powerful epigenetic effects in reversing procarcinogenic events.","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"320-328"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Metabolomic Insights Into Cancer. 代谢组学对癌症的新认识

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000740

Jiangjiang Zhu

{"title":"New Metabolomic Insights Into Cancer.","authors":"Jiangjiang Zhu","doi":"10.1097/PPO.0000000000000740","DOIUrl":"10.1097/PPO.0000000000000740","url":null,"abstract":"Abstract: Cancer has been marked by metabolic irregularities that fuel various aggressive activities such as rapid cell proliferation, evasion of the immune system, and spread to distant organs. Therefore, exploiting cancer metabolism for diagnosis, monitoring, or treatment has been extensively studied in the past couple of decades with various molecular and cellular techniques. More recently, investigating cancer diagnostics and treatments through advanced metabolomics has emerged, and these comprehensive approaches provide a holistic understanding of cancer metabolism, which supported the discovery of metabolic targets relevant across multiple cancer types and the development of more effective treatments. This study offers highlights of new knowledge on cancer metabolism enabled by recent metabolomics studies and their potential applications in aiding cancer research and predicting cancer treatment outcomes. Specifically, we discussed the use of advanced metabolomics in cancer metabolism, tumor microenvironment, and cancer immunotherapy studies to provide valuable insights that can shape future research efforts in the dynamic field of cancer metabolism research.","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"301-306"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing Drugs for Cancer Prevention: Targeting Mechanisms Common to Chronic Diseases. 预防癌症的药物再利用：针对慢性疾病的共同机制。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000746

Nirmal Choradia, Eva Szabo

引用次数: 0

Advancements in Understanding and Preventing Obesity-Related Colon Cancer. 了解和预防肥胖相关结肠癌的进展。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000744

Christine Shieh, Henry J Thompson, Eric McLaughlin, Chien-Wei Chiang, Hisham Hussan

引用次数: 0

Ecosystemic Approach to Understanding Gut Microbiome-Mediated Prevention of Colorectal Cancer. 以生态系统方法了解肠道微生物介导的结直肠癌预防。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000743

Tymofiy Lutsiv, Hisham Hussan, Henry J Thompson

{"title":"Ecosystemic Approach to Understanding Gut Microbiome-Mediated Prevention of Colorectal Cancer.","authors":"Tymofiy Lutsiv, Hisham Hussan, Henry J Thompson","doi":"10.1097/PPO.0000000000000743","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000743","url":null,"abstract":"Humans and their associated microorganisms coexist in complex symbiotic relationships. Continuously advancing research is demonstrating the crucial role of host-associated microbiota in the pathophysiology and etiology of disease and in mediating the prevention thereof. As an exemplar, the gut microbiota, especially colonic bacteria, have been extensively studied in colorectal cancer (CRC), and the growing body of evidence establishes new oncomicrobes and their oncometabolites associated with the initiation and promotion of carcinogenesis. Herein, we discuss the importance of approaching the gut microbiome as an ecosystem rather than an assortment of individual factors, especially in the context of cancer prevention. Furthermore, we argue that a dietary pattern effectively drives multiple nodes of the gut microbial ecosystem toward disease- or health-promoting qualities. In the modern circumstances of excessive consumption of ultraprocessed and animal-based foods and concomitant escalation of chronic disease burden worldwide, we focus on whole food-derived dietary fiber as a key to establishing a health-promoting eubiosis in the gut.","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"329-344"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What to Eat for Cancer Prevention: The Total Dietary Pattern as a Combination Treatment for Prevention. 吃什么预防癌症？作为预防综合疗法的总体膳食模式。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000741

Yiwen Zhang, Edward L Giovannucci

{"title":"What to Eat for Cancer Prevention: The Total Dietary Pattern as a Combination Treatment for Prevention.","authors":"Yiwen Zhang, Edward L Giovannucci","doi":"10.1097/PPO.0000000000000741","DOIUrl":"https://doi.org/10.1097/PPO.0000000000000741","url":null,"abstract":"Abstract: Over the past 2 decades, the search for dietary factors for developing cancer prevention guidelines has led to a significant expansion in the study of dietary patterns and their relation to cancer. Dietary patterns, which consider the types, amounts, variety, and combination of consumed foods, may encompass additive, synergistic, or interactive effects on human health, compared with individual nutrients or foods. In this review, we discuss the history and methodologies of dietary pattern research, describe common dietary indices used in cancer research, and summarize the existing evidence on dietary patterns and cancer risk. Current evidence supports the beneficial role of dietary patterns that are rich in vegetables, legumes, whole fruit, and whole grains and limited in added sugars, refined grains, processed foods, and red and processed meat in preventing various cancers, including breast, colorectal, and prostate cancers. Additionally, emerging evidence suggests that dietary patterns based on biological mechanisms, such as hyperinsulinemic diet and inflammatory diet, hold promise and may be priority areas for future research.","PeriodicalId":9655,"journal":{"name":"Cancer journal","volume":"30 5","pages":"307-312"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine and cancer care: Barriers and strategies to optimize delivery: Erratum. 远程医疗和癌症护理：远程医疗与癌症护理：优化服务的障碍与策略：勘误。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000748

引用次数: 0

Immunoprevention Strategies for Colorectal Cancer in Lynch Syndrome Carriers. 林奇综合征携带者结直肠癌的免疫预防策略。

IF 2.6 4区医学

Cancer journal Pub Date : 2024-09-01 DOI: 10.1097/PPO.0000000000000738

Charles M Bowen, Krishna M Sinha, Eduardo Vilar

引用次数: 0

Targets for Cancer Prevention: Evolving Methodologies in Basic and Epidemiological Sciences Identify Interrelated Pathways and the Need for Holistic Approaches. 癌症预防目标：基础科学和流行病学中不断发展的方法确定了相互关联的途径和整体方法的必要性。

IF 2.6 4区医学